Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxycarboxylic acid receptor 2 | Starlite/ChEMBL | References |
Mus musculus | hydroxycarboxylic acid receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | G-protein coupled receptor, putative | hydroxycarboxylic acid receptor 2 | 363 aa | 294 aa | 20.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1263 | 0.1904 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.6636 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1263 | 0.1904 |
Leishmania major | DNA polymerase eta, putative | 0.0032 | 0.3829 | 0.2937 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.1263 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1263 | 0.1904 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.1263 | 0.1904 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.1263 | 0.1904 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.1263 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1263 | 0.1904 |
Echinococcus granulosus | dna polymerase eta | 0.0046 | 0.6636 | 0.615 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1263 | 0.1904 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0046 | 0.6636 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0032 | 0.3829 | 0.4775 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1263 | 0.1904 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.1263 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1263 | 0.1904 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.002 | 0.1263 | 0.1904 |
Echinococcus multilocularis | dna polymerase eta | 0.0046 | 0.6636 | 0.615 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1263 | 0.1904 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.1263 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0046 | 0.6636 | 0.615 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0046 | 0.6636 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1263 | 0.1904 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.1263 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0046 | 0.6636 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0046 | 0.6636 | 0.615 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1263 | 0.1904 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 47 ml/min.kg | Plasma clearance in C57BL/6 mouse at 1 mg/kg, iv and 2 mg/kg, po | ChEMBL. | 19307116 |
F (ADMET) | = 57 % | Bioavailability in C57BL/6 mouse at 1 mg/kg, iv and 2 mg/kg, po | ChEMBL. | 19307116 |
IC50 (binding) | = 0.08 uM | Displacement of [3H]nicotinic acid from mouse GPR109a receptor | ChEMBL. | 19307116 |
IC50 (binding) | = 0.14 uM | Displacement of [3H]nicotinic acid from human GPR109a receptor | ChEMBL. | 19307116 |
T1/2 (ADMET) | = 1.8 hr | Plasma half life in C57BL/6 mouse at 1 mg/kg, iv and 2 mg/kg, po | ChEMBL. | 19307116 |
Vdss (ADMET) | = 1.79 L/Kg | Volume of distribution at steady state in C57BL/6 mouse at 1 mg/kg, iv and 2 mg/kg, po | ChEMBL. | 19307116 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.