Detailed information for compound 1018204

Basic information

Technical information
  • TDR Targets ID: 1018204
  • Name: 4,6-dichloro-3-[(E)-3-[(4-dimethylaminophenyl )amino]-3-oxoprop-1-enyl]-1H-indole-2-carboxy lic acid
  • MW: 418.273 | Formula: C20H17Cl2N3O3
  • H donors: 3 H acceptors: 3 LogP: 4.55 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)N(C)C)/C=C/c1c([nH]c2c1c(Cl)cc(c2)Cl)C(=O)O
  • InChi: 1S/C20H17Cl2N3O3/c1-25(2)13-5-3-12(4-6-13)23-17(26)8-7-14-18-15(22)9-11(21)10-16(18)24-19(14)20(27)28/h3-10,24H,1-2H3,(H,23,26)(H,27,28)/b8-7+
  • InChiKey: SIGCBOLTXGSTOV-BQYQJAHWSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 4,6-dichloro-3-[(E)-3-[(4-dimethylaminophenyl)amino]-3-oxo-prop-1-enyl]-1H-indole-2-carboxylic acid
  • 4,6-dichloro-3-[(E)-3-[(4-dimethylaminophenyl)amino]-3-keto-prop-1-enyl]-1H-indole-2-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0227 0.0918 0.0912
Trypanosoma brucei hypothetical protein, conserved 0.0227 0.0918 0.0912
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0227 0.0918 0.0918
Echinococcus granulosus geminin 0.0176 0.0635 0.0635
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0227 0.0918 0.1052
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1846 1 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0227 0.0918 0.0918
Trichomonas vaginalis conserved hypothetical protein 0.0588 0.2944 0.2939
Trichomonas vaginalis conserved hypothetical protein 0.1619 0.8727 0.8726
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0588 0.2944 1
Echinococcus multilocularis geminin 0.0176 0.0635 0.0635
Mycobacterium ulcerans putative regulatory protein 0.0588 0.2944 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.1846 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0227 0.0918 0.0912
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1846 1 1
Onchocerca volvulus 0.0064 0.0007 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0227 0.0918 0.1052
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0227 0.0918 0.0918
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0227 0.0918 0.1052
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0815 0.4217 1
Leishmania major hypothetical protein, conserved 0.0227 0.0918 0.0918
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0227 0.0918 0.1052
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0227 0.0918 0.2164
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0227 0.0918 0.1052
Giardia lamblia Fructose-bisphosphate aldolase 0.0304 0.1352 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.1846 1 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0227 0.0918 0.0918
Echinococcus multilocularis aminopeptidase N 0.0064 0.0007 0.0007
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0227 0.0918 0.3102
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1846 1 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0064 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0176 0.0635 0.0635
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.1258 0.6701 0.6699
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0064 0.0007 0.0007
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0227 0.0918 0.0918
Toxoplasma gondii aminopeptidase N protein 0.0064 0.0007 0.0008
Plasmodium falciparum GAF domain-related protein, putative 0.0588 0.2944 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.1846 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0112 0.0276 0.0269
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0227 0.0918 0.2164
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0064 0.0007 0.0007
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0963 0.1103
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0064 0.0007 0.0007
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0815 0.4217 0.4217
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0227 0.0918 0.0918
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0227 0.0918 0.1052
Trypanosoma brucei cAMP-specific phosphodiesterase 0.1846 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0227 0.0918 0.1052
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0227 0.0918 0.0918
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.1352 0.1345
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.1846 1 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0064 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.1846 1 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0227 0.0918 0.0912
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0227 0.0918 0.0918
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0227 0.0918 0.1052
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0064 0.0007 0.0007
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0304 0.1352 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.012 0.0321 0.0486
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0064 0.0007 0.0007
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1846 1 1
Loa Loa (eye worm) hypothetical protein 0.0227 0.0918 0.1413
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0227 0.0918 0.0912
Trichomonas vaginalis conserved hypothetical protein 0.0227 0.0918 0.0912
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0064 0.0007 0.0007
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0227 0.0918 0.3102
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1846 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1846 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0112 0.0276 0.0269
Brugia malayi hypothetical protein 0.0558 0.2776 0.6578
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0227 0.0918 0.0912
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0588 0.2944 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0227 0.0918 0.1052
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0227 0.0918 0.0918
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0064 0.0007 0.0007
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0815 0.4217 0.4213
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0227 0.0918 0.0912
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1846 1 1
Treponema pallidum fructose-bisphosphate aldolase 0.0304 0.1352 0.5
Loa Loa (eye worm) hypothetical protein 0.0227 0.0918 0.1413
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0227 0.0918 0.0912
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1846 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0227 0.0918 0.0912
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0227 0.0918 0.0918
Trypanosoma cruzi hypothetical protein, conserved 0.0227 0.0918 0.0912
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0815 0.4217 0.4213
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.1846 1 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1214 0.6456 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0815 0.4217 0.4217
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0227 0.0918 0.0912
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.012 0.0321 0.0744
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.1846 1 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0227 0.0918 0.0918
Toxoplasma gondii GAF domain-containing protein 0.0588 0.2944 0.3374
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0064 0.0007 0.0007
Toxoplasma gondii hypothetical protein 0.0588 0.2944 0.3374
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0227 0.0918 0.0918
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0227 0.0918 0.0918
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0227 0.0918 0.0912
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0064 0.0007 0.0007
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0227 0.0918 0.0912
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1846 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1846 1 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1846 1 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.0479 0.1627
Plasmodium falciparum phosphodiesterase gamma, putative 0.0227 0.0918 0.3102
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1846 1 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1846 1 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.1258 0.6701 0.6699
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0227 0.0918 0.0912
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.1352 0.1345
Loa Loa (eye worm) hypothetical protein 0.0227 0.0918 0.1413
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0227 0.0918 0.0918
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0227 0.0918 0.0918
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.1352 0.1345
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0227 0.0918 0.0912
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0227 0.0918 0.0918
Plasmodium falciparum phosphodiesterase delta, putative 0.0227 0.0918 0.3102
Leishmania major hypothetical protein, conserved 0.0227 0.0918 0.0918
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0064 0.0007 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.1352 0.1345
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0227 0.0918 0.1413
Trichomonas vaginalis conserved hypothetical protein 0.0227 0.0918 0.0912
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0227 0.0918 0.0912
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.1352 0.1345
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0227 0.0918 0.1052
Echinococcus granulosus potassium voltage gated channel subfamily H 0.012 0.0321 0.0321
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.1258 0.6701 0.6699
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0227 0.0918 0.1052
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0227 0.0918 0.0912
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0304 0.1352 1
Toxoplasma gondii aminopeptidase n, putative 0.0064 0.0007 0.0008
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0227 0.0918 0.1052
Trypanosoma cruzi hypothetical protein, conserved 0.0227 0.0918 0.0912
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0064 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0104 0.0232 0.0348
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1846 1 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0815 0.4217 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.1352 0.1345
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0227 0.0918 0.2164
Trypanosoma cruzi hypothetical protein, conserved 0.0227 0.0918 0.0912
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0227 0.0918 0.1052
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0227 0.0918 0.0912
Loa Loa (eye worm) PDE1B protein 0.0227 0.0918 0.1413
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0064 0.0007 0.0007
Mycobacterium ulcerans putative regulatory protein 0.0588 0.2944 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.1846 1 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.1846 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.012 0.0321 0.0321
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0588 0.2944 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0227 0.0918 0.0918
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0227 0.0918 0.0918
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1846 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1846 1 1
Schistosoma mansoni hypothetical protein 0.0176 0.0635 0.0635
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0064 0.0007 0.0007
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1846 1 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.1846 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0227 0.0918 0.0912
Leishmania major cAMP-specific phosphodiesterase, putative 0.0227 0.0918 0.0918
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0064 0.0007 0.0007
Trypanosoma brucei cAMP-specific phosphodiesterase 0.1846 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.1352 0.1345
Trichomonas vaginalis conserved hypothetical protein 0.1619 0.8727 0.8726
Plasmodium vivax phosphodiesterase gamma, putative 0.0227 0.0918 0.3102
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0064 0.0007 0.0007
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.0479 0.1627
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1214 0.6456 0.6456
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0064 0.0007 0.0007
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0227 0.0918 0.2164
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1846 1 1
Echinococcus granulosus aminopeptidase N 0.0064 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.1619 0.8727 0.8726
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0227 0.0918 0.0918
Plasmodium vivax hypothetical protein, conserved 0.0588 0.2944 1
Loa Loa (eye worm) hypothetical protein 0.0588 0.2944 0.4555
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0064 0.0007 0.0007
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0227 0.0918 0.3102
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0227 0.0918 0.1052
Toxoplasma gondii hypothetical protein 0.0588 0.2944 0.3374
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0815 0.4217 0.4217
Toxoplasma gondii hypothetical protein 0.1619 0.8727 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0227 0.0918 0.3102
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0227 0.0918 0.0912
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0227 0.0918 0.0918
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0227 0.0918 0.1052
Schistosoma mansoni aminopeptidase A (M01 family) 0.0064 0.0007 0.0007
Mycobacterium ulcerans aminopeptidase N PepN 0.0064 0.0007 0.0025
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1846 1 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.1846 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.0383 0.0383
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1846 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0227 0.0918 0.0912
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0963 0.1103
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0227 0.0918 0.3102
Onchocerca volvulus 0.0064 0.0007 0.5
Onchocerca volvulus 0.0064 0.0007 0.5
Loa Loa (eye worm) hypothetical protein 0.0815 0.4217 0.6529
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.1846 1 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1214 0.6456 0.6456
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.0383 0.0383
Toxoplasma gondii aminopeptidase N, putative 0.0064 0.0007 0.0008
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0227 0.0918 0.3102
Mycobacterium ulcerans aminopeptidase N PepN 0.0064 0.0007 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.1352 0.1345
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0227 0.0918 0.0912
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.1846 1 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0227 0.0918 0.3102
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0227 0.0918 0.0918
Mycobacterium leprae conserved hypothetical protein 0.0588 0.2944 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0227 0.0918 0.0918
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0815 0.4217 0.4213
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0227 0.0918 0.1052
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.1846 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0227 0.0918 0.0912
Echinococcus granulosus leukotriene A 4 hydrolase 0.1214 0.6456 0.6456

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.