TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 362.4 | Formula: C20H27O4P
H donors: 3 H acceptors: 4 LogP: 3.78 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cc(CCP(=O)(O)O)cc(c1Cc1ccc(c(c1)C(C)C)O)C
InChi: 1S/C20H27O4P/c1-13(2)18-11-16(5-6-20(18)21)12-19-14(3)9-17(10-15(19)4)7-8-25(22,23)24/h5-6,9-11,13,21H,7-8,12H2,1-4H3,(H2,22,23,24)
InChiKey: HAUMMAHCGKEHHL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	thyroid hormone receptor, alpha	Starlite/ChEMBL	References
Homo sapiens	thyroid hormone receptor, beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853
Brugia malayi	Nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853
Schistosoma mansoni	thyroid hormone receptor	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus multilocularis	thyroid hormone receptor alpha	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	Thyroid hormone receptor alpha, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Brugia malayi	Nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853
Schistosoma japonicum	expressed protein	Get druggable targets OG5_134830	All targets in OG5_134830
Loa Loa (eye worm)	nuclear hormone receptor-like 1	Get druggable targets OG5_156853	All targets in OG5_156853
Schistosoma japonicum	Thyroid hormone receptor alpha, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	Get druggable targets OG5_134830	All targets in OG5_134830
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_156853	All targets in OG5_156853
Schistosoma mansoni	thyroid hormone receptor	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative	Get druggable targets OG5_134830	All targets in OG5_134830

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	photoreceptor-specific nuclear receptor	thyroid hormone receptor, alpha	451 aa	372 aa	25.3 %
Brugia malayi	photoreceptor-specific nuclear receptor	thyroid hormone receptor, beta	461 aa	414 aa	24.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0198	0.3687	0.363
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0024	0.0266	0.0178
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0046	0.0694	0.0605
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0019	0.0165	0.0585
Echinococcus multilocularis	musashi	0.0032	0.0414	0.0328
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0658	0.0568
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0028	0.0346	0.481
Plasmodium falciparum	ataxin-2 like protein, putative	0.0054	0.0854	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0046	0.0694	0.061
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.079	0.1095
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0026	0.0297	0.1052
Schistosoma mansoni	hypothetical protein	0.0519	1	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0046	0.0694	0.1126
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0028	0.0346	0.481
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0046	0.0694	0.061
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0016	0.0095	0.0006
Schistosoma mansoni	aldehyde dehydrogenase	0.0072	0.12	0.1115
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0315
Brugia malayi	nuclear hormone receptor family member odr-7	0.0022	0.0215	0.0177
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0046	0.0694	0.061
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0152	0.278	0.2714
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0315
Brugia malayi	photoreceptor-specific nuclear receptor	0.0046	0.0694	0.0942
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0028	0.0346	0.0784
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0293	0.5559	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0658	0.0574
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0036	0.0505	0.0732
Brugia malayi	nuclear receptor RXR	0.0022	0.0215	0.0177
Mycobacterium ulcerans	thioesterase	0.0022	0.0226	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0078	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0266	0.0402
Loa Loa (eye worm)	histone methyltransferase	0.0019	0.0171	0.024
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0027	0.0314	0.0662
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.2519	0.4017
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0024	0.0265	0.0177
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0215	0.0177
Toxoplasma gondii	type I fatty acid synthase, putative	0.0019	0.0162	0.0521
Schistosoma mansoni	lamin	0.0032	0.0414	0.0322
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.0599	0.0239
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0022	0.0215	0.0126
Echinococcus multilocularis	lamin dm0	0.0032	0.0414	0.0328
Trichomonas vaginalis	ap endonuclease, putative	0.0036	0.0505	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0036	0.0505	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0078	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0694	0.1126
Brugia malayi	Nuclear hormone receptor-like 1	0.0312	0.5934	0.9316
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0016	0.0095	0.0006
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0028	0.0346	0.1225
Schistosoma mansoni	zinc finger protein	0.0022	0.0215	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0315
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0312	0.5934	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0063	0.1028	0.1691
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0046	0.0694	0.061
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0279	0.0279
Onchocerca volvulus		0.0063	0.1028	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0694	0.1126
Onchocerca volvulus	Protein ultraspiracle homolog	0.0046	0.0694	0.5896
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0024	0.0265	0.0177
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0022	0.0215	0.0126
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.079	0.1095
Loa Loa (eye worm)	hepatopoietin HPO2	0.0035	0.0477	0.0759
Trypanosoma brucei	PAB1-binding protein , putative	0.0054	0.0854	0.0741
Schistosoma mansoni	nuclear receptor	0.0022	0.0215	0.0121
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0046	0.0694	0.5896
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0046	0.0694	0.0942
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0215	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0694	0.1126
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0046	0.0694	0.061
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0215	0.0126
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0027	0.0314	0.0662
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0046	0.0694	0.061
Brugia malayi	nuclear receptor NHR-88	0.0046	0.0694	0.0942
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0104	0.0015
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0027	0.0314	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0694	0.1126
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0658	0.0568
Schistosoma mansoni	lamin	0.0032	0.0414	0.0322
Onchocerca volvulus		0.0032	0.0414	0.2454
Schistosoma mansoni	aldehyde dehydrogenase	0.0072	0.12	0.1115
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0022	0.0215	0.0126
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0022	0.0215	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0315
Schistosoma mansoni	ap endonuclease	0.0036	0.0505	0.0413
Brugia malayi	F/Y-rich N-terminus family protein	0.0019	0.0166	0.0099
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.004	0.0574	0.203
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0027	0.0314	0.1109
Trypanosoma cruzi	PAB1-binding protein , putative	0.0054	0.0854	0.0741
Echinococcus multilocularis	FTZ F1 alpha	0.0046	0.0694	0.061
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0022	0.0215	0.0126
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0139	0.2519	0.4017
Onchocerca volvulus		0.0032	0.0414	0.2454
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0266	0.0402
Echinococcus multilocularis	ecdysone induced protein 78C	0.0046	0.0694	0.061
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0104	0.0015
Loa Loa (eye worm)	steroid hormone receptor	0.0046	0.0694	0.1126
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0854	0.1396
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0046	0.0694	0.0605
Trichomonas vaginalis	ap endonuclease, putative	0.0036	0.0505	1
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0022	0.0211	0.172
Schistosoma mansoni	nuclear receptor nhr-48	0.0022	0.0215	0.0121
Schistosoma mansoni	cpg binding protein	0.0067	0.1099	0.1013
Schistosoma mansoni	thyroid hormone receptor	0.0198	0.3687	0.3626
Echinococcus granulosus	nuclear receptor nhr 48	0.0022	0.0215	0.0126
Schistosoma mansoni	ap endonuclease	0.0036	0.0505	0.0413
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0022	0.0215	0.0126
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.079	0.1288
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0022	0.0215	0.0121
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0046	0.0694	0.0942
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.0599	0.0239
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0028	0.0346	0.1225
Echinococcus granulosus	dnaJ subfamily B	0.048	0.9235	0.9228
Schistosoma mansoni	thyroid hormone receptor	0.0198	0.3687	0.3626
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0036	0.0505	0.0054
Echinococcus granulosus	intermediate filament protein	0.0032	0.0414	0.0328
Schistosoma mansoni	cpg binding protein	0.0067	0.1099	0.1013
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0293	0.5559	1
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0027	0.0314	0.1109
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0019	0.0171	0.0082
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0658	0.1065
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0266	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0672	0.1088
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0051	0.0785	0.1088
Mycobacterium ulcerans	polyketide synthase	0.0028	0.0346	0.0784
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0024	0.0266	0.0178
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0104	0.0015
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0046	0.0694	0.0942
Mycobacterium leprae	Polyketide synthase Pks13	0.004	0.0574	1
Echinococcus granulosus	lamin	0.0032	0.0414	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0315
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0017	0.0129	0.0362
Schistosoma mansoni	RAR-like nuclear receptor	0.0046	0.0694	0.0605
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0046	0.0694	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0315
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0046	0.0694	0.061
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0024	0.0266	0.0173
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0019	0.0171	0.0082
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0046	0.0694	0.0942
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0072	0.12	0.1422
Brugia malayi	nuclear receptor RXR	0.0024	0.0266	0.0259
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0046	0.0694	0.0942
Plasmodium vivax	ataxin-2 like protein, putative	0.0054	0.0854	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0266	0.0402
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0046	0.0694	0.061
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0015	0.0086	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0315
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0104	0.0127
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0036	0.0505	0.1372
Echinococcus granulosus	cpg binding protein	0.0067	0.1099	0.1018
Toxoplasma gondii	Erv1 / Alr family protein	0.0035	0.0477	0.2034
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0025	0.0279	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0127
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0027	0.0314	0.4065
Brugia malayi	exodeoxyribonuclease III family protein	0.0036	0.0505	0.064
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0694	0.1126
Brugia malayi	Nuclear hormone receptor E75	0.0022	0.0215	0.0177
Schistosoma mansoni	hypothetical protein	0.0024	0.0265	0.0172
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0599	0.0239
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0658	0.0574
Leishmania major	mitochondrial DNA polymerase beta	0.0293	0.5559	1
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	0.0035	0.0477	0.0391
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0046	0.0694	0.1126
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0028	0.0346	0.0784
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0036	0.0505	0.0054
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0022	0.0215	0.0121
Plasmodium falciparum	ataxin-2 like protein, putative	0.0054	0.0854	1
Mycobacterium ulcerans	polyketide synthase Pks13	0.004	0.0574	0.163
Trypanosoma cruzi	PAB1-binding protein , putative	0.0054	0.0854	0.0741
Brugia malayi	nuclear receptor NHR-67	0.0022	0.0215	0.0177
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0152	0.278	0.2714
Brugia malayi	Nuclear hormone receptor-like 1	0.0334	0.6362	1
Mycobacterium ulcerans	polyketide synthase	0.0027	0.0314	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0051	0.079	0.1288
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0046	0.0694	0.1126
Brugia malayi	Nuclear hormone receptor-like 1	0.0312	0.5934	0.9316
Brugia malayi	intermediate filament protein	0.0032	0.0414	0.0495
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0215	0.0126
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0046	0.0694	0.061
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0036	0.0505	0.5
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0027	0.0314	0.4065
Leishmania major	hypothetical protein, conserved	0.0054	0.0854	0.0741
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0028	0.0346	0.1225
Brugia malayi	orphan nuclear receptor NR2E1	0.0022	0.0215	0.0177
Schistosoma mansoni	cpg binding protein	0.0063	0.1028	0.0941
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0046	0.0694	0.0942
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0036	0.0505	0.5
Brugia malayi	tailless protein	0.0022	0.0215	0.0177
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.2519	0.4017
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0022	0.0226	0.2064
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0046	0.0694	0.0942
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0072	0.12	0.3954
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0104	0.0015
Toxoplasma gondii	LsmAD domain-containing protein	0.0054	0.0854	0.384
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0104	0.0015
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0022	0.0215	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0266	0.0402
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0123	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0694	0.1126
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0027	0.0314	0.0662
Echinococcus multilocularis	dnaJ subfamily B	0.048	0.9235	0.9228
Brugia malayi	hypothetical protein	0.0022	0.0215	0.0177
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0046	0.0694	0.0605
Brugia malayi	CXXC zinc finger family protein	0.0063	0.1028	0.1476
Toxoplasma gondii	hypothetical protein	0.0047	0.0718	0.319
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0046	0.0694	0.1126
Brugia malayi	conserved hypotetical protein	0.0022	0.0215	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0015	0.009	0.0103
Schistosoma mansoni	coup transcription factor	0.0046	0.0694	0.0605
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0046	0.0694	0.0605
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0036	0.0505	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0403	0.0633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0022	0.0211	0.028
Echinococcus multilocularis	cpg binding protein	0.0067	0.1099	0.1018
Echinococcus multilocularis	nuclear receptor nhr 48	0.0022	0.0215	0.0126
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0658	0.0568
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0072	0.12	0.4243
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0026	0.0297	0.1052
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0046	0.0694	0.1126
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0315
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0022	0.0226	0.0799
Echinococcus granulosus	thyroid hormone receptor alpha	0.0022	0.0215	0.0126
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0036	0.0505	0.0054
Toxoplasma gondii	exonuclease III APE	0.0036	0.0505	0.2166
Echinococcus granulosus	GPCR family 2	0.0016	0.0104	0.0015
Onchocerca volvulus	Fatty acid synthase homolog	0.0048	0.0736	0.6411
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0473	0.0588
Schistosoma mansoni	nuclear hormone receptor	0.0046	0.0694	0.0605
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0599	0.0239
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.004	0.0574	0.203
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0036	0.0505	0.1785
Brugia malayi	hypothetical protein	0.0022	0.0215	0.0177
Schistosoma mansoni	hypothetical protein	0.0016	0.0104	0.0009
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0046	0.0694	0.1126
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0694	0.1126
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0046	0.0694	0.061
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0215	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0414	0.0652
Schistosoma mansoni	hypothetical protein	0.0016	0.0104	0.0009
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0016	0.0095	0.0006
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0293	0.5559	1
Brugia malayi	hypothetical protein	0.0054	0.0854	0.1197
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0028	0.0346	0.481
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0025	0.0279	0.0987
Schistosoma mansoni	hypothetical protein	0.048	0.9235	0.9227
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0046	0.0694	0.061
Echinococcus multilocularis	lamin	0.0032	0.0414	0.0328
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0658	0.0574
Schistosoma mansoni	hypothetical protein	0.0152	0.278	0.271
Onchocerca volvulus		0.0025	0.0279	0.0787
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0036	0.0505	0.0054
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0119	0.2138	1
Loa Loa (eye worm)	hypothetical protein	0.031	0.5883	0.9913
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0036	0.0505	0.0805
Echinococcus granulosus	lamin dm0	0.0032	0.0414	0.0328
Onchocerca volvulus	Bile acid receptor homolog	0.0046	0.0694	0.5896
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0694	0.1126
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0082	0.009
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0046	0.0694	0.0942
Schistosoma mansoni	hypothetical protein	0.0519	1	1
Toxoplasma gondii	Erv1 / Alr family protein	0.0035	0.0477	0.2034
Brugia malayi	hypothetical protein	0.0035	0.0476	0.0593
Schistosoma mansoni	retinoic acid receptor RXR	0.0046	0.0694	0.0605
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0036	0.0505	0.0419
Loa Loa (eye worm)	intermediate filament protein	0.0032	0.0414	0.0652
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	0.0035	0.0477	0.0391
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0036	0.0505	0.0419
Brugia malayi	Augmenter of liver regeneration	0.0035	0.0477	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0315
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0776	0.0589
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0046	0.0694	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0315
Onchocerca volvulus		0.0046	0.0694	0.5896
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0022	0.0215	0.0177
Brugia malayi	steroid hormone receptor	0.0046	0.0694	0.0942
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0046	0.0694	0.0942
Brugia malayi	nuclear hormone receptor	0.0046	0.0694	0.0942
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0072	0.12	0.3954
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0022	0.0215	0.0315
Echinococcus granulosus	ecdysone induced protein 78C	0.0046	0.0694	0.061
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0027	0.0314	0.1109
Brugia malayi	hypothetical protein	0.0024	0.0266	0.0259
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0072	0.12	0.3954
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0072	0.12	0.112
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0046	0.0694	0.0942
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0022	0.0215	0.0126
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0046	0.0694	0.1126
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0658	0.0885
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0046	0.0694	0.0605
Brugia malayi	Nuclear hormone receptor E75	0.0022	0.0215	0.0177
Onchocerca volvulus		0.0047	0.0703	0.6009
Schistosoma mansoni	nuclear receptor	0.0022	0.0215	0.0121
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0046	0.0694	0.061
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0036	0.0505	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0315
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0046	0.0694	0.0942
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0072	0.12	0.112
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0473	0.0751
Loa Loa (eye worm)	fatty acid synthase	0.0026	0.0307	0.047
Brugia malayi	ecdysone receptor	0.0022	0.0215	0.0177
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0123	0.003
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0134	0.2419	0.2346
Schistosoma mansoni	intermediate filament proteins	0.0032	0.0414	0.0322
Mycobacterium ulcerans	thioesterase TesA	0.0022	0.0226	0.0336
Schistosoma mansoni	hypothetical protein	0.0035	0.0473	0.0381
Schistosoma mansoni	hypothetical protein	0.0016	0.0104	0.0009
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0024	0.0266	0.0173
Toxoplasma gondii	type I fatty acid synthase, putative	0.0028	0.0346	0.1406
Echinococcus multilocularis	geminin	0.0519	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0046	0.0694	0.0942
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0022	0.0218	0.077
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0016	0.0095	0.0006
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0022	0.0215	0.0126
Mycobacterium ulcerans	hypothetical protein	0.0154	0.2827	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0215	0.0315
Brugia malayi	ecdysteroid receptor	0.0046	0.0694	0.0942
Schistosoma mansoni	hypothetical protein	0.0016	0.0104	0.0009
Echinococcus granulosus	FTZ F1 alpha	0.0046	0.0694	0.061
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0032	0.0414	0.0652
Loa Loa (eye worm)	nuclear hormone receptor	0.0022	0.0215	0.0315
Loa Loa (eye worm)	DR-78	0.0022	0.0215	0.0315
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0658	0.0574
Brugia malayi	hypothetical protein	0.0024	0.0266	0.0259
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0027	0.0314	0.0662
Brugia malayi	nuclear hormone receptor	0.0022	0.0215	0.0177
Brugia malayi	Steroid receptor seven-up type 2	0.0046	0.0694	0.0942
Toxoplasma gondii	aldehyde dehydrogenase	0.0072	0.12	0.55
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0046	0.0694	0.0942
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0046	0.0694	0.061
Brugia malayi	Intermediate filament tail domain containing protein	0.0032	0.0414	0.0495
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0154	0.2827	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0022	0.0211	0.028

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 31.3 nM	Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay	ChEMBL.	18975928
Ki (binding)	= 378 nM	Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay	ChEMBL.	18975928

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL519215

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1018480