Detailed information for compound 1018809

Basic information

Technical information
  • TDR Targets ID: 1018809
  • Name: 2-[4-[(2-butyl-5-ethoxycarbonyl-6-oxopyrimidi n-1-yl)methyl]phenyl]benzoic acid
  • MW: 434.484 | Formula: C25H26N2O5
  • H donors: 1 H acceptors: 4 LogP: 3.9 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCc1ncc(c(=O)n1Cc1ccc(cc1)c1ccccc1C(=O)O)C(=O)OCC
  • InChi: 1S/C25H26N2O5/c1-3-5-10-22-26-15-21(25(31)32-4-2)23(28)27(22)16-17-11-13-18(14-12-17)19-8-6-7-9-20(19)24(29)30/h6-9,11-15H,3-5,10,16H2,1-2H3,(H,29,30)
  • InChiKey: LLTDCFCMXWWCTD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-[(2-butyl-5-ethoxycarbonyl-6-oxo-pyrimidin-1-yl)methyl]phenyl]benzoic acid
  • 2-[4-[(2-butyl-5-ethoxycarbonyl-6-oxo-1-pyrimidinyl)methyl]phenyl]benzoic acid
  • 2-[4-[(2-butyl-5-carbethoxy-6-keto-pyrimidin-1-yl)methyl]phenyl]benzoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major aldehyde dehydrogenase, putative 0.0011 0.0018 0.0001
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0064 0.0138
Echinococcus granulosus peregrin 0.004 0.0381 0.0441
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0209 0.0191
Trypanosoma brucei unspecified product 0.0124 0.1394 0.41
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0011 0.0018 0.0001
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0145 0.0657
Trypanosoma brucei DNA polymerase kappa, putative 0.0208 0.2411 0.7132
Trypanosoma brucei Metacaspase-4 0.0026 0.0209 0.0569
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0387 0.11
Trypanosoma cruzi DNA polymerase kappa, putative 0.0208 0.2411 0.7132
Brugia malayi Probable ClpP-like protease 0.0085 0.092 0.0903
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0021 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0021 0.0003
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.0784 0.3732
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0368 0.0351
Entamoeba histolytica hypothetical protein 0.0075 0.0806 0.3838
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0011 0.002 0.0089
Trichomonas vaginalis dullard protein, putative 0.0025 0.0199 0.0199
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0011 0.0018 0.0001
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0085 0.092 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0784 0.2283
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.002 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0021 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0208 0.2411 0.7132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0274 0.0256
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0199 0.0199
Trichomonas vaginalis set domain proteins, putative 0.025 0.2927 0.2927
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0021 0.0003
Trichomonas vaginalis dullard protein, putative 0.0025 0.0199 0.0199
Loa Loa (eye worm) glutaminase 0.0833 1 1
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0011 0.0018 0.0082
Echinococcus granulosus geminin 0.0687 0.823 1
Schistosoma mansoni ran 0.0021 0.0145 0.0127
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0191 0.2208 0.2268
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0011 0.0018 0.0001
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0025 0.0199 0.0187
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0387 0.374
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0209 0.0209
Brugia malayi Cell death protein 3 precursor 0.0026 0.0209 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0208 0.2411 0.7132
Loa Loa (eye worm) hypothetical protein 0.0032 0.0285 0.0268
Echinococcus granulosus caspase 2 0.0026 0.0209 0.0232
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0021 0.0003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0021 0.0003
Entamoeba histolytica hypothetical protein 0.0075 0.0806 0.3838
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0021 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0011 0.002 0.0189
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0025 0.0199 0.0844
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.0784 0.0767
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0625 0.0629
Loa Loa (eye worm) hypothetical protein 0.0026 0.0209 0.0191
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0387 0.11
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.092 0.5
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0209 0.2019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0021 0.0003
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0025 0.0199 0.022
Loa Loa (eye worm) hypothetical protein 0.0287 0.3373 0.336
Brugia malayi steroid hormone receptor 0.0011 0.0021 0.0003
Mycobacterium ulcerans DNA polymerase IV 0.0208 0.2411 0.2397
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0021 0.0003
Leishmania major aldehyde dehydrogenase, putative 0.0011 0.0018 0.0001
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0011 0.0018 0.0001
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0011 0.0018 0.0082
Echinococcus granulosus snurportin 1 0.0304 0.3582 0.4339
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0026 0.0209 0.0232
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.001 0.0018 0.0081
Brugia malayi Bromodomain containing protein 0.004 0.0381 0.0363
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0021 0.0009
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0011 0.0018 0.0001
Entamoeba histolytica acetyltransferase, GNAT family 0.0086 0.0939 0.4489
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0025 0.0112
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1093 0.1076
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0285 0.2755
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0536 0.0519
Plasmodium vivax DNA repair protein REV1, putative 0.0056 0.0567 0.5481
Echinococcus multilocularis snurportin 1 0.0304 0.3582 0.3691
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0199 0.0199
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0145 0.138
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0025 0.0007
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0021 0.0003
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0094 0.1035 0.3031
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0021 0.0003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0021 0.0003
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.002 0.0005
Schistosoma mansoni hypothetical protein 0.0031 0.0271 0.0253
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0191 0.2208 0.6527
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0011 0.0018 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0003
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0025 0.0008
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0784 0.2283
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0245 0.2518
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0003
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0025 0.0007
Echinococcus multilocularis peregrin 0.004 0.0381 0.0375
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0625 0.0629
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0021 0.0009
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0011 0.0018 0.0001
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0237 0.0651
Trichomonas vaginalis bromodomain-containing protein, putative 0.0094 0.1035 0.1035
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0186 0.2154 0.9756
Loa Loa (eye worm) hypothetical protein 0.0068 0.0712 0.0695
Trypanosoma brucei metacaspase MCA2 0.0026 0.0209 0.0569
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0021 0.0003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0021 0.0003
Schistosoma mansoni hypothetical protein 0.0068 0.0712 0.0695
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0806 0.0816
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0625 0.0739
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0094 0.1035 0.1035
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0094 0.1035 0.3031
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0209 0.0209
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0245 0.2465
Onchocerca volvulus 0.025 0.2927 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0285 0.0268
Plasmodium falciparum phd finger protein, putative 0.0032 0.0285 0.2899
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0209 0.0209
Schistosoma mansoni terminal deoxycytidyl transferase 0.0179 0.207 0.2055
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0209 0.0209
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1093 0.1076
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0387 0.037
Echinococcus granulosus dna polymerase kappa 0.0208 0.2411 0.2913
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0218 0.2534 0.2606
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0094 0.1035 0.1019
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0917 0.0901
Brugia malayi PHD-finger family protein 0.0032 0.0285 0.0268
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0034 0.0016
Onchocerca volvulus 0.0032 0.0274 0.0877
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0021 0.0003
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0216 0.0216
Echinococcus granulosus histone acetyltransferase KAT2B 0.0094 0.1035 0.1238
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.1627 0.1959
Trypanosoma cruzi DNA damage repair protein, putative 0.0056 0.0567 0.1637
Brugia malayi mbt repeat family protein 0.0053 0.0536 0.0519
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.092 0.5
Echinococcus granulosus importin subunit beta 1 0.0028 0.0237 0.0266
Trichomonas vaginalis dullard protein, putative 0.0025 0.0199 0.0199
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0237 0.1071
Schistosoma mansoni DNA polymerase eta 0.0287 0.3373 0.336
Plasmodium falciparum DNA repair protein REV1, putative 0.0056 0.0567 0.5959
Echinococcus granulosus CTD small phosphatase protein like 0.0025 0.0199 0.022
Echinococcus granulosus jumonji domain containing protein 0.0045 0.044 0.0513
Trichomonas vaginalis ran, putative 0.0021 0.0145 0.0145
Trypanosoma brucei unspecified product 0.0201 0.2326 0.688
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0111 0.1065
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0.0025 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0021 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0003
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0145 0.1403
Loa Loa (eye worm) hypothetical protein 0.0026 0.0209 0.0191
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0387 0.4092
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0108 0.0487
Trypanosoma cruzi metacaspase, putative 0.0026 0.0209 0.0569
Trypanosoma brucei DNA polymerase kappa, putative 0.0131 0.1478 0.4352
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0085 0.092 1
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0199 0.0181
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0085 0.092 1
Brugia malayi Importin beta-1 subunit 0.0028 0.0237 0.0219
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0625 0.0608
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0145 0.0379
Plasmodium vivax importin-beta 2, putative 0.0028 0.0237 0.2285
Brugia malayi AF-10 protein 0.0011 0.002 0.0002
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0011 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0084 0.0908 0.0891
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0908 0.2653
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0209 0.0569
Loa Loa (eye worm) hypothetical protein 0.0135 0.1526 0.151
Schistosoma mansoni hypothetical protein 0.0687 0.823 0.8227
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0021 0.0003
Trypanosoma cruzi metacaspase, putative 0.0026 0.0209 0.0569
Trypanosoma brucei DNA polymerase kappa, putative 0.0208 0.2411 0.7132
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0274 0.0265
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0285 0.1291
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0408 0.0404
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0387 0.11
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0536 0.0519
Echinococcus multilocularis dna polymerase kappa 0.0208 0.2411 0.2479
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0026 0.0209 0.0191
Onchocerca volvulus Huntingtin homolog 0.0134 0.1521 0.5166
Brugia malayi ImpB/MucB/SamB family protein 0.0179 0.207 0.2055
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.026 0.0294
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0209 0.0946
Trypanosoma cruzi DNA polymerase kappa, putative 0.0208 0.2411 0.7132
Brugia malayi PHD-finger family protein 0.0011 0.002 0.0002
Loa Loa (eye worm) acetyltransferase 0.032 0.378 0.3769
Leishmania major GTP-binding protein, putative 0.0021 0.0145 0.0379
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.092 0.4165
Brugia malayi jmjC domain containing protein 0.0106 0.1183 0.1167
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0021 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0021 0.0003
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0271 0.0253
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0565 0.0666
Plasmodium vivax SET domain protein, putative 0.0032 0.0274 0.2642
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0368 0.0426
Brugia malayi polk-prov protein 0.0084 0.0908 0.0891
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0026 0.0209 0.0198
Echinococcus granulosus dna polymerase eta 0.0287 0.3373 0.4085
Brugia malayi ecdysteroid receptor 0.0011 0.0021 0.0003
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0387 0.1727
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0209 0.0209
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0199 0.0181
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0245 0.2369
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0387 0.0387
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0625 0.0739
Schistosoma mansoni DNA helicase recq5 0.0011 0.0025 0.0007
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0011 0.0018 0.0001
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0565 0.0567
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.092 0.0903
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0176 0.1715
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0191 0.2208 1
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0536 0.0631
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0209 0.0191
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0021 0.0003
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0387 0.4092
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0094 0.1035 0.3031
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0094 0.1035 0.4686
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0145 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.0208 0.2411 0.7132
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0387 0.1798
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0285 0.0277
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0021 0.0003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0806 0.0959
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.0216 0.0216
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.092 0.0903
Giardia lamblia Histone acetyltransferase GCN5 0.0086 0.0939 0.4312
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0021 0.0003
Echinococcus multilocularis caspase 8 0.0026 0.0209 0.0198
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0199 0.1919
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0387 0.0387
Echinococcus multilocularis bloom syndrome protein 0.0027 0.0216 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0209 0.0209
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0271 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.0131 0.1478 0.4352
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0387 0.0369
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0237 0.0226
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0271 0.0308
Trypanosoma brucei DNA polymerase IV, putative 0.0201 0.2326 0.688
Echinococcus granulosus caspase 0.0026 0.0209 0.0232
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0011 0.0018 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0274 0.0256
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0021 0.0003
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0285 0.0268
Entamoeba histolytica protein kinase, putative 0.0094 0.1035 0.4956
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0011 0.0018 0.0001
Toxoplasma gondii aldehyde dehydrogenase 0.0191 0.2208 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0274 0.0311
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0199 0.0199
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0536 0.0519
Toxoplasma gondii hypothetical protein 0.0029 0.0245 0.111
Schistosoma mansoni coup transcription factor 0.0011 0.0021 0.0003
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0011 0.0018 0.0001
Brugia malayi glutaminase DH11.1 0.0833 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0806 0.0789
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0056 0.0567 0.2568
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0208 0.2411 0.2411
Brugia malayi Pre-SET motif family protein 0.022 0.2559 0.2545
Schistosoma mansoni DNA polymerase IV / kappa 0.0056 0.0567 0.055
Trypanosoma brucei DNA damage repair protein, putative 0.0056 0.0567 0.1637
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0285 0.0325
Brugia malayi nuclear receptor NHR-88 0.0011 0.0021 0.0003
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.0784 0.0793
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0209 0.0209
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0536 0.178
Schistosoma mansoni DNA helicase recq1 0.0011 0.0025 0.0007
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0021 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.0208 0.2411 0.7132
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0209 0.0946
Loa Loa (eye worm) hypothetical protein 0.0085 0.092 0.0903
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0209 0.0946
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0021 0.0003
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0106 0.1183 0.1418
Trypanosoma cruzi DNA polymerase eta, putative 0.0287 0.3373 1
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0567 0.1637
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0064 0.0138
Loa Loa (eye worm) hypothetical protein 0.0056 0.0567 0.055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1627 0.1612
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.092 0.4165
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0011 0.0018 0.0001
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0536 0.0519
Schistosoma mansoni ran 0.0021 0.0145 0.0127
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0011 0.0018 0.0001
Loa Loa (eye worm) hypothetical protein 0.0134 0.1521 0.1506
Schistosoma mansoni hypothetical protein 0.0031 0.0271 0.0253
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0011 0.0018 0.0001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0209 0.0209
Mycobacterium ulcerans aldehyde dehydrogenase 0.0191 0.2208 0.2193
Onchocerca volvulus Alhambra homolog 0.0032 0.0285 0.0917
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0179 0.207 0.2055
Schistosoma mansoni hypothetical protein 0.0025 0.0195 0.0177
Schistosoma mansoni hypothetical protein 0.0011 0.002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0003
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0368 0.0363
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0021 0.0003
Echinococcus granulosus bloom syndrome protein 0.0027 0.0216 0.024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0094 0.1029 0.1013
Plasmodium falciparum metacaspase-like protein 0.0026 0.0209 0.2073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0209 0.0209
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0387 0.0449
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.1627 0.1612
Plasmodium falciparum importin beta, putative 0.0028 0.0237 0.2371
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0536 0.0537
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0145 0.0379
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0145 0.0379
Leishmania major hypothetical protein, conserved 0.0025 0.0199 0.0538
Trypanosoma cruzi DNA polymerase kappa, putative 0.0208 0.2411 0.7132
Mycobacterium ulcerans aldehyde dehydrogenase 0.0191 0.2208 0.2193
Brugia malayi hypothetical protein 0.0134 0.1521 0.1506
Giardia lamblia PHD finger protein 15 0.0032 0.0285 0.125
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0368 0.0351
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.1627 0.1667
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0179 0.207 0.2125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0021 0.0003
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0011 0.0018 0.0082
Loa Loa (eye worm) hypothetical protein 0.0061 0.0625 0.0608
Leishmania major DNA polymerase kappa, putative 0.0056 0.0567 0.1637
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0199 0.0538
Plasmodium vivax JmjC domain containing protein 0.001 0.0018 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0908 0.2653
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0209 0.0209
Leishmania major DNA polymerase eta, putative 0.0163 0.187 0.552
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0567 0.1637
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0021 0.0003
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0285 0.1291
Trypanosoma cruzi DNA polymerase kappa, putative 0.0208 0.2411 0.7132
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0094 0.1035 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0536 0.0519
Brugia malayi ImpB/MucB/SamB family protein 0.0287 0.3373 0.336
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0209 0.0209
Entamoeba histolytica Ran family GTPase 0.0021 0.0145 0.0619
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1627 0.1612
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0011 0.0018 0.0001
Schistosoma mansoni hypothetical protein 0.0032 0.0285 0.0268
Giardia lamblia DNA damage repair protein 0.0056 0.0567 0.2569
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0085 0.092 0.9785
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.032 0.378 0.3897
Trypanosoma brucei DNA polymerase kappa, putative 0.0131 0.1478 0.4352
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0021 0.0003
Echinococcus multilocularis caspase 2 0.0026 0.0209 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0021 0.0003
Brugia malayi hypothetical protein 0.0075 0.0806 0.0789
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0271 0.0253
Trypanosoma brucei DNA polymerase kappa, putative 0.0208 0.2411 0.7132
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0085 0.092 0.0934
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0565 0.6067
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0034 0.0016
Echinococcus multilocularis geminin 0.0687 0.823 0.8508
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0274 0.1238
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0387 0.4006
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.0216 0.0198
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0171 0.0171
Onchocerca volvulus Cell death protein 3 homolog 0.0026 0.0209 0.0656
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0387 0.1684
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0021 0.0003
Schistosoma mansoni glutaminase 0.0833 1 1
Echinococcus granulosus dual specificity 0.0094 0.1035 0.1238
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0567 0.1637
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0271 0.0262
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0387 0.037
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0085 0.092 0.1098
Echinococcus granulosus GPCR family 2 0.0031 0.0271 0.0308
Schistosoma mansoni importin beta-1 0.0028 0.0237 0.0219
Loa Loa (eye worm) MBCTL1 0.0061 0.0625 0.0608
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0209 0.0209
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0387 0.0382
Schistosoma mansoni hypothetical protein 0.0031 0.0271 0.0253
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.2559 0.2545
Onchocerca volvulus 0.0011 0.0021 0.0009
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0011 0.0018 0.0082
Entamoeba histolytica protein kinase, putative 0.0094 0.1035 0.4956
Loa Loa (eye worm) hypothetical protein 0.0099 0.1093 0.1076
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0199 0.1919
Leishmania major DNA polymerase kappa, putative 0.0186 0.2154 0.6368
Trypanosoma brucei metacaspase 0.0026 0.0209 0.0569
Plasmodium falciparum histone acetyltransferase GCN5 0.0086 0.0939 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0025 0.0007
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1093 0.1076
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0021 0.0003
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0218 0.2534 0.3063
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.0784 0.0767
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0094 0.1035 0.4686
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0021 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0021 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0021 0.0003
Brugia malayi jmjC domain containing protein 0.0039 0.0368 0.0351
Loa Loa (eye worm) hypothetical protein 0.0025 0.0199 0.0181
Echinococcus multilocularis dna polymerase eta 0.0287 0.3373 0.3475
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0705 0.0688
Brugia malayi mbt repeat family protein 0.0053 0.0536 0.0519
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0274 0.0265
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0209 0.0569
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0011 0.0018 0.0001
Trichomonas vaginalis glutaminase, putative 0.0833 1 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.0784 0.0767
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0021 0.0003
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0784 0.2283
Leishmania major aldehyde dehydrogenase, putative 0.0011 0.0018 0.0001
Loa Loa (eye worm) hypothetical protein 0.0134 0.1521 0.1506
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0199 0.0199
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0025 0.0199 0.0879
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0712 0.0695
Schistosoma mansoni hypothetical protein 0.0031 0.0271 0.0253
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0021 0.0003
Trypanosoma cruzi DNA polymerase eta, putative 0.0163 0.187 0.552
Loa Loa (eye worm) hypothetical protein 0.0032 0.0274 0.0256
Mycobacterium ulcerans aldehyde dehydrogenase 0.0191 0.2208 0.2193
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0163 0.187 0.847
Entamoeba histolytica protein kinase domain containing protein 0.0094 0.1035 0.4956
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0536 0.0631
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0145 0.0127
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.002 0.0089
Entamoeba histolytica hypothetical protein 0.0075 0.0806 0.3838
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0002
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0064 0.0138
Onchocerca volvulus Huntingtin homolog 0.0134 0.1521 0.5166
Trypanosoma brucei DNA polymerase kappa, putative 0.0208 0.2411 0.7132
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0806 0.9671 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0179 0.207 1
Trypanosoma brucei DNA damage repair protein, putative 0.0056 0.0567 0.1637
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0625 0.0608
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.032 0.378 0.3769
Schistosoma mansoni hypothetical protein 0.0331 0.3914 0.3903
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0003
Entamoeba histolytica hypothetical protein 0.0075 0.0806 0.3838
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0179 0.207 0.2055
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0025 0.0007
Schistosoma mansoni hypothetical protein 0.0075 0.0806 0.0789
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0025 0.0073
Leishmania major DNA polymerase eta, putative 0.0287 0.3373 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.0784 0.2283
Trypanosoma brucei DNA polymerase kappa, putative 0.0208 0.2411 0.7132
Mycobacterium tuberculosis Conserved hypothetical protein 0.0179 0.207 0.937
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0271 0.0253
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0007
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0021 0.0003
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0025 0.0008
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0094 0.1035 0.3031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.1627 0.1667
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0064 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0274 0.0256
Echinococcus multilocularis dual specificity 0.0094 0.1035 0.1053
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0536 0.0537
Onchocerca volvulus 0.0053 0.0536 0.178
Trypanosoma brucei unspecified product 0.0124 0.1394 0.41
Loa Loa (eye worm) hypothetical protein 0.0094 0.1029 0.1013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0274 0.0256
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0567 0.1637
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.0253
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0021 0.0009
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0025 0.0007
Leishmania major DNA damage repair protein, putative 0.0056 0.0567 0.1637
Schistosoma mansoni hypothetical protein 0.0687 0.823 0.8227
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0025 0.0112
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0147 0.0129
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0025 0.0199 0.196
Schistosoma mansoni aldehyde dehydrogenase 0.0191 0.2208 0.2193
Plasmodium falciparum metacaspase 1 0.0026 0.0209 0.2073
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0145 0.0155
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0271 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.0186 0.2154 0.6368
Mycobacterium ulcerans hypothetical protein 0.0056 0.0567 0.055
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0003
Trypanosoma brucei DNA polymerase eta, putative 0.0287 0.3373 1
Entamoeba histolytica hypothetical protein 0.0094 0.1035 0.4956
Loa Loa (eye worm) hypothetical protein 0.0028 0.0237 0.0219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0021 0.0003
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0171 0.0456
Leishmania major importin beta-1 subunit, putative 0.0023 0.0171 0.0456
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0408 0.0474
Echinococcus multilocularis 0.0025 0.0199 0.0187
Toxoplasma gondii histone lysine demethylase JMJD6a 0.001 0.0018 0.0081
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0021 0.0003
Trypanosoma brucei metacaspase MCA3 0.0026 0.0209 0.0569
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0021 0.0003
Leishmania major metacaspase, putative 0.0026 0.0209 0.0569
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0179 0.207 0.2498
Echinococcus multilocularis caspase 0.0026 0.0209 0.0198
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.3582 0.357
Mycobacterium ulcerans DNA polymerase IV 0.0208 0.2411 0.2397
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0191 0.2208 0.2666
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0025 0.0199 0.0538
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0565 0.2497
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.1627 0.1959
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0021 0.0003
Mycobacterium ulcerans glutaminase 0.0833 1 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0145 0.0594
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0064 0.0224
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0025 0.0199 0.0899
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0003
Trypanosoma brucei metacaspase 5, putative 0.0026 0.0209 0.0569
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0021 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0021 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0208 0.2411 0.7132
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0011 0.0018 0.0001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0209 0.0209
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0026 0.0209 0.0191
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0237 0.0651
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0025 0.0199 0.0181
Trypanosoma cruzi metacaspase, putative 0.0026 0.0209 0.0569
Brugia malayi Protein kinase domain containing protein 0.0094 0.1035 0.1019
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0021 0.0003
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0021 0.0003
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0011 0.0018 0.0001
Loa Loa (eye worm) RecQ helicase 0.0027 0.0216 0.0198
Trypanosoma brucei DNA polymerase IV, putative 0.0208 0.2411 0.7132
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0063 0.0652 0.2951
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.044 0.0437
Schistosoma mansoni aldehyde dehydrogenase 0.0191 0.2208 0.2193
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0021 0.0003
Trypanosoma brucei chrX additional, unordered contigs 0.0056 0.0567 0.1637
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0021 0.0003
Toxoplasma gondii exonuclease III APE 0.0041 0.0387 0.1753
Loa Loa (eye worm) hypothetical protein 0.0025 0.0195 0.0177
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1035 0.1019
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0085 0.092 0.8888
Trypanosoma cruzi DNA damage repair protein, putative 0.0056 0.0567 0.1637
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0021 0.0003
Brugia malayi nuclear hormone receptor 0.0011 0.0021 0.0003
Echinococcus granulosus caspase 8 0.0026 0.0209 0.0232
Echinococcus multilocularis GPCR, family 2 0.0031 0.0271 0.0262
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.002 0.0017
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0021 0.0003
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0186 0.2154 0.6368
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.1627 0.1612
Plasmodium vivax metacaspase 1, putative 0.0026 0.0209 0.2019
Giardia lamblia DINP protein human, muc B family 0.0186 0.2154 1
Brugia malayi RNA, U transporter 1 0.0081 0.0874 0.0857
Schistosoma mansoni ap endonuclease 0.0041 0.0387 0.037
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0106 0.1183 0.1206
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0145 0.0127
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0011 0.0018 0.0001
Echinococcus granulosus histone acetyltransferase KAT2B 0.0311 0.3671 0.4448
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.0784 0.0932
Trichomonas vaginalis DNA polymerase eta, putative 0.0208 0.2411 0.2411
Entamoeba histolytica hypothetical protein 0.0023 0.0171 0.0745
Schistosoma mansoni peptidase Clp (S14 family) 0.0085 0.092 0.0903
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0021 0.0003
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0021 0.0003
Trypanosoma cruzi metacaspase, putative 0.0026 0.0209 0.0569
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0565 0.2497
Schistosoma mansoni hypothetical protein 0.0304 0.3582 0.357
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0021 0.0003
Brugia malayi acetyltransferase, GNAT family protein 0.032 0.378 0.3769
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0003
Schistosoma mansoni caspase-3 (C14 family) 0.0026 0.0209 0.0191
Brugia malayi Pre-SET motif family protein 0.0032 0.0274 0.0256
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0021 0.0003
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0368 0.0351
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0387 0.11
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.1627 0.1612
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0171 0.0171
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.0245 0.2518
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0209 0.0209
Schistosoma mansoni ap endonuclease 0.0041 0.0387 0.037
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0209 0.0209

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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