Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.3378 | 0.2673 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.3391 | 0.3541 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.9228 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.724 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.2951 | 0.4076 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0535 | 0.0739 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.3818 | 0.4014 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4163 | 0.4395 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.7886 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.724 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0535 | 0.0679 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0191 | 0.0242 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.2951 | 0.4076 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0535 | 0.0739 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease (functional) | = 75 % | Tested for the percentage decrease in replication of FIV-34TF10 at a concentration of 0.1 nM | ChEMBL. | 12113829 |
Reverse transcriptase activity (functional) | = 390 | Effect of the compound on replication of FIV 34TF10 in chronically infected feline glial cell lines G355-5 at 0.1 nM conc; RT activity per microg/mL of protein concentration | ChEMBL. | 12113829 |
Reverse transcriptase activity (functional) | = 475 | Effect of the compound on replication of FIV 34TF10 in chronically infected feline glial cell lines G355-5 at 10 nM conc; RT activity per microg/mL of protein concentration | ChEMBL. | 12113829 |
Reverse transcriptase activity (functional) | = 480 | Effect of the compound on replication of FIV 34TF10 in chronically infected feline glial cell lines G355-5 at 1000 nM conc; RT activity per microg/mL of protein concentration | ChEMBL. | 12113829 |
Reverse transcriptase activity (functional) | = 490 | Effect of the compound on replication of FIV 34TF10 in chronically infected feline glial cell lines G355-5 at 100 nM conc; RT activity per microg/mL of protein concentration | ChEMBL. | 12113829 |
Reverse transcriptase activity (functional) | = 665 | Effect of the compound on replication of FIV 34TF10 in chronically infected feline glial cell lines G355-5 at 0.01 nM conc; RT activity per microg/mL of protein concentration | ChEMBL. | 12113829 |
Reverse transcriptase activity (functional) | = 800 | Effect of the compound on replication of FIV 34TF10 in chronically infected feline glial cell lines G355-5 at 1 nM conc; RT activity per microg/mL of protein concentration | ChEMBL. | 12113829 |
Reverse transcriptase activity (functional) | = 950 | Effect of the compound on replication of FIV 34TF10 in chronically infected feline glial cell lines G355-5 at 10000 nM conc; RT activity per microg/mL of protein concentration | ChEMBL. | 12113829 |
Reverse transcriptase activity (functional) | = 1200 | Effect of the compound on replication of FIV 34TF10 in chronically infected feline glial cell lines G355-5 at 0 nM conc; RT activity per microg/mL of protein concentration | ChEMBL. | 12113829 |
Reverse transcriptase activity (functional) | = 1590 | Effect of the compound on replication of FIV 34TF10env in chronically infected feline glial cell lines G355-5 at 0 nM conc; RT activity per microg/mL of protein concentration | ChEMBL. | 12113829 |
Reverse transcriptase activity (functional) | = 1600 | Effect of the compound on replication of FIV 34TF10env in chronically infected feline glial cell lines G355-5 at 1 nM conc; RT activity per microg/mL of protein concentration | ChEMBL. | 12113829 |
Reverse transcriptase activity (functional) | = 1700 | Effect of the compound on replication of FIV 34TF10env in chronically infected feline glial cell lines G355-5 at 10 nM conc; RT activity per microg/mL of protein concentration | ChEMBL. | 12113829 |
Reverse transcriptase activity (functional) | = 1800 | Effect of the compound on replication of FIV 34TF10env in chronically infected feline glial cell lines G355-5 at 10000 nM conc; RT activity per microg/mL of protein concentration | ChEMBL. | 12113829 |
Reverse transcriptase activity (functional) | = 1900 | Effect of the compound on replication of FIV 34TF10env in chronically infected feline glial cell lines G355-5 at 100 nM conc; RT activity per microg/mL of protein concentration | ChEMBL. | 12113829 |
Reverse transcriptase activity (functional) | = 1990 | Effect of the compound on replication of FIV 34TF10env in chronically infected feline glial cell lines G355-5 at 0.1 nM conc; RT activity per microg/mL of protein concentration | ChEMBL. | 12113829 |
Reverse transcriptase activity (functional) | = 2000 | Effect of the compound on replication of FIV 34TF10env in chronically infected feline glial cell lines G355-5 at 0.01 nM conc; RT activity per microg/mL of protein concentration | ChEMBL. | 12113829 |
Reverse transcriptase activity (functional) | = 2100 | Effect of the compound on replication of FIV 34TF10env in chronically infected feline glial cell lines G355-5 at 1000 nM conc; RT activity per microg/mL of protein concentration | ChEMBL. | 12113829 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.