Detailed information for compound 1019458

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 506.66 | Formula: C28H34N4O3S
  • H donors: 2 H acceptors: 3 LogP: 4.31 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(CN1CCN(CC1)c1ccccc1OC(C)C)CNC(=O)c1cccnc1Sc1ccccc1
  • InChi: 1S/C28H34N4O3S/c1-21(2)35-26-13-7-6-12-25(26)32-17-15-31(16-18-32)20-22(33)19-30-27(34)24-11-8-14-29-28(24)36-23-9-4-3-5-10-23/h3-14,21-22,33H,15-20H2,1-2H3,(H,30,34)
  • InChiKey: PCYHTKXWAXOVSV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0294 0.0214
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0105 0.0186
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0105 0.0142
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0105 0.0105
Schistosoma mansoni tar DNA-binding protein 0.034 0.3871 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0111 0.0196
Schistosoma mansoni hypothetical protein 0.0184 0.2044 0.5281
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0639 0.4451
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.1061 0.1883
Echinococcus granulosus survival motor neuron protein 1 0.0491 0.5633 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0294 0.0522
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0027
Echinococcus multilocularis geminin 0.0184 0.2044 0.2044
Schistosoma mansoni ap endonuclease 0.0018 0.0105 0.0271
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0342 0.0477
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0097 0.0743
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0294 0.0522
Echinococcus granulosus pyruvate kinase 0.0018 0.0097 0.0172
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0639 0.0639
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0664 0.1179
Echinococcus multilocularis pyruvate kinase 0.0035 0.0294 0.0294
Brugia malayi Inositol-1 0.0043 0.0395 0.0702
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0395 0.2526
Echinococcus multilocularis survival motor neuron protein 1 0.0491 0.5633 0.5633
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0196
Loa Loa (eye worm) hypothetical protein 0.0078 0.0807 0.1433
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.1101 0.1101
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0015 0.0027
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.034 0.3871 0.6872
Schistosoma mansoni tar DNA-binding protein 0.034 0.3871 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0387 0.0687
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0121 0.1305 0.1359
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0015 0.0015
Mycobacterium tuberculosis Conserved protein 0.0121 0.1305 0.1359
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0527 0.0935
Schistosoma mansoni pyruvate kinase 0.0035 0.0294 0.0759
Brugia malayi hypothetical protein 0.0491 0.5633 1
Toxoplasma gondii exonuclease III APE 0.0018 0.0105 0.0805
Brugia malayi hypothetical protein 0.0035 0.0302 0.0536
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0395 0.2526
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0015 0.0027
Echinococcus granulosus GPCR family 2 0.0017 0.0091 0.0161
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0104 0.1101 0.1954
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0091 0.0161
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0121 0.1305 0.2316
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0182 0.0323
Brugia malayi nuclear hormone receptor 0.0011 0.0015 0.0027
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0015 0.0027
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0294 0.1373
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0235
Entamoeba histolytica hypothetical protein 0.0035 0.0302 0.679
Loa Loa (eye worm) hypothetical protein 0.0166 0.1828 0.3245
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0664 0.0664
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0015 0.0027
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0015 0.0027
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0111 0.0111
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0015 0.0027
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0015 0.0039
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0294 0.0522
Plasmodium falciparum pyruvate kinase 0.0035 0.0294 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0121 0.1305 0.1359
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0235
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0527 0.0935
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0395 0.2526
Loa Loa (eye worm) hypothetical protein 0.0047 0.0443 0.0786
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0294 0.1373
Echinococcus multilocularis zinc finger protein 0.0022 0.0143 0.0143
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0395 0.0395
Echinococcus granulosus pyruvate kinase 0.0018 0.0097 0.0172
Brugia malayi nuclear receptor NHR-88 0.0011 0.0015 0.0027
Schistosoma mansoni pyruvate kinase 0.0018 0.0097 0.025
Loa Loa (eye worm) TAR-binding protein 0.034 0.3871 0.6872
Echinococcus multilocularis tar DNA binding protein 0.034 0.3871 0.3871
Echinococcus multilocularis pyruvate kinase 0.0018 0.0097 0.0097
Onchocerca volvulus 0.0121 0.1305 0.6096
Schistosoma mansoni hypothetical protein 0.0023 0.0157 0.0406
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0192 0.214 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0639 0.1134
Mycobacterium tuberculosis Probable esterase LipL 0.0121 0.1305 0.1359
Schistosoma mansoni hypothetical protein 0.0037 0.0325 0.0839
Echinococcus granulosus zinc finger protein 0.0022 0.0143 0.0254
Brugia malayi ecdysteroid receptor 0.0011 0.0015 0.0027
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0294 0.1694
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0294 0.1694
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0395 1
Loa Loa (eye worm) hypothetical protein 0.0166 0.1828 0.3245
Leishmania major pyruvate kinase 0.0035 0.0294 0.1694
Loa Loa (eye worm) beta-lactamase 0.0121 0.1305 0.2316
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0395 0.2419
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0395 0.0702
Brugia malayi beta-lactamase family protein 0.0121 0.1305 0.2316
Loa Loa (eye worm) hypothetical protein 0.0121 0.1305 0.2316
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0015 0.0027
Brugia malayi Muscleblind-like protein 0.0166 0.1828 0.3245
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0015 0.0027
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0105 0.0142
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0105 0.041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.1101 0.1954
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0527 0.0935
Loa Loa (eye worm) hypothetical protein 0.0054 0.0527 0.0935
Brugia malayi Bromodomain containing protein 0.0042 0.0386 0.0686
Loa Loa (eye worm) hypothetical protein 0.0121 0.1305 0.2316
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0294 0.1694
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0015 0.0015
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0182 0.0182
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0105 0.0142
Schistosoma mansoni ap endonuclease 0.0018 0.0105 0.0271
Brugia malayi Bromodomain containing protein 0.0083 0.0863 0.1531
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.1101 0.2843
Schistosoma mansoni inositol monophosphatase 0.0043 0.0395 0.1021
Mycobacterium ulcerans lipase LipD 0.0121 0.1305 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0121 0.1305 0.337
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0639 0.1651
Loa Loa (eye worm) inositol-1 0.0043 0.0395 0.0702
Schistosoma mansoni hypothetical protein 0.0184 0.2044 0.5281
Trichomonas vaginalis D-aminoacylase, putative 0.0121 0.1305 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0035 0.0294 0.0522
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0111 0.0196
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0015 0.0039
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0015 0.0071
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0027
Entamoeba histolytica hypothetical protein 0.0035 0.0302 0.679
Mycobacterium tuberculosis Probable lipase LipD 0.0121 0.1305 0.1359
Loa Loa (eye worm) hypothetical protein 0.0491 0.5633 1
Schistosoma mansoni zinc finger protein 0.0022 0.0143 0.037
Giardia lamblia Pyruvate kinase 0.0035 0.0294 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0091 0.0161
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0182 0.047
Onchocerca volvulus 0.0121 0.1305 0.6096
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0015 0.0039
Schistosoma mansoni inositol monophosphatase 0.0043 0.0395 0.1021
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0015 0.0027
Brugia malayi RNA binding protein 0.034 0.3871 0.6872
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0294 0.1575
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0111 0.0286
Toxoplasma gondii ABC1 family protein 0.0121 0.1305 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0395 0.3029
Brugia malayi beta-lactamase family protein 0.0121 0.1305 0.2316
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0015 0.0027
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0294 0.1575
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0121 0.1305 0.2316
Echinococcus multilocularis beta LACTamase domain containing family member 0.0121 0.1305 0.1305
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0294 0.1631
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0015 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0111 0.0286
Schistosoma mansoni hypothetical protein 0.0017 0.0088 0.0227
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0105 0.0142
Schistosoma mansoni pyruvate kinase 0.0035 0.0294 0.0759
Leishmania major hypothetical protein, conserved 0.0121 0.1305 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0171 0.0304
Entamoeba histolytica hypothetical protein 0.0035 0.0302 0.679
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0121 0.1305 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0639 0.4451
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0015 0.0039
Echinococcus multilocularis pyruvate kinase 0.0018 0.0097 0.0097
Echinococcus multilocularis muscleblind protein 1 0.0166 0.1828 0.1828
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0015 0.0039
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0111 0.0286
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0121 0.1305 0.1359
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0015 0.0027
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0015 0.0027
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0294 0.0522
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0104 0.1101 0.1954
Loa Loa (eye worm) hypothetical protein 0.0192 0.214 0.3799
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0639 0.4451
Schistosoma mansoni hypothetical protein 0.0035 0.0302 0.078
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0161
Echinococcus granulosus pyruvate kinase 0.0035 0.0294 0.0522
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0015 0.0015
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0015 0.0039
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0091 0.0161
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0395 0.2419
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0773 0.8932 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0015 0.0027
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0091 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0037 0.0325 0.0577
Echinococcus granulosus beta LACTamase domain containing family member 0.0121 0.1305 0.2316
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0015 0.0039
Mycobacterium leprae Probable lipase LipE 0.0121 0.1305 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0015 0.0027
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0015 0.0027
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0235
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0118 0.021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.1101 0.1101
Echinococcus granulosus pyruvate kinase 0.0035 0.0294 0.0522
Echinococcus multilocularis pyruvate kinase 0.0018 0.0097 0.0097
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0012 0.0021
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0395 0.2419
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0111 0.0111
Echinococcus multilocularis pyruvate kinase 0.0035 0.0294 0.0294
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0015 0.0015
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0015 0.0027
Brugia malayi N-terminal motif family protein 0.0192 0.214 0.3799
Brugia malayi steroid hormone receptor 0.0011 0.0015 0.0027
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0091 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0015 0.0027
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0091 0.0091
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.1305 1
Schistosoma mansoni tar DNA-binding protein 0.034 0.3871 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0395 1
Echinococcus granulosus pyruvate kinase 0.0018 0.0097 0.0172
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0395 0.2419
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0015 0.0027
Mycobacterium tuberculosis Conserved protein 0.0121 0.1305 0.1359
Leishmania major pyruvate kinase 0.0035 0.0294 0.1694
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0342 0.0269
Mycobacterium tuberculosis Conserved protein 0.0121 0.1305 0.1359
Mycobacterium ulcerans beta-lactamase 0.0121 0.1305 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0027
Brugia malayi PHD-finger family protein 0.0028 0.0212 0.0377
Echinococcus multilocularis GPCR, family 2 0.0017 0.0091 0.0091
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0356 0.0356
Brugia malayi TAR-binding protein 0.034 0.3871 0.6872
Echinococcus multilocularis pyruvate kinase 0.0027 0.0209 0.0209
Mycobacterium tuberculosis Probable hydrolase 0.0121 0.1305 0.1359
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0111 0.0286
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0015 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.0121 0.1305 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0015 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.1101 0.2843
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0121 0.1305 0.337
Schistosoma mansoni bromodomain containing protein 0.007 0.071 0.1835
Loa Loa (eye worm) hypothetical protein 0.0121 0.1305 0.2316
Plasmodium vivax hypothetical protein, conserved 0.0121 0.1305 1
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.1305 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0015 0.0015
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0015 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0015 0.0027
Schistosoma mansoni zinc finger protein 0.0017 0.0088 0.0227
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0027
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0015 0.0015
Trichomonas vaginalis penicillin-binding protein, putative 0.0121 0.1305 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0294 0.0522
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.1101 0.2843
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0294 0.2253
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0015 0.0027
Mycobacterium ulcerans esterase/lipase LipP 0.0121 0.1305 1
Loa Loa (eye worm) RNA binding protein 0.034 0.3871 0.6872
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0105 0.041
Echinococcus granulosus muscleblind protein 0.0166 0.1828 0.3245
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0091 0.0091
Brugia malayi RNA recognition motif domain containing protein 0.034 0.3871 0.6872
Onchocerca volvulus 0.01 0.1061 0.4957
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0639 0.453
Onchocerca volvulus 0.0121 0.1305 0.6096
Schistosoma mansoni tar DNA-binding protein 0.034 0.3871 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0015 0.0015
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0105 0.0067
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0015 0.0015
Entamoeba histolytica hypothetical protein 0.0035 0.0302 0.679
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0015 0.0027
Schistosoma mansoni coup transcription factor 0.0011 0.0015 0.0039
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0015 0.0027
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0302 0.0302
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0121 0.1305 0.2316
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0015 0.0039
Schistosoma mansoni survival motor neuron protein 0.01 0.1061 0.274
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0325 0.0577
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0027
Mycobacterium leprae conserved hypothetical protein 0.0121 0.1305 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0395 0.2526
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0105 0.0186
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0356 0.0631
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0105 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0015 0.0027
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0294 0.1373
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.1101 0.1954
Trichomonas vaginalis penicillin-binding protein, putative 0.0121 0.1305 1
Echinococcus multilocularis muscleblind protein 0.0166 0.1828 0.1828
Schistosoma mansoni hypothetical protein 0.01 0.1061 0.274
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0015 0.0027
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0015 0.0039
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0171 0.229
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0639 0.4898
Onchocerca volvulus 0.0011 0.0015 0.0071
Mycobacterium tuberculosis Probable lipase LipE 0.0121 0.1305 0.1359
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0639 0.0605
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0302 0.078
Chlamydia trachomatis pyruvate kinase 0.0035 0.0294 0.5
Loa Loa (eye worm) hypothetical protein 0.0121 0.1305 0.2316
Loa Loa (eye worm) hypothetical protein 0.0045 0.0418 0.0742
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0015 0.0071
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0105 0.0186
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0015 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0015 0.0027
Echinococcus granulosus tar DNA binding protein 0.034 0.3871 0.6872
Trichomonas vaginalis esterase, putative 0.0121 0.1305 1
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0294 0.1575
Schistosoma mansoni tar DNA-binding protein 0.034 0.3871 1
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0157 0.0279
Loa Loa (eye worm) hypothetical protein 0.0024 0.0171 0.0304
Trichomonas vaginalis D-aminoacylase, putative 0.0121 0.1305 1
Echinococcus granulosus geminin 0.0184 0.2044 0.3629
Loa Loa (eye worm) hypothetical protein 0.0121 0.1305 0.2316
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0294 0.1694
Brugia malayi beta-lactamase 0.0121 0.1305 0.2316
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0015 0.0027
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0302 0.0536
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0639 0.1651
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0235
Trypanosoma brucei hypothetical protein, conserved 0.0121 0.1305 1
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0015 0.0071
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0015 0.0039
Mycobacterium ulcerans hypothetical protein 0.0121 0.1305 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0015 0.0027

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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