TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 480.559 | Formula: C23H20N4O4S2
H donors: 4 H acceptors: 4 LogP: 1.91 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@]12SS[C@@]3(C(=O)N1C)N(C2=O)[C@H]1Nc2c([C@]1([C@@H]3O)c1c[nH]c3c1cccc3)cccc2
InChi: 1S/C23H20N4O4S2/c1-26-20(31)23-17(29)22(14-10-24-15-8-4-2-6-12(14)15)13-7-3-5-9-16(13)25-18(22)27(23)19(30)21(26,11-28)32-33-23/h2-10,17-18,24-25,28-29H,11H2,1H3/t17-,18+,21+,22+,23-/m0/s1
InChiKey: NHOTYQNKQTXECK-HMKLVTIHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0269	0.9223	0.9214
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0166	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0117	0.0108
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0326	0.0293
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0166	0.5
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0085	0.2597	0.295
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0521	0.0408
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0326	0.0308
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0845	0.0737
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.0326	0.0293
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.0326	0.0293
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0166	0.5
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0166	0.0149
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0326	0.0211
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0326	0.0334
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0166	0.5
Trypanosoma cruzi	major cysteine proteinase, putative	0.0051	0.1398	0.7177
Brugia malayi	intermediate filament protein	0.0027	0.0521	0.0517
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.0166	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0326	0.037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1902	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0166	0.0149
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0118	0.0101
Leishmania major	cathepsin L-like protease	0.0017	0.0166	0.0271
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0326	0.0211
Schistosoma mansoni	lamin	0.0027	0.0521	0.0408
Onchocerca volvulus	Protein ultraspiracle homolog	0.0022	0.0326	0.4494
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0166	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.1902	1
Loa Loa (eye worm)	fibroinase	0.0017	0.0166	0.0189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0166	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0326	0.0293
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0326	0.0334
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0022	0.0326	0.4494
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0326	0.0293
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0326	0.037
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.0326	0.0293
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0326	0.0308
Leishmania major	cathepsin L-like protease	0.0065	0.1902	1
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0166	0.0111
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0326	0.0334
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0166	0.0111
Echinococcus multilocularis	lamin dm0	0.0027	0.0521	0.0504
Entamoeba histolytica	hypothetical protein	0.0036	0.0845	1
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0117	0.01
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0069	0.0079
Echinococcus multilocularis	GA binding protein alpha chain	0.0085	0.2597	0.2584
Trypanosoma cruzi	cruzipain precursor, putative	0.0065	0.1902	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0166	0.5
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0326	0.0308
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0118	0.0101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0166	0.5
Echinococcus granulosus	intermediate filament protein	0.0027	0.0521	0.0546
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0166	0.5
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0118	0.0101
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0117	0.0055
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0117	0.0133
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0117	0.01
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0845	0.0829
Leishmania major	cathepsin L-like protease	0.0017	0.0166	0.0271
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0166	0.5
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0118	0.0109
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.0326	0.0293
Schistosoma mansoni	gabp alpha	0.0085	0.2597	0.2509
Echinococcus granulosus	GPCR family 2	0.0016	0.0117	0.0108
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1902	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1902	1
Schistosoma mansoni	thyroid hormone receptor	0.029	1	1
Onchocerca volvulus		0.0027	0.0521	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0326	0.037
Plasmodium vivax	vivapain-2	0.0017	0.0166	1
Brugia malayi	nuclear hormone receptor	0.0022	0.0326	0.0293
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0017	0.0166	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0326	0.037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1902	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0166	0.5
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0326	0.0211
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1902	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0118	0.0101
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0118	0.0134
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0326	0.0334
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0166	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0326	0.037
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0166	0.005
Echinococcus multilocularis	cysteine protease	0.0017	0.0166	0.0149
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0326	0.037
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.0326	0.0293
Schistosoma mansoni	thyroid hormone receptor	0.029	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0166	0.5
Schistosoma mansoni	coup transcription factor	0.0022	0.0326	0.0211
Leishmania major	cathepsin L-like protease	0.0017	0.0166	0.0271
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.0326	0.0293
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0269	0.9223	0.9222
Echinococcus granulosus	lamin	0.0027	0.0521	0.0546
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0117	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0326	0.037
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0326	0.037
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.1345	0.1461
Echinococcus granulosus	GA binding protein alpha chain	0.0085	0.2597	0.2802
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2155	0.2448
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0326	0.0211
Toxoplasma gondii	cathepsin CPL	0.0017	0.0166	1
Leishmania major	cathepsin L-like protease	0.0017	0.0166	0.0271
Echinococcus multilocularis	musashi	0.0027	0.0521	0.0504
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0326	0.037
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0326	0.0211
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0166	0.5
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0118	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0503	0.0571
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0166	0.0111
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0326	0.0293
Leishmania major	cathepsin L-like protease	0.0065	0.1902	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0326	0.0334
Brugia malayi	hypothetical protein	0.0036	0.0845	0.0888
Schistosoma mansoni	hypothetical protein	0.0036	0.0845	0.0737
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.0326	0.0293
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0326	0.0334
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1902	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0326	0.0211
Brugia malayi	steroid hormone receptor	0.0022	0.0326	0.0293
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.0326	0.0334
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0166	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0521	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0326	0.037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1902	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0166	0.5
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0326	0.0308
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0521	0.0591
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0166	0.005
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0521	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0326	0.037
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0166	0.0189
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.0326	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0777	0.0882
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0118	0.0056
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0166	0.5
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0166	0.0189
Brugia malayi	Ets-domain containing protein	0.0085	0.2597	0.2894
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0326	0.0334
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0326	0.0334
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.0166	0.0271
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0269	0.9223	1
Echinococcus multilocularis	cysteine protease	0.0017	0.0166	0.0149
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0166	0.0111
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0017	0.0166	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.0166	0.0161
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0166	0.5
Brugia malayi	Fli-1 protein	0.0257	0.8803	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0326	0.037
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0166	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.1345	0.1528
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1902	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0326	0.0211
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0326	0.0308
Leishmania major	cathepsin L-like protease	0.0065	0.1902	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0166	0.5
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.1345	0.1528
Plasmodium vivax	vivapain-2	0.0017	0.0166	1
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0166	0.0111
Brugia malayi	Ets-domain containing protein	0.0085	0.2597	0.2894
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0326	0.0308
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.0326	0.0211
Echinococcus granulosus	cathepsin l1	0.0017	0.0166	0.0161
Echinococcus multilocularis	lamin	0.0027	0.0521	0.0504
Echinococcus granulosus	lamin dm0	0.0027	0.0521	0.0546
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0166	0.0271
Schistosoma mansoni	hypothetical protein	0.0034	0.0777	0.0667
Entamoeba histolytica	hypothetical protein	0.0036	0.0845	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0166	0.5
Loa Loa (eye worm)	ctsf protein	0.0017	0.0166	0.0189
Onchocerca volvulus		0.0027	0.0521	1
Onchocerca volvulus	Bile acid receptor homolog	0.0022	0.0326	0.4494
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.1902	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0166	0.5
Schistosoma mansoni	lamin	0.0027	0.0521	0.0408
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0326	0.0308
Onchocerca volvulus		0.0022	0.0326	0.4494
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0166	0.5
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0166	0.0149
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0166	0.5
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0166	0.0111
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.006	0.1697	0.8855
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0017	0.0166	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0326	0.0293
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.1902	1
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0118	0.0056
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0326	0.0308
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0166	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0326	0.0211
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1902	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1902	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0777	0.081
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0845	0.0899
Loa Loa (eye worm)	fli-1 protein	0.0257	0.8803	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0326	0.0293
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0326	0.037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.1902	1
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0521	0.0591
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0326	0.0293
Schistosoma mansoni	ets-related	0.0257	0.8803	0.8788
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0117	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0018	0.002
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0118	0.0101
Loa Loa (eye worm)	cysteine protease	0.0017	0.0166	0.0189
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0326	0.037
Leishmania major	cathepsin L-like protease	0.0017	0.0166	0.0271
Brugia malayi	ecdysteroid receptor	0.0022	0.0326	0.0293
Entamoeba histolytica	hypothetical protein	0.0036	0.0845	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0326	0.037
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0166	0.0189
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.0326	0.0293
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0326	0.0211
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.1345	0.1461
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0326	0.0293
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0166	0.5
Entamoeba histolytica	hypothetical protein	0.0036	0.0845	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0166	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0117	0.0133
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0117	0.01
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0016	0.0118	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0326	0.037

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.7 uM	Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay	ChEMBL.	22583079
ID50 (functional)	= 0.56 uM	Cytotoxicity against mouse P388 cells after 1 to 11 days by MTT assay	ChEMBL.	15620259

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	22583079

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL519884

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1019553