Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0049 | 0.1447 | 0.1447 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.2287 | 0.2287 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0049 | 0.1447 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0954 | 0.0954 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0142 | 0.7623 | 0.7623 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.2287 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.01 | 0.4805 | 0.4805 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.01 | 0.4805 | 0.4805 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.2287 | 0.5 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.01 | 0.4805 | 0.529 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0954 | 0.0954 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0049 | 0.1447 | 1 |
Echinococcus multilocularis | protein patched | 0.0043 | 0.1055 | 0.1055 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1697 | 0.1548 |
Schistosoma mansoni | patched 1 | 0.0043 | 0.1055 | 0.1055 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0043 | 0.1055 | 0.1055 |
Echinococcus multilocularis | protein dispatched 1 | 0.0049 | 0.1453 | 0.1453 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0159 | 0.8715 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0074 | 0.3097 | 0.3097 |
Brugia malayi | CHE-14 protein | 0.0043 | 0.1055 | 0.0775 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.2287 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1781 | 0.1453 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.4805 | 0.518 |
Brugia malayi | Bromodomain containing protein | 0.0049 | 0.1445 | 0.1245 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1055 | 0.0558 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.2287 | 0.2287 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1633 | 0.1271 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0042 | 0.101 | 0.101 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0602 | 0.0602 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.01 | 0.4805 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0043 | 0.1055 | 0.1055 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.2287 | 0.2287 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0042 | 0.1012 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.2287 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1697 | 0.1548 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0043 | 0.1055 | 0.0558 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0042 | 0.1012 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0092 | 0.4278 | 0.4657 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0101 | 0.4906 | 0.4906 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1198 | 0.0735 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0954 | 0.0954 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0043 | 0.1055 | 0.1055 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.2287 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0042 | 0.101 | 0.101 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0159 | 0.8715 | 0.8715 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0159 | 0.8715 | 0.8715 |
Loa Loa (eye worm) | acetyltransferase | 0.0159 | 0.8715 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0152 | 0.8244 | 0.8244 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0142 | 0.7623 | 0.7623 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1697 | 0.135 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.3696 | 0.3813 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.2287 | 0.2287 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.2287 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0078 | 0.3374 | 0.3374 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0049 | 0.1447 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1697 | 0.135 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1689 | 0.134 |
Echinococcus multilocularis | geminin | 0.0178 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0954 | 0.0954 |
Echinococcus multilocularis | expressed conserved protein | 0.0094 | 0.4406 | 0.4406 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0602 | 0.0229 |
Echinococcus granulosus | expressed conserved protein | 0.0094 | 0.4406 | 0.4406 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0074 | 0.3097 | 0.3097 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.