Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | protein patched | 0.0557 | 0.3398 | 0.3398 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1352 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0634 | 0.4043 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0557 | 0.3398 | 0.3398 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1352 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0557 | 0.3398 | 0.3398 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0634 | 0.4043 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1352 | 1 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0634 | 0.4043 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1352 | 1 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0557 | 0.3398 | 0.3398 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1352 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0634 | 0.4043 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0557 | 0.3398 | 0.3398 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0557 | 0.3398 | 0.3398 |
Schistosoma mansoni | patched 1 | 0.0557 | 0.3398 | 0.3398 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1352 | 1 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0557 | 0.3398 | 0.3398 |
Loa Loa (eye worm) | hypothetical protein | 0.1352 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1352 | 1 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1352 | 1 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0557 | 0.3398 | 0.3398 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.