Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.00683018 | 0.115845 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.00683018 | 0.115845 | 0.115845 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0218161 | 0.510265 | 0.510265 |
Loa Loa (eye worm) | hypothetical protein | 0.00683018 | 0.115845 | 0.115845 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.00683018 | 0.115845 | 0.115845 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.00683018 | 0.115845 | 0.115845 |
Onchocerca volvulus | 0.00683018 | 0.115845 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0404235 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.00683018 | 0.115845 | 0.115845 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.00683018 | 0.115845 | 0.115845 |
Brugia malayi | Carboxylesterase family protein | 0.00683018 | 0.115845 | 0.115845 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0218161 | 0.510265 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00683018 | 0.115845 | 0.115845 |
Giardia lamblia | Beta tubulin | 0.00242866 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00683018 | 0.115845 | 0.115845 |
Plasmodium falciparum | tubulin beta chain | 0.00242866 | 0 | 0.5 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0167763 | 0.377621 | 0.663697 |
Onchocerca volvulus | 0.00683018 | 0.115845 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0404235 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0404235 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.00683018 | 0.115845 | 0.115845 |
Loa Loa (eye worm) | carboxylesterase | 0.00683018 | 0.115845 | 0.115845 |
Echinococcus granulosus | acetylcholinesterase | 0.0404235 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.00683018 | 0.115845 | 0.115845 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.00683018 | 0.115845 | 0.227029 |
Plasmodium vivax | tubulin beta chain, putative | 0.00242866 | 0 | 0.5 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0218161 | 0.510265 | 1 |
Echinococcus multilocularis | neuroligin | 0.00683018 | 0.115845 | 0.115845 |
Loa Loa (eye worm) | carboxylesterase | 0.0404235 | 1 | 1 |
Onchocerca volvulus | 0.00683018 | 0.115845 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0404235 | 1 | 1 |
Onchocerca volvulus | 0.00683018 | 0.115845 | 0.5 | |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0218161 | 0.510265 | 1 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0167763 | 0.377621 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.00683018 | 0.115845 | 0.227029 |
Loa Loa (eye worm) | hypothetical protein | 0.00683018 | 0.115845 | 0.115845 |
Brugia malayi | Carboxylesterase family protein | 0.00683018 | 0.115845 | 0.115845 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.00683018 | 0.115845 | 0.115845 |
Loa Loa (eye worm) | hypothetical protein | 0.00683018 | 0.115845 | 0.115845 |
Loa Loa (eye worm) | hypothetical protein | 0.00683018 | 0.115845 | 0.115845 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0218161 | 0.510265 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0218161 | 0.510265 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0404235 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.00683018 | 0.115845 | 0.115845 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.00683018 | 0.115845 | 0.115845 |
Loa Loa (eye worm) | carboxylesterase | 0.00683018 | 0.115845 | 0.115845 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0404235 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0404235 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.00242866 | 0 | 0.5 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0218161 | 0.510265 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.00683018 | 0.115845 | 0.115845 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0218161 | 0.510265 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00683018 | 0.115845 | 0.115845 |
Echinococcus multilocularis | acetylcholinesterase | 0.0404235 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0218161 | 0.510265 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0404235 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0218161 | 0.510265 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0404235 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.00683018 | 0.115845 | 0.115845 |
Brugia malayi | Carboxylesterase family protein | 0.00683018 | 0.115845 | 0.115845 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00683018 | 0.115845 | 0.115845 |
Brugia malayi | Carboxylesterase family protein | 0.00683018 | 0.115845 | 0.115845 |
Loa Loa (eye worm) | hypothetical protein | 0.0404235 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.00683018 | 0.115845 | 0.115845 |
Giardia lamblia | Beta tubulin | 0.00242866 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0218161 | 0.510265 | 0.510265 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0218161 | 0.510265 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00683018 | 0.115845 | 0.115845 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.7 uM | Antimalarial activity against Plasmodium falciparum W2 assessed as plasmodial LDH activity after 72 hrs | ChEMBL. | 21530018 |
IC50 (functional) | = 1.79 uM | Antimalarial activity against Plasmodium falciparum D6 assessed as plasmodial LDH activity after 72 hrs | ChEMBL. | 21530018 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 21530018 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.