Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen receptor 2 (ER beta) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | estrogen receptor 2 (ER beta) | 495 aa | 418 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0084 | 0.0056 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.4939 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0237 | 0.0369 | 0.0095 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0237 | 0.0369 | 0.0315 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.0277 | 0.0222 |
Schistosoma mansoni | gliotactin | 0.0237 | 0.0369 | 0.0315 |
Brugia malayi | Carboxylesterase family protein | 0.0237 | 0.0369 | 0.1341 |
Brugia malayi | Carboxylesterase family protein | 0.0237 | 0.0369 | 0.1341 |
Loa Loa (eye worm) | carboxylesterase | 0.0237 | 0.0369 | 0.0369 |
Loa Loa (eye worm) | hypothetical protein | 0.14 | 0.2752 | 0.2752 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0084 | 0.0056 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0237 | 0.0369 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0237 | 0.0369 | 1 |
Brugia malayi | hypothetical protein | 0.0237 | 0.0369 | 0.1341 |
Echinococcus granulosus | acetylcholinesterase | 0.14 | 0.2752 | 0.2546 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Echinococcus granulosus | carboxylesterase 5A | 0.14 | 0.2752 | 0.2546 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0084 | 0.0056 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0084 | 0.0056 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.4939 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.14 | 0.2752 | 0.2546 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0237 | 0.0369 | 0.0315 |
Loa Loa (eye worm) | ammd protein | 0.0084 | 0.0056 | 0.0056 |
Onchocerca volvulus | 0.0237 | 0.0369 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Mycobacterium leprae | Possible lipase LipU | 0.0084 | 0.0056 | 0.5 |
Brugia malayi | aryl-acylamidase | 0.0084 | 0.0056 | 0.0203 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0237 | 0.0369 | 0.0095 |
Loa Loa (eye worm) | aryl-acylamidase | 0.0084 | 0.0056 | 0.0056 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0084 | 0.0056 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0237 | 0.0369 | 0.0095 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0237 | 0.0369 | 0.0315 |
Leishmania major | ecotin, putative | 0.0084 | 0.0056 | 0.5 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0084 | 0.0056 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.14 | 0.2752 | 0.2752 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0237 | 0.0369 | 0.0095 |
Onchocerca volvulus | 0.0237 | 0.0369 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.14 | 0.2752 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0237 | 0.0369 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0084 | 0.0056 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0084 | 0.0056 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0237 | 0.0369 | 0.1341 |
Echinococcus multilocularis | acetylcholinesterase | 0.14 | 0.2752 | 0.2546 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0237 | 0.0369 | 0.0315 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0525 | 0.096 | 0.0703 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0237 | 0.0369 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Onchocerca volvulus | 0.0237 | 0.0369 | 1 | |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0237 | 0.0369 | 0.0095 |
Echinococcus multilocularis | carboxylesterase 5A | 0.14 | 0.2752 | 0.2546 |
Loa Loa (eye worm) | carboxylesterase | 0.0237 | 0.0369 | 0.0369 |
Loa Loa (eye worm) | carboxylesterase | 0.14 | 0.2752 | 0.2752 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Loa Loa (eye worm) | hypothetical protein | 0.14 | 0.2752 | 0.2752 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0525 | 0.096 | 0.0703 |
Brugia malayi | Carboxylesterase family protein | 0.0237 | 0.0369 | 0.1341 |
Onchocerca volvulus | 0.0237 | 0.0369 | 1 | |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0084 | 0.0056 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0237 | 0.0369 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.4939 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0237 | 0.0369 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.0277 | 0.0222 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0525 | 0.096 | 0.0703 |
Onchocerca volvulus | 0.0237 | 0.0369 | 1 | |
Echinococcus multilocularis | hormone sensitive lipase | 0.4939 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.14 | 0.2752 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0237 | 0.0369 | 0.0315 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.4939 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0237 | 0.0369 | 0.0095 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0237 | 0.0369 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Echinococcus granulosus | acetylcholinesterase | 0.14 | 0.2752 | 0.2546 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.14 | 0.2752 | 0.2711 |
Echinococcus granulosus | neuropeptide s receptor | 0.0525 | 0.096 | 0.0703 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0237 | 0.0369 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0237 | 0.0369 | 0.0095 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 45 nM | Binding affinity to ERbeta | ChEMBL. | 17459530 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.