Detailed information for compound 1020519

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 390.367 | Formula: C21H15FN4O3
  • H donors: 2 H acceptors: 3 LogP: 0.92 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N[C@@]2(C)c3n([C@H]1C[C@@]12C(=O)Nc2c1cccc2)c(=O)c1c(n3)ccc(c1)F
  • InChi: 1S/C21H15FN4O3/c1-20-18-23-13-7-6-10(22)8-11(13)17(28)26(18)15(16(27)25-20)9-21(20)12-4-2-3-5-14(12)24-19(21)29/h2-8,15H,9H2,1H3,(H,24,29)(H,25,27)/t15-,20-,21-/m0/s1
  • InChiKey: QRCPSLHLLIYSPT-JHVJFLLYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0168 0.0168
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0168 0.024
Brugia malayi Pax transcription factor protein 2 0.0237 0.6678 0.9538
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.1712 0.1712
Schistosoma mansoni hypothetical protein 0.0065 0.1712 0.1712
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.1413 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0168 0.0168
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0959 0.0959
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.1378 0.1378
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0168 0.024
Brugia malayi ecdysteroid receptor 0.0011 0.0168 0.024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0168 0.024
Loa Loa (eye worm) nuclear factor I 0.0009 0.0119 0.017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0377 0.1364
Mycobacterium tuberculosis Conserved protein 0.0037 0.0918 0.0859
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0337 0.0337
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0168 0.0168
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0918 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0918 0.5876
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0018 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0959 0.6214
Brugia malayi MH2 domain containing protein 0.0248 0.7001 1
Schistosoma mansoni smad 0.0008 0.0067 0.0067
Schistosoma mansoni smad1 5 8 and 0.0017 0.0337 0.0337
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0037 0.0918 0.1311
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.1048 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0168 0.024
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0263 0.0393
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0959 0.6214
Loa Loa (eye worm) beta-lactamase 0.0037 0.0918 0.1311
Brugia malayi mothers against decapentaplegic homolog 3 0.0008 0.0067 0.0096
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0263 0.041
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0959 0.6214
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0918 0.0859
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.1413 1
Toxoplasma gondii exonuclease III APE 0.0018 0.0377 0.1921
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1413 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0168 0.0168
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.1378 0.1969
Loa Loa (eye worm) hypothetical protein 0.0037 0.0918 0.1311
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0263 0.0052
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1413 1
Schistosoma mansoni hypothetical protein 0.0352 1 1
Trypanosoma brucei glucosidase, putative 0.0038 0.0959 0.6214
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0337 0.0337
Brugia malayi Glycosyl hydrolases family 31 protein 0.0173 0.4847 0.6923
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0168 0.0168
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.1378 0.1378
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0131 0.0131
Loa Loa (eye worm) Smad1 0.0017 0.0337 0.0481
Schistosoma mansoni Smad4 0.0017 0.0337 0.0337
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0918 0.0918
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.1712 0.1712
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.1413 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0168 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0168 0.024
Toxoplasma gondii ABC1 family protein 0.0037 0.0918 0.6143
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0026
Loa Loa (eye worm) hypothetical protein 0.0011 0.0168 0.024
Schistosoma mansoni DNA helicase recq5 0.001 0.0131 0.0131
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0263 0.0375
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0026
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.4295 0.6135
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0168 0.024
Brugia malayi MAP kinase sur-1 0.0054 0.1413 0.2018
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0067 0.0096
Schistosoma mansoni hypothetical protein 0.0065 0.1712 0.1712
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0131 0.0131
Schistosoma mansoni DNA helicase recq1 0.001 0.0131 0.0131
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0959 0.6214
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.4295 0.4295
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0037 0.0918 0.1311
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.5734 0.8191
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0337 0.0337
Mycobacterium ulcerans lipase LipD 0.0037 0.0918 1
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0018 0.0026
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0131 0.0131
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.1378 0.1378
Brugia malayi MH1 domain containing protein 0.0009 0.0119 0.017
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.1048 0.0957
Brugia malayi hypothetical protein 0.0006 0.0018 0.0026
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0168 0.0168
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0959 0.6214
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0168 0.0168
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0918 0.0918
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0168 0.0168
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0918 1
Trypanosoma brucei protein kinase, putative 0.0054 0.1413 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0263 0.041
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0168 0.024
Echinococcus granulosus mothers against decapentaplegic 2 0.0008 0.0067 0.0067
Mycobacterium tuberculosis Conserved protein 0.0037 0.0918 0.0859
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0918 0.0859
Brugia malayi MH1 domain containing protein 0.0017 0.0337 0.0481
Echinococcus granulosus mothers against decapentaplegic 6 0.0008 0.0067 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0168 0.024
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0918 0.7179
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.1712 0.2445
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0377 0.0539
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0168 0.024
Schistosoma mansoni Smad4 0.0008 0.0067 0.0067
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0131 0.0187
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0918 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.1712 0.2445
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0168 0.0168
Onchocerca volvulus 0.0037 0.0918 0.1375
Schistosoma mansoni hypothetical protein 0.0065 0.1712 0.1712
Brugia malayi nuclear hormone receptor 0.0011 0.0168 0.024
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0918 0.0859
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0026
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0131 0.00000000099885
Brugia malayi beta-lactamase 0.0037 0.0918 0.1311
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0263 0.041
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.1413 0.1338
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0168 0.0168
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.1048 0.0879
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.4295 0.4295
Brugia malayi MH2 domain containing protein 0.0017 0.0337 0.0481
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0168 0.0252
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0959 0.1369
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0026
Brugia malayi MH1 domain containing protein 0.0017 0.0337 0.0481
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0337 0.0481
Loa Loa (eye worm) hypothetical protein 0.0119 0.3278 0.4682
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0168 0.0168
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0011 0.0168 0.024
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0377 0.2684
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.1413 0.1413
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0168 0.0168
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0918 0.5876
Mycobacterium tuberculosis Conserved protein 0.0037 0.0918 0.0859
Echinococcus granulosus Smad4 0.0017 0.0337 0.0337
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0342 0.9712 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.4847 0.4847
Schistosoma mansoni smad1 5 8 and 0.0017 0.0337 0.0337
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0531 0.0758
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.1712 0.1712
Onchocerca volvulus 0.0237 0.6678 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0263 0.041
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0131 0.0131
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0959 0.6214
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1413 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.1413 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0918 0.5876
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.001 0.0131 0.0187
Echinococcus multilocularis GPCR, family 2 0.0065 0.1712 0.1712
Loa Loa (eye worm) hypothetical protein 0.0204 0.5734 0.8191
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0168 0.0168
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0377 0.1364
Loa Loa (eye worm) hypothetical protein 0.0011 0.0168 0.024
Brugia malayi nuclear receptor NHR-88 0.0011 0.0168 0.024
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0959 0.6214
Loa Loa (eye worm) hypothetical protein 0.0009 0.0119 0.017
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0263 0.041
Giardia lamblia DNA repair protein RAD52 0.0342 0.9712 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0168 0.024
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.1157 0.8006
Schistosoma mansoni hypothetical protein 0.0065 0.1712 0.1712
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.1413 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0959 0.6214
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0168 0.024
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0168 0.0168
Onchocerca volvulus 0.0037 0.0918 0.1375
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.3872 0.5531
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0018 0.0018
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.1413 0.2018
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0067 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0168 0.024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0168 0.024
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0531 0.2645
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0168 0.024
Schistosoma mansoni ap endonuclease 0.0018 0.0377 0.0377
Brugia malayi MH2 domain containing protein 0.0008 0.0067 0.0096
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.1413 0.1413
Schistosoma mansoni ap endonuclease 0.0018 0.0377 0.0377
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1378 0.1378
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0918 0.5876
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0018 0.0018
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0959 0.1369
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.1157 0.1157
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0918 0.1311
Echinococcus granulosus smad 0.0017 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0011 0.0168 0.024
Brugia malayi Latrophilin receptor protein 2 0.0065 0.1712 0.2445
Leishmania major hypothetical protein, conserved 0.0037 0.0918 0.5876
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0168 0.0168
Entamoeba histolytica hypothetical protein 0.0097 0.2656 0.2571
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0263 0.041
Loa Loa (eye worm) hypothetical protein 0.0011 0.0168 0.024
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0959 0.0784
Schistosoma mansoni smad 0.0017 0.0337 0.0337
Brugia malayi hypothetical protein 0.0006 0.0018 0.0026
Loa Loa (eye worm) RecQ helicase 0.0024 0.0531 0.0758
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0168 0.0168
Echinococcus granulosus GPCR family 2 0.0065 0.1712 0.1712
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0918 0.0859
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1413 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0168 0.024
Echinococcus granulosus lysosomal alpha glucosidase 0.0173 0.4847 0.4847
Loa Loa (eye worm) MH2 domain-containing protein 0.0248 0.7001 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0377 0.079
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0263 0.041
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0959 0.6214
Onchocerca volvulus 0.0011 0.0168 0.0252
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0168 0.0168
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0918 0.0859
Mycobacterium ulcerans hypothetical protein 0.0037 0.0918 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.5734 0.8191
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0377 0.1364
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0959 0.6458
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.1413 0.1413
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0263 0.041
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0305 0.1357
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0168 0.0168
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0918 0.0859
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.1712 0.1712
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0387 0.0387
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0168 0.0252
Echinococcus granulosus histone acetyltransferase KAT2B 0.015 0.4171 0.4171
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0263 0.041
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.1413 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.1378 0.1969
Loa Loa (eye worm) pax transcription factor protein 2 0.0237 0.6678 0.9538
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0377 0.1364
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0018 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0168 0.024
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.1157 1
Mycobacterium leprae Probable lipase LipE 0.0037 0.0918 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.0918 0.1311
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0097 0.2656 0.2571
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0377 0.0377
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0263 0.041
Brugia malayi steroid hormone receptor 0.0011 0.0168 0.024
Brugia malayi MH1 domain containing protein 0.0009 0.0119 0.017
Schistosoma mansoni alpha-glucosidase 0.0149 0.4151 0.4151
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0377 0.0377
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0168 0.0168
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0377 0.0539
Trichomonas vaginalis esterase, putative 0.0037 0.0918 0.5876
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1378 0.1378
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0168 0.024
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.1413 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0037 0.0918 0.1311
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0377 0.0257
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0131 0.0187
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0168 0.024
Loa Loa (eye worm) hypothetical protein 0.0014 0.0263 0.0375
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0168 0.024
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0026
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0918 0.5876
Schistosoma mansoni hypothetical protein 0.014 0.3872 0.3872
Onchocerca volvulus 0.0037 0.0918 0.1375
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0959 0.6214
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.4847 0.4847
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0337 0.0481
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0168 0.024
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0168 0.0168
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0018 0.0018
Echinococcus multilocularis geminin 0.0352 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0168 0.0168
Schistosoma mansoni smad1 5 8 and 0.0017 0.0337 0.0337
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0918 0.0918
Schistosoma mansoni coup transcription factor 0.0011 0.0168 0.0168
Echinococcus multilocularis mothers against decapentaplegic 2 0.0008 0.0067 0.0067
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0173 0.4847 0.6923
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0918 0.1311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0168 0.024
Schistosoma mansoni Smad4 0.0008 0.0067 0.0067
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0959 0.6214
Echinococcus multilocularis Smad4 0.0017 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0011 0.0168 0.024
Loa Loa (eye worm) hypothetical protein 0.0011 0.0168 0.024
Brugia malayi beta-lactamase family protein 0.0037 0.0918 0.1311
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0008 0.0067 0.0096
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.5734 0.8191
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0008 0.0067 0.0101
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.1413 0.1413
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0337 0.0337
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0263 0.041
Loa Loa (eye worm) transcription factor SMAD2 0.0248 0.7001 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.1378 0.1378
Brugia malayi MH2 domain containing protein 0.0017 0.0337 0.0481
Brugia malayi beta-lactamase family protein 0.0037 0.0918 0.1311
Loa Loa (eye worm) acetyltransferase 0.0154 0.4295 0.6135
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0168 0.0168
Echinococcus granulosus bloom syndrome protein 0.0024 0.0531 0.0531
Schistosoma mansoni alpha-glucosidase 0.0149 0.4151 0.4151
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.6676 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0531 0.2645
Brugia malayi Smad1 0.0017 0.0337 0.0481
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1378 0.1378
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0531 0.0531
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0918 0.0918
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0168 0.024
Echinococcus multilocularis mothers against decapentaplegic 6 0.0008 0.0067 0.0067
Schistosoma mansoni alpha glucosidase 0.0038 0.0959 0.0959
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0959 0.0959
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0918 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0168 0.024
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0168 0.0252
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.1157 0.8006
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.1413 0.1413
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.1157 0.7869
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0168 0.024
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0918 0.5876
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0918 0.5876
Loa Loa (eye worm) hypothetical protein 0.0037 0.0918 0.1311
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0131 0.0187
Loa Loa (eye worm) hypothetical protein 0.014 0.3872 0.5531
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0263 0.041
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0959 0.6214
Loa Loa (eye worm) hypothetical protein 0.0011 0.0168 0.024
Loa Loa (eye worm) hypothetical protein 0.0065 0.1712 0.2445
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0918 0.5876
Onchocerca volvulus 0.01 0.274 0.4103
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0168 0.0168
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.1157 0.7869
Brugia malayi nuclear receptor RXR 0.0006 0.0018 0.0026
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0959 0.0784
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0018 0.0018
Mycobacterium ulcerans beta-lactamase 0.0037 0.0918 1
Schistosoma mansoni hypothetical protein 0.0352 1 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0377 0.5
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.1413 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0377 0.1364
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0377 0.0172
Echinococcus multilocularis smad 0.0017 0.0337 0.0337
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0377 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0168 0.0168
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0448 0.3458
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0377 0.1364

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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