Detailed information for compound 1020752

Basic information

Technical information
  • TDR Targets ID: 1020752
  • Name: 6-[2-[5-chloro-2-[(2,4,6-trifluorophenyl)meth oxy]phenyl]phenyl]pyridine-2-carboxylic acid
  • MW: 469.84 | Formula: C25H15ClF3NO3
  • H donors: 1 H acceptors: 3 LogP: 6.39 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)c1ccccc1c1cccc(n1)C(=O)O)OCc1c(F)cc(cc1F)F
  • InChi: 1S/C25H15ClF3NO3/c26-14-8-9-24(33-13-19-20(28)11-15(27)12-21(19)29)18(10-14)16-4-1-2-5-17(16)22-6-3-7-23(30-22)25(31)32/h1-12H,13H2,(H,31,32)
  • InChiKey: BVLCSIUFDMFIQQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[2-[5-chloro-2-[(2,4,6-trifluorophenyl)methoxy]phenyl]phenyl]-2-pyridinecarboxylic acid
  • 6-[2-[5-chloro-2-(2,4,6-trifluorobenzyl)oxy-phenyl]phenyl]picolinic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0106 0.0383 0.2691
Echinococcus granulosus muscleblind protein 0.0157 0.0609 0.06
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.0655 0.1697
Plasmodium vivax hypothetical protein, conserved 0.007 0.022 0.2729
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.009 0.1006
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0383 0.1118
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0351 0.1486 0.47
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0097 0.0339 0.033
Schistosoma mansoni thyroid hormone receptor 0.005 0.0129 0.0129
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.01 0.1138
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0025 0.0014 0.0004
Brugia malayi Bromodomain containing protein 0.0044 0.0101 0.0289
Onchocerca volvulus 0.0025 0.0014 0.0013
Schistosoma mansoni hypothetical protein 0.0025 0.0014 0.0014
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.009 0.008
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0142 0.0544 1
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0254 0.17
Mycobacterium ulcerans putative regulatory protein 0.004 0.0085 0.0156
Trichomonas vaginalis mercuric reductase, putative 0.0066 0.0203 0.0572
Loa Loa (eye worm) heterochromatin protein 1 0.015 0.0579 0.1832
Echinococcus granulosus chromobox protein 1 0.015 0.0579 0.057
Echinococcus granulosus zinc finger protein 0.0029 0.0036 0.0026
Echinococcus granulosus mitogen activated protein kinase 0.0106 0.0383 0.0374
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.022 0.0623
Entamoeba histolytica hypothetical protein 0.007 0.0219 0.3984
Schistosoma mansoni alpha glucosidase 0.0078 0.0254 0.0254
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0045 0.0105 0.0277
Leishmania major cathepsin L-like protease 0.0074 0.0236 0.1289
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0044 0.0034
Schistosoma mansoni cpg binding protein 0.0089 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0044
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0106 0.0383 0.2226
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0167 0.0654 0.8501
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0078 0.0254 0.4645
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.003
Leishmania major cytochrome p450-like protein 0.0031 0.0041 0.0044
Loa Loa (eye worm) hypothetical protein 0.0082 0.0274 0.0866
Loa Loa (eye worm) hypothetical protein 0.007 0.022 0.0695
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0306 0.1281 0.4035
Schistosoma mansoni chromobox protein 0.0025 0.0014 0.0014
Loa Loa (eye worm) helicase 0.0025 0.0014 0.0044
Plasmodium vivax SET domain protein, putative 0.0097 0.0341 0.4337
Loa Loa (eye worm) hypothetical protein 0.0041 0.009 0.0284
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.0129 0.0407
Schistosoma mansoni nuclear hormone receptor 0.005 0.0129 0.0129
Echinococcus granulosus GPCR family 2 0.0097 0.0339 0.033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0045 0.0105 0.0277
Loa Loa (eye worm) hypothetical protein 0.0026 0.0022 0.0071
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0104 0.0539
Schistosoma mansoni chromobox protein 0.015 0.0579 0.0579
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.009 0.1006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.0129 0.0407
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0014 0.0195
Brugia malayi Calcitonin receptor-like protein seb-1 0.0306 0.1281 0.4035
Echinococcus granulosus cpg binding protein 0.0097 0.0338 0.0329
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0109 0.0396 0.0864
Mycobacterium tuberculosis Conserved protein 0.007 0.022 0.0063
Schistosoma mansoni thyroid hormone receptor 0.005 0.0129 0.0129
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0078 0.0254 0.0729
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.0129 0.0119
Mycobacterium ulcerans aldehyde dehydrogenase 0.0377 0.16 0.552
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0142 0.0544 0.1607
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0072 0.0062
Loa Loa (eye worm) intermediate filament protein 0.0111 0.0401 0.1268
Echinococcus granulosus neuropeptide receptor A26 0.1458 0.6466 0.6463
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0438 0.1874 0.6276
Brugia malayi hypothetical protein 0.0041 0.009 0.0254
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.0416 0.2441
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0032 0.0046 0.0046
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0114 0.0416 0.1329
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0341 0.0341
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.013 0.049 0.0481
Loa Loa (eye worm) hypothetical protein 0.006 0.0172 0.0544
Loa Loa (eye worm) hypothetical protein 0.0074 0.0235 0.0742
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0317 0.133 1
Brugia malayi nuclear receptor RXR 0.0026 0.0022 0.004
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.0129 0.0378
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0129 0.0378
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0109 0.0396 0.0724
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0224 0.0214
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0034 0.0061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0142 0.0544 0.1607
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0129 0.0119
Loa Loa (eye worm) hypothetical protein 0.0071 0.0225 0.0712
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0167 0.0654 0.0645
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0066 0.0203 0.0573
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0114 0.0416 0.122
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0487 0.2094 0.7146
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0066 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0306 0.1281 0.4053
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0053 0.0143 0.0134
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0129 0.0129
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0129 0.0348
Loa Loa (eye worm) hypothetical protein 0.0026 0.0022 0.0071
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0066 0.0203 0.1077
Schistosoma mansoni hypothetical protein 0.0041 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.007 0.022 0.0695
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0066 0.0203 0.2506
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0097 0.0339 0.033
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0167 0.0654 0.4037
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0075 0.0241 0.0241
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0044 0.0034
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.0578 0.4201
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.022 0.0623
Brugia malayi ecdysteroid receptor 0.005 0.0129 0.0378
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0148 0.0568 0.1771
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.003
Echinococcus granulosus short transient receptor potential channel 6 0.0068 0.0209 0.0199
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0254 0.0729
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.0416 0.295
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0057 0.0162 0.1966
Brugia malayi Glycosyl hydrolases family 31 protein 0.0078 0.0254 0.0777
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0129 0.0378
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0236 0.1557
Treponema pallidum fructose-bisphosphate aldolase 0.0142 0.0544 0.7756
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0142 0.0544 0.1607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0236 0.1557
Echinococcus multilocularis dnaJ subfamily B 0.1274 0.5637 0.5633
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.0129 0.0378
Toxoplasma gondii histone lysine methyltransferase SET1 0.0179 0.0711 0.4393
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0032 0.0022
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0377 0.16 0.5247
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0036 0.0291
Schistosoma mansoni hypothetical protein 0.0097 0.0339 0.0339
Schistosoma mansoni hypothetical protein 0.0097 0.0339 0.0339
Giardia lamblia Kinase, CMGC MAPK 0.0106 0.0383 0.6374
Echinococcus multilocularis transient receptor potential gamma protein 0.01 0.0354 0.0344
Brugia malayi beta-lactamase 0.007 0.022 0.0666
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0106 0.0383 0.2691
Schistosoma mansoni aldehyde dehydrogenase 0.0377 0.16 0.16
Plasmodium vivax glutathione reductase, putative 0.0192 0.0767 1
Brugia malayi Probable ClpP-like protease 0.0167 0.0654 0.2046
Trichomonas vaginalis maltase-glucoamylase, putative 0.0078 0.0254 0.0729
Schistosoma mansoni polycystin 1-related 0.0041 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.003
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0075 0.0241 0.0232
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0032 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0172 0.0478
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0377 0.16 0.1592
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0022 0.004
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0034 0.0061
Schistosoma mansoni transient receptor potential channel 0.0068 0.0209 0.0209
Schistosoma mansoni chromobox protein 0.015 0.0579 0.0579
Trichomonas vaginalis set domain proteins, putative 0.0757 0.3312 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0167 0.0654 1
Brugia malayi Doublecortin family protein 0.0041 0.009 0.0254
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0049 0.0123 0.0361
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0282 0.0813
Loa Loa (eye worm) hypothetical protein 0.0053 0.0143 0.0454
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0066 0.0203 0.1301
Echinococcus granulosus lamin dm0 0.0111 0.0401 0.0392
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0236 0.1557
Giardia lamblia Fructose-bisphosphate aldolase 0.0142 0.0544 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0097 0.0339 0.033
Echinococcus multilocularis GPCR, family 2 0.0097 0.0339 0.033
Loa Loa (eye worm) hypothetical protein 0.005 0.0129 0.0407
Mycobacterium tuberculosis Probable oxidoreductase 0.0487 0.2094 0.7102
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0383 0.1118
Leishmania major hypothetical protein, conserved 0.007 0.022 0.1184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0236 0.1557
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0078 0.0254 0.0729
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.003
Echinococcus multilocularis mitogen activated protein kinase 0.0106 0.0383 0.0374
Loa Loa (eye worm) DR-78 0.0024 0.001 0.003
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0111 0.0401 0.1268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.0129 0.0407
Schistosoma mansoni hypothetical protein 0.0148 0.0568 0.0568
Loa Loa (eye worm) inositol-1 0.0114 0.0416 0.1318
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.0129 0.0129
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0019 0.001
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.022 0.0063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0045 0.0105 0.0277
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0306 0.1281 0.4053
Trypanosoma brucei protein kinase, putative 0.0106 0.0383 0.2691
Loa Loa (eye worm) hypothetical protein 0.007 0.022 0.0695
Brugia malayi cytoplasmic intermediate filament protein 0.0059 0.017 0.0509
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0063 0.0148
Brugia malayi hypothetical protein 0.0026 0.0022 0.004
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0666 0.29 0.9175
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.022 0.0063
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.0129 0.0119
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0097 0.0341 0.0331
Giardia lamblia NADH oxidase lateral transfer candidate 0.0066 0.0203 0.2321
Loa Loa (eye worm) calpain family protein 1 0.005 0.0129 0.0409
Trichomonas vaginalis chromobox protein, putative 0.015 0.0579 0.1713
Trypanosoma cruzi trypanothione reductase, putative 0.0066 0.0203 0.1301
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0167 0.0654 0.1821
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.0317 0.0307
Echinococcus granulosus peptidase Clp S14 family 0.0109 0.0396 0.0386
Entamoeba histolytica hypothetical protein 0.0025 0.0014 0.0195
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0658 0.2866 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0114 0.0416 0.2537
Brugia malayi Glycosyl hydrolases family 31 protein 0.0029 0.0034 0.0078
Brugia malayi PHD-finger family protein 0.0035 0.0061 0.0163
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.022 0.0666
Onchocerca volvulus 0.0041 0.009 0.0243
Toxoplasma gondii hypothetical protein 0.0057 0.0162 0.0934
Schistosoma mansoni hypothetical protein 0.007 0.0219 0.0219
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0066 0.0203 0.1301
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.0129 0.0129
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.0578 0.4201
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.0129 0.036
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0044
Loa Loa (eye worm) hypothetical protein 0.005 0.0129 0.0409
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0044
Echinococcus multilocularis zinc finger protein 0.0029 0.0036 0.0026
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.001 0.001
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0248 0.1018 0.101
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0084 0.0282 0.0825
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0026 0.0022 0.0013
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0129 0.0723
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0129 0.0119
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0254 0.0729
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.0129 0.0129
Onchocerca volvulus 0.0122 0.0451 0.1337
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0066 0.0203 0.1301
Loa Loa (eye worm) hypothetical protein 0.0097 0.0339 0.1073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0066 0.0203 0.1301
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0025 0.0014 0.0014
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0004 0.0012
Echinococcus multilocularis inositol monophosphatase 1 0.0114 0.0416 0.0407
Treponema pallidum NADH oxidase 0.0066 0.0203 0.0826
Echinococcus multilocularis FTZ F1 alpha 0.005 0.0129 0.0119
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0078 0.0254 0.4645
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.0578 0.3476
Mycobacterium tuberculosis Conserved protein 0.007 0.022 0.0063
Onchocerca volvulus 0.0203 0.0818 0.2449
Echinococcus granulosus chromobox protein 2 0.0025 0.0014 0.0004
Loa Loa (eye worm) hypothetical protein 0.0115 0.0421 0.1331
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0066 0.0203 0.1077
Loa Loa (eye worm) hypothetical protein 0.0026 0.0022 0.0071
Onchocerca volvulus 0.0066 0.02 0.0577
Echinococcus granulosus histone lysine methyltransferase setb 0.0115 0.0421 0.0411
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.013 0.049 0.1526
Schistosoma mansoni inositol monophosphatase 0.0114 0.0416 0.0416
Loa Loa (eye worm) hypothetical protein 0.0157 0.0609 0.1927
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0045 0.0105 0.0277
Loa Loa (eye worm) hypothetical protein 0.0029 0.0034 0.0108
Trichomonas vaginalis chromobox protein, putative 0.015 0.0579 0.1713
Schistosoma mansoni nuclear hormone receptor 0.0024 0.001 0.001
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0254 0.0729
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0449 0.1923 0.6461
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0236 0.1557
Loa Loa (eye worm) latrophilin receptor protein 2 0.0097 0.0339 0.1073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0236 0.1557
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.034 0.0331
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0236 0.1557
Plasmodium vivax thioredoxin reductase, putative 0.0192 0.0767 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0106 0.0383 0.0374
Mycobacterium ulcerans hypothetical protein 0.0167 0.0655 0.2173
Echinococcus multilocularis muscleblind protein 0.0157 0.0609 0.06
Mycobacterium tuberculosis Probable reductase 0.0438 0.1874 0.6276
Mycobacterium tuberculosis Probable dehydrogenase 0.0438 0.1874 0.6276
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.001 0.003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.034 0.1076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0142 0.0544 0.1607
Trichomonas vaginalis chromobox protein, putative 0.0091 0.0311 0.09
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0066 0.0203 0.1301
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0066 0.0203 0.0193
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.009 0.008
Echinococcus granulosus calpain A 0.0075 0.0241 0.0232
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.003
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0167 0.0654 0.2171
Loa Loa (eye worm) hypothetical protein 0.0183 0.0727 0.2301
Schistosoma mansoni lamin 0.0111 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.003
Schistosoma mansoni survival motor neuron protein 0.0148 0.0568 0.0568
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0383 0.1118
Echinococcus multilocularis neutral alpha glucosidase AB 0.0078 0.0254 0.0245
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.022 0.022
Onchocerca volvulus 0.0041 0.009 0.0243
Trypanosoma brucei glucosidase, putative 0.0078 0.0254 0.17
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0085 0.0076
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.009 0.008
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0465 0.1996 0.6316
Brugia malayi Inositol-1 0.0114 0.0416 0.1291
Mycobacterium ulcerans beta-lactamase 0.007 0.022 0.0632
Brugia malayi Associated with TFs and helicases family protein 0.0025 0.0014 0.0014
Toxoplasma gondii NADPH-glutathione reductase 0.0066 0.0203 0.119
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0106 0.0383 0.1211
Echinococcus multilocularis calpain family protein 1, d 0.005 0.0129 0.012
Schistosoma mansoni hypothetical protein 0.0097 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.003
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0066 0.0203 0.2506
Echinococcus multilocularis thyroid hormone receptor alpha 0.005 0.0129 0.0119
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0034 0.0061
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0167 0.0654 0.0645
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0236 0.1557
Schistosoma mansoni transient receptor potential channel 0.0068 0.0209 0.0209
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0438 0.1874 0.6332
Loa Loa (eye worm) hypothetical protein 0.007 0.022 0.0695
Mycobacterium ulcerans aldehyde dehydrogenase 0.0377 0.16 0.552
Schistosoma mansoni cpg binding protein 0.0097 0.0338 0.0338
Onchocerca volvulus 0.0148 0.0568 0.169
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0122 0.0451 0.0451
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0066 0.0203 0.1301
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0057 0.0162 0.1966
Schistosoma mansoni chromobox protein 0.0025 0.0014 0.0014
Schistosoma mansoni cpg binding protein 0.0097 0.0338 0.0338
Schistosoma mansoni aryl hydrocarbon receptor 0.0055 0.0149 0.0149
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.022 0.0623
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0034 0.0061
Leishmania major hypothetical protein, conserved 0.0029 0.0036 0.0011
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.013 0.049 0.1591
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0014 0.0195
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0129 0.0119
Brugia malayi SET domain containing protein 0.003 0.0039 0.0092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0142 0.0544 0.1607
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0115 0.0421 0.0411
Brugia malayi nuclear receptor NHR-88 0.005 0.0129 0.0378
Loa Loa (eye worm) CHromoDomain protein family member 0.0032 0.0046 0.0145
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0036 0.0291
Brugia malayi Glycosyl hydrolases family 31 protein 0.0351 0.1486 0.4684
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0026 0.0022 0.0071
Loa Loa (eye worm) cytochrome P450 family protein 0.0064 0.0192 0.0606
Echinococcus granulosus Chromobox protein 3 0.0025 0.0014 0.0004
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0091 0.0311 0.0912
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0438 0.1874 0.6276
Brugia malayi beta-lactamase family protein 0.007 0.022 0.0666
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.003
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.022 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.0129 0.0378
Echinococcus multilocularis neuropeptide s receptor 0.1458 0.6466 0.6463
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0044
Brugia malayi bHLH-PAS transcription factor 0.004 0.0085 0.024
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.009 0.008
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.0129 0.0119
Echinococcus granulosus dnaJ subfamily B 0.1274 0.5637 0.5633
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0026 0.0022 0.0013
Echinococcus granulosus short transient receptor potential channel 6 0.0068 0.0209 0.0199
Schistosoma mansoni alpha-glucosidase 0.0302 0.1265 0.1265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.0129 0.0407
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.022 0.022
Schistosoma mansoni transient receptor potential channel 4 0.01 0.0354 0.0354
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.001 0.001
Onchocerca volvulus 0.0025 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0044
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0104 0.0539
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0236 0.1557
Schistosoma mansoni rab6-interacting 0.0041 0.009 0.009
Entamoeba histolytica hypothetical protein 0.0025 0.0014 0.0195
Entamoeba histolytica hypothetical protein 0.007 0.0219 0.3984
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.133 1
Brugia malayi hypothetical protein 0.0026 0.0022 0.004
Brugia malayi calpain family protein 1 0.0071 0.0225 0.0684
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.034 0.0331
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.013 0.049 0.2913
Brugia malayi nuclear hormone receptor 0.005 0.0129 0.0378
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.0129 0.0119
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.0129 0.0129
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0129 0.0119
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.013 0.049 0.049
Mycobacterium ulcerans lipase LipD 0.007 0.022 0.0632
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0045 0.0105 0.0277
Echinococcus granulosus TRP transient receptor potential channel 0.004 0.0085 0.0075
Schistosoma mansoni zinc finger protein 0.0029 0.0036 0.0036
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0036 0.0138
Echinococcus multilocularis RUN 0.0041 0.009 0.008
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0114 0.0416 0.7642
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.003
Echinococcus multilocularis mitogen activated protein kinase 3 0.0106 0.0383 0.0374
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.022 0.0623
Brugia malayi hypothetical protein 0.0142 0.0542 0.169
Leishmania major cathepsin L-like protease 0.0074 0.0236 0.1289
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0129 0.1522
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.022 0.1431
Loa Loa (eye worm) hypothetical protein 0.0051 0.0134 0.0425
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0658 0.2866 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.0129 0.0119
Brugia malayi PAS domain containing protein 0.0055 0.0149 0.0442
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.0129 0.0119
Onchocerca volvulus Bile acid receptor homolog 0.005 0.0129 0.036
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.133 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0377 0.16 1
Mycobacterium tuberculosis Probable hydrolase 0.007 0.022 0.0063
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0071 0.0225 0.0225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.0129 0.0407
Echinococcus granulosus neutral alpha glucosidase AB 0.0078 0.0254 0.0245
Loa Loa (eye worm) hypothetical protein 0.007 0.022 0.0695
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0236 0.1557
Brugia malayi acetyltransferase, GNAT family protein 0.0164 0.0643 0.2009
Brugia malayi hypothetical protein 0.0025 0.0014 0.0014
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0129 0.0378
Loa Loa (eye worm) hypothetical protein 0.004 0.0083 0.0263
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0148 0.0877
Loa Loa (eye worm) hypothetical protein 0.005 0.0129 0.0409
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0254 0.0729
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0114 0.0416 0.4731
Toxoplasma gondii aldehyde dehydrogenase 0.0377 0.16 1
Echinococcus granulosus RUN 0.0041 0.009 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0383 0.0383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.0129 0.0407
Schistosoma mansoni alpha-glucosidase 0.0302 0.1265 0.1265
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0034 0.0061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0045 0.0105 0.0277
Brugia malayi intermediate filament protein 0.0111 0.0401 0.1242
Trichomonas vaginalis glutathione reductase, putative 0.0066 0.0203 0.0572
Onchocerca volvulus 0.007 0.022 0.0636
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0102 0.0363 0.0742
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.003
Onchocerca volvulus Huntingtin homolog 0.0142 0.0542 0.1612
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0167 0.0654 0.2171
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0114 0.0416 0.122
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0129 0.0378
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0224 0.0214
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0059 0.017 0.0537
Entamoeba histolytica hypothetical protein 0.0025 0.0014 0.0195
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0082 0.0274 0.5004
Loa Loa (eye worm) hypothetical protein 0.005 0.0129 0.0407
Echinococcus granulosus thioredoxin glutathione reductase 0.0192 0.0767 0.0758
Echinococcus granulosus geminin 0.0198 0.0794 0.0785
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.0129 0.0129
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0236 0.1557
Schistosoma mansoni hypothetical protein 0.0198 0.0794 0.0794
Onchocerca volvulus 0.004 0.0085 0.0229
Loa Loa (eye worm) hypothetical protein 0.01 0.0354 0.1119
Loa Loa (eye worm) hypothetical protein 0.0142 0.0542 0.1715
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.009 0.008
Loa Loa (eye worm) hypothetical protein 0.0066 0.02 0.0634
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0167 0.0654 0.4037
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0036 0.0291
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.0129 0.0407
Echinococcus multilocularis Chromobox protein 3 0.0025 0.0014 0.0004
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.013 0.049 0.108
Echinococcus multilocularis survival motor neuron protein 1 0.0723 0.316 0.3154
Brugia malayi Cytochrome P450 family protein 0.0031 0.0041 0.01
Mycobacterium ulcerans aldehyde dehydrogenase 0.0377 0.16 0.552
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.022 0.0695
Loa Loa (eye worm) hypothetical protein 0.0046 0.0112 0.0354
Loa Loa (eye worm) hypothetical protein 0.0142 0.0542 0.1715
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0041 0.013
Plasmodium falciparum thioredoxin reductase 0.0066 0.0203 0.2506
Brugia malayi Protein cec-1. 0.0025 0.0014 0.0014
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0066 0.0203 0.0193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0236 0.1557
Echinococcus granulosus intermediate filament protein 0.0111 0.0401 0.0392
Onchocerca volvulus 0.0757 0.3312 1
Brugia malayi Pre-SET motif family protein 0.0666 0.29 0.9172
Loa Loa (eye worm) hypothetical protein 0.005 0.0129 0.0407
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.0129 0.0129
Entamoeba histolytica hypothetical protein 0.007 0.0219 0.3984
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.0129 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.0129 0.0378
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0044
Echinococcus multilocularis cpg binding protein 0.0097 0.0338 0.0329
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0152
Mycobacterium ulcerans hypothetical protein 0.007 0.022 0.0632
Brugia malayi glutathione reductase 0.0192 0.0767 0.2405
Loa Loa (eye worm) CYP4Cod1 0.0031 0.0041 0.013
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0097 0.0339 0.033
Schistosoma mansoni zinc finger protein 0.0024 0.001 0.001
Trichomonas vaginalis sucrase-isomaltase, putative 0.0078 0.0254 0.0729
Schistosoma mansoni nuclear hormone receptor 0.0024 0.001 0.001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0022 0.0022
Loa Loa (eye worm) calpain family protein 1 0.0071 0.0225 0.0712
Trichomonas vaginalis maltase-glucoamylase, putative 0.0029 0.0034 0.0061
Echinococcus multilocularis calpain A 0.0075 0.0241 0.0232
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0383 0.1118
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0435 0.1376
Leishmania major mitochondrial DNA polymerase beta 0.0317 0.133 0.8274
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0032 0.0032
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0066 0.0203 0.0613
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0192 0.0767 0.212
Brugia malayi CXXC zinc finger family protein 0.0089 0.0306 0.0941
Loa Loa (eye worm) hypothetical protein 0.005 0.0129 0.0407
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0129 0.0348
Loa Loa (eye worm) hypothetical protein 0.0157 0.0609 0.1927
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.001 0.003
Plasmodium falciparum glutathione reductase 0.0192 0.0767 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0034 0.0061
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0066 0.0203 0.0573
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.034 0.034
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0167 0.0654 0.8501
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0108 0.0392 0.124
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.01 0.1781
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0049 0.0123 0.0361
Schistosoma mansoni peptidase Clp (S14 family) 0.0167 0.0654 0.0654
Onchocerca volvulus 0.0111 0.0401 0.1185
Brugia malayi Transient-receptor-potential like protein 0.004 0.0085 0.0239
Echinococcus granulosus histone acetyltransferase KAT2B 0.0157 0.0611 0.0602
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0092 0.0316 0.0307
Schistosoma mansoni inositol monophosphatase 0.0114 0.0416 0.0416
Echinococcus granulosus Chromo domain 0.0025 0.0014 0.0004
Brugia malayi Bromodomain containing protein 0.0087 0.0295 0.0907
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0066 0.0203 0.1301
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0025 0.0014 0.0004
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0036 0.0014
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0066 0.0203 0.1301
Onchocerca volvulus 0.0111 0.0401 0.1185
Trypanosoma brucei cytochrome P450, putative 0.0031 0.0041 0.0053
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0899 0.3952 0.3946
Schistosoma mansoni coup transcription factor 0.005 0.0129 0.0129
Brugia malayi beta-lactamase family protein 0.007 0.022 0.0666
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.022 0.0063
Onchocerca volvulus 0.007 0.022 0.0636
Schistosoma mansoni hypothetical protein 0.0209 0.0845 0.0845
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0129 0.0119
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.022 0.021
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0082 0.0274 0.5004
Echinococcus multilocularis geminin 0.0198 0.0794 0.0785
Echinococcus multilocularis lamin dm0 0.0111 0.0401 0.0392
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.0129 0.0378
Echinococcus multilocularis muscleblind protein 1 0.0157 0.0609 0.06
Loa Loa (eye worm) hypothetical protein 0.0026 0.0022 0.0071
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0658 0.2866 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0026 0.0019 0.001
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0254 0.0729
Schistosoma mansoni loxhd1 0.0041 0.009 0.009
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.022 0.0632
Brugia malayi hypothetical protein 0.0029 0.0036 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0129 0.0378
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0025 0.0014 0.0014
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0106 0.0383 0.2691
Mycobacterium leprae conserved hypothetical protein 0.007 0.022 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.0129 0.0378
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.0129 0.0378
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.022 0.021
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.003
Loa Loa (eye worm) hypothetical protein 0.0071 0.0225 0.0712
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0014 0.0195
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.0129 0.0119
Echinococcus multilocularis thioredoxin glutathione reductase 0.0192 0.0767 0.0758
Brugia malayi calpain family protein 1 0.0071 0.0225 0.0684
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0034 0.0061
Brugia malayi hypothetical protein 0.0723 0.316 1
Brugia malayi hypothetical protein 0.007 0.0219 0.0664
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0114
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0045 0.0105 0.0277
Loa Loa (eye worm) hypothetical protein 0.0209 0.0845 0.2674
Loa Loa (eye worm) beta-lactamase 0.007 0.022 0.0695
Echinococcus granulosus lysosomal alpha glucosidase 0.0351 0.1486 0.1477
Loa Loa (eye worm) hypothetical protein 0.0053 0.0144 0.0455
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0187 0.0743 0.2329
Echinococcus multilocularis musashi 0.0111 0.0401 0.0392
Schistosoma mansoni microtubule-associated protein tau 0.2243 1 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0066 0.0203 0.1077
Brugia malayi Valyl-tRNA synthetase 0.0025 0.0014 0.0014
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0066 0.0203 0.2506
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0219 0.0209
Schistosoma mansoni rab6-interacting 0.0041 0.009 0.009
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0129 0.0723
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0129 0.0378
Loa Loa (eye worm) hypothetical protein 0.007 0.022 0.0695
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0066 0.0203 0.119
Leishmania major alpha glucosidase II subunit, putative 0.0078 0.0254 0.1407
Echinococcus granulosus transient receptor potential gamma protein 0.01 0.0354 0.0344
Schistosoma mansoni nuclear receptor 0.0024 0.001 0.001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0104 0.0539
Mycobacterium leprae Probable lipase LipE 0.007 0.022 0.0212
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0164 0.0643 0.0634
Echinococcus multilocularis microtubule associated protein 2 0.2243 1 1
Schistosoma mansoni intermediate filament proteins 0.0111 0.0401 0.0401
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.0129 0.0119
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0075 0.0241 0.0232
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0102 0.0363 0.06
Echinococcus multilocularis chromobox protein 2 0.0025 0.0014 0.0004
Schistosoma mansoni transient receptor potential channel 0.01 0.0354 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0282 0.0813
Echinococcus granulosus chromobox protein 1 0.015 0.0579 0.057
Loa Loa (eye worm) CXXC zinc finger family protein 0.0089 0.0306 0.0968
Echinococcus multilocularis Chromo domain 0.0025 0.0014 0.0004
Schistosoma mansoni nuclear receptor 0.0024 0.001 0.001
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.0416 0.295
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0078 0.0254 0.1516
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0236 0.1557
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0106 0.0383 0.2325
Brugia malayi CHD4 protein 0.0032 0.0046 0.0115
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0041 0.0053
Brugia malayi chromobox protein homolog 3 0.0084 0.0282 0.0865
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0066 0.0203 0.1301
Schistosoma mansoni single-minded 0.0055 0.0149 0.0149
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0438 0.1874 0.6276
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0167 0.0654 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0032 0.0046 0.0036
Loa Loa (eye worm) acetyltransferase 0.0164 0.0643 0.2033
Schistosoma mansoni hypothetical protein 0.0198 0.0794 0.0794
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.022 0.0623
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.022 0.0063
Brugia malayi Heterochromatin protein 1 0.015 0.0579 0.1807
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0036 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0066 0.0203 0.1301
Loa Loa (eye worm) doublecortin family protein 0.0041 0.009 0.0284
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0167 0.0654 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0435 0.1376
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0438 0.1874 0.6276
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0165 0.1008
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0167 0.0654 0.207
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.0129 0.0378
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0036 0.0014
Brugia malayi follicle stimulating hormone receptor 0.0465 0.1996 0.6305
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.022 0.1431
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0097 0.0339 0.1046
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0053 0.0143 0.0134
Loa Loa (eye worm) hypothetical protein 0.0051 0.0134 0.0425
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0115 0.0421 0.0421
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0097 0.0341 0.206
Brugia malayi MAP kinase sur-1 0.0106 0.0383 0.1184
Echinococcus granulosus neuropeptide s receptor 0.1458 0.6466 0.6463
Brugia malayi MH2 domain containing protein 0.0118 0.0435 0.1349
Loa Loa (eye worm) steroid hormone receptor 0.005 0.0129 0.0407
Leishmania major cathepsin L-like protease 0.0074 0.0236 0.1289
Onchocerca volvulus 0.005 0.0129 0.0362
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0122 0.0451 0.1426
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.0129 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0178 0.0706 0.21
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0219 0.0219
Echinococcus multilocularis TRP (transient receptor potential) channel 0.004 0.0085 0.0075
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.022 0.0632
Brugia malayi steroid hormone receptor 0.005 0.0129 0.0378
Onchocerca volvulus 0.0089 0.0306 0.0897
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0115 0.0421 0.0421
Toxoplasma gondii thioredoxin reductase 0.0192 0.0767 0.4749
Loa Loa (eye worm) glutathione reductase 0.0192 0.0767 0.2428
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0248 0.1018 0.101
Brugia malayi Latrophilin receptor protein 2 0.0097 0.0339 0.1046
Echinococcus multilocularis chromobox protein 1 0.015 0.0579 0.057
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0022 0.004
Loa Loa (eye worm) hypothetical protein 0.0041 0.009 0.0284
Echinococcus multilocularis short transient receptor potential channel 6 0.0068 0.0209 0.0199
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0106 0.0383 0.2691
Loa Loa (eye worm) hypothetical protein 0.005 0.0129 0.0407
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.0014 0.0014
Loa Loa (eye worm) histone methyltransferase 0.0031 0.0044 0.0138
Plasmodium falciparum glutathione reductase 0.0066 0.0203 0.2506
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.013 0.049 0.1591
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.0014 0.0014
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0066 0.0203 0.1077
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0041 0.013
Brugia malayi hypoxia-induced factor 1 0.0169 0.0663 0.2075
Echinococcus multilocularis lysosomal alpha glucosidase 0.0351 0.1486 0.1477
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0114 0.0416 0.295
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0193 0.0773 0.0773
Echinococcus multilocularis neuropeptide receptor A26 0.1458 0.6466 0.6463
Trichomonas vaginalis inositol monophosphatase, putative 0.0114 0.0416 0.122
Loa Loa (eye worm) hypothetical protein 0.0723 0.316 1
Brugia malayi M-phase phosphoprotein, mpp8 0.0025 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0022 0.0071
Echinococcus granulosus FTZ F1 alpha 0.0767 0.3354 0.3348
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0066 0.0203 0.1301
Loa Loa (eye worm) thioredoxin reductase 0.0192 0.0767 0.2428
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0142 0.0544 0.1607
Toxoplasma gondii hypothetical protein 0.0051 0.0133 0.0753
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.0129 0.0119
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0487 0.2094 0.7102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0142 0.0544 0.1607
Loa Loa (eye worm) hypothetical protein 0.0111 0.0401 0.1268
Plasmodium falciparum thioredoxin reductase 0.0192 0.0767 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0142 0.0544 0.1607
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0106 0.0383 0.2691
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0219 0.0209
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.001 0.003
Onchocerca volvulus 0.005 0.0129 0.036
Loa Loa (eye worm) hypothetical protein 0.0084 0.0282 0.0893
Schistosoma mansoni lipoxygenase 0.0173 0.0683 0.0683
Loa Loa (eye worm) hypothetical protein 0.005 0.0129 0.0407
Echinococcus granulosus single minded 2 0.004 0.0085 0.0076
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.0129 0.0119
Schistosoma mansoni lipoxygenase 0.0248 0.1018 0.1018
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0075 0.0241 0.0241
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.0317 0.0307
Trypanosoma brucei trypanothione reductase 0.0192 0.0767 0.5658
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0029 0.0034 0.0074
Loa Loa (eye worm) hypothetical protein 0.005 0.0129 0.0407
Mycobacterium tuberculosis Conserved protein 0.007 0.022 0.0063
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0104 0.0539
Brugia malayi Pre-SET motif family protein 0.0097 0.0341 0.1051
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0066 0.0203 0.0573
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0129 0.0378
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0254 0.17
Toxoplasma gondii ABC1 family protein 0.007 0.022 0.1296
Brugia malayi Muscleblind-like protein 0.0157 0.0609 0.1902
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.009 0.008
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0072 0.0062
Schistosoma mansoni bromodomain containing protein 0.0075 0.0241 0.0241
Entamoeba histolytica hypothetical protein 0.007 0.0219 0.3984
Loa Loa (eye worm) hypothetical protein 0.0187 0.0743 0.2352
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0078 0.0254 0.0805
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0106 0.0383 0.2226
Loa Loa (eye worm) hypothetical protein 0.004 0.0085 0.0269
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0109 0.0396 0.0724
Echinococcus multilocularis short transient receptor potential channel 6 0.0068 0.0209 0.0199
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0067 0.0207 0.1335
Brugia malayi latrophilin 2 splice variant baaae 0.0209 0.0845 0.2651
Onchocerca volvulus 0.007 0.022 0.0636
Schistosoma mansoni aldehyde dehydrogenase 0.0377 0.16 0.16
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.034 0.1049
Loa Loa (eye worm) hypoxia-induced factor 1 0.0169 0.0663 0.2099
Echinococcus granulosus mixed lineage leukemia protein mll 0.0026 0.0019 0.001
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.003
Brugia malayi Thioredoxin reductase 0.0192 0.0767 0.2405
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.034 0.0331
Trypanosoma cruzi trypanothione reductase, putative 0.0192 0.0767 0.5658
Brugia malayi Steroid receptor seven-up type 2 0.005 0.0129 0.0378
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.0129 0.0129
Echinococcus granulosus inositol monophosphatase 1 0.0114 0.0416 0.0407
Brugia malayi Intermediate filament tail domain containing protein 0.0111 0.0401 0.1242
Brugia malayi hypothetical protein 0.0041 0.009 0.0254
Trichomonas vaginalis esterase, putative 0.007 0.022 0.0623
Onchocerca volvulus Huntingtin homolog 0.0142 0.0542 0.1612
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.0129 0.0129
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0236 0.1557
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0032 0.0046 0.0036
Leishmania major trypanothione reductase 0.0192 0.0767 0.4682
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0172 0.0478
Schistosoma mansoni lamin 0.0111 0.0401 0.0401
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0377 0.16 0.1592
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0164 0.0643 0.0643
Schistosoma mansoni hypothetical protein 0.0097 0.0339 0.0339
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0045 0.0105 0.0277
Echinococcus multilocularis peptidase Clp (S14 family) 0.0109 0.0396 0.0386
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0.0034 0.0569
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0026 0.0022 0.0022
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0487 0.2094 0.7102
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0019 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0236 0.1557
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.034 0.0331
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0066 0.0203 0.2506
Brugia malayi hypothetical protein 0.0183 0.0727 0.2278
Trypanosoma brucei hypothetical protein, conserved 0.007 0.022 0.1431
Echinococcus granulosus lamin 0.0111 0.0401 0.0392
Echinococcus multilocularis chromobox protein 1 0.015 0.0579 0.057
Brugia malayi Cytochrome P450 family protein 0.0031 0.0041 0.01
Brugia malayi F/Y-rich N-terminus family protein 0.0033 0.0051 0.0132
Echinococcus granulosus survival motor neuron protein 1 0.0723 0.316 0.3154
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0167 0.0654 1
Brugia malayi Cytochrome P450 family protein 0.0064 0.0192 0.0578
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.022 0.0063
Loa Loa (eye worm) hypothetical protein 0.005 0.0129 0.0407
Trichomonas vaginalis chromobox protein, putative 0.0091 0.0311 0.09
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.013 0.049 0.0481
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0142 0.0544 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0351 0.1486 0.1477
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0041 0.0053
Echinococcus multilocularis lamin 0.0111 0.0401 0.0392
Schistosoma mansoni hypothetical protein 0.1274 0.5637 0.5637
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0066 0.0203 0.1301
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0056 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0063 0.0148
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.034 0.034

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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