Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.2002 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.5037 | 0.5037 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0919 | 0.0919 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.4057 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.3224 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.3165 | 0.3165 |
Trichomonas vaginalis | chromobox protein, putative | 0.0072 | 0.3809 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3165 | 0.3165 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3165 | 0.3165 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.3165 | 0.4778 |
Brugia malayi | Heterochromatin protein 1 | 0.0072 | 0.3809 | 0.5751 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0027 | 0.0041 |
Brugia malayi | hypothetical protein | 0.0091 | 0.5016 | 0.7572 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0919 | 0.1388 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1256 | 0.1896 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.3224 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0919 | 0.0919 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0076 | 0.4057 | 0.4057 |
Onchocerca volvulus | 0.0032 | 0.1256 | 0.6276 | |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0484 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0076 | 0.4057 | 0.4057 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.3165 | 0.4778 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0919 | 0.1388 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.3224 | 0.3224 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.3165 | 0.3165 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0484 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0072 | 0.3809 | 0.3809 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0072 | 0.3809 | 0.5751 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0091 | 0.5037 | 0.7604 |
Echinococcus multilocularis | chromobox protein 1 | 0.0072 | 0.3809 | 0.3809 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3165 | 0.3165 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0484 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.017 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.3165 | 0.4778 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.3224 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.3165 | 0.4778 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0484 | 1 |
Echinococcus granulosus | lamin | 0.0026 | 0.0919 | 0.0919 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.6624 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.004 | 0.1808 | 0.2729 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3165 | 0.3165 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0484 | 0.1501 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.3224 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0484 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0091 | 0.5037 | 0.7604 |
Echinococcus multilocularis | geminin | 0.017 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0076 | 0.4057 | 0.6125 |
Onchocerca volvulus | 0.0026 | 0.0919 | 0.4592 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.3224 | 1 |
Schistosoma mansoni | lamin | 0.0026 | 0.0919 | 0.0919 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0484 | 0.1193 |
Trichomonas vaginalis | chromobox protein, putative | 0.0072 | 0.3809 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.3224 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.3165 | 0.4778 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0919 | 0.1388 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.004 | 0.1808 | 0.9031 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.5037 | 0.5037 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.5037 | 0.5037 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.5037 | 0.5037 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.4057 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0919 | 0.1388 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0919 | 0.0919 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0919 | 0.1388 |
Schistosoma mansoni | hypothetical protein | 0.017 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0076 | 0.4057 | 0.4057 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.3224 | 0.3224 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.3224 | 0.3224 |
Schistosoma mansoni | chromobox protein | 0.0072 | 0.3809 | 0.3809 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.1808 | 0.4746 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.5037 | 0.5037 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.4057 | 0.4057 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1808 | 0.2729 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.2002 | 0.5254 |
Schistosoma mansoni | eyes absent homolog | 0.0091 | 0.5016 | 0.5016 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0058 | 0.0087 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0484 | 0.1271 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0484 | 0.0484 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0889 | 0.1342 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0484 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0027 | 0.0041 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0484 | 0.5 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0058 | 0.0058 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0484 | 0.5 |
Onchocerca volvulus | 0.0026 | 0.0919 | 0.4592 | |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0484 | 0.0484 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.1808 | 0.4746 |
Schistosoma mansoni | chromobox protein | 0.0072 | 0.3809 | 0.3809 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.4057 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.6624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.5016 | 0.7572 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.6624 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.5037 | 0.5037 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.5037 | 0.5037 |
Brugia malayi | RNA binding protein | 0.0062 | 0.3165 | 0.4778 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0484 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.0146 | 0.0221 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0029 | 0.1062 | 0.2789 |
Echinococcus multilocularis | chromobox protein 1 | 0.0072 | 0.3809 | 0.3809 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0146 | 0.0221 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.4057 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0484 | 0.0484 |
Schistosoma mansoni | lamin | 0.0026 | 0.0919 | 0.0919 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0484 | 0.1271 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0029 | 0.1062 | 0.2789 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0919 | 0.0919 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.5016 | 0.7572 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.3224 | 0.3224 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3165 | 0.3165 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.2002 | 0.5254 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0484 | 0.0731 |
Echinococcus granulosus | chromobox protein 1 | 0.0072 | 0.3809 | 0.3809 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0484 | 0.0484 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0919 | 0.0919 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0058 | 0.0058 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0919 | 0.0919 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 71.11 uM | Antiproliferative activity against human MDA-MB-453 cells assessed as cell survival after 72 hrs by MTT assay | ChEMBL. | 21733686 |
IC50 (functional) | = 87.24 uM | Antiproliferative activity against human MDA-MB-361 cells assessed as cell survival after 72 hrs by MTT assay | ChEMBL. | 21733686 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.