TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 403.302 | Formula: C21H20Cl2N2O2
H donors: 1 H acceptors: 2 LogP: 4.74 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)C(=O)N/C(=C(/c1ccccc1)\Cl)/C(=O)N1CCCCC1
InChi: 1S/C21H20Cl2N2O2/c22-17-11-9-16(10-12-17)20(26)24-19(18(23)15-7-3-1-4-8-15)21(27)25-13-5-2-6-14-25/h1,3-4,7-12H,2,5-6,13-14H2,(H,24,26)/b19-18-
InChiKey: QOSUEFJQYBOCSK-HNENSFHCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0335	0.119
Brugia malayi	jmjC domain containing protein	0.0095	0.1546	0.232
Loa Loa (eye worm)	hypothetical protein	0.015	0.2642	0.3908
Trypanosoma brucei	Heat shock protein 83, putative	0.0034	0.0335	0.119
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0047	0.0596	0.2284
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0335	0.119
Plasmodium falciparum	heat shock protein 90	0.0034	0.0335	0.1139
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0344	0.6486	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0185	0.0533
Leishmania major	heat shock protein 83-1	0.0034	0.0335	0.119
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0185	0.0478
Echinococcus multilocularis	muscleblind protein 1	0.0304	0.5694	0.5667
Plasmodium falciparum	thioredoxin reductase	0.0047	0.0596	0.2284
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0359	0.0299
Plasmodium falciparum	glutathione reductase	0.0047	0.0596	0.2284
Leishmania major	heat shock protein 83-1	0.0034	0.0335	0.119
Echinococcus multilocularis	tar DNA binding protein	0.0264	0.4907	0.4875
Echinococcus granulosus	thioredoxin glutathione reductase	0.0136	0.2365	0.2317
Leishmania major	heat shock protein 83-1	0.0034	0.0335	0.119
Echinococcus granulosus	peregrin	0.0029	0.0239	0.0177
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0335	0.119
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0047	0.0596	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0136	0.2354	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0047	0.0596	0.2328
Mycobacterium ulcerans	heat shock protein 90	0.0027	0.0199	0.2549
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0216	0.3945	0.3907
Trypanosoma cruzi	heat shock protein 85, putative	0.0027	0.0199	0.0603
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0047	0.0596	0.0537
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0047	0.0596	0.2328
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0063	0.0922	0.0865
Schistosoma mansoni	jumonji domain containing protein	0.0075	0.1159	0.1104
Plasmodium falciparum	glutathione reductase	0.0136	0.2354	1
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0027	0.0199	0.0137
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0047	0.0596	0.0894
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0464	0.0404
Leishmania major	trypanothione reductase	0.0136	0.2354	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0063	0.0922	0.1384
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0063	0.001
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0047	0.0596	0.0831
Toxoplasma gondii	thioredoxin reductase	0.0136	0.2354	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0047	0.0596	0.0537
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0239	0.0249
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0239	0.0177
Schistosoma mansoni	hypothetical protein	0.0063	0.0922	0.0865
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0309	0.5801	0.8934
Onchocerca volvulus	Heat shock factor protein 2 homolog	0.0103	0.1712	0.3351
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1712	0.2499
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.02	0.3642	0.5421
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0464	0.0404
Leishmania major	heat shock protein 83-1	0.0034	0.0335	0.119
Echinococcus multilocularis	heat shock protein 90	0.0027	0.0199	0.0137
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0335	0.119
Loa Loa (eye worm)	RNA binding protein	0.0264	0.4907	0.7338
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0239	0.0267
Onchocerca volvulus		0.025	0.4636	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.0596	0.2336
Trichomonas vaginalis	heat shock protein, putative	0.0021	0.0076	0.0247
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0047	0.0596	0.2336
Loa Loa (eye worm)	endoplasmin	0.0034	0.0335	0.0413
Echinococcus granulosus	heat shock protein 90	0.0027	0.0199	0.0137
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0216	0.3945	0.3907
Echinococcus granulosus	tar DNA binding protein	0.0264	0.4907	0.4875
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0095	0.1546	0.1493
Schistosoma mansoni	hypothetical protein	0.0521	1	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0309	0.5801	0.8934
Echinococcus granulosus	GPCR family 2	0.0063	0.0922	0.0865
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0047	0.0596	1
Loa Loa (eye worm)	heat shock protein 90	0.0034	0.0335	0.0413
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0047	0.0596	0.2328
Trichomonas vaginalis	endoplasmin, putative	0.0021	0.0076	0.0247
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0047	0.0596	0.2336
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0047	0.0596	0.1897
Brugia malayi	RNA binding protein	0.0264	0.4907	0.7363
Giardia lamblia	Grp94/Hsp90	0.0027	0.0199	0.2549
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.0359	0.045
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0063	0.0922	0.0865
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0063	0.001
Schistosoma mansoni	hypothetical protein	0.0137	0.2383	0.2335
Trypanosoma cruzi	heat shock protein 85, putative	0.0034	0.0335	0.1199
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0185	0.0542
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0047	0.0596	0.0537
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0063	0.0094
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0047	0.0596	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0047	0.0596	0.2328
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0185	0.0478
Leishmania major	heat shock protein 83-1	0.0034	0.0335	0.119
Leishmania major	heat shock protein 83-1	0.0034	0.0335	0.119
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0185	0.0542
Schistosoma mansoni	heat shock protein	0.0034	0.0335	0.0274
Plasmodium vivax	heat shock protein 86, putative	0.0034	0.0335	0.0695
Leishmania major	heat shock protein 83-1	0.0034	0.0335	0.119
Trichomonas vaginalis	heat shock protein, putative	0.0027	0.0199	0.2549
Echinococcus granulosus	heat shock protein 90	0.0034	0.0335	0.0274
Brugia malayi	hypothetical protein	0.0026	0.0185	0.0277
Toxoplasma gondii	heat shock protein 90, putative	0.0034	0.0335	0.0695
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.4907	0.4875
Echinococcus multilocularis	GPCR, family 2	0.0063	0.0922	0.0865
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0047	0.0596	0.2328
Entamoeba histolytica	heat shock protein 90, putative	0.0034	0.0335	0.1654
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0063	0.0922	0.1303
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0034	0.0335	0.5112
Echinococcus granulosus	endoplasmin	0.0027	0.0199	0.0137
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.4907	0.4875
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0344	0.6486	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0047	0.0596	1
Schistosoma mansoni	hypothetical protein	0.0063	0.0922	0.0865
Leishmania major	heat shock protein 83-1	0.0034	0.0335	0.119
Trypanosoma cruzi	heat shock protein 85, putative	0.0034	0.0335	0.1199
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0063	0.001
Brugia malayi	Bromodomain containing protein	0.0029	0.0239	0.0358
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0047	0.0596	0.2328
Plasmodium vivax	thioredoxin reductase, putative	0.0136	0.2354	1
Trypanosoma brucei	trypanothione reductase	0.0136	0.2354	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0047	0.0596	0.2336
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0185	0.0185
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.4907	0.4875
Trypanosoma brucei	heat shock protein 90, putative	0.0034	0.0335	0.119
Echinococcus multilocularis	geminin	0.0521	1	1
Loa Loa (eye worm)	TAR-binding protein	0.0264	0.4907	0.7338
Brugia malayi	PHD-finger family protein	0.0029	0.0239	0.0358
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0047	0.0596	1
Mycobacterium tuberculosis	Probable reductase	0.0309	0.5801	0.8934
Brugia malayi	Muscleblind-like protein	0.0304	0.5694	0.8544
Treponema pallidum	NADH oxidase	0.0047	0.0596	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0047	0.0596	0.2336
Trypanosoma cruzi	heat shock protein 90, putative	0.0034	0.0335	0.1199
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0047	0.0596	0.2336
Mycobacterium tuberculosis	Probable dehydrogenase	0.0309	0.5801	0.8934
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2383	0.3515
Loa Loa (eye worm)	hypothetical protein	0.005	0.0649	0.0888
Brugia malayi	Calcitonin receptor-like protein seb-1	0.02	0.3642	0.5464
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0136	0.2354	0.3568
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0095	0.1546	0.1493
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0047	0.0596	0.2336
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0335	0.119
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0922	0.1303
Leishmania major	heat shock protein 83-1	0.0034	0.0335	0.119
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0047	0.0596	0.1897
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.4907	0.4875
Brugia malayi	Latrophilin receptor protein 2	0.0063	0.0922	0.1384
Echinococcus multilocularis	muscleblind protein	0.0304	0.5694	0.5667
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0359	0.0299
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0239	0.0715
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0309	0.5801	0.8934
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0239	0.0177
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0063	0.001
Leishmania major	heat shock protein 83-1	0.0034	0.0335	0.119
Trichomonas vaginalis	heat shock protein, putative	0.0034	0.0335	0.5112
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0027	0.0199	0.2549
Entamoeba histolytica	heat shock transcription factor, putative	0.0103	0.1712	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0344	0.6486	1
Leishmania major	heat shock protein 83-1	0.0034	0.0335	0.119
Brugia malayi	HSF-type DNA-binding domain containing protein	0.0103	0.1712	0.2569
Brugia malayi	Pax transcription factor protein 2	0.025	0.4636	0.6956
Echinococcus multilocularis	heat shock protein	0.0034	0.0335	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0304	0.5694	0.853
Echinococcus multilocularis	heat shock protein 90	0.0034	0.0335	0.0274
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0034	0.0349	0.0523
Schistosoma mansoni	hypothetical protein	0.0521	1	1
Echinococcus multilocularis	endoplasmin	0.0027	0.0199	0.0137
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0047	0.0596	0.2336
Trypanosoma cruzi	Heat shock protein 83, putative	0.0034	0.0335	0.1199
Leishmania major	heat shock protein 83-1	0.0034	0.0335	0.119
Plasmodium falciparum	thioredoxin reductase	0.0136	0.2354	1
Toxoplasma gondii	NADPH-glutathione reductase	0.0047	0.0596	0.1897
Mycobacterium tuberculosis	Probable oxidoreductase	0.0344	0.6486	1
Schistosoma mansoni	hypothetical protein	0.0063	0.0922	0.0865
Brugia malayi	MH2 domain containing protein	0.0124	0.213	0.3196
Schistosoma mansoni	heat shock protein	0.0034	0.0335	0.0274
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0034	0.0349	0.0523
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.0359	0.0299
Brugia malayi	glutathione reductase	0.0136	0.2354	0.3532
Leishmania major	heat shock protein 83-1	0.0034	0.0335	0.119
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0239	0.0177
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0309	0.5801	0.8934
Brugia malayi	heat shock protein 90	0.0034	0.0335	0.0503
Echinococcus granulosus	heat shock protein	0.0034	0.0335	0.0274
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0047	0.0596	0.2336
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0027	0.0199	0.0594
Schistosoma mansoni	endoplasmin	0.0034	0.0335	0.0274
Brugia malayi	RNA recognition motif domain containing protein	0.0264	0.4907	0.7363
Loa Loa (eye worm)	transcription factor SMAD2	0.0124	0.213	0.3132
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0047	0.0596	0.5
Leishmania major	hypothetical protein, conserved	0.0026	0.0185	0.0533
Echinococcus granulosus	lysine specific demethylase 5A	0.0035	0.0359	0.0299
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0063	0.0094
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0136	0.2365	0.2317
Loa Loa (eye worm)	glutathione reductase	0.0136	0.2354	0.3471
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0353	0.6664	1
Brugia malayi	TAR-binding protein	0.0264	0.4907	0.7363
Entamoeba histolytica	heat shock protein 90, putative	0.0034	0.0335	0.1654
Trichomonas vaginalis	heat shock protein, putative	0.0027	0.0199	0.2549
Echinococcus multilocularis	peregrin	0.0029	0.0239	0.0177
Leishmania major	heat shock protein 83-1	0.0034	0.0335	0.119
Leishmania major	heat shock protein 83-1	0.0034	0.0335	0.119
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0239	0.0267
Brugia malayi	latrophilin 2 splice variant baaae	0.0137	0.2383	0.3576
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0047	0.0596	0.2284
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.085	0.1193
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0239	0.0249
Trichomonas vaginalis	glutathione reductase, putative	0.0047	0.0596	1
Brugia malayi	Thioredoxin reductase	0.0136	0.2354	0.3532
Schistosoma mansoni	endoplasmin	0.0034	0.0335	0.0274
Trichomonas vaginalis	mercuric reductase, putative	0.0047	0.0596	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0034	0.0335	0.1199
Echinococcus granulosus	muscleblind protein	0.0304	0.5694	0.5667
Onchocerca volvulus		0.015	0.2642	0.5467
Loa Loa (eye worm)	pax transcription factor protein 2	0.025	0.4636	0.6927
Loa Loa (eye worm)	hypothetical protein	0.0353	0.6664	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0264	0.4907	0.7338
Entamoeba histolytica	heat shock transcription factor, putative	0.0103	0.1712	1
Plasmodium vivax	endoplasmin, putative	0.0034	0.0335	0.0695
Trichomonas vaginalis	heat shock protein, putative	0.0027	0.0199	0.2549
Leishmania major	heat shock protein 83-1	0.0034	0.0335	0.119
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.4907	0.4875
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0335	0.119
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0047	0.0596	0.1897
Schistosoma mansoni	hypothetical protein	0.0063	0.0922	0.0865
Trypanosoma cruzi	heat shock protein 90, putative	0.0027	0.0199	0.0603
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0063	0.001
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0047	0.0596	0.2328
Plasmodium vivax	glutathione reductase, putative	0.0136	0.2354	1
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0047	0.0596	1
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0309	0.5801	0.8911
Brugia malayi	Endoplasmin precursor	0.0034	0.0335	0.0503
Trypanosoma brucei	heat shock protein 90, putative	0.0034	0.0335	0.119
Toxoplasma gondii	heat shock protein HSP90	0.0034	0.0335	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0304	0.5694	0.853
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0335	0.119
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0335	0.119
Loa Loa (eye worm)	thioredoxin reductase	0.0136	0.2354	0.3471
Brugia malayi	hypothetical protein	0.015	0.2642	0.3965
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0047	0.0596	0.2328
Entamoeba histolytica	heat shock transcription factor, putative	0.0103	0.1712	1
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0027	0.0199	0.0212
Loa Loa (eye worm)	MH2 domain-containing protein	0.0124	0.213	0.3132
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0239	0.0249
Giardia lamblia	PHD finger protein 15	0.0029	0.0239	0.3298
Schistosoma mansoni	hypothetical protein	0.0029	0.0239	0.0177
Brugia malayi	jmjC domain containing protein	0.0035	0.0359	0.0539
Leishmania major	heat shock protein 83-1	0.0034	0.0335	0.119

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1807368

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1021206