Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.2903 | 0.2616 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1276 | 0.1276 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0749 | 0.0749 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.5718 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1276 | 0.1276 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0749 | 0.1977 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.2903 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1276 | 0.1276 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.2903 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.2903 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.3788 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.3788 | 1 |
Echinococcus multilocularis | musashi | 0.0027 | 0.3788 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0389 | 0.0389 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0749 | 0.1977 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.2903 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.2903 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.2903 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.2903 | 0.2903 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.3788 | 0.6116 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.2903 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.1276 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.2903 | 1 |
Onchocerca volvulus | 0.0027 | 0.3788 | 1 | |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0749 | 0.0375 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.1276 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.2903 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0749 | 0.0375 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0749 | 0.1977 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.2903 | 0.2903 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.2903 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.3788 | 0.3788 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0749 | 0.1977 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.3788 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.2903 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.2903 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.1276 | 0.139 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.2903 | 0.2616 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1276 | 0.1276 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.3788 | 0.3788 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.3788 | 0.3788 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.2903 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.1276 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 0.3788 | 0.6116 |
Echinococcus multilocularis | lamin | 0.0027 | 0.3788 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.5718 | 0.5718 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.3654 | 0.3654 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.5718 | 0.5545 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.2903 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1276 | 0.1276 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0749 | 0.1977 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.2903 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.3788 | 0.6116 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.3788 | 0.3537 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0749 | 0.1977 |
Onchocerca volvulus | 0.0027 | 0.3788 | 1 | |
Echinococcus granulosus | lamin | 0.0027 | 0.3788 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0749 | 0.0749 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.2903 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.2903 | 0.2616 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.3788 | 0.3537 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.2903 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.2903 | 0.2903 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.2903 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.