Detailed information for compound 1021464

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1551.85 | Formula: C64H122N30O15
  • H donors: 26 H acceptors: 15 LogP: -10.88 Rotable bonds: 71
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)C(C)C)CCCNC(=N)N)CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]([C@H](O)C)N)CCC(=O)N)CCCNC(=N)N)C)CCCNC(=N)N)CCCNC(=N)N)CCCNC(=N)N
  • InChi: 1S/C64H122N30O15/c1-33(2)47(59(108)109)93-56(105)42(21-13-31-83-64(77)78)91-51(100)37(16-6-8-26-66)86-50(99)36(15-5-7-25-65)87-53(102)40(19-11-29-81-62(73)74)90-54(103)41(20-12-30-82-63(75)76)89-52(101)39(18-10-28-80-61(71)72)85-48(97)34(3)84-49(98)38(17-9-27-79-60(69)70)88-55(104)43(23-24-45(67)96)92-57(106)44-22-14-32-94(44)58(107)46(68)35(4)95/h33-44,46-47,95H,5-32,65-66,68H2,1-4H3,(H2,67,96)(H,84,98)(H,85,97)(H,86,99)(H,87,102)(H,88,104)(H,89,101)(H,90,103)(H,91,100)(H,92,106)(H,93,105)(H,108,109)(H4,69,70,79)(H4,71,72,80)(H4,73,74,81)(H4,75,76,82)(H4,77,78,83)/t34-,35+,36-,37-,38-,39-,40-,41-,42-,43-,44-,46-,47-/m0/s1
  • InChiKey: WLIXRCCTZYYOIP-KSUXCDCSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens furin (paired basic amino acid cleaving enzyme) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Proprotein convertase subtilisin/kexin type 6 precursor, putative Get druggable targets OG5_127788 All targets in OG5_127788
Candida albicans subtilisin-like endoprotease involved in processing C. albicans Sap2 Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 Get druggable targets OG5_127788 All targets in OG5_127788
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus granulosus furin Get druggable targets OG5_127788 All targets in OG5_127788
Brugia malayi endoprotease bli-4 precursor Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum Furin-like protease 1, isoforms 1/1-X/2 precursor, putative Get druggable targets OG5_127788 All targets in OG5_127788
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase Get druggable targets OG5_127788 All targets in OG5_127788
Giardia lamblia High cysteine membrane protein Group 2 Get druggable targets OG5_127788 All targets in OG5_127788
Loa Loa (eye worm) endoprotease bli-4 Get druggable targets OG5_127788 All targets in OG5_127788
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase Get druggable targets OG5_127788 All targets in OG5_127788
Brugia malayi celfurPC protein Get druggable targets OG5_127788 All targets in OG5_127788
Candida albicans subtilisin-like endoprotease involved in processing C. albicans Sap2 Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum Endoprotease bli-4 precursor, putative Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus multilocularis Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 Get druggable targets OG5_127788 All targets in OG5_127788
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae Probable lipase LipE 0.0037 0.0588 0.5
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.022 0.0327
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0433 0.7366
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0178 0.0181
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0588 1
Brugia malayi Importin beta-1 subunit 0.0032 0.0433 0.0642
Trichomonas vaginalis set domain proteins, putative 0.027 0.7589 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.27 0.3558
Echinococcus multilocularis Furin 1 0.0042 0.0723 0.0723
Plasmodium falciparum T-complex protein 1 subunit beta 0.0025 0.022 0.1668
Schistosoma mansoni thyroid hormone receptor 0.0155 0.413 0.4216
Entamoeba histolytica hypothetical protein 0.0035 0.0529 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.2648 0.2704
Echinococcus multilocularis tumor protein p63 0.035 1 1
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.022 0.022
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0034 0.0495 0.0652
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0875 0.0893
Toxoplasma gondii ABC1 family protein 0.0037 0.0588 1
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0433 0.0433
Brugia malayi beta-lactamase family protein 0.0037 0.0588 0.0872
Echinococcus granulosus importin subunit beta 1 0.0032 0.0433 0.0433
Loa Loa (eye worm) hypothetical protein 0.0106 0.2648 0.2704
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.022 0.0225
Echinococcus granulosus serine protein kinase ATM 0.0024 0.02 0.02
Onchocerca volvulus 0.0037 0.0588 0.0139
Loa Loa (eye worm) hypothetical protein 0.0037 0.0588 0.06
Loa Loa (eye worm) endoprotease bli-4 0.0177 0.4787 0.4888
Mycobacterium ulcerans hypothetical protein 0.0037 0.0588 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0489 0.05
Entamoeba histolytica Ran family GTPase 0.0024 0.0178 0.3363
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0097 0.1646
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.022 0.0225
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0529 0.0529
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0311 0.5296
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0473 0.0473
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0588 0.0588
Brugia malayi hypothetical protein 0.0028 0.0311 0.0462
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0042 0.0723 0.0738
Loa Loa (eye worm) proprotein convertase 2 0.0042 0.0723 0.0738
Loa Loa (eye worm) hypothetical protein 0.0242 0.6748 0.689
Echinococcus granulosus geminin 0.0189 0.5152 0.5152
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0875 0.0893
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0495 0.0652
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0588 1
Echinococcus granulosus GPCR family 2 0.0033 0.0473 0.0473
Loa Loa (eye worm) hypothetical protein 0.0032 0.0433 0.0442
Brugia malayi proprotein convertase 2 0.0111 0.281 0.4164
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0025 0.022 0.3747
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0178 0.3022
Schistosoma mansoni hypothetical protein 0.0033 0.0473 0.0483
Echinococcus granulosus neuroendocrine convertase 2 0.0111 0.281 0.281
Loa Loa (eye worm) hypothetical protein 0.0037 0.0588 0.06
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0185 0.5019 0.5019
Entamoeba histolytica hypothetical protein 0.0035 0.0529 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0495 0.0652
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.02 0.0204
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.0037 0.0588 0.06
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0473 0.07
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0178 0.1232
Echinococcus multilocularis neuroendocrine convertase 2 0.0111 0.281 0.281
Schistosoma mansoni hypothetical protein 0.0049 0.0951 0.0971
Trichomonas vaginalis hypothetical protein 0.0034 0.0495 0.0652
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0875 0.0875
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.02 0.02
Schistosoma mansoni ran 0.0024 0.0178 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.02 0.0263
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0025 0.022 0.3747
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0489 0.05
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0723 0.0952
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0473 0.0483
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.107 0.107
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0185 0.5019 0.5019
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.025 0.4254
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0433 0.7366
Toxoplasma gondii FATC domain-containing protein 0.0024 0.02 0.3393
Loa Loa (eye worm) hypothetical protein 0.0072 0.1641 0.1676
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.107 0.1092
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0433 0.7366
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0588 0.0775
Schistosoma mansoni hypothetical protein 0.0189 0.5152 0.526
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0588 0.0775
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0001 0.0018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.2648 0.3924
Leishmania major hypothetical protein, conserved 0.0037 0.0588 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0237 0.6603 0.6742
Entamoeba histolytica hypothetical protein 0.0035 0.0529 1
Onchocerca volvulus 0.0037 0.0588 0.0139
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0529 0.054
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0588 0.06
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0489 0.05
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.107 0.107
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0951 0.1409
Loa Loa (eye worm) hypothetical protein 0.0021 0.0097 0.0099
Brugia malayi RNA, U transporter 1 0.0092 0.2217 0.3285
Schistosoma mansoni hypothetical protein 0.0344 0.9794 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0875 0.0893
Schistosoma mansoni importin beta-1 0.0032 0.0433 0.0442
Loa Loa (eye worm) hypothetical protein 0.0028 0.0311 0.0318
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0025 0.022 0.4169
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0723 0.0952
Onchocerca volvulus 0.027 0.7589 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0473 0.0473
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0025 0.022 0.1038
Loa Loa (eye worm) hypothetical protein 0.0033 0.0473 0.0483
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0178 0.3022
Brugia malayi Pre-SET motif family protein 0.0237 0.6603 0.9784
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0588 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0723 0.0952
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0495 0.0652
Echinococcus granulosus Furin 1 0.0042 0.0723 0.0723
Loa Loa (eye worm) beta-lactamase 0.0037 0.0588 0.06
Brugia malayi hypothetical protein 0.0242 0.6748 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0144 0.3783 0.3783
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0108 0.27 0.27
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.1008 0.1029
Toxoplasma gondii t-complex protein beta subunit 0.0025 0.022 0.3747
Brugia malayi beta-lactamase 0.0037 0.0588 0.0872
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0311 0.5296
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.107 0.1586
Brugia malayi beta-lactamase family protein 0.0037 0.0588 0.0872
Giardia lamblia TCP-1 chaperonin subunit beta 0.0025 0.022 0.1527
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0723 0.0952
Leishmania major T-complex protein 1, beta subunit, putative 0.0025 0.022 0.3747
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0311 0.5234
Loa Loa (eye worm) T-complex protein 1 0.0025 0.022 0.0225
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.3143 0.3208
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.2648 0.3924
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.107 0.107
Leishmania major hypothetical protein, conserved 0.0028 0.0311 0.5296
Echinococcus granulosus snurportin 1 0.0344 0.9794 0.9794
Echinococcus multilocularis 0.0143 0.3758 0.3758
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.02 0.3393
Loa Loa (eye worm) hypothetical protein 0.0053 0.107 0.1092
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0588 1
Echinococcus multilocularis geminin 0.0189 0.5152 0.5152
Onchocerca volvulus 0.0051 0.1008 0.073
Entamoeba histolytica hypothetical protein 0.0026 0.025 0.4734
Loa Loa (eye worm) hypothetical protein 0.0037 0.0588 0.06
Brugia malayi endoprotease bli-4 precursor 0.0177 0.4787 0.7094
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0588 0.0775
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.025 0.033
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0177 0.4787 0.4888
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0473 0.0473
Brugia malayi hypothetical protein 0.0035 0.0529 0.0783
Schistosoma mansoni hypothetical protein 0.0033 0.0473 0.0483
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0495 0.0652
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0001 0.0018
Brugia malayi neuroendocrine convertase 1 precursor 0.0111 0.281 0.4164
Mycobacterium ulcerans beta-lactamase 0.0037 0.0588 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0529 0.0529
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.6748 0.6748
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.022 0.0225
Schistosoma mansoni hypothetical protein 0.0285 0.8033 0.8201
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0344 0.9794 1
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.022 0.022
Brugia malayi celfurPC protein 0.0143 0.3758 0.5569
Loa Loa (eye worm) MBCTL1 0.0053 0.107 0.1092
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0588 0.0775
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0034 0.0495 0.0652
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.27 0.3558
Schistosoma mansoni hypothetical protein 0.0144 0.3783 0.3862
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0034 0.0495 0.0652
Schistosoma mansoni furin-1 (S08 family) 0.0077 0.1781 0.1818
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0495 0.0652
Loa Loa (eye worm) hypothetical protein 0.0069 0.1553 0.1586
Onchocerca volvulus 0.0049 0.0951 0.065
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0311 0.5296
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.022 0.0327
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0025 0.022 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0495 0.0652
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0495 0.0652
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0723 0.0952
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0495 0.0652
Trichomonas vaginalis importin beta-1, putative 0.0026 0.025 0.033
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0875 0.0543
Leishmania major importin beta-1 subunit, putative 0.0026 0.025 0.4254
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.02 0.3393
Schistosoma mansoni hypothetical protein 0.0189 0.5152 0.526
Schistosoma mansoni hypothetical protein 0.0034 0.0495 0.0505
Schistosoma mansoni survival motor neuron protein 0.0049 0.0951 0.0971
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.413 0.413
Schistosoma mansoni ran 0.0024 0.0178 0.0181
Echinococcus granulosus furin 0.0177 0.4787 0.4787
Loa Loa (eye worm) hypothetical protein 0.0051 0.1008 0.1029
Schistosoma mansoni hypothetical protein 0.0035 0.0529 0.054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0489 0.05
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0489 0.0489
Schistosoma mansoni hypothetical protein 0.0033 0.0473 0.0483
Echinococcus multilocularis GPCR, family 2 0.0033 0.0473 0.0473
Entamoeba histolytica hypothetical protein 0.0024 0.02 0.3776
Leishmania major GTP-binding protein, putative 0.0024 0.0178 0.3022
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0588 0.0775
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0588 0.06
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0311 0.5234
Brugia malayi Pre-SET motif family protein 0.0034 0.0489 0.0725
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.02 0.0296
Trichomonas vaginalis esterase, putative 0.0037 0.0588 0.0775
Plasmodium falciparum importin beta, putative 0.0032 0.0433 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0875 0.0875
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0473 0.0473
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0178 0.0263
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0875 0.0893
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0875 0.0893
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0588 0.0872
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.1641 0.2432
Brugia malayi MH2 domain containing protein 0.0122 0.3143 0.4657
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.6748 0.6748
Loa Loa (eye worm) hypothetical protein 0.0177 0.4787 0.4888
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0588 0.06
Onchocerca volvulus 0.0047 0.0875 0.0543
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0875 0.0875
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0588 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.3143 0.3208
Onchocerca volvulus 0.0037 0.0588 0.0139
Trichomonas vaginalis chaperonin, putative 0.0025 0.022 0.029
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0588 0.5
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0311 0.5296
Brugia malayi mbt repeat family protein 0.0047 0.0875 0.1297
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0108 0.27 0.27
Brugia malayi mbt repeat family protein 0.0047 0.0875 0.1297
Trichomonas vaginalis ran, putative 0.0024 0.0178 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0495 0.0652
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0723 0.0952
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0178 0.0178
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0473 0.07
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0178 0.0178
Mycobacterium ulcerans lipase LipD 0.0037 0.0588 0.5
Schistosoma mansoni hypothetical protein 0.0072 0.1641 0.1676
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0495 0.0652
Giardia lamblia High cysteine membrane protein Group 2 0.0066 0.1443 1
Plasmodium vivax SET domain protein, putative 0.0034 0.0489 0.7594
Loa Loa (eye worm) hypothetical protein 0.0037 0.0588 0.06
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.107 0.107
Loa Loa (eye worm) hypothetical protein 0.0037 0.0588 0.06
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0311 0.3258
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0588 0.0588
Loa Loa (eye worm) hypothetical protein 0.0034 0.0489 0.05
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0489 0.8321
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0489 0.0489
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0495 0.0652
Schistosoma mansoni thyroid hormone receptor 0.0155 0.413 0.4216
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0144 0.3783 0.3783
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0178 0.3022
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0489 0.0489
Giardia lamblia Furin precursor putative serine protease 0.0034 0.0495 0.343
Plasmodium vivax importin-beta 2, putative 0.0032 0.0433 0.6224
Echinococcus multilocularis snurportin 1 0.0344 0.9794 0.9794
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0875 0.0875
Schistosoma mansoni hypothetical protein 0.0033 0.0473 0.0483
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0588 0.5
Brugia malayi hypothetical protein 0.0018 0.0012 0.0017
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.025 0.033
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0178 0.3022
Entamoeba histolytica hypothetical protein 0.0035 0.0529 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.6637 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.048 uM Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage ChEMBL. 17537721

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.