TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 903.022 | Formula: C48H60F2N6O9
H donors: 4 H acceptors: 5 LogP: 4.95 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: CNC(=O)Nc1ccc2c(c1)c1CCN3C[C@@H](C[C@](c1[nH]2)(C(=O)OC)c1cc2c(cc1OC)N([C@@H]1[C@@]42CCN2[C@H]4[C@@]([C@H]([C@]1(O)C(=O)OC)OC(=O)C)(CC)C=CC2)C)C[C@H](C3)C(F)(F)C
InChi: 1S/C48H60F2N6O9/c1-9-45-14-10-16-56-18-15-46(38(45)56)32-21-33(36(62-6)22-35(32)54(5)39(46)48(61,42(59)64-8)40(45)65-26(2)57)47(41(58)63-7)23-27-19-28(44(3,49)50)25-55(24-27)17-13-30-31-20-29(52-43(60)51-4)11-12-34(31)53-37(30)47/h10-12,14,20-22,27-28,38-40,53,61H,9,13,15-19,23-25H2,1-8H3,(H2,51,52,60)/t27-,28-,38+,39-,40-,45-,46-,47+,48+/m1/s1
InChiKey: ZQTWDAFXNWPKBY-NSAXJFTOSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0102	0.0102
Onchocerca volvulus		0.1192	0.6681	0.6672
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0925	0.5133	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0352	0.1814	0.1814
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0352	0.1814	0.1814
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1192	0.6681	0.6178
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0233	0.113	0.113
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1766	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.1766	1	1
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1814	0.1814
Entamoeba histolytica	cysteine proteinase 1, putative	0.0925	0.5133	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0028	0.0028
Brugia malayi	Cathepsin L-like precursor	0.1766	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1192	0.6681	0.5946
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0352	0.1814	0.1814
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0352	0.1814	0.0572
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0352	0.1814	0.1814
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1766	1	1
Echinococcus granulosus	high affinity choline transporter 1	0.039	0.2036	0.2014
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Plasmodium vivax	vivapain-1	0.0925	0.5133	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Loa Loa (eye worm)	hypothetical protein	0.1192	0.6681	0.6681
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0352	0.1814	0.0572
Entamoeba histolytica	cysteine proteinase, putative	0.0925	0.5133	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0352	0.1814	0.0572
Schistosoma mansoni	cathepsin S (C01 family)	0.0352	0.1814	0.1814
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0925	0.5133	0.2343
Brugia malayi	Cathepsin L-like precursor	0.1192	0.6681	0.6681
Loa Loa (eye worm)	hypothetical protein	0.0573	0.3097	0.3097
Toxoplasma gondii	cathepsin CPC1	0.0352	0.1814	0.1791
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0352	0.1814	0.0572
Schistosoma mansoni	inositol transporter	0.0043	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.1192	0.6681	0.6681
Trypanosoma cruzi	cysteine peptidase, putative	0.1766	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1766	1	1
Echinococcus multilocularis	cathepsin L	0.0352	0.1814	0.1791
Entamoeba histolytica	cysteine proteinase, putative	0.0925	0.5133	0.4054
Onchocerca volvulus		0.0266	0.1317	0.1293
Plasmodium vivax	vivapain-3	0.0925	0.5133	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0352	0.1814	0.1814
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1766	1	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0352	0.1814	0.1814
Loa Loa (eye worm)	hypothetical protein	0.039	0.2036	0.2036
Brugia malayi	cathepsin B-like cysteine proteinase	0.1373	0.7729	0.7729
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Leishmania major	cysteine peptidase A (CPA)	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0352	0.1814	0.0572
Brugia malayi	cathepsin F-like cysteine proteinase	0.0573	0.3097	0.3097
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1192	0.6681	0.6681
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0573	0.3097	0.3097
Loa Loa (eye worm)	hypothetical protein	0.0573	0.3097	0.3097
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1766	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0573	0.3097	0.1568
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0668	0.3643	0.2679
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1766	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0352	0.1814	0.1814
Plasmodium vivax	unspecified product	0.0573	0.3097	0.1568
Loa Loa (eye worm)	fibroinase	0.1766	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0925	0.5133	0.5133
Leishmania major	cathepsin L-like protease	0.1766	1	1
Brugia malayi	Pre-SET motif family protein	0.0233	0.113	0.113
Loa Loa (eye worm)	hypothetical protein	0.0573	0.3097	0.3097
Leishmania major	cathepsin L-like protease	0.1766	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0925	0.5133	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0573	0.3097	0.3097
Leishmania major	cathepsin L-like protease	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1192	0.6681	0.6178
Echinococcus granulosus	cathepsin b	0.1373	0.7729	0.7722
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0352	0.1814	0.0572
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1766	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0352	0.1814	0.0572
Onchocerca volvulus	Cathepsin L homolog	0.0352	0.1814	0.1791
Loa Loa (eye worm)	hypothetical protein	0.1192	0.6681	0.6681
Trichomonas vaginalis	conserved hypothetical protein	0.0352	0.1814	0.0572
Echinococcus granulosus	cathepsin l1	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.091	0.5045	0.5032
Entamoeba histolytica	cysteine proteinase, putative	0.1766	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0925	0.5133	0.5133
Brugia malayi	fibroinase precursor	0.0352	0.1814	0.1814
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1766	1	1
Brugia malayi	Cathepsin L-like precursor	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Echinococcus granulosus	cathepsin L	0.0925	0.5133	0.5119
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0925	0.5133	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0925	0.5133	0.5133
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1766	1	1
Onchocerca volvulus		0.1766	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Echinococcus multilocularis	cathepsin L	0.0925	0.5133	0.5119
Leishmania major	cathepsin L-like protease	0.1766	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0668	0.3643	0.3643
Onchocerca volvulus	Cathepsin L homolog	0.1766	1	1
Brugia malayi	Cathepsin L-like precursor	0.1192	0.6681	0.6681
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1373	0.7729	0.7729
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1766	1	1
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1814	0.1814
Schistosoma mansoni	cathepsin C	0.0352	0.1814	0.1814
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0925	0.5133	0.4394
Toxoplasma gondii	cathepsin B	0.0668	0.3643	0.3626
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1766	1	1
Toxoplasma gondii	cathepsin CPC2	0.0352	0.1814	0.1791
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0352	0.1814	0.0572
Echinococcus granulosus	cathepsin l1	0.1192	0.6681	0.6672
Giardia lamblia	Cathepsin B precursor	0.0668	0.3643	1
Brugia malayi	Papain family cysteine protease containing protein	0.0352	0.1814	0.1814
Toxoplasma gondii	cathepsin CPL	0.1766	1	1
Trypanosoma cruzi	cysteine protease, putative	0.0925	0.5133	0.4054
Echinococcus multilocularis	cathepsin L cysteine protease	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0352	0.1814	0.0572
Onchocerca volvulus		0.1766	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0352	0.1814	0.1814
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1766	1	1
Echinococcus granulosus	cathepsin L	0.0352	0.1814	0.1791
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0925	0.5133	0.2343
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1814	0.1814
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0352	0.1814	0.0572
Schistosoma mansoni	inositol transporter	0.0043	0.0028	0.0028
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Loa Loa (eye worm)	cysteine protease	0.1766	1	1
Onchocerca volvulus	Cathepsin L homolog	0.1766	1	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0352	0.1814	0.1814
Entamoeba histolytica	cysteine proteinase 2	0.0925	0.5133	0.4054
Plasmodium vivax	vivapain-2	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0352	0.1814	0.0572
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1373	0.7729	0.7729
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0102	0.0102
Echinococcus granulosus	cathepsin L cysteine protease	0.0925	0.5133	0.5119
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1766	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0573	0.3097	0.3097
Trypanosoma cruzi	cysteine peptidase, putative	0.1766	1	1
Schistosoma mansoni	sodium/solute symporter	0.0043	0.0028	0.0028
Onchocerca volvulus		0.1766	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0352	0.1814	0.1814
Echinococcus multilocularis	cathepsin b	0.1373	0.7729	0.7722
Trypanosoma cruzi	cysteine peptidase, putative	0.1766	1	1
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1373	0.7729	0.7729
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0352	0.1814	0.0572
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0925	0.5133	0.4394
Plasmodium vivax	unspecified product	0.0925	0.5133	0.4054
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1373	0.7729	0.7729
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0352	0.1814	0.1814
Entamoeba histolytica	cysteine proteinase, putative	0.0925	0.5133	0.4054
Schistosoma mansoni	cathepsin s	0.0573	0.3097	0.3097
Trypanosoma cruzi	cruzipain precursor, putative	0.0573	0.3097	0.1568
Onchocerca volvulus		0.1766	1	1
Leishmania major	cathepsin L-like protease	0.1766	1	1
Brugia malayi	Sodium:solute symporter family protein	0.0043	0.0028	0.0028
Loa Loa (eye worm)	cathepsin B	0.0668	0.3643	0.3643
Schistosoma mansoni	cathepsin F (C01 family)	0.1192	0.6681	0.6681
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0352	0.1814	0.1814
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1766	1	1
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0925	0.5133	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.1766	1	1
Loa Loa (eye worm)	hypothetical protein	0.1373	0.7729	0.7729
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1814	0.1814
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0925	0.5133	0.5133
Echinococcus multilocularis	high affinity choline transporter 1	0.039	0.2036	0.2014
Leishmania major	cathepsin L-like protease	0.1766	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0352	0.1814	0.1814
Entamoeba histolytica	cysteine protease, putative	0.1766	1	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0102	0.0102
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1373	0.7729	0.7225
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0352	0.1814	0.0572
Leishmania major	cathepsin L-like protease	0.1766	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Onchocerca volvulus		0.1766	1	1
Echinococcus granulosus	cathepsin b	0.1373	0.7729	0.7722
Brugia malayi	Cathepsin L-like precursor	0.1766	1	1
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1814	0.1814
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Loa Loa (eye worm)	hypothetical protein	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0352	0.1814	0.1791
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Plasmodium vivax	vivapain-2	0.1766	1	1
Onchocerca volvulus		0.0352	0.1814	0.1791
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0102	0.0102
Entamoeba histolytica	cysteine proteinase, putative	0.1192	0.6681	0.5946
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0925	0.5133	0.5133
Onchocerca volvulus		0.1766	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1766	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1766	1	1
Brugia malayi	Cathepsin L-like precursor	0.1766	1	1
Schistosoma mansoni	high-affinity choline transporter	0.039	0.2036	0.2036
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1814	0.1814
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1766	1	1
Brugia malayi	Cathepsin L-like precursor	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0352	0.1814	0.0572
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Giardia lamblia	Cathepsin B precursor	0.0668	0.3643	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0352	0.1814	0.1814
Entamoeba histolytica	cysteine proteinase, putative	0.1766	1	1
Brugia malayi	cathepsin L-like precursor	0.1192	0.6681	0.6681
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0352	0.1814	0.1814
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0352	0.1814	0.1814
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0352	0.1814	0.0572
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Echinococcus multilocularis	cathepsin b	0.1373	0.7729	0.7722
Echinococcus multilocularis	cathepsin L cysteine protease	0.1766	1	1
Brugia malayi	GH02984p	0.039	0.2036	0.2036
Trypanosoma cruzi	cysteine peptidase, putative	0.0925	0.5133	0.4054
Schistosoma mansoni	cathepsin B (C01 family)	0.0352	0.1814	0.1814
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0352	0.1814	0.1814
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0352	0.1814	0.0572
Leishmania major	cathepsin L-like protease	0.1766	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0925	0.5133	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1766	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0352	0.1814	0.1814
Echinococcus multilocularis	cysteine protease	0.1766	1	1
Giardia lamblia	Cathepsin B precursor	0.0668	0.3643	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0352	0.1814	0.0572
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1766	1	1
Echinococcus multilocularis	cysteine protease	0.1766	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.1766	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0668	0.3643	0.2235
Echinococcus granulosus	cysteine protease	0.0925	0.5133	0.5119
Onchocerca volvulus		0.1766	1	1
Brugia malayi	cathepsin L precursor	0.0352	0.1814	0.1814
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1766	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0352	0.1814	0.1814
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0352	0.1814	0.0572
Loa Loa (eye worm)	ctsf protein	0.1766	1	1
Onchocerca volvulus	Cathepsin F homolog	0.1766	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 35.1 uM	Cytotoxicity against human A549 cells by SRB assay	ChEMBL.	18653334

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL526493

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1021517