TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 437.442 | Formula: C23H21F2N5O2
H donors: 1 H acceptors: 3 LogP: 3.83 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)n1c(=O)n(c2c1nc(NCC1CC1)nc2)Cc1c(F)cccc1F
InChi: 1S/C23H21F2N5O2/c1-32-16-5-2-4-15(10-16)30-21-20(12-27-22(28-21)26-11-14-8-9-14)29(23(30)31)13-17-18(24)6-3-7-19(17)25/h2-7,10,12,14H,8-9,11,13H2,1H3,(H,26,27,28)
InChiKey: FUIDWXLLDCWFBC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	adenosine A1 receptor	Starlite/ChEMBL	References
Homo sapiens	adenosine A2a receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	hypothetical protein	adenosine A1 receptor	326 aa	305 aa	21.0 %
Brugia malayi	follicle stimulating hormone receptor	adenosine A2a receptor	412 aa	336 aa	22.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	somatostatin receptor	0.0008	0.0071	0.0027
Schistosoma mansoni	hypothetical protein	0.0008	0.0071	0.0081
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0008	0.0071	0.0027
Echinococcus multilocularis	serotonin receptor	0.0008	0.0071	0.0027
Brugia malayi	hypothetical protein	0.0008	0.0071	0.0072
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0.0044	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0052	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0008	0.0071	0.0027
Brugia malayi	TAR-binding protein	0.0139	0.2528	0.6781
Loa Loa (eye worm)	hypothetical protein	0.001	0.0098	0.0146
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.001	0.0098	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Schistosoma mansoni	aldehyde dehydrogenase	0.0068	0.1188	0.1359
Schistosoma mansoni	tar DNA-binding protein	0.0139	0.2528	0.2892
Onchocerca volvulus		0.0008	0.0071	0.0072
Brugia malayi	Serotonin receptor	0.0008	0.0071	0.0072
Echinococcus granulosus	neuropeptide receptor A26	0.0534	1	1
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0103	0.016
Echinococcus multilocularis	serotonin receptor	0.0008	0.0071	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Brugia malayi	Dopamine receptor protein 2	0.0008	0.0071	0.0072
Echinococcus multilocularis	allatostatin A receptor	0.0008	0.0071	0.0027
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0052	1
Echinococcus granulosus	g-protein coupled receptor	0.0008	0.0071	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Onchocerca volvulus		0.0008	0.0071	0.0072
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0008	0.0071	0.0081
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0008	0.0071	0.0027
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0008	0.0071	0.0072
Schistosoma mansoni	regulator of G protein signaling	0.001	0.0098	0.0112
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0008	0.0071	0.0027
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0008	0.0071	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0062	0.1085	0.9063
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0098	0.0054
Echinococcus multilocularis	g-protein coupled receptor	0.0008	0.0071	0.0027
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0008	0.0071	0.0027
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.1188	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0008	0.0071	0.0027
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0008	0.0071	0.0081
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0008	0.0071	0.0072
Schistosoma mansoni	neuropeptide receptor	0.0008	0.0071	0.0081
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0008	0.0071	0.0072
Echinococcus granulosus	sex peptide receptor	0.0008	0.0071	0.0027
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0478	0.1185
Schistosoma mansoni	growth hormone secretagogue receptor	0.0008	0.0071	0.0081
Onchocerca volvulus		0.003	0.0478	0.1185
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0052	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Brugia malayi	sulfakinin receptor protein	0.0008	0.0071	0.0072
Onchocerca volvulus		0.0008	0.0071	0.0072
Schistosoma mansoni	dishevelled	0.001	0.0098	0.0112
Schistosoma mansoni	neuropeptide f receptor 76f	0.0008	0.0071	0.0081
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0008	0.0071	0.0072
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.1188	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0008	0.0071	0.0027
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0098	0.0054
Brugia malayi	regulator of G-protein signaling egl-10	0.001	0.0098	0.0146
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.001	0.0098	0.0146
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0008	0.0071	0.0081
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0252	0.0208
Echinococcus granulosus	GPCR family 2	0.0018	0.0252	0.0208
Echinococcus granulosus	lamin	0.003	0.0478	0.0436
Schistosoma mansoni	amine GPCR	0.0008	0.0071	0.0081
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0252	0.0566
Brugia malayi	hypothetical protein	0.0008	0.0071	0.0072
Echinococcus granulosus	biogenic amine 5HT receptor	0.0008	0.0071	0.0027
Schistosoma mansoni	opsin-like receptor	0.0008	0.0071	0.0081
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.001	0.0098	0.0146
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0068	0.1188	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.0987	0.2575
Echinococcus multilocularis	fmrfamide receptor	0.0008	0.0071	0.0027
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0052	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Brugia malayi	DIX domain containing protein	0.001	0.0098	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Echinococcus granulosus	7tm_1 domain containing protein	0.0008	0.0071	0.0027
Echinococcus multilocularis	lamin	0.003	0.0478	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Echinococcus multilocularis	neuropeptide receptor A26	0.0534	1	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Brugia malayi	hypothetical protein	0.0008	0.0071	0.0072
Trypanosoma cruzi	guanine nucleotide releasing protein, putative	0.0007	0.0044	0.5
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0185	0.0384
Onchocerca volvulus		0.0008	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0008	0.0071	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Trichomonas vaginalis	helicase, putative	0.0007	0.0052	1
Echinococcus multilocularis	g protein coupled receptor	0.0008	0.0071	0.0027
Echinococcus multilocularis	dro:myosuppressin receptor	0.0008	0.0071	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Echinococcus multilocularis	dnaJ subfamily B	0.0468	0.8739	0.8733
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Schistosoma mansoni	intermediate filament proteins	0.003	0.0478	0.0547
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0008	0.0071	0.0027
Echinococcus multilocularis	cpg binding protein	0.0035	0.0566	0.0524
Brugia malayi	RNA recognition motif domain containing protein	0.0139	0.2528	0.6781
Brugia malayi	larval opioid receptor	0.0008	0.0071	0.0072
Brugia malayi	hypothetical protein	0.0008	0.0071	0.0072
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0052	1
Echinococcus multilocularis	neuropeptide receptor	0.0008	0.0071	0.0027
Echinococcus multilocularis	somatostatin receptor	0.0008	0.0071	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0468	0.1156
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Echinococcus granulosus	tar DNA binding protein	0.0139	0.2528	0.2494
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.1188	0.5
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0.0044	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0008	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.007	0.1226	0.1403
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0052	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0008	0.0071	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Loa Loa (eye worm)	G-protein coupled receptor	0.0008	0.0071	0.0072
Schistosoma mansoni	neuropeptide receptor	0.0008	0.0071	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0174	0.0355
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0098	0.0146
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0103	0.0059
Schistosoma mansoni	amine GPCR	0.0008	0.0071	0.0081
Echinococcus granulosus	intermediate filament protein	0.003	0.0478	0.0436
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0008	0.0071	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Schistosoma mansoni	adenoreceptor	0.0008	0.0071	0.0081
Onchocerca volvulus		0.0008	0.0071	0.0072
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0008	0.0071	0.0027
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0008	0.0071	0.0081
Echinococcus granulosus	serotonin receptor	0.0008	0.0071	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0252	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0008	0.0071	0.0081
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0008	0.0071	0.0027
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0007	0.0044	0.0051
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0007	0.0038	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0252	0.0566
Schistosoma mansoni	z-protein (S1r protein)	0.001	0.0098	0.0112
Brugia malayi	Dopamine receptor	0.0008	0.0071	0.0072
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0185	0.0141
Brugia malayi	putative neuropeptide receptor	0.0008	0.0071	0.0072
Entamoeba histolytica	hypothetical protein	0.0007	0.0044	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0008	0.0071	0.0072
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.0987	0.2575
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0793	0.0752
Onchocerca volvulus		0.0008	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0008	0.0071	0.0027
Echinococcus granulosus	dnaJ subfamily B	0.0468	0.8739	0.8733
Onchocerca volvulus		0.0008	0.0071	0.0072
Brugia malayi	G-protein coupled receptor	0.0008	0.0071	0.0072
Schistosoma mansoni	hypothetical protein	0.0018	0.0252	0.0288
Echinococcus granulosus	7TM GPCR rhodopsin	0.0008	0.0071	0.0027
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0065	0.0021
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0.0044	0.5
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0007	0.0044	0.0051
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0008	0.0071	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0174	0.0355
Echinococcus multilocularis	lamin dm0	0.003	0.0478	0.0436
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0793	0.0907
Schistosoma mansoni	hypothetical protein	0.0008	0.0071	0.0081
Schistosoma mansoni	hypothetical protein	0.0018	0.0252	0.0288
Schistosoma mansoni	biogenic amine receptor	0.0008	0.0071	0.0081
Schistosoma mansoni	neuropeptide F-like receptor	0.0008	0.0071	0.0081
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0008	0.0071	0.0081
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0052	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0647	0.1645
Brugia malayi	Serotonin receptor	0.0008	0.0071	0.0072
Brugia malayi	AKH receptor	0.0008	0.0071	0.0072
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0008	0.0071	0.0027
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0068	0.1188	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0052	1
Loa Loa (eye worm)	DIX domain-containing protein	0.001	0.0098	0.0146
Onchocerca volvulus		0.001	0.0098	0.0146
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0793	0.2043
Schistosoma mansoni	hypothetical protein	0.0008	0.0071	0.0081
Echinococcus granulosus	neuropeptide Y receptor	0.0008	0.0071	0.0027
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0008	0.0071	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Schistosoma mansoni	cpg binding protein	0.0035	0.0566	0.0648
Echinococcus granulosus	hypothetical protein	0.0008	0.0071	0.0027
Echinococcus granulosus	rhodopsin orphan GPCR	0.0008	0.0071	0.0027
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0068	0.1188	0.1148
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0008	0.0071	0.0081
Echinococcus granulosus	rhodopsin orphan GPCR	0.0008	0.0071	0.0027
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0008	0.0071	0.0072
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0008	0.0071	0.0027
Brugia malayi	N-terminal motif family protein	0.0201	0.3706	1
Brugia malayi	intermediate filament protein	0.003	0.0478	0.1185
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0052	1
Schistosoma mansoni	lamin	0.003	0.0478	0.0547
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0008	0.0071	0.0027
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0007	0.0044	0.0051
Trypanosoma cruzi	hypothetical protein	0.0007	0.0044	0.5
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0252	0.0566
Loa Loa (eye worm)	neuropeptide F receptor	0.0008	0.0071	0.0072
Schistosoma mansoni	neuropeptide F-like receptor	0.0008	0.0071	0.0081
Loa Loa (eye worm)	melatonin receptor type 1A	0.0008	0.0071	0.0072
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0647	0.1645
Schistosoma mansoni	biogenic amine receptor	0.0008	0.0071	0.0081
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0008	0.0071	0.0072
Brugia malayi	G protein-coupled receptor	0.0008	0.0071	0.0072
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0008	0.0071	0.0027
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0201	0.3706	1
Loa Loa (eye worm)	TAR-binding protein	0.0139	0.2528	0.6781
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0008	0.0071	0.0027
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0008	0.0071	0.0081
Onchocerca volvulus		0.0033	0.0531	0.1329
Schistosoma mansoni	neuropeptide receptor	0.0008	0.0071	0.0081
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0.0044	0.5
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0215	0.0466
Onchocerca volvulus		0.0008	0.0071	0.0072
Echinococcus multilocularis	sex peptide receptor	0.0008	0.0071	0.0027
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0052	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0098	0.0146
Loa Loa (eye worm)	RNA binding protein	0.0139	0.2528	0.6781
Echinococcus multilocularis	g protein coupled receptor	0.0008	0.0071	0.0027
Loa Loa (eye worm)	neuropeptide F receptor	0.0008	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Echinococcus granulosus	neuropeptides capa receptor	0.0008	0.0071	0.0027
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0008	0.0071	0.0081
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0008	0.0071	0.0027
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0008	0.0071	0.0081
Brugia malayi	neuropeptide F receptor	0.0008	0.0071	0.0072
Brugia malayi	putative neuropeptide receptor NPR1	0.0008	0.0071	0.0072
Onchocerca volvulus		0.0008	0.0071	0.0072
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0793	0.2043
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0008	0.0071	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Echinococcus granulosus	tm gpcr rhodopsin	0.0008	0.0071	0.0027
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0008	0.0071	0.0027
Loa Loa (eye worm)	TYRA-2 protein	0.0008	0.0071	0.0072
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.0987	0.2575
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0098	0.0054
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0008	0.0071	0.0072
Brugia malayi	Dopamine receptor protein 1	0.0008	0.0071	0.0072
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0007	0.0044	0.0051
Echinococcus granulosus	fmrfamide receptor	0.0008	0.0071	0.0027
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0098	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Schistosoma mansoni	hypothetical protein	0.0039	0.0647	0.074
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0098	0.0146
Brugia malayi	follicle stimulating hormone receptor	0.0008	0.0071	0.0072
Echinococcus granulosus	G protein coupled receptor 139	0.0008	0.0071	0.0027
Echinococcus granulosus	tm gpcr rhodopsin	0.0008	0.0071	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0098	0.0054
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0008	0.0071	0.0081
Echinococcus granulosus	neuropeptide receptor	0.0008	0.0071	0.0027
Schistosoma mansoni	hypothetical protein	0.0018	0.0252	0.0288
Onchocerca volvulus		0.003	0.0478	0.1185
Brugia malayi	hypothetical protein	0.0008	0.0071	0.0072
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0008	0.0071	0.0027
Loa Loa (eye worm)	hypothetical protein	0.003	0.0478	0.1185
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0008	0.0071	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Echinococcus granulosus	neuropeptide receptor	0.0008	0.0071	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0008	0.0071	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Schistosoma mansoni	dishevelled	0.001	0.0098	0.0112
Brugia malayi	hypothetical protein	0.0008	0.0071	0.0072
Echinococcus multilocularis	G protein coupled receptor 139	0.0008	0.0071	0.0027
Echinococcus granulosus	rhodopsin orphan GPCR	0.0008	0.0071	0.0027
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0008	0.0071	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0103	0.0059
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0065	0.0074
Schistosoma mansoni	lamin	0.003	0.0478	0.0547
Echinococcus granulosus	orexin receptor type 2	0.0008	0.0071	0.0027
Brugia malayi	hypothetical protein	0.0008	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Echinococcus granulosus	g protein coupled receptor	0.0008	0.0071	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Schistosoma mansoni	tar DNA-binding protein	0.0139	0.2528	0.2892
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0793	0.0907
Echinococcus multilocularis	orexin receptor type 2	0.0008	0.0071	0.0027
Echinococcus multilocularis	tar DNA binding protein	0.0139	0.2528	0.2494
Schistosoma mansoni	hypothetical protein	0.0468	0.8739	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0008	0.0071	0.0027
Brugia malayi	RE15519p	0.0008	0.0071	0.0072
Echinococcus multilocularis	fmrfamide receptor	0.0008	0.0071	0.0027
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0008	0.0071	0.0072
Echinococcus multilocularis	musashi	0.003	0.0478	0.0436
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0531	0.1329
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0.0044	0.5
Echinococcus granulosus	g protein coupled receptor	0.0008	0.0071	0.0027
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0098	0.0054
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0008	0.0071	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Schistosoma mansoni	amine GPCR	0.0008	0.0071	0.0081
Brugia malayi	RNA binding protein	0.0139	0.2528	0.6781
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0052	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0793	0.0752
Onchocerca volvulus		0.0008	0.0071	0.0072
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0052	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0252	0.0208
Echinococcus granulosus	rhodopsin orphan GPCR	0.0008	0.0071	0.0027
Echinococcus granulosus	cpg binding protein	0.0035	0.0566	0.0524
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0008	0.0071	0.0027
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0065	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Brugia malayi	hypothetical protein	0.0008	0.0071	0.0072
Brugia malayi	Melatonin receptor type 1A	0.0008	0.0071	0.0072
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0008	0.0071	0.0027
Loa Loa (eye worm)	hypothetical protein	0.001	0.0098	0.0146
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0008	0.0071	0.0027
Echinococcus multilocularis	neuropeptide Y receptor	0.0008	0.0071	0.0027
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0068	0.1188	0.1148
Toxoplasma gondii	aldehyde dehydrogenase	0.0068	0.1188	1
Echinococcus multilocularis	neuropeptide receptor	0.0008	0.0071	0.0027
Echinococcus granulosus	neuropeptide Y receptor	0.0008	0.0071	0.0027
Echinococcus multilocularis	neuropeptides capa receptor	0.0008	0.0071	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Schistosoma mansoni	hypothetical protein	0.0008	0.0071	0.0081
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0008	0.0071	0.0081
Echinococcus granulosus	allatostatin A receptor	0.0008	0.0071	0.0027
Schistosoma mansoni	myosin xvIII	0.0008	0.0071	0.0081
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0008	0.0071	0.0081
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0.0044	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0008	0.0071	0.0027
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0252	0.0208
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0098	0.0054
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0.0044	0.5
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Onchocerca volvulus		0.0008	0.0071	0.0072
Brugia malayi	hypothetical protein	0.001	0.0098	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0008	0.0071	0.0081
Brugia malayi	hypothetical protein	0.001	0.0098	0.0146
Echinococcus granulosus	rhodopsin orphan GPCR	0.0008	0.0071	0.0027
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.01	0.0153
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0008	0.0071	0.0027
Schistosoma mansoni	cpg binding protein	0.0035	0.0566	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0.0044	0.5
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0531	0.1329
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0098	0.0054
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0.0044	0.5
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0008	0.0071	0.0081
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0252	0.0208
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0793	0.0752
Schistosoma mansoni	tar DNA-binding protein	0.0139	0.2528	0.2892
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0008	0.0071	0.0081
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0052	1
Schistosoma mansoni	neuropeptide receptor	0.0008	0.0071	0.0081
Onchocerca volvulus		0.0008	0.0071	0.0072
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0008	0.0071	0.0027
Onchocerca volvulus		0.0008	0.0071	0.0072
Schistosoma mansoni	hypothetical protein	0.0018	0.0252	0.0288
Echinococcus granulosus	Pleckstrin G protein interacting region	0.001	0.0098	0.0054
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0008	0.0071	0.0027
Schistosoma mansoni	amine GPCR	0.0008	0.0071	0.0081
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0478	0.1185
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0793	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0008	0.0071	0.0081
Onchocerca volvulus		0.0008	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0.0044	0.5
Brugia malayi	ORL1-like opioid receptor	0.0008	0.0071	0.0072
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0008	0.0071	0.0027
Schistosoma mansoni	amine GPCR	0.0008	0.0071	0.0081
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0008	0.0071	0.0027
Brugia malayi	hypothetical protein	0.0008	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0201	0.3706	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0008	0.0071	0.0027
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0185	0.0141
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0008	0.0071	0.0072
Onchocerca volvulus		0.0008	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0008	0.0071	0.0027
Brugia malayi	G-protein coupled receptor	0.0008	0.0071	0.0072
Brugia malayi	GnHR receptor homolog	0.0008	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Schistosoma mansoni	biogenic amine receptor	0.0008	0.0071	0.0081
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0008	0.0071	0.0072
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0008	0.0071	0.0081
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0052	1
Trypanosoma cruzi	hypothetical protein	0.0007	0.0044	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0008	0.0071	0.0072
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0008	0.0071	0.0072
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0052	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0068	0.1188	0.1359
Echinococcus granulosus	tm gpcr rhodopsin	0.0008	0.0071	0.0027
Echinococcus granulosus	neuropeptide FF receptor 2	0.0008	0.0071	0.0027
Brugia malayi	hypothetical protein	0.0008	0.0071	0.0072
Schistosoma mansoni	ras GTP exchange factor	0.0007	0.0044	0.0051
Brugia malayi	G protein-coupled receptor F59B2.13	0.0008	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0987	0.2575
Schistosoma mansoni	opsin-like receptor	0.0008	0.0071	0.0081
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0478	0.1185
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0.0044	0.5
Onchocerca volvulus		0.0008	0.0071	0.0072
Schistosoma mansoni	tar DNA-binding protein	0.0139	0.2528	0.2892
Echinococcus multilocularis	neuropeptides capa receptor	0.0008	0.0071	0.0027
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0008	0.0071	0.0081
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.001	0.0098	0.0054
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0139	0.2528	0.6781
Schistosoma mansoni	dep domain containing protein	0.001	0.0098	0.0112
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0215	0.0466
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0008	0.0071	0.0027
Echinococcus multilocularis	neuropeptide s receptor	0.0534	1	1
Schistosoma mansoni	cpg binding protein	0.0033	0.0531	0.0608
Onchocerca volvulus		0.0008	0.0071	0.0072
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0.0044	0.5
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0007	0.0044	0.5
Echinococcus granulosus	g protein coupled receptor	0.0008	0.0071	0.0027
Schistosoma mansoni	opsin-like receptor	0.0008	0.0071	0.0081
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0052	1
Brugia malayi	neuropeptide F receptor	0.0008	0.0071	0.0072
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0252	0.0208
Echinococcus granulosus	neuropeptides capa receptor	0.0008	0.0071	0.0027
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0008	0.0071	0.0027
Schistosoma mansoni	tar DNA-binding protein	0.0139	0.2528	0.2892
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0065	0.0021
Echinococcus granulosus	lamin dm0	0.003	0.0478	0.0436
Schistosoma mansoni	histamine h1 receptor	0.0008	0.0071	0.0081
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0793	0.0907
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0052	1
Echinococcus multilocularis	g protein coupled receptor	0.0008	0.0071	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0071	0.0072
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0065	0.0021

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 499 nM	Displacement of [3H]SCH-58261 from human recombinant adenosine A2A receptor expressed in HEK293 cells	ChEMBL.	19181527
Ki (binding)	= 1072 nM	Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in CHOK1 cells	ChEMBL.	19181527

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL523815

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1021663