Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0076 | 0.3884 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.2121 | 0.5062 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0054 | 0.254 | 0.6415 |
Plasmodium vivax | glutathione reductase, putative | 0.0054 | 0.254 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0019 | 0.0313 | 0.0475 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0019 | 0.0313 | 0.0475 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0138 | 0.7773 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0019 | 0.0313 | 0.0475 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0019 | 0.0313 | 0.0475 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0076 | 0.3884 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0313 | 0.0475 |
Loa Loa (eye worm) | inositol-1 | 0.0076 | 0.3884 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0076 | 0.3884 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0019 | 0.0313 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0054 | 0.254 | 0.6415 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0076 | 0.3884 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0019 | 0.0313 | 0.0475 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1813 | 0.1548 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0138 | 0.7773 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0124 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable reductase | 0.0124 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0124 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0124 | 0.6906 | 0.8837 |
Brugia malayi | glutathione reductase | 0.0054 | 0.254 | 0.654 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0076 | 0.3884 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0313 | 0.0475 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0124 | 0.6906 | 0.8837 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.2121 | 0.1866 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0019 | 0.0313 | 0.0475 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1813 | 0.42 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0019 | 0.0313 | 0.0475 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0313 | 0.0475 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0019 | 0.0313 | 0.0475 |
Loa Loa (eye worm) | glutathione reductase | 0.0054 | 0.254 | 0.6415 |
Plasmodium falciparum | thioredoxin reductase | 0.0054 | 0.254 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0076 | 0.3884 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0789 | 0.1743 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0019 | 0.0313 | 0.0475 |
Schistosoma mansoni | inositol monophosphatase | 0.0076 | 0.3884 | 0.3686 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0019 | 0.0313 | 0.0475 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.2121 | 0.5062 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0313 | 0.0475 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0313 | 0.0475 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0076 | 0.3884 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1813 | 0.4668 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0068 | 0.3386 | 0.4119 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0019 | 0.0313 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1813 | 0.1548 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0054 | 0.254 | 0.6237 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0076 | 0.3884 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.2121 | 0.5062 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0076 | 0.3884 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.2121 | 0.5461 |
Brugia malayi | Thioredoxin reductase | 0.0054 | 0.254 | 0.654 |
Toxoplasma gondii | thioredoxin reductase | 0.0054 | 0.254 | 0.6237 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0076 | 0.3884 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0313 | 0.0475 |
Trypanosoma brucei | trypanothione reductase | 0.0054 | 0.254 | 0.6415 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.2121 | 0.5297 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0138 | 0.7773 | 1 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0019 | 0.0313 | 0.0475 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.2121 | 0.1866 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.2121 | 0.1866 |
Plasmodium falciparum | glutathione reductase | 0.0054 | 0.254 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1813 | 0.42 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.2121 | 0.5062 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0054 | 0.254 | 0.2985 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0313 | 0.0475 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0124 | 0.6906 | 0.8023 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0019 | 0.0313 | 0.0807 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0054 | 0.254 | 0.6237 |
Brugia malayi | Cytochrome P450 family protein | 0.0016 | 0.0135 | 0.0349 |
Leishmania major | trypanothione reductase | 0.0054 | 0.254 | 0.6415 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0054 | 0.254 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0789 | 0.2031 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0124 | 0.6906 | 0.8837 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0138 | 0.7773 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0016 | 0.0135 | 0.0349 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0076 | 0.3884 | 1 |
Brugia malayi | Inositol-1 | 0.0076 | 0.3884 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0076 | 0.3884 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0076 | 0.3884 | 1 |
Treponema pallidum | NADH oxidase | 0.0019 | 0.0313 | 0.5 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0019 | 0.0313 | 0.0475 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0313 | 0.0475 |
Schistosoma mansoni | inositol monophosphatase | 0.0076 | 0.3884 | 0.3686 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.