Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.108 | 0.5 |
Onchocerca volvulus | 0.0036 | 0.108 | 1 | |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.108 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.2918 | 0.4289 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.108 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.2918 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0129 | 0.5435 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.108 | 0.2197 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.108 | 0.2054 |
Brugia malayi | beta-lactamase | 0.0036 | 0.108 | 0.2054 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0664 | 0.1193 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0664 | 0.1185 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.108 | 0.0791 |
Brugia malayi | hypothetical protein | 0.0075 | 0.2918 | 0.5864 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.2918 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.108 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.108 | 0.2197 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.4913 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.014 | 0.5918 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0089 | 0.018 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0628 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0628 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.108 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0628 | 0.1278 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0664 | 0.1088 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.108 | 0.2197 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0075 | 0.2918 | 0.4289 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.108 | 0.1793 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0023 | 0.0046 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.4913 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.108 | 0.2197 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.108 | 0.2197 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.108 | 0.1953 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.108 | 0.2197 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.108 | 0.2197 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.108 | 0.0791 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0129 | 0.5435 | 0.9181 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0201 | 0.0234 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.108 | 1 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0664 | 0.1088 |
Schistosoma mansoni | thyroid hormone receptor | 0.014 | 0.5918 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.2918 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.2918 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0664 | 0.1352 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.108 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.108 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0075 | 0.2918 | 0.4911 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.108 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.108 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.108 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0664 | 0.1352 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.108 | 0.2197 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.108 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.108 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0664 | 0.1185 |
Onchocerca volvulus | 0.0036 | 0.108 | 1 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.108 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.108 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.014 | 0.5918 | 1 |
Onchocerca volvulus | 0.0036 | 0.108 | 1 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0664 | 0.1193 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.108 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0664 | 0.1352 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0628 | 0.1118 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.108 | 0.2054 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.108 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.108 | 0.2054 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.5435 | 0.9081 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0075 | 0.2918 | 0.5349 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.108 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.108 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.4913 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0642 | 0.1306 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0664 | 0.1088 |
Echinococcus granulosus | lamin | 0.0027 | 0.0664 | 0.1185 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 12.5 ug ml-1 | Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 28 days by agar dilution method | ChEMBL. | 21665469 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.