Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Huntingtin homolog | 0.0138 | 0.3338 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0284 | 0.8359 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.3338 | 0.3993 |
Plasmodium falciparum | glutathione reductase | 0.0053 | 0.0442 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0087 | 0.159 | 0.1849 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0345 | 0.035 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0121 | 0.2774 | 0.5588 |
Echinococcus granulosus | lamin dm0 | 0.0087 | 0.159 | 0.1849 |
Loa Loa (eye worm) | acetyltransferase | 0.0159 | 0.4082 | 0.4884 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0087 | 0.159 | 0.1902 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0057 | 0.0572 | 0.0358 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0159 | 0.4082 | 0.4882 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.0641 | 0.0764 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0047 | 0.0228 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0053 | 0.0442 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0087 | 0.159 | 0.19 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0155 | 0.3929 | 0.4666 |
Brugia malayi | Fli-1 protein | 0.0222 | 0.6214 | 0.7433 |
Echinococcus multilocularis | lamin | 0.0087 | 0.159 | 0.1849 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0053 | 0.0442 | 0.0467 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0135 | 0.3237 | 0.6698 |
Schistosoma mansoni | intermediate filament proteins | 0.0087 | 0.159 | 0.19 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0345 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1536 | 0.1837 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0121 | 0.2774 | 0.5588 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0157 | 0.4007 | 0.3871 |
Schistosoma mansoni | tar DNA-binding protein | 0.0284 | 0.8359 | 1 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0073 | 0.1123 | 0.1286 |
Schistosoma mansoni | tar DNA-binding protein | 0.0284 | 0.8359 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0053 | 0.0442 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0284 | 0.8359 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0157 | 0.4007 | 0.373 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.0641 | 0.0766 |
Brugia malayi | glutathione reductase | 0.0053 | 0.0442 | 0.0527 |
Schistosoma mansoni | tar DNA-binding protein | 0.0284 | 0.8359 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0053 | 0.0442 | 0.0529 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0121 | 0.2774 | 0.5588 |
Mycobacterium tuberculosis | Probable reductase | 0.0121 | 0.2774 | 0.5588 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0073 | 0.1123 | 0.1286 |
Brugia malayi | hypothetical protein | 0.0138 | 0.3338 | 0.3991 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0054 | 0.0065 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0043 | 0.0094 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0284 | 0.8359 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0157 | 0.4007 | 0.3871 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0345 | 0.0411 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0332 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0087 | 0.159 | 0.1902 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0121 | 0.2774 | 0.5588 |
Brugia malayi | TAR-binding protein | 0.0284 | 0.8359 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0053 | 0.0442 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.076 | 0.0909 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0332 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0047 | 0.0228 | 0.0209 |
Brugia malayi | intermediate filament protein | 0.0087 | 0.159 | 0.19 |
Brugia malayi | Ets-domain containing protein | 0.0073 | 0.1123 | 0.1341 |
Echinococcus multilocularis | musashi | 0.0087 | 0.159 | 0.1849 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0135 | 0.3237 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0087 | 0.159 | 0.1849 |
Onchocerca volvulus | Huntingtin homolog | 0.0138 | 0.3338 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0159 | 0.4082 | 0.485 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0641 | 0.0766 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0345 | 0.035 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0345 | 0.0413 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0047 | 0.0228 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0046 | 0.0212 | 0.0251 |
Plasmodium vivax | glutathione reductase, putative | 0.0053 | 0.0442 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0002 | 0.0002 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.0641 | 0.0764 |
Schistosoma mansoni | ets-related | 0.0222 | 0.6214 | 0.7433 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0073 | 0.1123 | 0.1343 |
Schistosoma mansoni | gabp alpha | 0.0073 | 0.1123 | 0.1341 |
Loa Loa (eye worm) | fli-1 protein | 0.0222 | 0.6214 | 0.7434 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0159 | 0.4082 | 0.4882 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0121 | 0.2774 | 0.5588 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0175 | 0.4615 | 1 |
Echinococcus granulosus | lamin | 0.0087 | 0.159 | 0.1849 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0135 | 0.3237 | 0.6698 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0053 | 0.0442 | 0.0467 |
Toxoplasma gondii | thioredoxin reductase | 0.0053 | 0.0442 | 0.9345 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0332 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0053 | 0.0442 | 0.0225 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0345 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.3338 | 0.3993 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0345 | 0.0411 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.159 | 0.1902 |
Loa Loa (eye worm) | TAR-binding protein | 0.0284 | 0.8359 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0073 | 0.1123 | 0.1341 |
Schistosoma mansoni | lamin | 0.0087 | 0.159 | 0.19 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0043 | 0.0094 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0054 | 0.0457 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0053 | 0.0442 | 0.0225 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0345 | 0.0411 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0046 | 0.0212 | 0.0254 |
Mycobacterium ulcerans | hypothetical protein | 0.0175 | 0.4615 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0135 | 0.3237 | 0.6698 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0345 | 0.0411 |
Brugia malayi | Thioredoxin reductase | 0.0053 | 0.0442 | 0.0527 |
Schistosoma mansoni | lamin | 0.0087 | 0.159 | 0.19 |
Echinococcus multilocularis | tar DNA binding protein | 0.0284 | 0.8359 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0284 | 0.8359 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0284 | 0.8359 | 1 |
Brugia malayi | RNA binding protein | 0.0284 | 0.8359 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0284 | 0.8359 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.