TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 320.817 | Formula: C16H21ClN4O
H donors: 1 H acceptors: 2 LogP: 4.42 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: N#CN1CCCCN1C(=O)C(C(C)C)Nc1ccc(cc1)Cl
InChi: 1S/C16H21ClN4O/c1-12(2)15(19-14-7-5-13(17)6-8-14)16(22)21-10-4-3-9-20(21)11-18/h5-8,12,15,19H,3-4,9-10H2,1-2H3
InChiKey: BKMARWROUWRNAF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0332	0.0528
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.1106	0.104
Loa Loa (eye worm)	cathepsin B	0.0065	0.1471	0.3337
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0046	0.1028	0.0961
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0059	0.133	0.299
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.133	0.8189
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0065	0.1471	0.1471
Entamoeba histolytica	cysteine proteinase 1, putative	0.0033	0.0695	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.133	0.133
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0015	0.0261	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0261	0.0354
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0076	0.1741	0.1679
Schistosoma mansoni	cathepsin F (C01 family)	0.0041	0.0897	0.0897
Brugia malayi	Latrophilin receptor protein 2	0.0046	0.1028	0.2251
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.133	0.8189
Onchocerca volvulus		0.0059	0.133	1
Onchocerca volvulus		0.0059	0.133	1
Schistosoma mansoni	cpg binding protein	0.0029	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0332	0.0528
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0015	0.0261	0.0261
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0076	0.1741	1
Plasmodium vivax	unspecified product	0.0018	0.0332	0.0476
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0015	0.0261	0.1432
Echinococcus multilocularis	dnaJ subfamily B	0.0415	1	1
Loa Loa (eye worm)	hypothetical protein	0.01	0.234	0.5479
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0695	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0695	0.4054
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0041	0.0897	0.1625
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0015	0.0261	0.1432
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0118	0.0044
Brugia malayi	Papain family cysteine protease containing protein	0.0015	0.0261	0.0361
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0695	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0015	0.0261	0.1432
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0147	0.347	0.8267
Schistosoma mansoni	cpg binding protein	0.0031	0.0648	0.0648
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0059	0.133	0.7224
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0695	0.4054
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0065	0.1471	1
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.133	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0332	0.0528
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.1242	0.6627
Brugia malayi	cathepsin L precursor	0.0015	0.0261	0.0361
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0015	0.0261	0.0261
Schistosoma mansoni	peptidase Clp (S14 family)	0.0076	0.1741	0.1741
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0897	0.1922
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0695	0.4054
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.1741	0.5
Echinococcus multilocularis	cathepsin L	0.0033	0.0695	0.0625
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0261	0.1432
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.133	0.8189
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	0.4173	0.4173
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.133	0.9004
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0608	0.1214
Toxoplasma gondii	hypothetical protein	0.0026	0.0533	0.1838
Brugia malayi	Cathepsin L-like precursor	0.0059	0.133	0.2995
Onchocerca volvulus		0.0059	0.133	1
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0695	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.133	0.9004
Brugia malayi	Cathepsin L-like precursor	0.0041	0.0897	0.1927
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0261	0.1432
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.133	0.9004
Giardia lamblia	Cathepsin B precursor	0.0065	0.1471	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0041	0.0897	0.5935
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.133	0.8189
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.1741	0.5
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0015	0.0261	0.0261
Brugia malayi	Cathepsin L-like precursor	0.0059	0.133	0.2995
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0695	0.4054
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0046	0.1028	0.0961
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0695	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0261	0.0354
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.133	0.9004
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0089	0.2058	0.4789
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0015	0.0261	0.0361
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.1106	0.104
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0059	0.133	0.1265
Toxoplasma gondii	cathepsin B	0.0065	0.1471	0.8174
Schistosoma mansoni	hypothetical protein	0.0046	0.1028	0.1028
Echinococcus multilocularis	cathepsin b	0.0176	0.4173	0.4129
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0695	0.4054
Giardia lamblia	Cathepsin B precursor	0.0065	0.1471	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0147	0.347	0.8267
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0015	0.0261	0.0261
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.133	0.9004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.133	0.9004
Echinococcus multilocularis	cpg binding protein	0.0031	0.0648	0.0578
Onchocerca volvulus		0.0059	0.133	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0261	0.0354
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.2058	0.1998
Echinococcus multilocularis	cathepsin b	0.0176	0.4173	0.4129
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0015	0.0261	0.1432
Schistosoma mansoni	cpg binding protein	0.0031	0.0648	0.0648
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.133	0.8189
Echinococcus granulosus	cathepsin L	0.0015	0.0261	0.0188
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0695	0.4502
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.133	0.2733
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.133	0.2733
Loa Loa (eye worm)	hypothetical protein	0.0147	0.347	0.8266
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0015	0.0261	0.0261
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.133	0.9004
Onchocerca volvulus		0.0059	0.133	1
Echinococcus granulosus	cathepsin l1	0.0059	0.133	0.1265
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0015	0.0261	0.1432
Echinococcus multilocularis	cathepsin L	0.0015	0.0261	0.0188
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.1403	0.1403
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.133	0.8189
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.133	0.9004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.133	0.9004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.133	0.9004
Brugia malayi	fibroinase precursor	0.0015	0.0261	0.0361
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.0695	0.1429
Schistosoma mansoni	cathepsin B (C01 family)	0.0015	0.0261	0.0261
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.133	0.9004
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.133	0.2733
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0059	0.133	0.1265
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0332	0.0534
Brugia malayi	Papain family cysteine protease containing protein	0.0015	0.0261	0.0361
Schistosoma mansoni	hypothetical protein	0.0046	0.1028	0.1028
Loa Loa (eye worm)	hypothetical protein	0.0176	0.4173	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0059	0.133	0.1265
Brugia malayi	Cathepsin L-like precursor	0.0041	0.0897	0.1927
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.133	0.9004
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0015	0.0261	0.0361
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0695	0.4054
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0046	0.1028	0.0961
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	0.4173	0.4173
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0261	0.0354
Trypanosoma cruzi	cysteine proteinase, putative	0.0033	0.0695	0.1108
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.133	0.9004
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0033	0.0695	0.0695
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.1741	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.133	0.9004
Brugia malayi	cathepsin F-like cysteine proteinase	0.0018	0.0332	0.0534
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0076	0.1741	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0015	0.0261	0.1432
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0059	0.133	0.1265
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0695	0.4054
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0608	0.1208
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.1106	0.5
Onchocerca volvulus	Cathepsin L homolog	0.0059	0.133	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0118	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0897	0.1922
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0015	0.0261	0.1432
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0033	0.0695	0.2929
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0695	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.133	0.9004
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.2058	0.1998
Schistosoma mansoni	cathepsin s	0.0018	0.0332	0.0332
Echinococcus multilocularis	cathepsin L cysteine protease	0.0059	0.133	0.1265
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.2058	0.2058
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0059	0.133	0.9004
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0015	0.0261	0.0361
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0015	0.0261	0.1432
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0897	0.1922
Entamoeba histolytica	cysteine proteinase, putative	0.0041	0.0897	0.5946
Toxoplasma gondii	cathepsin CPL	0.0059	0.133	0.7224
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0015	0.0261	0.0261
Trypanosoma cruzi	cysteine peptidase, putative	0.0033	0.0695	0.1108
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.133	0.9004
Loa Loa (eye worm)	hypothetical protein	0.0059	0.133	0.299
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0261	0.1432
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0046	0.1028	0.0961
Brugia malayi	Cathepsin L-like precursor	0.0059	0.133	0.2995
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0076	0.1741	0.5
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.1741	1
Brugia malayi	Cathepsin L-like precursor	0.0059	0.133	0.2995
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0695	0.4054
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.2058	0.1998
Brugia malayi	latrophilin 2 splice variant baaae	0.01	0.234	0.5483
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.133	0.9004
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0695	0.4054
Onchocerca volvulus		0.0059	0.133	1
Echinococcus granulosus	cathepsin b	0.0176	0.4173	0.4129
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0089	0.2058	0.4785
Brugia malayi	Papain family cysteine protease containing protein	0.0059	0.133	0.2995
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0033	0.0695	0.0695
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0059	0.133	0.299
Onchocerca volvulus	Cathepsin L homolog	0.0059	0.133	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.1741	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0015	0.0261	0.0261
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.2058	0.2058
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1028	0.2246
Echinococcus multilocularis	cathepsin L cysteine protease	0.0059	0.133	0.1265
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0261	0.1432
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0147	0.347	0.8266
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.1106	0.4744
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.133	0.9004
Onchocerca volvulus		0.0059	0.133	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0015	0.0261	0.0361
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0033	0.0695	0.0695
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.133	0.2733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0261	0.1432
Loa Loa (eye worm)	cysteine protease	0.0059	0.133	0.299
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.133	0.9004
Brugia malayi	cathepsin B-like cysteine proteinase	0.0176	0.4173	1
Echinococcus multilocularis	cysteine protease	0.0059	0.133	0.1265
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.133	0.9004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.133	0.9004
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0015	0.0261	0.0354
Plasmodium vivax	vivapain-3	0.0033	0.0695	0.2929
Onchocerca volvulus	Cathepsin F homolog	0.0059	0.133	1
Loa Loa (eye worm)	fibroinase	0.0059	0.133	0.299
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.1741	0.5
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0176	0.4173	0.4173
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.133	0.9004
Brugia malayi	Papain family cysteine protease containing protein	0.0015	0.0261	0.0361
Giardia lamblia	Cathepsin B precursor	0.0065	0.1471	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0015	0.0261	0.1432
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0026	0.0533	0.1838
Brugia malayi	Cathepsin L-like precursor	0.0059	0.133	0.2995
Trypanosoma cruzi	cysteine peptidase, putative	0.0018	0.0332	0.018
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.133	0.8189
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0695	0.4054
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0046	0.1028	0.2251
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0059	0.133	0.7224
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0033	0.0695	0.1108
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0015	0.0261	0.0354
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.133	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.1741	0.5
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0046	0.1028	0.2246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0059	0.133	0.9004
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0332	0.0528
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0065	0.1471	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0261	0.0354
Schistosoma mansoni	cathepsin C	0.0015	0.0261	0.0261
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	0.4173	0.4173
Echinococcus granulosus	cpg binding protein	0.0031	0.0648	0.0578
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.1741	1
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.0695	0.1429
Schistosoma mansoni	cathepsin S (C01 family)	0.0015	0.0261	0.0261
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.133	0.8189
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0059	0.133	0.7224
Onchocerca volvulus		0.0029	0.0608	0.3239
Schistosoma mansoni	hypothetical protein	0.0046	0.1028	0.1028
Entamoeba histolytica	cysteine protease, putative	0.0059	0.133	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.1106	0.5
Schistosoma mansoni	hypothetical protein	0.0046	0.1028	0.1028
Schistosoma mansoni	hypothetical protein	0.0415	1	1
Echinococcus granulosus	cathepsin l1	0.0041	0.0897	0.0829
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0015	0.0261	0.1432
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.2058	0.1998
Brugia malayi	cathepsin L-like cysteine proteinase	0.0015	0.0261	0.0361
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0695	0.4054
Echinococcus granulosus	cathepsin b	0.0176	0.4173	0.4129
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0015	0.0261	0.1432
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0261	0.1432
Trypanosoma cruzi	cruzipain precursor, putative	0.0059	0.133	0.2733
Trypanosoma cruzi	cysteine proteinase, putative	0.0033	0.0695	0.1108
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1741	0.4004
Loa Loa (eye worm)	ctsf protein	0.0059	0.133	0.299
Schistosoma mansoni	hypothetical protein	0.01	0.234	0.234
Plasmodium vivax	vivapain-2	0.0059	0.133	0.7224
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0076	0.1741	0.1679
Echinococcus granulosus	cysteine protease	0.0033	0.0695	0.0625
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0074	0.0074
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0176	0.4173	1
Echinococcus multilocularis	GPCR, family 2	0.0046	0.1028	0.0961
Entamoeba histolytica	cysteine proteinase 2	0.0033	0.0695	0.4054
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0065	0.1471	0.3093
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.133	0.8189
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0065	0.1471	1
Echinococcus granulosus	GPCR family 2	0.0046	0.1028	0.0961
Brugia malayi	cathepsin L-like precursor	0.0041	0.0897	0.1927
Plasmodium vivax	vivapain-1	0.0033	0.0695	0.2929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0041	0.0897	0.5935
Brugia malayi	Cathepsin L-like precursor	0.0059	0.133	0.2995
Echinococcus multilocularis	cysteine protease	0.0059	0.133	0.1265
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.133	0.133
Trypanosoma cruzi	cysteine protease, putative	0.0033	0.0695	0.1108
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.133	0.9004
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0015	0.0261	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0261	0.0354
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0533	0.1838
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.133	0.8189
Brugia malayi	Probable ClpP-like protease	0.0076	0.1741	0.4008
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0015	0.0261	0.0261
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0261	0.1432
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0261	0.1432
Echinococcus granulosus	cathepsin L	0.0033	0.0695	0.0625
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0041	0.0897	0.1927
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0695	0.4502
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0695	0.4054
Echinococcus granulosus	cathepsin L cysteine protease	0.0033	0.0695	0.0625
Plasmodium vivax	unspecified product	0.0033	0.0695	0.2929
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.2058	0.2058
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0018	0.0332	0.0534
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.133	0.8189
Trypanosoma cruzi	cruzipain precursor, putative	0.0018	0.0332	0.018
Onchocerca volvulus		0.0041	0.0897	0.5946
Plasmodium vivax	vivapain-2	0.0059	0.133	0.7224

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 24 nM	Inhibition of human recombinant cathepsin K	ChEMBL.	18571402
IC50 (binding)	= 110 nM	Inhibition of human recombinant cathepsin B	ChEMBL.	18571402
IC50 (binding)	= 610 nM	Inhibition of human recombinant cathepsin L	ChEMBL.	18571402

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL523166

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1022483