TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 382.405 | Formula: C19H26O8
H donors: 2 H acceptors: 4 LogP: -0.91 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@]12C[C@H](OC(=O)C)C(=C[C@H]1O[C@H]1[C@]3([C@]2(C)[C@H](OC(=O)C)[C@H]1O)OC3)C
InChi: 1S/C19H26O8/c1-9-5-13-18(7-20,6-12(9)25-10(2)21)17(4)15(26-11(3)22)14(23)16(27-13)19(17)8-24-19/h5,12-16,20,23H,6-8H2,1-4H3/t12-,13+,14+,15+,16+,17+,18+,19+/m0/s1
InChiKey: UROCTWOJYLMRHO-LVJXWLTRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	delta-like protein 1	0.0114	0.1084	0.2908
Loa Loa (eye worm)	hypothetical protein	0.0351	0.3727	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.0214	0.0575
Brugia malayi	latrophilin 2 splice variant baaae	0.0074	0.0648	0.1739
Echinococcus granulosus	slit 2 protein	0.0114	0.1084	0.2908
Echinococcus multilocularis	neurogenic locus protein delta	0.0114	0.1084	0.1084
Onchocerca volvulus		0.028	0.2933	0.7828
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0222	0.0934
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.0073	0.0073
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0238	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.0073	0.0195
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0222	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0222	0.0596
Loa Loa (eye worm)	inositol-1	0.0037	0.0238	0.0638
Toxoplasma gondii	EGF family domain-containing protein	0.0114	0.1084	1
Brugia malayi	hypothetical protein	0.0028	0.0139	0.0372
Brugia malayi	Blistered cuticle protein 3	0.0351	0.3727	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0169	0.0453
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0037	0.0238	0.0334
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0072	0.062	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Brugia malayi	Inositol-1	0.0037	0.0238	0.0638
Loa Loa (eye worm)	MH2 domain-containing protein	0.0121	0.1166	0.3127
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Onchocerca volvulus		0.0351	0.3727	1
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0205	0.0549
Toxoplasma gondii	aldehyde dehydrogenase	0.0072	0.062	0.5718
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.0073	0.0195
Echinococcus granulosus	protein jagged 1	0.0114	0.1084	0.2908
Brugia malayi	Animal haem peroxidase family protein	0.0351	0.3727	1
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0055	0.0436	0.0436
Echinococcus multilocularis	peroxidasin	0.0351	0.3727	0.3727
Loa Loa (eye worm)	hypothetical protein	0.0351	0.3727	1
Loa Loa (eye worm)	mbt repeat family protein	0.0055	0.0436	0.1169
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0222	0.0596
Echinococcus multilocularis	notch	0.0114	0.1084	0.1084
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0099	0.0923	0.2475
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0194	0.0817
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0073	0.0195
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0691	0.5
Leishmania major	hypothetical protein, conserved	0.0028	0.0139	0.2236
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1762	0.4727
Brugia malayi	beta-lactamase	0.0036	0.0222	0.0596
Onchocerca volvulus		0.0035	0.0214	0.0388
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0238	0.0638
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0214	0.0575
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.0073	0.0195
Brugia malayi	Pre-SET motif family protein	0.0246	0.2556	0.6857
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.0073	0.0195
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0222	0.0596
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.0392	0.1647
Schistosoma mansoni	notch	0.0114	0.1084	0.2908
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0073	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0109	0.1031	0.2765
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0222	0.0596
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0073	0.0195
Schistosoma mansoni	hypothetical protein	0.0167	0.1673	0.4489
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0063	0.052	0.1396
Schistosoma mansoni	hypothetical protein	0.0034	0.0205	0.0549
Schistosoma mansoni	notch	0.0114	0.1084	0.2908
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0139	0.5827
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0078	0.0691	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0099	0.0923	0.2475
Onchocerca volvulus	Peroxidasin homolog	0.0351	0.3727	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0139	0.2006
Loa Loa (eye worm)	animal heme peroxidase	0.0351	0.3727	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.0073	0.0195
Echinococcus multilocularis	neural cadherin	0.0114	0.1084	0.1084
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.0691	0.6375
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0205	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0351	0.3727	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.0073	0.0195
Brugia malayi	Cadherin domain containing protein	0.0114	0.1084	0.2908
Brugia malayi	nuclear hormone receptor	0.0023	0.0073	0.0195
Loa Loa (eye worm)	animal heme peroxidase	0.0351	0.3727	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0222	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0073	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1762	0.4727
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0114	0.1084	0.2908
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0035	0.0214	0.0214
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0063	0.052	0.052
Onchocerca volvulus		0.0036	0.0222	0.0409
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0238	0.0058
Schistosoma mansoni	hypothetical protein	0.0114	0.1084	0.2908
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.0073	0.0195
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0078	0.0691	1
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0222	0.3216
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0691	0.5
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Onchocerca volvulus	Huntingtin homolog	0.0124	0.1201	0.3087
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.0073	0.0195
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.0073	0.0195
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0063	0.052	0.052
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.0073	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0222	0.1768
Schistosoma mansoni	hypothetical protein	0.0114	0.1084	0.2908
Schistosoma mansoni	peroxidasin	0.0351	0.3727	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0121	0.1166	0.3127
Echinococcus multilocularis	fibropellin Ia	0.0114	0.1084	0.1084
Echinococcus multilocularis	protein jagged 1	0.0114	0.1084	0.1084
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0222	0.0596
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.0392	0.1647
Brugia malayi	EGF-like domain containing protein	0.0114	0.1084	0.2908
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0222	0.9341
Onchocerca volvulus	Slit protein homolog	0.0114	0.1084	0.2767
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0205	0.0205
Brugia malayi	TAR-binding protein	0.0075	0.0654	0.1755
Brugia malayi	RNA recognition motif domain containing protein	0.0075	0.0654	0.1755
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0008	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0351	0.3727	1
Echinococcus multilocularis	lamin dm0	0.0031	0.0169	0.0169
Brugia malayi	steroid hormone receptor	0.0023	0.0073	0.0195
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.0139	0.1279
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0222	0.9341
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0222	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0351	0.3727	1
Brugia malayi	EGF-like domain containing protein	0.0114	0.1084	0.2908
Schistosoma mansoni	cell polarity protein	0.0114	0.1084	0.2908
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.0073	0.0195
Brugia malayi	RNA binding protein	0.0075	0.0654	0.1755
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0055	0.0436	0.0993
Brugia malayi	EGF-like domain containing protein	0.0114	0.1084	0.2908
Echinococcus multilocularis	lamin	0.0031	0.0169	0.0169
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0222	0.9341
Schistosoma mansoni	sex comb on midleg homolog	0.0055	0.0436	0.1169
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0214	0.0575
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0169	0.0453
Echinococcus multilocularis	geminin	0.0167	0.1673	0.1673
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0008	0.0021
Brugia malayi	EGF-like domain containing protein	0.0114	0.1084	0.2908
Echinococcus multilocularis	polycomb protein SCMH1	0.0055	0.0436	0.0436
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.0214	0.1977
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0238	0.0058
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0222	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0351	0.3727	1
Echinococcus granulosus	GPCR family 2	0.0034	0.0205	0.0549
Schistosoma mansoni	notch	0.0114	0.1084	0.2908
Brugia malayi	Peroxidasin	0.0351	0.3727	1
Schistosoma mansoni	sex comb on midleg homolog	0.0055	0.0436	0.1169
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.0691	0.6375
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.0238	0.2195
Onchocerca volvulus	Huntingtin homolog	0.0124	0.1201	0.3087
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0073	0.0195
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0023	0.0073	0.0073
Schistosoma mansoni	tar DNA-binding protein	0.0075	0.0654	0.1755
Echinococcus granulosus	neural cadherin	0.0114	0.1084	0.2908
Echinococcus multilocularis	protein jagged 1	0.0114	0.1084	0.1084
Brugia malayi	beta-lactamase family protein	0.0036	0.0222	0.0596
Loa Loa (eye worm)	RNA binding protein	0.0075	0.0654	0.1755
Brugia malayi	Pre-SET motif family protein	0.0035	0.0214	0.0575
Schistosoma mansoni	hypothetical protein	0.0114	0.1084	0.2908
Giardia lamblia	High cysteine protein	0.0114	0.1084	0.5
Trichomonas vaginalis	set domain proteins, putative	0.028	0.2933	1
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0691	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.0073	0.0195
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0222	0.0934
Schistosoma mansoni	lamin	0.0031	0.0169	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0351	0.3727	1
Echinococcus granulosus	geminin	0.0167	0.1673	0.4489
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0072	0.062	0.8481
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0099	0.0923	0.2475
Echinococcus granulosus	polycomb protein SCMH1	0.0055	0.0436	0.1169
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.0139	0.2006
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0205	0.0549
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0222	0.0596
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0205	0.0549
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0238	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0222	0.0596
Onchocerca volvulus		0.0351	0.3727	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.0073	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0027	0.0122	0.1759
Echinococcus granulosus	notch	0.0114	0.1084	0.2908
Echinococcus granulosus	neurogenic locus notch protein	0.0114	0.1084	0.2908
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0218	0.2239	0.2239
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0222	0.0934
Schistosoma mansoni	laminin gamma-3 chain	0.0114	0.1084	0.2908
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.0139	0.5827
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0073	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Echinococcus granulosus	neurogenic locus protein delta	0.0114	0.1084	0.2908
Loa Loa (eye worm)	hypothetical protein	0.0351	0.3727	1
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0078	0.0691	0.0691
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0073	0.0195
Echinococcus granulosus	intermediate filament protein	0.0031	0.0169	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0222	0.0934
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0075	0.0654	0.1755
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.0073	0.0073
Brugia malayi	Probable ClpP-like protease	0.0078	0.0691	0.1854
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0073	0.0195
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0222	0.0934
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0205	0.0205
Brugia malayi	mbt repeat family protein	0.0055	0.0436	0.1169
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.0073	0.0195
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0214	0.0214
Loa Loa (eye worm)	blistered cuticle protein 3	0.0351	0.3727	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0222	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0124	0.1201	0.3222
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0073	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0099	0.0923	0.2475
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Echinococcus granulosus	lamin dm0	0.0031	0.0169	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0351	0.3727	1
Echinococcus multilocularis	muscleblind protein 1	0.0175	0.1762	0.1762
Brugia malayi	GCC2 and GCC3 family protein	0.0114	0.1084	0.2908
Loa Loa (eye worm)	hypothetical protein	0.0063	0.052	0.1396
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0114	0.1084	0.1084
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.0073	0.0195
Toxoplasma gondii	hypothetical protein	0.0027	0.0122	0.1121
Echinococcus granulosus	lamin	0.0031	0.0169	0.0453
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.0392	0.1051
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.0214	0.0575
Echinococcus granulosus	SAM and MBT domain containing protein	0.0055	0.0436	0.1169
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.0073	0.0195
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0238	0.0638
Schistosoma mansoni	peptidase Clp (S14 family)	0.0078	0.0691	0.1854
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0073	0.0195
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0109	0.1031	0.2765
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.0392	0.0392
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0246	0.2556	0.6857
Echinococcus granulosus	protein jagged 2	0.0114	0.1084	0.2908
Schistosoma mansoni	aldehyde dehydrogenase	0.0072	0.062	0.1663
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0072	0.062	0.8481
Brugia malayi	EGF-like domain containing protein	0.0114	0.1084	0.2908
Onchocerca volvulus		0.0114	0.1084	0.2767
Brugia malayi	intermediate filament protein	0.0031	0.0169	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Brugia malayi	ecdysteroid receptor	0.0023	0.0073	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Onchocerca volvulus		0.0031	0.0169	0.0264
Loa Loa (eye worm)	MBCTL1	0.0063	0.052	0.1396
Schistosoma mansoni	coup transcription factor	0.0023	0.0073	0.0195
Echinococcus granulosus	histone acetyltransferase MYST2	0.0063	0.052	0.1396
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0238	0.3838
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0238	0.0238
Onchocerca volvulus	Peroxidase homolog	0.0351	0.3727	1
Echinococcus multilocularis	protein jagged 2	0.0114	0.1084	0.1084
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0099	0.0923	0.2475
Brugia malayi	Muscle positioning protein 4	0.0114	0.1084	0.2908
Onchocerca volvulus	Peroxidasin homolog	0.0351	0.3727	1
Echinococcus granulosus	muscleblind protein	0.0175	0.1762	0.4727
Loa Loa (eye worm)	hypothetical protein	0.0351	0.3727	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Schistosoma mansoni	retinoic acid receptor RXR	0.0023	0.0073	0.0195
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0691	1
Brugia malayi	Delta serrate ligand family protein	0.0114	0.1084	0.2908
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0109	0.1031	0.2765
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0073	0.0195
Brugia malayi	Calcium binding EGF domain containing protein	0.0114	0.1084	0.2908
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0238	0.5
Echinococcus multilocularis	slit 2 protein	0.0114	0.1084	0.1084
Loa Loa (eye worm)	hypothetical protein	0.0351	0.3727	1
Echinococcus multilocularis	neurogenic locus notch protein	0.0114	0.1084	0.1084
Schistosoma mansoni	slit	0.0114	0.1084	0.2908
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.0073	0.0195
Brugia malayi	Muscleblind-like protein	0.0175	0.1762	0.4727
Loa Loa (eye worm)	TAR-binding protein	0.0075	0.0654	0.1755
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0222	0.0596
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0109	0.1031	0.2765
Schistosoma mansoni	hypothetical protein	0.0114	0.1084	0.2908
Onchocerca volvulus		0.0114	0.1084	0.2767
Loa Loa (eye worm)	hypothetical protein	0.0351	0.3727	1
Echinococcus granulosus	tar DNA binding protein	0.0075	0.0654	0.1755
Onchocerca volvulus		0.0351	0.3727	1
Brugia malayi	Cadherin domain containing protein	0.0114	0.1084	0.2908
Echinococcus multilocularis	neurogenic locus notch protein	0.0114	0.1084	0.1084
Echinococcus multilocularis	musashi	0.0031	0.0169	0.0169
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0073	0.0195
Schistosoma mansoni	hypothetical protein	0.0034	0.0205	0.0549
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0139	0.5827
Brugia malayi	MH2 domain containing protein	0.0121	0.1166	0.3127
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0214	0.0575
Onchocerca volvulus	Peroxidase homolog	0.0351	0.3727	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.0073	0.0195
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.0073	0.0195
Leishmania major	hypothetical protein, conserved	0.0036	0.0222	0.3585
Onchocerca volvulus		0.0114	0.1084	0.2767
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.0073	0.0195
Loa Loa (eye worm)	animal heme peroxidase	0.0351	0.3727	1
Echinococcus granulosus	neurogenic locus notch protein	0.0114	0.1084	0.2908
Brugia malayi	EGF-like domain containing protein	0.0114	0.1084	0.2908
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0078	0.0691	0.1854
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0691	1
Echinococcus granulosus	neurogenic locus notch protein 4	0.0114	0.1084	0.2908
Brugia malayi	mbt repeat family protein	0.0055	0.0436	0.1169
Onchocerca volvulus		0.0036	0.0222	0.0409
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.0073	0.0195
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0073	0.0073
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0073	0.0195
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0169	0.0453
Toxoplasma gondii	ABC1 family protein	0.0036	0.0222	0.205
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0238	1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0222	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0073	0.0195
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0222	0.1768
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0073	0.0195
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.0073	0.0195
Loa Loa (eye worm)	notch protein	0.0114	0.1084	0.2908
Echinococcus multilocularis	tar DNA binding protein	0.0075	0.0654	0.0654
Brugia malayi	Animal haem peroxidase family protein	0.0351	0.3727	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0205	0.0549
Echinococcus multilocularis	muscleblind protein	0.0175	0.1762	0.1762
Echinococcus granulosus	protein jagged 1	0.0114	0.1084	0.2908
Onchocerca volvulus	Neurogenic locus notch homolog	0.0114	0.1084	0.2767
Schistosoma mansoni	hypothetical protein	0.0336	0.3551	0.9526
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0218	0.2239	0.6008
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0205	0.0549
Onchocerca volvulus	Putative cubilin	0.0114	0.1084	0.2767
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0114	0.1084	0.2908
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.0073	0.0073
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.0073	0.0195
Schistosoma mansoni	hypothetical protein	0.0167	0.1673	0.4489
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0214	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0169	0.0453
Echinococcus granulosus	peroxidasin	0.0351	0.3727	1
Brugia malayi	hypothetical protein	0.0351	0.3727	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0073	0.0195
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0222	0.0596
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0169	0.0453
Schistosoma mansoni	notch	0.0114	0.1084	0.2908
Brugia malayi	hypothetical protein	0.0124	0.1201	0.3222
Schistosoma mansoni	lamin	0.0031	0.0169	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.0073	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Schistosoma mansoni	hypothetical protein	0.0114	0.1084	0.2908
Schistosoma mansoni	tar DNA-binding protein	0.0075	0.0654	0.1755
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0114	0.1084	0.2767
Loa Loa (eye worm)	hypothetical protein	0.0351	0.3727	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0073	0.0195
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0099	0.0923	0.0923
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0114	0.1084	0.1084
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0072	0.062	0.062
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0063	0.052	0.1396
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0072	0.062	0.2607
Onchocerca volvulus		0.0114	0.1084	0.2767
Schistosoma mansoni	notch	0.0114	0.1084	0.2908
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0139	0.2006
Schistosoma mansoni	peroxidasin	0.0351	0.3727	1
Schistosoma mansoni	septate junction protein	0.0114	0.1084	0.2908
Schistosoma mansoni	notch	0.0114	0.1084	0.2908
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0222	0.0934
Brugia malayi	Animal haem peroxidase family protein	0.0351	0.3727	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0099	0.0923	0.2475
Onchocerca volvulus	Chorion peroxidase homolog	0.0351	0.3727	1
Schistosoma mansoni	tar DNA-binding protein	0.0075	0.0654	0.1755
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0073	0.0195
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.0073	0.0195
Brugia malayi	Animal haem peroxidase family protein	0.0351	0.3727	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0023	0.0073	0.0195
Echinococcus granulosus	protein jagged 2	0.0114	0.1084	0.2908
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0648	0.1739
Schistosoma mansoni	aldehyde dehydrogenase	0.0072	0.062	0.1663
Schistosoma mansoni	tar DNA-binding protein	0.0075	0.0654	0.1755
Onchocerca volvulus	Dual oxidase homolog	0.0351	0.3727	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0205	0.0549
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0073	0.0195
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0238	0.0058
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0072	0.062	0.8481
Brugia malayi	hypothetical protein	0.0018	0.0026	0.0071
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.0073	0.0195
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0063	0.052	0.1396
Echinococcus multilocularis	neurogenic locus protein delta	0.0114	0.1084	0.1084
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0691	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0072	0.062	0.1663
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0163	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0351	0.3727	1
Loa Loa (eye worm)	Notch2	0.0114	0.1084	0.2908
Onchocerca volvulus		0.0114	0.1084	0.2767
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0691	0.1854
Echinococcus granulosus	fibropellin Ia	0.0114	0.1084	0.2908
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0122	0.1759
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.0073	0.0195
Brugia malayi	Calcium binding EGF domain containing protein	0.0114	0.1084	0.2908
Loa Loa (eye worm)	hypothetical protein	0.0124	0.1201	0.3222
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Schistosoma mansoni	hypothetical protein	0.0034	0.0205	0.0549
Brugia malayi	notch-like transmembrane receptor	0.0114	0.1084	0.2908
Brugia malayi	beta-lactamase family protein	0.0036	0.0222	0.0596
Onchocerca volvulus		0.0031	0.0169	0.0264
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0073	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0436	0.1169
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0073	0.0195
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.0073	0.0195
Brugia malayi	Calcium binding EGF domain containing protein	0.0114	0.1084	0.2908
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.0073	0.0195
Schistosoma mansoni	hypothetical protein	0.0114	0.1084	0.2908
Loa Loa (eye worm)	animal heme peroxidase	0.0351	0.3727	1
Schistosoma mansoni	tar DNA-binding protein	0.0075	0.0654	0.1755
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0073	0.0195
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0222	0.0596
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0073	0.0073
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0238	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0205	0.0549
Brugia malayi	EGF-like domain containing protein	0.0114	0.1084	0.2908
Onchocerca volvulus		0.0036	0.0222	0.0409
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.0073	0.0073
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0691	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0139	0.0372
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.0392	0.4744
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.0073	0.0195
Onchocerca volvulus		0.0055	0.0436	0.0993
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0034	0.02	0.0536
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0033	0.0194	0.1278
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0055	0.0436	0.1169
Schistosoma mansoni	hypothetical protein	0.0114	0.1084	0.2908
Plasmodium vivax	SET domain protein, putative	0.0035	0.0214	0.3102
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.023	0.2377	1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0222	0.0934
Brugia malayi	Animal haem peroxidase family protein	0.0351	0.3727	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0099	0.0923	0.0923
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1084	0.2908
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0099	0.0923	0.2475
Schistosoma mansoni	hypothetical protein	0.0074	0.0648	0.1739

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL523782

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1022863