Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 1 | 0.5 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 1 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 1 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 1 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 1 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 1 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 1 | 0.5 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0019 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 1 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 1 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 1 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 1 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 1 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 1 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 1 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 1 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 57.9 uM | Cytotoxicity against human HFF cells | ChEMBL. | 19457669 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.