TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 337.781 | Formula: C14H12ClN3O3S
H donors: 4 H acceptors: 4 LogP: 1.71 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OCC(c1csc(n1)NC(=O)c1cc2c([nH]1)ccc(c2)Cl)O
InChi: 1S/C14H12ClN3O3S/c15-8-1-2-9-7(3-8)4-10(16-9)13(21)18-14-17-11(6-22-14)12(20)5-19/h1-4,6,12,16,19-20H,5H2,(H,17,18,21)
InChiKey: NHRCUMOGCMNBTH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphorylase, glycogen, liver	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Brugia malayi	carbohydrate phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	Glycogen phosphorylase, brain form, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	Glycosyl transferase family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Loa Loa (eye worm)	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Giardia lamblia	Glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium parvum	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Chlamydia trachomatis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium hominis	glycogen phosphorylase 1	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Onchocerca volvulus	Glycogen phosphorylase homolog	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	Glycosyl transferase, family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.006	0.0578	0.5018
Schistosoma mansoni	lamin	0.0058	0.0559	0.087
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0068	0.005
Onchocerca volvulus	Huntingtin homolog	0.012	0.139	0.7403
Schistosoma mansoni	pyruvate kinase	0.0033	0.0217	0.0338
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0068	0.005
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0021	0.0057	0.0057
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0217	0.0199
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0493	0.6422	0.6422
Brugia malayi	TAR-binding protein	0.0276	0.3492	0.348
Toxoplasma gondii	peptidylprolyl isomerase	0.0039	0.0295	0.315
Plasmodium vivax	ataxin-2 like protein, putative	0.0057	0.0543	0.5809
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.1529	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0493	0.6422	1
Onchocerca volvulus		0.0086	0.0936	0.4881
Brugia malayi	hypothetical protein	0.0057	0.0543	0.0526
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0068	0.005
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0068	0.005
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0086	0.0936	0.0919
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0018	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.012	0.139	0.1374
Loa Loa (eye worm)	TAR-binding protein	0.0276	0.3492	0.348
Schistosoma mansoni	glycogen phosphorylase	0.0056	0.0531	0.0827
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0068	0.005
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0068	0.005
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.1529	1
Giardia lamblia	Pyruvate kinase	0.0033	0.0217	0.1421
Echinococcus granulosus	glycogen phosphorylase	0.013	0.1529	0.1529
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0021	0.0057	0.0057
Mycobacterium ulcerans	esterase/lipase LipP	0.0086	0.0936	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0068	0.0107
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0068	0.0107
Brugia malayi	intermediate filament protein	0.0058	0.0559	0.0541
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0021	0.0057	0.0057
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0021	0.0057	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0082	0.0064
Toxoplasma gondii	ABC1 family protein	0.0086	0.0936	1
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.0021	0.0057	0.0057
Trichomonas vaginalis	rotamase, putative	0.0039	0.0295	0.1617
Echinococcus multilocularis	tar DNA binding protein	0.0276	0.3492	0.3492
Echinococcus multilocularis	geminin	0.0203	0.2512	0.2512
Schistosoma mansoni	rotamase	0.004	0.0307	0.0479
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.004	0.0307	0.0289
Brugia malayi	guanine nucleotide-binding protein G(o), alpha subunit, putative	0.0021	0.0057	0.0038
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0068	0.0107
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0068	0.0068
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0056	0.0531	0.0449
Brugia malayi	Guanine nucleotide-binding protein alpha-6 subunit, putative	0.0021	0.0057	0.0038
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.0068	0.0107
Schistosoma mansoni	coup transcription factor	0.0022	0.0068	0.0107
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.0021	0.0057	0.0088
Trypanosoma brucei	PAB1-binding protein , putative	0.0057	0.0543	0.4541
Chlamydia trachomatis	glycogen phosphorylase	0.013	0.1529	1
Brugia malayi	hypothetical protein	0.0043	0.0353	0.0335
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0028	0.0151	0.0151
Echinococcus multilocularis	expressed protein	0.0021	0.0057	0.0057
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0155	0.1857	0.1842
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0137	0.0118
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-6 subunit	0.0021	0.0057	0.0038
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0018	0.0029
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0068	0.005
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.006	0.0578	0.3778
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.061	0.0949
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0021	0.0057	0.0057
Trichomonas vaginalis	ap endonuclease, putative	0.006	0.0578	0.3539
Brugia malayi	carbohydrate phosphorylase	0.013	0.1529	0.1514
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0137	0.0118
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.0021	0.0057	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0057	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0068	0.005
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0068	0.0068
Mycobacterium tuberculosis	Conserved protein	0.0086	0.0936	0.1027
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0026	0.0117	0.0117
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0021	0.0057	0.0088
Mycobacterium tuberculosis	Conserved protein	0.0086	0.0936	0.1027
Echinococcus granulosus	beta LACTamase domain containing family member	0.0086	0.0936	0.0936
Brugia malayi	guanine nucleotide-binding protein G-o protein alpha subunit	0.0021	0.0057	0.0038
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0086	0.0936	0.0936
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0217	0.0892
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.006	0.0578	1
Schistosoma mansoni	ap endonuclease	0.006	0.0578	0.09
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0068	0.0068
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.061	0.5462
Schistosoma mansoni	lamin	0.0058	0.0559	0.087
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0039	0.0295	0.1617
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0021	0.0057	0.0088
Echinococcus multilocularis	pyruvate kinase	0.0026	0.0123	0.0123
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0021	0.0057	0.0057
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0022	0.0068	0.0066
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0217	0.0199
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0068	0.0068
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0068	0.005
Echinococcus granulosus	lamin dm0	0.0058	0.0559	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0151	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0057	0.0038
Schistosoma mansoni	tar DNA-binding protein	0.0276	0.3492	0.5438
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0021	0.0057	0.0088
Schistosoma mansoni	hypothetical protein	0.0026	0.0117	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0057	0.0038
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0068	0.0068
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0068	0.0107
Mycobacterium tuberculosis	Probable esterase LipL	0.0086	0.0936	0.1027
Brugia malayi	guanine nucleotide-binding protein alpha-3 subunit, putative	0.0021	0.0057	0.0038
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.1529	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0493	0.6422	1
Brugia malayi	hypothetical protein	0.0037	0.027	0.0252
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.006	0.0578	0.5018
Brugia malayi	beta-lactamase family protein	0.0086	0.0936	0.0919
Schistosoma mansoni	tar DNA-binding protein	0.0276	0.3492	0.5438
Onchocerca volvulus	Bile acid receptor homolog	0.0022	0.0068	0.0066
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.006	0.0578	0.3539
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0217	0.0199
Trichomonas vaginalis	D-aminoacylase, putative	0.0086	0.0936	0.5968
Loa Loa (eye worm)	hypothetical protein	0.0758	1	1
Echinococcus granulosus	pyruvate kinase	0.0033	0.0217	0.0217
Onchocerca volvulus	Huntingtin homolog	0.012	0.139	0.7403
Echinococcus granulosus	Smad4	0.0018	0.0018	0.0018
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0018	0.0018	0.0018
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0021	0.0057	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0936	0.0919
Onchocerca volvulus		0.0022	0.0068	0.0066
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0276	0.3492	0.348
Echinococcus granulosus	mothers against decapentaplegic 5	0.0018	0.0018	0.0018
Entamoeba histolytica	pyruvate kinase, putative	0.0023	0.0082	0.0174
Echinococcus multilocularis	expressed protein	0.004	0.0307	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0559	0.0541
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0217	0.0217
Giardia lamblia	Glycogen phosphorylase	0.013	0.1529	1
Onchocerca volvulus		0.0086	0.0936	0.4881
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0936	0.0919
Schistosoma mansoni	smad	0.0018	0.0018	0.0029
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.0068	0.0068
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0068	0.0107
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.061	0.0949
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0057	0.0038
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0033	0.0217	0.0199
Leishmania major	hypothetical protein, conserved	0.0086	0.0936	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.006	0.0578	0.6175
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0217	0.0892
Mycobacterium tuberculosis	Probable lipase LipE	0.0086	0.0936	0.1027
Trichomonas vaginalis	ap endonuclease, putative	0.006	0.0578	0.3539
Loa Loa (eye worm)	hypothetical protein	0.012	0.139	0.1374
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0438	0.042
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.1529	0.1529
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0936	0.0919
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0068	0.005
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.006	0.0578	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0493	0.6422	1
Echinococcus granulosus	glycogen phosphorylase	0.013	0.1529	0.1529
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.0068	0.005
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0068	0.005
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0028	0.0151	0.0151
Brugia malayi	ecdysteroid receptor	0.0022	0.0068	0.005
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0031	0.0193	0.0175
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.1529	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0086	0.0936	0.1457
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0018	0.0018	0.0029
Schistosoma mansoni	Smad4	0.0018	0.0018	0.0029
Mycobacterium tuberculosis	Conserved protein	0.0086	0.0936	0.1027
Trichomonas vaginalis	D-aminoacylase, putative	0.0086	0.0936	0.5968
Onchocerca volvulus		0.0058	0.0559	0.2789
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.0068	0.005
Echinococcus granulosus	expressed protein	0.004	0.0307	0.0307
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0068	0.005
Brugia malayi	steroid hormone receptor	0.0022	0.0068	0.005
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0353	0.0549
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0021	0.0057	0.0088
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0227	0.0209
Schistosoma mansoni	intermediate filament proteins	0.0058	0.0559	0.087
Echinococcus granulosus	intermediate filament protein	0.0058	0.0559	0.0559
Brugia malayi	hypothetical protein	0.0021	0.0057	0.0038
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0086	0.0936	0.1027
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0493	0.6422	0.6422
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.0021	0.0057	0.0038
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.006	0.0578	0.5018
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.006	0.0578	0.5018
Echinococcus granulosus	expressed protein	0.0021	0.0057	0.0057
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0068	0.0107
Loa Loa (eye worm)	transcription factor SMAD2	0.0269	0.3405	0.3393
Mycobacterium ulcerans	lipase LipD	0.0086	0.0936	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0936	0.0919
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0068	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0936	0.0919
Schistosoma mansoni	ap endonuclease	0.006	0.0578	0.09
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0068	0.005
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0068	0.005
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-12 subunit	0.0021	0.0057	0.0038
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.0021	0.0057	0.0038
Loa Loa (eye worm)	beta-lactamase	0.0086	0.0936	0.0919
Plasmodium vivax	pyruvate kinase, putative	0.0033	0.0217	0.2323
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.061	0.5462
Loa Loa (eye worm)	pyruvate kinase-PB	0.0023	0.0082	0.0064
Schistosoma mansoni	survival motor neuron protein	0.0155	0.1857	0.2892
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.006	0.0578	0.5018
Schistosoma mansoni	hypothetical protein	0.0203	0.2512	0.3911
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0057	0.0038
Echinococcus granulosus	survival motor neuron protein 1	0.0758	1	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.006	0.0578	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0438	0.042
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0086	0.0936	0.1457
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0353	0.0353
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0018	0.0018	0.0018
Entamoeba histolytica	glycogen phosphorylase, putative	0.0056	0.0531	0.3222
Mycobacterium leprae	Probable lipase LipE	0.0086	0.0936	1
Entamoeba histolytica	hypothetical protein	0.0043	0.0353	0.2011
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0068	0.005
Leishmania major	hypothetical protein, conserved	0.0057	0.0543	0.4541
Schistosoma mansoni	hypothetical protein	0.0043	0.0353	0.0549
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0307	0.1703
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.1529	0.1529
Schistosoma mansoni	hypothetical protein	0.0034	0.0227	0.0353
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0493	0.6422	0.6422
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0033	0.0217	0.0199
Mycobacterium ulcerans	beta-lactamase	0.0086	0.0936	1
Onchocerca volvulus		0.0058	0.0559	0.2789
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0039	0.0295	0.1078
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.004	0.0307	0.0289
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0021	0.0057	0.0088
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0021	0.0057	0.0057
Brugia malayi	RNA binding protein	0.0276	0.3492	0.348
Brugia malayi	MH2 domain containing protein	0.0269	0.3405	0.3393
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0493	0.6422	0.6416
Plasmodium falciparum	ataxin-2 like protein, putative	0.0057	0.0543	0.9407
Trichomonas vaginalis	D-aminoacylase, putative	0.0086	0.0936	0.5968
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0039	0.0295	0.1078
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0544	0.0527
Brugia malayi	cytoplasmic intermediate filament protein	0.0031	0.0193	0.0175
Schistosoma mansoni	tar DNA-binding protein	0.0276	0.3492	0.5438
Plasmodium falciparum	ataxin-2 like protein, putative	0.0057	0.0543	0.9407
Echinococcus multilocularis	lamin	0.0058	0.0559	0.0559
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.0068	0.005
Brugia malayi	nuclear hormone receptor	0.0022	0.0068	0.005
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0021	0.0057	0.0088
Brugia malayi	beta-lactamase family protein	0.0086	0.0936	0.0919
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0086	0.0936	0.1027
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.061	0.0561
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0068	0.005
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0021	0.0057	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0068	0.005
Plasmodium falciparum	pyruvate kinase	0.0033	0.0217	0.3761
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0039	0.0295	0.1078
Brugia malayi	RNA recognition motif domain containing protein	0.0276	0.3492	0.348
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.0068	0.005
Echinococcus granulosus	geminin	0.0203	0.2512	0.2512
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.006	0.0578	0.0578
Treponema pallidum	exodeoxyribonuclease (exoA)	0.006	0.0578	0.5
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.061	0.061
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.0068	0.005
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0021	0.0057	0.0088
Loa Loa (eye worm)	RNA binding protein	0.0276	0.3492	0.348
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0018	0.0029
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0068	0.0068
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0021	0.0057	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0227	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0068	0.005
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.061	0.061
Echinococcus multilocularis	survival motor neuron protein 1	0.0758	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.0068	0.005
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0068	0.0068
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0058	0.0559	0.0541
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.006	0.0578	0.0515
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.0068	0.005
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0021	0.0057	0.0088
Brugia malayi	beta-lactamase	0.0086	0.0936	0.0919
Trichomonas vaginalis	rotamase, putative	0.004	0.0307	0.1703
Schistosoma mansoni	hypothetical protein	0.0155	0.1857	0.2892
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0438	0.042
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.061	0.5462
Loa Loa (eye worm)	MH2 domain-containing protein	0.0269	0.3405	0.3393
Entamoeba histolytica	hypothetical protein	0.0043	0.0353	0.2011
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0068	0.0107
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0353	0.0353
Echinococcus granulosus	pyruvate kinase	0.0033	0.0217	0.0217
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0068	0.0068
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0068	0.005
Mycobacterium ulcerans	hypothetical protein	0.0086	0.0936	1
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0068	0.0107
Echinococcus multilocularis	Smad4	0.0018	0.0018	0.0018
Plasmodium vivax	hypothetical protein, conserved	0.0086	0.0936	1
Brugia malayi	exodeoxyribonuclease III family protein	0.006	0.0578	0.056
Entamoeba histolytica	glycogen phosphorylase, putative	0.0056	0.0531	0.3222
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0068	0.0068
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0068	0.0068
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.061	0.6516
Schistosoma mansoni	pyruvate kinase	0.0033	0.0217	0.0338
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0068	0.0068
Brugia malayi	G-protein alpha subunit	0.0021	0.0057	0.0038
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.061	0.5462
Echinococcus granulosus	Glycosyl transferase family 35	0.013	0.1529	0.1529
Echinococcus multilocularis	smad	0.0018	0.0018	0.0018
Loa Loa (eye worm)	glycogen phosphorylase	0.013	0.1529	0.1514
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0217	0.1091
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0068	0.0068
Schistosoma mansoni	tar DNA-binding protein	0.0276	0.3492	0.5438
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.0021	0.0057	0.0088
Trypanosoma cruzi	PAB1-binding protein , putative	0.0057	0.0543	0.4541
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0021	0.0057	0.0088
Trichomonas vaginalis	penicillin-binding protein, putative	0.0086	0.0936	0.5968
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0493	0.6422	0.6422
Entamoeba histolytica	hypothetical protein	0.0043	0.0353	0.2011
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0217	0.0217
Mycobacterium tuberculosis	Probable lipase LipD	0.0086	0.0936	0.1027
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0543	0.0526
Brugia malayi	Guanine nucleotide-binding protein alpha-12 subunit, putative	0.0021	0.0057	0.0038
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0068	0.005
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0936	0.0919
Trypanosoma cruzi	PAB1-binding protein , putative	0.0057	0.0543	0.4541
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0068	0.005
Onchocerca volvulus	Glycogen phosphorylase homolog	0.013	0.1529	0.8179
Echinococcus multilocularis	musashi	0.0058	0.0559	0.0559
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0217	0.0892
Loa Loa (eye worm)	G protein alpha subunit 3	0.0021	0.0057	0.0038
Echinococcus granulosus	tar DNA binding protein	0.0276	0.3492	0.3492
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0493	0.6422	0.6416
Brugia malayi	hypothetical protein	0.012	0.139	0.1374
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0068	0.0107
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0086	0.0936	0.1027
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.0068	0.005
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0217	0.0199
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0056	0.0531	0.437
Toxoplasma gondii	exonuclease III APE	0.006	0.0578	0.6175
Entamoeba histolytica	hypothetical protein	0.0043	0.0353	0.2011
Trypanosoma cruzi	hypothetical protein, conserved	0.0086	0.0936	1
Schistosoma mansoni	tar DNA-binding protein	0.0276	0.3492	0.5438
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0068	0.0068
Echinococcus multilocularis	lamin dm0	0.0058	0.0559	0.0559
Entamoeba histolytica	glycogenphosphorylase, putative	0.0056	0.0531	0.3222
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.0021	0.0057	0.0057
Mycobacterium tuberculosis	Probable hydrolase	0.0086	0.0936	0.1027
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.0068	0.005
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0068	0.005
Toxoplasma gondii	LsmAD domain-containing protein	0.0057	0.0543	0.5809
Trichomonas vaginalis	penicillin-binding protein, putative	0.0086	0.0936	0.5968
Echinococcus granulosus	lamin	0.0058	0.0559	0.0559
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0438	0.042
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0039	0.0295	0.1078
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0068	0.0068
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.0021	0.0057	0.0038
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0086	0.0936	0.0919
Trypanosoma brucei	hypothetical protein, conserved	0.0086	0.0936	1
Loa Loa (eye worm)	intermediate filament protein	0.0058	0.0559	0.0541
Onchocerca volvulus		0.0155	0.1857	1
Toxoplasma gondii	pyruvate kinase PyK1	0.0033	0.0217	0.2323
Mycobacterium leprae	conserved hypothetical protein	0.0086	0.0936	1
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0068	0.005
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0018	0.0029
Schistosoma mansoni	glycogen phosphorylase	0.013	0.1529	0.2381
Brugia malayi	Intermediate filament tail domain containing protein	0.0058	0.0559	0.0541
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0068	0.0068
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0026	0.0117	0.0117
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0068	0.005
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0086	0.0936	1
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0217	0.1091
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0552	0.7212	1
Schistosoma mansoni	glycogen phosphorylase	0.013	0.1529	0.2381
Onchocerca volvulus		0.0086	0.0936	0.4881
Trypanosoma cruzi	hypothetical protein, conserved	0.0086	0.0936	1
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0068	0.0107
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0068	0.0068
Trichomonas vaginalis	esterase, putative	0.0086	0.0936	0.5968
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.0068	0.0068
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0021	0.0057	0.0088
Echinococcus multilocularis	Glycosyl transferase, family 35	0.013	0.1529	0.1529
Onchocerca volvulus	Protein ultraspiracle homolog	0.0022	0.0068	0.0066
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.006	0.0578	0.056
Schistosoma mansoni	hypothetical protein	0.0203	0.2512	0.3911
Echinococcus granulosus	smad	0.0018	0.0018	0.0018
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0021	0.0057	0.0088

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 10 uM	Inhibition of human liver glycogen phosphorylase a	ChEMBL.	18434170

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL523215

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1023292