Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0691 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0691 | 0.0751 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0691 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0143 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0691 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0691 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0691 | 0.0691 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0691 | 0.0691 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0691 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0691 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0691 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0691 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0691 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.9197 | 0.9197 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0691 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0691 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0133 | 0.9197 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0691 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0143 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0691 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0691 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0691 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0691 | 0.0691 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0691 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0691 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0133 | 0.9197 | 0.9197 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.