Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0125 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0125 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0125 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0125 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0125 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0125 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0125 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0125 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0125 | 1 | 0.5 |
Leishmania major | prostaglandin f synthase, putative | 0.0125 | 1 | 0.5 |
Onchocerca volvulus | 0.0125 | 1 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.0125 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0125 | 1 | 0.5 |
Onchocerca volvulus | 0.0125 | 1 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0125 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0125 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0125 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0125 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0125 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0125 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0125 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0125 | 1 | 0.5 |
Onchocerca volvulus | 0.0125 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0125 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0125 | 1 | 1 |
Onchocerca volvulus | 0.0125 | 1 | 0.5 | |
Onchocerca volvulus | 0.0125 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0125 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0125 | 1 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.0125 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0125 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0125 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0125 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0125 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0125 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0125 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0125 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0125 | 1 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0125 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0125 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0125 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0125 | 1 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0125 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0125 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0125 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0125 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0125 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0125 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0125 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0125 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0125 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0125 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0125 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0125 | 1 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0125 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0125 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0125 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0125 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0125 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0125 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0125 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0125 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0125 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0125 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0125 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0125 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0125 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0125 | 1 | 0.5 |
Schistosoma mansoni | pol-related | 0.0125 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0125 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0125 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0125 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0125 | 1 | 0.5 |
Onchocerca volvulus | 0.0125 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0125 | 1 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.0125 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0125 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0125 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 14 mm | Antifungal activity against Candida albicans ATCC 2091 assessed as growth inhibition zone at 50 ug after 24 hrs by Kirby-Bauer agar diffusion assay | ChEMBL. | 18672374 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.