Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0988 | 0.0988 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0988 | 0.0988 |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.0574 | 0.0504 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0988 | 0.0988 |
Loa Loa (eye worm) | RNA binding protein | 0.0149 | 0.5157 | 0.5157 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.0574 | 0.0504 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0106 | 0.3466 | 0.4895 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0068 | 0.1979 | 0.2638 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.018 | 0.6378 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0106 | 0.3466 | 0.3466 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0988 | 0.0988 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0988 | 0.0988 |
Trichomonas vaginalis | esterase, putative | 0.0042 | 0.0988 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0988 | 0.0988 |
Onchocerca volvulus | 0.0032 | 0.0574 | 0.0701 | |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.018 | 0.6378 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.0574 | 0.0574 |
Onchocerca volvulus | Huntingtin homolog | 0.0144 | 0.4978 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0988 | 0.1133 |
Schistosoma mansoni | lamin | 0.0032 | 0.0574 | 0.0504 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0988 | 0.0988 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0068 | 0.1979 | 0.1115 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.018 | 0.6378 | 1 |
Echinococcus multilocularis | geminin | 0.0192 | 0.6828 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0551 | 0.0551 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.018 | 0.6378 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.018 | 0.6378 | 0.6378 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 0.6828 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0149 | 0.5157 | 0.7462 |
Echinococcus granulosus | tar DNA binding protein | 0.0149 | 0.5157 | 0.7462 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0062 | 0.1763 | 0.248 |
Echinococcus multilocularis | musashi | 0.0032 | 0.0574 | 0.0504 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0988 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.0574 | 0.0574 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0988 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0988 | 0.5 |
Echinococcus granulosus | lamin | 0.0032 | 0.0574 | 0.0504 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0574 | 0.0574 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0988 | 0.0988 |
Onchocerca volvulus | 0.0032 | 0.0574 | 0.0701 | |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0988 | 0.0988 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.018 | 0.6378 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0032 | 0.0574 | 0.0504 |
Schistosoma mansoni | lipoxygenase | 0.0065 | 0.1868 | 0.2469 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0062 | 0.1763 | 0.248 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.6378 | 0.6378 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.018 | 0.6378 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0065 | 0.1868 | 0.2469 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.4978 | 0.4978 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.018 | 0.6378 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0106 | 0.3466 | 0.4895 |
Loa Loa (eye worm) | doublecortin family protein | 0.0023 | 0.0241 | 0.0241 |
Brugia malayi | hypothetical protein | 0.0144 | 0.4978 | 0.4978 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0273 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0988 | 0.1133 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0988 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0988 | 0.1133 |
Brugia malayi | Doublecortin family protein | 0.0023 | 0.0241 | 0.0241 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.018 | 0.6378 | 0.9316 |
Brugia malayi | TAR-binding protein | 0.0149 | 0.5157 | 0.5157 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.018 | 0.6378 | 0.9316 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.018 | 0.6378 | 0.9316 |
Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.0062 | 0.1763 | 0.1439 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0988 | 0.1133 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0068 | 0.1979 | 0.1839 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0118 | 0.3953 | 0.55 |
Schistosoma mansoni | tar DNA-binding protein | 0.0149 | 0.5157 | 0.7462 |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.0574 | 0.0504 |
Onchocerca volvulus | 0.0042 | 0.0988 | 0.1576 | |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0118 | 0.3953 | 0.3335 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0988 | 0.1216 |
Schistosoma mansoni | tar DNA-binding protein | 0.0149 | 0.5157 | 0.7462 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 0.6828 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.018 | 0.6378 | 1 |
Schistosoma mansoni | lamin | 0.0032 | 0.0574 | 0.0504 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.0574 | 0.0574 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0118 | 0.3953 | 0.5634 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0106 | 0.3466 | 0.4895 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0063 | 0.1801 | 0.1801 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0988 | 0.5 |
Echinococcus granulosus | geminin | 0.0192 | 0.6828 | 1 |
Echinococcus multilocularis | lamin | 0.0032 | 0.0574 | 0.0504 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0106 | 0.3466 | 0.4895 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0068 | 0.1979 | 0.1839 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0118 | 0.3953 | 0.3335 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.027 | 0.9878 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0988 | 0.0988 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0068 | 0.1979 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0144 | 0.4978 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.018 | 0.6378 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0149 | 0.5157 | 0.7462 |
Brugia malayi | RNA binding protein | 0.0149 | 0.5157 | 0.5157 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0106 | 0.3466 | 0.4895 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0988 | 0.5 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0118 | 0.3953 | 0.5634 |
Onchocerca volvulus | 0.0042 | 0.0988 | 0.1576 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0106 | 0.3466 | 0.4895 |
Loa Loa (eye worm) | TAR-binding protein | 0.0149 | 0.5157 | 0.5157 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0988 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0241 | 0.0241 |
Schistosoma mansoni | tar DNA-binding protein | 0.0149 | 0.5157 | 0.7462 |
Toxoplasma gondii | hypothetical protein | 0.0062 | 0.1763 | 0.1439 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0042 | 0.0988 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0106 | 0.3466 | 0.4895 |
Onchocerca volvulus | 0.0042 | 0.0988 | 0.1576 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0106 | 0.3466 | 0.3466 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0068 | 0.1979 | 0.1979 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.018 | 0.6378 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0988 | 0.0988 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.0574 | 0.0574 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0149 | 0.5157 | 0.5157 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0068 | 0.1979 | 0.2638 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0149 | 0.5157 | 0.5157 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0068 | 0.1979 | 0.2638 |
Schistosoma mansoni | tar DNA-binding protein | 0.0149 | 0.5157 | 0.7462 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.4978 | 0.4978 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0988 | 0.0988 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0241 | 0.0241 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.018 | 0.6378 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0065 | 0.1868 | 0.2469 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 89 % | Inhibition of Escherichia coli ATCC 35695 biofilm formation after 24 hrs by crystal violet reporter assay | ChEMBL. | 21737267 |
MIC (functional) | = 8 ug ml-1 | Antimicrobial activity against Escherichia coli ATCC 35695 after 16 hrs by broth microdilution method | ChEMBL. | 21737267 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.