Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0336 | 0.3314 | 0.4965 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0293 | 0.2817 | 0.8499 |
Echinococcus granulosus | smad | 0.005 | 0.0065 | 0.0195 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0102 | 0.0655 | 1 |
Brugia malayi | Smad1 | 0.005 | 0.0065 | 0.0065 |
Schistosoma mansoni | smad1 5 8 and | 0.005 | 0.0065 | 0.0097 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0102 | 0.0655 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0925 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.0026 | 0.0026 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.1759 |
Schistosoma mansoni | smad1 5 8 and | 0.005 | 0.0065 | 0.0097 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0061 | 0.0183 | 0.0763 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0293 | 0.2817 | 0.2817 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0293 | 0.2817 | 0.2817 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0096 | 0.0583 | 0.8859 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0107 | 0.071 | 0.3315 |
Brugia malayi | TAR-binding protein | 0.0336 | 0.3314 | 0.3314 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0061 | 0.0183 | 0.0554 |
Brugia malayi | MH2 domain containing protein | 0.074 | 0.7901 | 0.7901 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.1406 | 0.2106 |
Echinococcus granulosus | geminin | 0.0169 | 0.1406 | 0.4243 |
Schistosoma mansoni | smad | 0.005 | 0.0065 | 0.0097 |
Schistosoma mansoni | tar DNA-binding protein | 0.0336 | 0.3314 | 0.4965 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0293 | 0.2817 | 0.2817 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.2817 | 0.2817 |
Schistosoma mansoni | hypothetical protein | 0.0293 | 0.2817 | 0.422 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0336 | 0.3314 | 0.3314 |
Brugia malayi | MH2 domain containing protein | 0.005 | 0.0065 | 0.0065 |
Schistosoma mansoni | tar DNA-binding protein | 0.0336 | 0.3314 | 0.4965 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0102 | 0.0655 | 1 |
Brugia malayi | MH1 domain containing protein | 0.005 | 0.0065 | 0.0065 |
Mycobacterium tuberculosis | Probable reductase | 0.0107 | 0.071 | 0.3315 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0096 | 0.0583 | 0.8859 |
Brugia malayi | Isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.0583 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.1406 | 0.2106 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.0026 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.1403 | 0.1403 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0102 | 0.0655 | 1 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.005 | 0.0065 | 0.0097 |
Echinococcus granulosus | tar DNA binding protein | 0.0336 | 0.3314 | 1 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0061 | 0.0183 | 0.2506 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.209 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0061 | 0.0183 | 0.5 |
Echinococcus granulosus | Smad4 | 0.005 | 0.0065 | 0.0195 |
Brugia malayi | hypothetical protein | 0.0168 | 0.1403 | 0.1403 |
Echinococcus multilocularis | tar DNA binding protein | 0.0336 | 0.3314 | 0.3898 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0632 | 0.6675 | 0.6675 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0061 | 0.0183 | 0.0183 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.005 | 0.0065 | 0.0195 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0655 | 0.0655 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0242 | 0.0242 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0925 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.0047 | 0.0026 | 0.0026 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0061 | 0.0183 | 0.0275 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0107 | 0.071 | 0.3315 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0061 | 0.0183 | 0.0216 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.074 | 0.7901 | 0.7901 |
Brugia malayi | MH1 domain containing protein | 0.005 | 0.0065 | 0.0065 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.0026 | 0.0078 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0925 | 1 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.005 | 0.0065 | 0.0076 |
Schistosoma mansoni | hypothetical protein | 0.0293 | 0.2817 | 0.422 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0336 | 0.3314 | 0.3314 |
Loa Loa (eye worm) | Smad1 | 0.005 | 0.0065 | 0.0065 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0107 | 0.071 | 0.3315 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.8859 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0293 | 0.2817 | 0.3313 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0102 | 0.0655 | 1 |
Brugia malayi | RNA binding protein | 0.0336 | 0.3314 | 0.3314 |
Echinococcus granulosus | GPCR family 2 | 0.0293 | 0.2817 | 0.8499 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0107 | 0.071 | 0.3315 |
Brugia malayi | isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.0583 |
Echinococcus multilocularis | smad | 0.005 | 0.0065 | 0.0076 |
Brugia malayi | hypothetical protein | 0.0102 | 0.0655 | 0.0655 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0107 | 0.071 | 0.3315 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.0026 | 0.0026 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0119 | 0.0846 | 0.3974 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.005 | 0.0065 | 0.0076 |
Brugia malayi | MH2 domain containing protein | 0.005 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.074 | 0.7901 | 0.7901 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0119 | 0.0846 | 0.3974 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0096 | 0.0583 | 0.2697 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.0026 | 0.0026 |
Echinococcus multilocularis | geminin | 0.0169 | 0.1406 | 0.1654 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.005 | 0.0065 | 0.0065 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0293 | 0.2817 | 0.3313 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0046 | 0.0013 | 0.0016 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.0686 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0096 | 0.0583 | 0.8859 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.005 | 0.0065 | 0.0065 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0061 | 0.0183 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0119 | 0.0846 | 0.3974 |
Schistosoma mansoni | hypothetical protein | 0.0632 | 0.6675 | 1 |
Onchocerca volvulus | 0.0168 | 0.1403 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0336 | 0.3314 | 0.4965 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.0686 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.0583 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0053 | 0.0096 | 0.0096 |
Echinococcus multilocularis | GPCR, family 2 | 0.0293 | 0.2817 | 0.3313 |
Schistosoma mansoni | smad1 5 8 and | 0.005 | 0.0065 | 0.0097 |
Loa Loa (eye worm) | RNA binding protein | 0.0336 | 0.3314 | 0.3314 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0096 | 0.0583 | 0.8859 |
Schistosoma mansoni | hypothetical protein | 0.0293 | 0.2817 | 0.422 |
Echinococcus multilocularis | Smad4 | 0.005 | 0.0065 | 0.0076 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0046 | 0.0013 | 0.004 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0102 | 0.0655 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0102 | 0.0655 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.0686 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0119 | 0.0846 | 1 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.005 | 0.0065 | 0.0195 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.0686 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0096 | 0.0583 | 0.8859 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0293 | 0.2817 | 0.8499 |
Schistosoma mansoni | Smad4 | 0.005 | 0.0065 | 0.0097 |
Loa Loa (eye worm) | TAR-binding protein | 0.0336 | 0.3314 | 0.3314 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0096 | 0.0583 | 0.8859 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0013 | 0.002 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0096 | 0.0583 | 0.0686 |
Schistosoma mansoni | hypothetical protein | 0.0293 | 0.2817 | 0.422 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0096 | 0.0583 | 0.8859 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.0873 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0102 | 0.0655 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0096 | 0.0583 | 0.8859 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0793 | 0.8501 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0336 | 0.3314 | 0.4965 |
Loa Loa (eye worm) | hypothetical protein | 0.0632 | 0.6675 | 0.6675 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.