Detailed information for compound 1024988

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 354.284 | Formula: C15H13F3N4O3
  • H donors: 2 H acceptors: 4 LogP: 1.35 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCOCn1nc(nc1C#Cc1ccc(cc1)C(F)(F)F)C(=O)N
  • InChi: 1S/C15H13F3N4O3/c16-15(17,18)11-4-1-10(2-5-11)3-6-12-20-14(13(19)24)21-22(12)9-25-8-7-23/h1-2,4-5,23H,7-9H2,(H2,19,24)
  • InChiKey: DGVXEJLSUHTSEN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni pyruvate dehydrogenase 0.0013 0.0043 0.0072
Trypanosoma brucei heat shock protein, putative 0.0065 0.1104 1
Onchocerca volvulus 0.0102 0.1858 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0651 0.0651
Schistosoma mansoni hypothetical protein 0.0303 0.5969 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0199 0.1469
Trypanosoma cruzi heat shock protein 90, putative 0.0065 0.1104 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0043
Leishmania major heat shock protein 83-1 0.0065 0.1104 0.8744
Trypanosoma brucei heat shock protein, putative 0.0065 0.1104 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1257 0.2105
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.1104 1
Loa Loa (eye worm) TOPoisomerase family member 0.0013 0.0043 0.0043
Brugia malayi kinase, mitochondrial precursor 0.0013 0.0043 0.0043
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0296 0.3197
Brugia malayi intermediate filament protein 0.0032 0.0431 0.0431
Leishmania major heat shock protein 83-1 0.0065 0.1104 0.8744
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0052 0.0833 1
Leishmania major heat shock protein 83-1 0.0065 0.1104 0.8744
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0199 0.0199
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1257 0.2105
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1257 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.009 0.009
Echinococcus multilocularis lamin 0.0032 0.0431 0.0431
Trypanosoma brucei heat shock protein, putative 0.0065 0.1104 1
Toxoplasma gondii Hsp90 domain-containing protein 0.0027 0.0318 0.2263
Schistosoma mansoni importin beta-1 0.0028 0.0352 0.059
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.0043 0.0232
Echinococcus granulosus intermediate filament protein 0.0032 0.0431 0.0431
Leishmania major heat shock protein 83-1 0.0065 0.1104 0.8744
Plasmodium vivax heat shock protein, putative 0.0027 0.0318 0.2588
Leishmania major heat shock protein 83-1 0.0065 0.1104 0.8744
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0242 0.1879
Toxoplasma gondii heat shock protein 75, putative 0.0027 0.0318 0.2263
Brugia malayi Hsp90 protein 0.0027 0.0318 0.0318
Echinococcus multilocularis endoplasmin 0.0052 0.0833 0.0833
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.021 0.4077 0.4077
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0558 0.4856
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0431 0.0431
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0163 0.0989
Loa Loa (eye worm) hypothetical protein 0.0032 0.0419 0.0419
Toxoplasma gondii heat shock protein HSP90 0.0065 0.1104 0.8744
Echinococcus granulosus importin subunit beta 1 0.0028 0.0352 0.0352
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0296 0.2081
Echinococcus granulosus snurportin 1 0.0303 0.5969 0.5969
Echinococcus granulosus geminin 0.0183 0.3516 0.3516
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0043
Echinococcus granulosus heat shock protein 0.0065 0.1104 0.1104
Mycobacterium ulcerans hypothetical protein 0.0026 0.0296 0.2081
Schistosoma mansoni tar DNA-binding protein 0.021 0.4077 0.683
Brugia malayi heat shock protein 90 0.0065 0.1104 0.1104
Trypanosoma brucei heat shock protein, putative 0.0065 0.1104 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0242 0.1879
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0431 0.0431
Leishmania major heat shock protein 83-1 0.0065 0.1104 0.8744
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.009 0.009
Schistosoma mansoni endoplasmin 0.0065 0.1104 0.185
Entamoeba histolytica hypothetical protein 0.0043 0.0651 0.5734
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0043
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0296 0.238
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0199 0.0199
Plasmodium vivax endoplasmin, putative 0.0065 0.1104 1
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.269 0.269
Plasmodium falciparum importin beta, putative 0.0028 0.0352 0.2914
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.1104 1
Leishmania major heat shock protein 83-1 0.0065 0.1104 0.8744
Trichomonas vaginalis heat shock protein, putative 0.004 0.0589 0.5145
Trypanosoma cruzi heat shock protein, putative 0.0027 0.0318 0.2588
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0833 0.7443
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0013 0.0043 0.0232
Trypanosoma brucei heat shock protein 84, putative 0.0027 0.0318 0.2588
Brugia malayi RNA, U transporter 1 0.0081 0.1423 0.1423
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0833 0.7443
Loa Loa (eye worm) heat shock protein 75 0.0027 0.0318 0.0318
Schistosoma mansoni DNA topoisomerase II 0.0013 0.0043 0.0072
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.269 0.269
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0296
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0013 0.0043 0.0043
Entamoeba histolytica Ran family GTPase 0.0021 0.0199 0.1469
Brugia malayi TAR-binding protein 0.021 0.4077 0.4077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0142 0.0813
Treponema pallidum heat shock protein 90 0.0052 0.0833 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0015 0.0078 0.0078
Echinococcus granulosus survival motor neuron protein 1 0.05 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0142 0.0813
Echinococcus multilocularis lamin dm0 0.0032 0.0431 0.0431
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0125 0.0125
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0296 0.3197
Echinococcus granulosus heat shock protein 90 0.0052 0.0833 0.0833
Plasmodium falciparum endoplasmin, putative 0.004 0.0589 0.5145
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0242 0.1879
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0163 1
Brugia malayi RNA recognition motif domain containing protein 0.021 0.4077 0.4077
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0296 0.2081
Mycobacterium ulcerans heat shock protein 90 0.0052 0.0833 0.6507
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0651 0.0651
Schistosoma mansoni hypothetical protein 0.0102 0.1858 0.3112
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.063 0.4835
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0013 0.0043 0.0043
Onchocerca volvulus 0.0032 0.0431 0.2321
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0352 0.2548
Trypanosoma brucei Heat shock protein 83, putative 0.0065 0.1104 1
Trypanosoma cruzi heat shock protein 90, putative 0.0052 0.0833 0.7443
Plasmodium falciparum heat shock protein 90 0.0065 0.1104 1
Echinococcus granulosus lamin 0.0032 0.0431 0.0431
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0296 0.2081
Echinococcus multilocularis snurportin 1 0.0303 0.5969 0.5969
Schistosoma mansoni ran 0.0021 0.0199 0.0333
Leishmania major heat shock protein 83-1 0.0065 0.1104 0.8744
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0296 0.238
Toxoplasma gondii heat shock protein 90, putative 0.0065 0.1104 0.8744
Schistosoma mansoni tar DNA-binding protein 0.021 0.4077 0.683
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0296 0.2081
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0296 0.2081
Leishmania major heat shock protein 83-1 0.0065 0.1104 0.8744
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0352 0.2914
Schistosoma mansoni tar DNA-binding protein 0.021 0.4077 0.683
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.269 0.4506
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0199 0.1469
Schistosoma mansoni hypothetical protein 0.0183 0.3516 0.589
Plasmodium vivax importin-beta 2, putative 0.0028 0.0352 0.2914
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0318 0.2588
Schistosoma mansoni endoplasmin 0.0065 0.1104 0.185
Leishmania major heat shock protein, putative 0.0027 0.0318 0.2263
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.063 0.4835
Echinococcus multilocularis survival motor neuron protein 1 0.05 1 1
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0027 0.0318 0.0318
Leishmania major heat shock protein 83-1 0.0065 0.1104 0.8744
Brugia malayi Importin beta-1 subunit 0.0028 0.0352 0.0352
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0027 0.0318 0.171
Plasmodium vivax heat shock protein 90, putative 0.0027 0.0318 0.2588
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0296
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.2608 0.2608
Schistosoma mansoni hypothetical protein 0.0043 0.0651 0.1091
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.063 0.063
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.063 0.553
Leishmania major heat shock protein 83-1 0.0065 0.1104 0.8744
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.1104 1
Trypanosoma brucei heat shock protein, putative 0.0065 0.1104 1
Leishmania major heat shock protein 83-1 0.0065 0.1104 0.8744
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0651 0.1091
Schistosoma mansoni survival motor neuron protein 0.0102 0.1858 0.3112
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1257 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0163 0.0163
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0833 0.7443
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0199 0.1469
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0032 0.0431 0.0431
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0027 0.0318 0.0318
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0296 0.2081
Loa Loa (eye worm) TAR-binding protein 0.021 0.4077 0.4077
Leishmania major heat shock protein 83-1 0.0065 0.1104 0.8744
Onchocerca volvulus 0.0032 0.0431 0.2321
Echinococcus multilocularis musashi 0.0032 0.0431 0.0431
Echinococcus multilocularis heat shock protein 90 0.0065 0.1104 0.1104
Echinococcus granulosus tar DNA binding protein 0.021 0.4077 0.4077
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.0043 0.0043
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0125 0.0125
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0199 0.0199
Brugia malayi Endoplasmin precursor 0.0065 0.1104 0.1104
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.1104 1
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1257 1
Schistosoma mansoni ran 0.0021 0.0199 0.0333
Trichomonas vaginalis heat shock protein, putative 0.0065 0.1104 1
Loa Loa (eye worm) endoplasmin 0.0065 0.1104 0.1104
Schistosoma mansoni heat shock protein 0.0027 0.0318 0.0532
Trypanosoma brucei heat shock protein, putative 0.0065 0.1104 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.063 0.553
Leishmania major heat shock protein 83-1 0.0065 0.1104 0.8744
Trypanosoma cruzi Heat shock protein 83, putative 0.0065 0.1104 1
Giardia lamblia Grp94/Hsp90 0.0052 0.0833 0.7443
Loa Loa (eye worm) hypothetical protein 0.0015 0.0078 0.0078
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0558 0.4856
Giardia lamblia Heat shock protein HSP 90-alpha 0.0052 0.0833 0.7443
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0199 0.0199
Brugia malayi hypothetical protein 0.0043 0.0651 0.0651
Echinococcus granulosus endoplasmin 0.0052 0.0833 0.0833
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0242 0.1879
Leishmania major heat shock protein 83-1 0.0065 0.1104 0.8744
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0163 0.0989
Echinococcus multilocularis tar DNA binding protein 0.021 0.4077 0.4077
Giardia lamblia Heat shock protein HSP 90-alpha 0.0065 0.1104 1
Echinococcus multilocularis heat shock protein 0.0065 0.1104 0.1104
Schistosoma mansoni lamin 0.0032 0.0431 0.0722
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0296 0.0296
Onchocerca volvulus 0.0026 0.0296 0.1591
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0296 0.2081
Leishmania major heat shock protein 83-1 0.0065 0.1104 0.8744
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.1104 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0199 0.1469
Loa Loa (eye worm) hypothetical protein 0.05 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1257 1
Loa Loa (eye worm) heat shock protein 90 0.0065 0.1104 0.1104
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0558 0.4856
Loa Loa (eye worm) RNA binding protein 0.021 0.4077 0.4077
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0296 0.238
Entamoeba histolytica hypothetical protein 0.0043 0.0651 0.5734
Echinococcus multilocularis geminin 0.0183 0.3516 0.3516
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0052 0.0833 0.6507
Entamoeba histolytica hypothetical protein 0.0023 0.0242 0.1879
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0199 0.1469
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0013 0.0043 0.0043
Schistosoma mansoni lamin 0.0032 0.0431 0.0722
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0163 0.1132
Schistosoma mansoni hypothetical protein 0.0183 0.3516 0.589
Leishmania major importin beta-1 subunit, putative 0.0023 0.0242 0.1643
Trypanosoma brucei heat shock protein, putative 0.0065 0.1104 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0142 0.0813
Trichomonas vaginalis endoplasmin, putative 0.004 0.0589 0.5145
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0558 0.4855
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0296 0.0296
Schistosoma mansoni intermediate filament proteins 0.0032 0.0431 0.0722
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0833 0.7443
Loa Loa (eye worm) hypothetical protein 0.0019 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0163 0.0163
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0052 0.0833 0.6507
Leishmania major heat shock protein 83-1 0.0065 0.1104 0.8744
Echinococcus granulosus heat shock protein 90 0.0065 0.1104 0.1104
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0163 0.1132
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1257 1
Entamoeba histolytica hypothetical protein 0.0043 0.0651 0.5734
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0052 0.0833 1
Trichomonas vaginalis ran, putative 0.0021 0.0199 0.1469
Plasmodium vivax heat shock protein 86, putative 0.0065 0.1104 1
Entamoeba histolytica hypothetical protein 0.0043 0.0651 0.5734
Brugia malayi Probable DNA topoisomerase II 0.0013 0.0043 0.0043
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0199 0.1285
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0027 0.0318 0.2588
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1257 0.1257
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0352 0.0352
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.1858 0.1858
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0296 0.2081
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0296 0.2081
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0318 0.2588
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0013 0.0043 0.0043
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0013 0.0043 0.0043
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.0043 0.0232
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.009 0.009
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.1104 1
Schistosoma mansoni heat shock protein 0.0065 0.1104 0.185
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0199 0.1469
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0431 0.0431
Echinococcus multilocularis heat shock protein 90 0.0052 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0019 0.0163 0.0163
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0296 0.2081
Loa Loa (eye worm) acetyltransferase 0.0143 0.269 0.269
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0142 0.0813
Loa Loa (eye worm) hypothetical protein 0.0028 0.0352 0.0352
Schistosoma mansoni heat shock protein 0.0065 0.1104 0.185
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.1104 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0052 0.0833 0.0833
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0318 0.2588
Schistosoma mansoni tar DNA-binding protein 0.021 0.4077 0.683
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1257 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.063 0.553
Echinococcus granulosus lamin dm0 0.0032 0.0431 0.0431
Trypanosoma brucei heat shock protein, putative 0.0065 0.1104 1
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.0043 0.0043
Leishmania major GTP-binding protein, putative 0.0021 0.0199 0.1285
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0352 0.2914
Schistosoma mansoni tar DNA-binding protein 0.021 0.4077 0.683
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1257 0.1257
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0296 0.2081
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.5969 0.5969
Brugia malayi RNA binding protein 0.021 0.4077 0.4077
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0296 0.2081

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 20 ug ml-1 Cytotoxicity against human Huh-5-2 cells ChEMBL. 18445526

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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