Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.1414 | 0.3027 |
Loa Loa (eye worm) | glutathione reductase | 0.0052 | 0.1041 | 0.1197 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.0421 | 0.0673 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0108 | 0.0074 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0176 | 0.4433 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0035 | 0.0568 | 0.0606 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0382 | 0.2969 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0052 | 0.1041 | 0.1197 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.4819 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0185 | 0.0865 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0568 | 0.0984 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0185 | 0.0619 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0119 | 0.2879 | 0.6411 |
Echinococcus multilocularis | dual specificity | 0.0098 | 0.2302 | 0.2302 |
Echinococcus granulosus | GPCR family 2 | 0.0035 | 0.0568 | 0.0568 |
Echinococcus multilocularis | musashi | 0.003 | 0.0421 | 0.0421 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0119 | 0.2879 | 0.6411 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0052 | 0.1041 | 0.1082 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0018 | 0.0104 | 0.0104 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0508 | 0.3086 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.0104 | 0.007 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0333 | 0.8768 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2288 | 0.2629 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0162 | 0.4065 | 0.4644 |
Onchocerca volvulus | 0.0331 | 0.8703 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0098 | 0.2302 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.1414 | 0.1512 |
Onchocerca volvulus | 0.026 | 0.6759 | 0.7653 | |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0382 | 0.2969 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.1683 | 0.335 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0043 | 0.005 |
Schistosoma mansoni | tar DNA-binding protein | 0.0144 | 0.3554 | 0.7317 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0098 | 0.2302 | 0.2645 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0508 | 0.0508 |
Echinococcus granulosus | geminin | 0.019 | 0.4819 | 0.4819 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0185 | 0.0172 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.0568 | 0.0568 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.1014 | 0.1165 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0162 | 0.4065 | 0.8401 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0047 | 0.0895 | 0.0913 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0055 | 0.1128 | 0.2172 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0018 | 0.0104 | 0.0104 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0119 | 0.2879 | 0.6411 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0047 | 0.0895 | 0.0913 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0508 | 0.0508 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0111 | 0.2645 | 0.3039 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0158 | 0.3943 | 0.4431 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0158 | 0.3943 | 0.4431 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0421 | 0.0437 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.0568 | 0.0568 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0185 | 0.0094 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0382 | 0.0321 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0111 | 0.2645 | 0.3004 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0185 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0508 | 0.0584 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0508 | 0.0857 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0665 | 0.2269 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0144 | 0.3554 | 0.4054 |
Plasmodium vivax | glutathione reductase, putative | 0.0052 | 0.1041 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.8703 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0052 | 0.1041 | 0.1153 |
Trichomonas vaginalis | set domain proteins, putative | 0.026 | 0.6759 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0119 | 0.2879 | 0.6411 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0333 | 0.8768 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0132 | 0.3244 | 0.7254 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0098 | 0.2302 | 0.2537 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0052 | 0.1041 | 0.2165 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0098 | 0.2302 | 0.2537 |
Mycobacterium tuberculosis | Probable reductase | 0.0119 | 0.2879 | 0.6411 |
Toxoplasma gondii | thioredoxin reductase | 0.0052 | 0.1041 | 0.7154 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1128 | 0.1296 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.1414 | 0.3027 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2288 | 0.2629 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.0421 | 0.0421 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0185 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0111 | 0.2645 | 0.3004 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1014 | 0.1014 |
Onchocerca volvulus | 0.0055 | 0.1128 | 0.0854 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0508 | 0.0857 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0144 | 0.3554 | 0.4083 |
Trypanosoma brucei | trypanothione reductase | 0.0052 | 0.1041 | 0.1082 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.1414 | 0.3027 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0568 | 0.0984 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0132 | 0.3244 | 0.7254 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0665 | 0.2269 |
Leishmania major | trypanothione reductase | 0.0052 | 0.1041 | 0.1082 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.0421 | 0.0421 |
Brugia malayi | Protein kinase domain containing protein | 0.0098 | 0.2302 | 0.2608 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0421 | 0.0437 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0048 | 0.0918 | 0.1223 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.1414 | 0.1414 |
Plasmodium falciparum | thioredoxin reductase | 0.0052 | 0.1041 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0035 | 0.0568 | 0.0606 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.0568 | 0.0568 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1014 | 0.193 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0382 | 0.0321 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0044 | 0.0809 | 0.7519 |
Brugia malayi | RNA binding protein | 0.0144 | 0.3554 | 0.4054 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0185 | 0.0185 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0421 | 0.0484 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0508 | 0.0857 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0185 | 0.0213 |
Schistosoma mansoni | lamin | 0.003 | 0.0421 | 0.0673 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0052 | 0.1041 | 0.1041 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0048 | 0.0918 | 0.0918 |
Plasmodium falciparum | glutathione reductase | 0.0052 | 0.1041 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.2645 | 0.3039 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0185 | 0.0185 |
Entamoeba histolytica | protein kinase, putative | 0.0098 | 0.2302 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0054 | 0.1085 | 0.7485 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.1414 | 0.2779 |
Brugia malayi | hypothetical protein | 0.0331 | 0.8703 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0185 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0568 | 0.0984 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0185 | 0.0094 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.4819 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0508 | 0.4313 |
Brugia malayi | TAR-binding protein | 0.0144 | 0.3554 | 0.4054 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0229 | 0.5891 | 0.6769 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.1014 | 0.1121 |
Echinococcus multilocularis | lamin | 0.003 | 0.0421 | 0.0421 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0185 | 0.115 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.1414 | 0.1414 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0158 | 0.3943 | 0.4431 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0185 | 0.0122 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0158 | 0.394 | 0.394 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0508 | 0.0537 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1683 | 0.1934 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0665 | 0.0665 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0333 | 0.8768 | 1 |
Schistosoma mansoni | lamin | 0.003 | 0.0421 | 0.0673 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0508 | 0.0857 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0098 | 0.2302 | 0.2537 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0382 | 0.0392 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0421 | 0.0484 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0052 | 0.1041 | 0.1041 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1014 | 0.1014 |
Entamoeba histolytica | protein kinase, putative | 0.0098 | 0.2302 | 1 |
Echinococcus multilocularis | geminin | 0.019 | 0.4819 | 0.4819 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0421 | 0.0484 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0382 | 0.2124 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.0421 | 0.0421 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0382 | 0.2969 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0132 | 0.3244 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0185 | 0.0187 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0665 | 0.0665 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0665 | 0.119 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0044 | 0.0809 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.0568 | 0.0568 |
Schistosoma mansoni | tar DNA-binding protein | 0.0144 | 0.3554 | 0.7317 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0098 | 0.2302 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.1414 | 0.3027 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0057 | 0.1177 | 0.1238 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0098 | 0.2302 | 0.4661 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0665 | 0.119 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.1414 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1014 | 0.193 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0185 | 0.0865 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0333 | 0.8768 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0144 | 0.3554 | 0.4083 |
Mycobacterium ulcerans | hypothetical protein | 0.0176 | 0.4433 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0475 | 0.0475 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0185 | 0.0172 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0132 | 0.3244 | 0.7254 |
Brugia malayi | Pre-SET motif family protein | 0.0229 | 0.5891 | 0.6753 |
Schistosoma mansoni | tar DNA-binding protein | 0.0144 | 0.3554 | 0.7317 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0665 | 0.2269 |
Echinococcus granulosus | dual specificity | 0.0098 | 0.2302 | 0.2302 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.1414 | 0.2779 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0018 | 0.0104 | 0.5 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0098 | 0.2302 | 0.2537 |
Echinococcus multilocularis | GPCR, family 2 | 0.0035 | 0.0568 | 0.0568 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0035 | 0.0568 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0568 | 0.0653 |
Echinococcus granulosus | lamin | 0.003 | 0.0421 | 0.0421 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0048 | 0.0918 | 0.6213 |
Onchocerca volvulus | 0.0033 | 0.0508 | 0.0105 | |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0185 | 0.0122 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1014 | 0.193 |
Schistosoma mansoni | tar DNA-binding protein | 0.0144 | 0.3554 | 0.7317 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0406 | 0.0467 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0048 | 0.0918 | 0.1223 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0382 | 0.0439 |
Schistosoma mansoni | tar DNA-binding protein | 0.0144 | 0.3554 | 0.7317 |
Brugia malayi | glutathione reductase | 0.0052 | 0.1041 | 0.1153 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0382 | 0.0321 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0076 | 0.1683 | 0.1894 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0052 | 0.1041 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0144 | 0.3554 | 0.4083 |
Loa Loa (eye worm) | acetyltransferase | 0.0162 | 0.4065 | 0.4671 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0048 | 0.0918 | 0.8684 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0044 | 0.0809 | 0.2947 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0185 | 0.0187 |
Echinococcus multilocularis | tumor protein p63 | 0.0378 | 1 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0048 | 0.0918 | 0.6213 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0568 | 0.0984 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0665 | 0.2269 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0047 | 0.0895 | 0.0913 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1014 | 0.1014 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0119 | 0.2879 | 0.6411 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0185 | 0.0094 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0162 | 0.4065 | 0.4065 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0185 | 0.0094 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0508 | 0.0508 |
Echinococcus multilocularis | tar DNA binding protein | 0.0144 | 0.3554 | 0.3554 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0665 | 0.0718 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0382 | 0.0321 |
Echinococcus granulosus | tar DNA binding protein | 0.0144 | 0.3554 | 0.3554 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0047 | 0.0895 | 0.0913 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1014 | 0.1014 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 23 % | Growth inhibition of Mycobacterium tuberculosis H37Rv ATCC 27294 after 5 to 8 days by microplate alamar blue assay | ChEMBL. | 21752642 |
MIC99 (functional) | < 6.25 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 5 to 8 days by microplate alamar blue assay | ChEMBL. | 21752642 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.