Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | 0.0038 | 0.0032 | 0.0055 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0105 | 0.016 | 0.9553 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0043 | 0.0043 | 0.0843 |
Schistosoma mansoni | Tata binding protein associated factor (M01 family) | 0.0105 | 0.016 | 0.0432 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0108 | 0.0166 | 0.0166 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0105 | 0.016 | 0.0423 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0108 | 0.0166 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0032 | 0.0032 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0054 | 0.0062 | 0.2301 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0105 | 0.016 | 0.9553 |
Brugia malayi | hypothetical protein | 0.0105 | 0.016 | 0.0152 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0037 | 0.0032 | 0.0076 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0105 | 0.016 | 1 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0105 | 0.016 | 0.9553 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0105 | 0.016 | 0.9553 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0105 | 0.016 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0105 | 0.016 | 0.0423 |
Loa Loa (eye worm) | glutathione reductase | 0.0038 | 0.0032 | 0.0032 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0043 | 0.0116 |
Brugia malayi | cytochrome P450 | 0.0043 | 0.0043 | 0.0035 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0105 | 0.016 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0086 | 0.0123 | 0.8342 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0033 | 0.0025 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0105 | 0.016 | 0.9553 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0043 | 0.0043 | 0.0968 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0108 | 0.0166 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0043 | 0.0043 | 0.0843 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.016 | 0.016 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0105 | 0.016 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0041 | 0.0041 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0105 | 0.016 | 0.0423 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.1979 | 0.37 | 1 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0105 | 0.016 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.006 | 0.0163 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0105 | 0.016 | 0.0423 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0043 | 0.0043 | 0.0843 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.1979 | 0.37 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0105 | 0.016 | 0.0432 |
Brugia malayi | Peptidase family M1 containing protein | 0.0105 | 0.016 | 0.0152 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0108 | 0.0166 | 1 |
Schistosoma mansoni | aminopeptidase A (M01 family) | 0.0105 | 0.016 | 0.0432 |
Entamoeba histolytica | aminopeptidase, putative | 0.0105 | 0.016 | 0.9553 |
Brugia malayi | Peptidase family M1 containing protein | 0.0105 | 0.016 | 0.0152 |
Leishmania major | cytochrome p450-like protein | 0.0043 | 0.0043 | 0.0843 |
Trypanosoma brucei | polo-like protein kinase | 0.0108 | 0.0166 | 1 |
Leishmania major | puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0105 | 0.016 | 0.9553 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.006 | 0.0153 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0108 | 0.0166 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.006 | 0.0153 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.006 | 0.006 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0108 | 0.0166 | 0.0439 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.006 | 0.0163 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0108 | 0.0166 | 1 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0105 | 0.016 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.006 | 0.0163 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0108 | 0.0166 | 0.0448 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0105 | 0.016 | 0.9553 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.0073 | 0.0189 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0043 | 0.0043 | 0.0968 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0043 | 0.0043 | 0.0106 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0105 | 0.016 | 0.9553 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0004 | 0.001 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0043 | 0.0043 | 0.0968 |
Brugia malayi | Bromodomain containing protein | 0.0075 | 0.0102 | 0.0094 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0105 | 0.016 | 0.9553 |
Trypanosoma brucei | trypanothione reductase | 0.0038 | 0.0032 | 0.0055 |
Brugia malayi | Thioredoxin reductase | 0.0038 | 0.0032 | 0.0024 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0043 | 0.0043 | 0.0968 |
Giardia lamblia | Kinase, PLK | 0.0108 | 0.0166 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0105 | 0.016 | 0.0423 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0108 | 0.0166 | 0.0439 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.1979 | 0.37 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0121 | 0.019 | 0.0182 |
Brugia malayi | hypothetical protein | 0.091 | 0.168 | 0.1674 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.008 | 0.0217 |
Trypanosoma brucei | aminopeptidase, putative | 0.0105 | 0.016 | 0.9553 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0086 | 0.0123 | 0.8342 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0037 | 0.0032 | 0.0085 |
Brugia malayi | Cytochrome P450 family protein | 0.0043 | 0.0043 | 0.0035 |
Echinococcus multilocularis | 0.0043 | 0.0043 | 0.0106 | |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0094 | 0.0094 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0108 | 0.0166 | 1 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0105 | 0.016 | 0.9553 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0105 | 0.016 | 0.9553 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0079 | 0.011 | 0.5769 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0029 | 0.0068 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0105 | 0.016 | 0.9553 |
Leishmania major | cytochrome p450-like protein | 0.0043 | 0.0043 | 0.0843 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0108 | 0.0166 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0086 | 0.0123 | 0.8342 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0043 | 0.0043 | 0.0968 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0037 | 0.0032 | 0.0076 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0105 | 0.016 | 0.9553 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0108 | 0.0166 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0105 | 0.016 | 0.0423 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0043 | 0.0043 | 0.0968 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.006 | 0.0153 |
Loa Loa (eye worm) | cytochrome P450 | 0.0043 | 0.0043 | 0.0043 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0043 | 0.0043 | 0.0968 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0043 | 0.0043 | 0.083 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0095 | 0.0142 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0105 | 0.016 | 0.0152 |
Echinococcus multilocularis | aminopeptidase N | 0.0105 | 0.016 | 0.0423 |
Echinococcus granulosus | aminopeptidase N | 0.0105 | 0.016 | 0.0423 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0108 | 0.0166 | 0.0158 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.006 | 0.0052 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0086 | 0.0123 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0038 | 0.0038 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0043 | 0.0043 | 0.0968 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0108 | 0.0166 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0043 | 0.0043 | 0.0968 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0105 | 0.016 | 0.0423 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0038 | 0.0032 | 0.0032 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0105 | 0.016 | 0.9553 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0043 | 0.0043 | 0.0968 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0043 | 0.0043 | 0.0968 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0105 | 0.016 | 0.0423 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0037 | 0.0032 | 0.0085 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0037 | 0.0032 | 0.0076 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0037 | 0.0032 | 0.0024 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0105 | 0.016 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0105 | 0.016 | 0.0423 |
Brugia malayi | Cytochrome P450 family protein | 0.0079 | 0.011 | 0.0102 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0043 | 0.0043 | 0.0968 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0086 | 0.0123 | 0.8165 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.1979 | 0.37 | 0.37 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0029 | 0.0029 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0105 | 0.016 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0105 | 0.016 | 0.0423 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0029 | 0.0068 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0079 | 0.011 | 0.5868 |
Leishmania major | cytochrome p450-like protein | 0.0079 | 0.011 | 0.5868 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0079 | 0.011 | 0.5868 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0105 | 0.016 | 0.0423 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0105 | 0.016 | 0.0423 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0105 | 0.016 | 0.9553 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0037 | 0.0032 | 0.0076 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0108 | 0.0166 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0105 | 0.016 | 0.9553 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0043 | 0.0043 | 0.0968 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.5313 | 1 | 1 |
Brugia malayi | TATA binding protein associated factor | 0.0105 | 0.016 | 0.0152 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0043 | 0.0043 | 0.0968 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0105 | 0.016 | 0.9553 |
Toxoplasma gondii | aminopeptidase N protein | 0.0105 | 0.016 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0043 | 0.0043 | 0.0968 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0043 | 0.0043 | 0.0843 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.016 | 0.016 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0108 | 0.0166 | 1 |
Loa Loa (eye worm) | TATA binding protein associated factor | 0.0105 | 0.016 | 0.016 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0108 | 0.0166 | 1 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0037 | 0.0032 | 0.0076 |
Brugia malayi | glutathione reductase | 0.0038 | 0.0032 | 0.0024 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0105 | 0.016 | 0.9553 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0079 | 0.011 | 0.011 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0037 | 0.0032 | 0.0076 |
Brugia malayi | Cytochrome P450 family protein | 0.0079 | 0.011 | 0.0102 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0086 | 0.0123 | 0.8342 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0095 | 0.0142 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0086 | 0.0123 | 0.8342 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.0073 | 0.0189 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0054 | 0.0062 | 0.2301 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0079 | 0.011 | 0.011 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0043 | 0.0043 | 0.0968 |
Schistosoma mansoni | cytochrome P450 | 0.0043 | 0.0043 | 0.0116 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0043 | 0.0043 | 0.0968 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0121 | 0.019 | 0.019 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0038 | 0.0033 | 0.008 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.006 | 0.0153 |
Loa Loa (eye worm) | aminopeptidase N | 0.0105 | 0.016 | 0.016 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0038 | 0.0033 | 0.008 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0043 | 0.0043 | 0.0843 |
Leishmania major | trypanothione reductase | 0.0038 | 0.0032 | 0.0055 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0105 | 0.016 | 0.0432 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0095 | 0.0142 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0079 | 0.011 | 0.5868 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0105 | 0.016 | 0.016 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0043 | 0.0043 | 0.0968 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.016 | 0.016 |
Brugia malayi | hypothetical protein | 0.0105 | 0.016 | 0.0152 |
Schistosoma mansoni | kinase | 0.0055 | 0.0065 | 0.0176 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0043 | 0.0043 | 0.0968 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0095 | 0.0142 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0043 | 0.0043 | 0.0968 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0079 | 0.011 | 0.011 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.