TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 566.51 | Formula: C29H25F7N2O2
H donors: 1 H acceptors: 2 LogP: 7.52 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: Fc1ccc(cc1)c1ccc(cc1N(C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C(=O)NC1CCCCC1
InChi: 1S/C29H25F7N2O2/c1-38(27(40)19-13-20(28(31,32)33)16-21(14-19)29(34,35)36)25-15-18(26(39)37-23-5-3-2-4-6-23)9-12-24(25)17-7-10-22(30)11-8-17/h7-16,23H,2-6H2,1H3,(H,37,39)
InChiKey: BMSXMNNYSLYMQG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tachykinin receptor 2	Starlite/ChEMBL	References
Homo sapiens	tachykinin receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04224 tachykinin receptor 3, putative	Get druggable targets OG5_137770	All targets in OG5_137770

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Loa Loa (eye worm)	animal heme peroxidase	0.0443	0.4485	0.4485
Loa Loa (eye worm)	hypothetical protein	0.0188	0.1846	0.1846
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0298	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0024	0.0019
Loa Loa (eye worm)	TYRA-2 protein	0.0012	0.0024	0.0024
Schistosoma mansoni	hypothetical protein	0.0108	0.1024	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1545	0.1545
Echinococcus multilocularis	G protein coupled receptor 139	0.0012	0.0024	0.0019
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0426	0.0422
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0106	0.1004	0.1
Onchocerca volvulus		0.0134	0.1288	0.2834
Schistosoma mansoni	hypothetical protein	0.0108	0.1024	0.1002
Schistosoma mansoni	lipoxygenase	0.0088	0.081	0.0788
Entamoeba histolytica	hypothetical protein	0.0038	0.0298	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0024	0.0019
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0049	0.0414	0.041
Echinococcus multilocularis	slit 2 protein	0.0108	0.1024	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Schistosoma mansoni	notch	0.0108	0.1024	0.1002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Schistosoma mansoni	microtubule-associated protein tau	0.0761	0.7779	0.7774
Echinococcus multilocularis	Niemann Pick C1 protein	0.0402	0.406	0.4058
Onchocerca volvulus		0.0021	0.0121	0.0217
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0024	0.0019
Echinococcus multilocularis	neuropeptide receptor A26	0.0361	0.3641	0.3638
Brugia malayi	G-protein coupled receptor	0.0012	0.0024	0.0019
Schistosoma mansoni	hypothetical protein	0.0027	0.0186	0.0163
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0024	0.0019
Onchocerca volvulus		0.0443	0.4485	1
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Schistosoma mansoni	notch	0.0108	0.1024	0.1002
Brugia malayi	hypothetical protein	0.0012	0.0024	0.0019
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0012	0.0024	0.0019
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0024	0.0019
Brugia malayi	TAR-binding protein	0.0064	0.0563	0.0559
Schistosoma mansoni	hypothetical protein	0.0027	0.0186	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0028	0.0023
Loa Loa (eye worm)	plexin A	0.001	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Schistosoma mansoni	hypothetical protein	0.0021	0.0121	0.0097
Brugia malayi	hypothetical protein	0.0017	0.0082	0.0078
Loa Loa (eye worm)	animal heme peroxidase	0.0443	0.4485	0.4485
Schistosoma mansoni	rab6-interacting	0.0021	0.0121	0.0097
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0188	0.1852	1
Loa Loa (eye worm)	animal heme peroxidase	0.0443	0.4485	0.4485
Echinococcus multilocularis	protein patched	0.0402	0.406	0.4058
Echinococcus multilocularis	somatostatin receptor	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0976	1	1
Onchocerca volvulus		0.0159	0.1545	0.3409
Schistosoma mansoni	laminin gamma-3 chain	0.0108	0.1024	0.1002
Echinococcus granulosus	neuropeptide Y receptor	0.0012	0.0024	0.0019
Loa Loa (eye worm)	neuropeptide F receptor	0.0012	0.0024	0.0024
Brugia malayi	neuropeptide F receptor	0.0012	0.0024	0.0019
Loa Loa (eye worm)	doublecortin family protein	0.0021	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Echinococcus multilocularis	fmrfamide receptor	0.0012	0.0024	0.0019
Echinococcus granulosus	7TM GPCR rhodopsin	0.0012	0.0024	0.0019
Brugia malayi	larval opioid receptor	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0185	0.0185
Schistosoma mansoni	peroxidasin	0.0443	0.4485	0.4472
Echinococcus granulosus	allatostatin A receptor	0.0012	0.0024	0.0019
Echinococcus multilocularis	Polycystic kidney disease protein	0.0021	0.0121	0.0116
Brugia malayi	Doublecortin family protein	0.0021	0.0121	0.0116
Loa Loa (eye worm)	Notch2	0.0108	0.1024	0.1024
Echinococcus granulosus	g-protein coupled receptor	0.0012	0.0024	0.0019
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0012	0.0024	0.0019
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.018	0.0122
Schistosoma mansoni	hypothetical protein	0.0027	0.0186	0.0163
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0012	0.0024	0.0019
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0012	0.0024	0.0024
Onchocerca volvulus	Chorion peroxidase homolog	0.0443	0.4485	1
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Brugia malayi	hypothetical protein	0.0064	0.0562	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0514	0.0514
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0402	0.406	0.406
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0012	0.0024	0.0024
Schistosoma mansoni	slit	0.0108	0.1024	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Echinococcus granulosus	fibropellin Ia	0.0108	0.1024	0.1019
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0108	0.1024	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0121	0.0121
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0027	0.0186	0.0182
Echinococcus granulosus	neuropeptide s receptor	0.0361	0.3641	0.3638
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Onchocerca volvulus		0.0159	0.1545	0.3409
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0024	0.0155	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Brugia malayi	thymidylate synthase	0.0134	0.1288	0.1284
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0012	0.0024	0.0019
Echinococcus granulosus	neuropeptide receptor	0.0012	0.0024	0.0019
Echinococcus granulosus	Protein patched homolog 1	0.0402	0.406	0.4058
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Brugia malayi	latrophilin 2 splice variant baaae	0.0059	0.0514	0.051
Loa Loa (eye worm)	hypothetical protein	0.0443	0.4485	0.4485
Brugia malayi	putative neuropeptide receptor	0.0012	0.0024	0.0019
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0458	0.464	1
Brugia malayi	Cadherin domain containing protein	0.0108	0.1024	0.1019
Onchocerca volvulus		0.0108	0.1024	0.2241
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0024	0.0019
Schistosoma mansoni	hypothetical protein	0.0108	0.1024	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0443	0.4485	0.4485
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0024	0.0019
Echinococcus multilocularis	microtubule associated protein 2	0.0761	0.7779	0.7778
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0012	0.0024	0.0019
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0121	0.0116
Brugia malayi	Melatonin receptor type 1A	0.0012	0.0024	0.0019
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0121	0.0116
Echinococcus multilocularis	dihydrofolate reductase	0.0055	0.0468	0.0464
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0054	0.0463	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0186	0.0186
Schistosoma mansoni	loxhd1	0.0021	0.0121	0.0097
Onchocerca volvulus		0.0159	0.1545	0.3409
Schistosoma mansoni	dihydrofolate reductase	0.0055	0.0468	0.0446
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0012	0.0024	0.0019
Mycobacterium tuberculosis	Hypothetical protein	0.0064	0.0562	0.4095
Brugia malayi	GH02984p	0.0027	0.0185	0.018
Echinococcus multilocularis	translocator protein	0.0159	0.1545	0.1541
Giardia lamblia	High cysteine protein	0.0108	0.1024	0.1342
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Echinococcus granulosus	neuropeptides capa receptor	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0086	0.0797	0.0797
Brugia malayi	Cytochrome P450 family protein	0.0035	0.0268	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0135	0.1299	0.1295
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0426	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.018	0.0122
Echinococcus multilocularis	protein dispatched 1	0.0402	0.406	0.4058
Brugia malayi	SH2 domain containing protein	0.0188	0.1846	0.1842
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0024	0.0019
Echinococcus multilocularis	dro:myosuppressin receptor	0.0012	0.0024	0.0019
Echinococcus multilocularis	serotonin receptor	0.0012	0.0024	0.0019
Trypanosoma brucei	protein kinase, putative	0.0054	0.0463	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Schistosoma mansoni	notch	0.0108	0.1024	0.1002
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0121	0.0116
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0027	0.0186	0.0182
Echinococcus granulosus	GPCR family 2	0.0027	0.0186	0.0182
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0024	0.0019
Brugia malayi	ORL1-like opioid receptor	0.0012	0.0024	0.0019
Brugia malayi	hypothetical protein	0.0012	0.0024	0.0019
Brugia malayi	RNA binding protein	0.0064	0.0563	0.0559
Onchocerca volvulus		0.0159	0.1545	0.3409
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0027	0.0186	0.0182
Echinococcus granulosus	solute carrier family 5	0.0106	0.1004	0.1
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0054	0.0463	0.0406
Brugia malayi	TspO/MBR family protein	0.0159	0.1545	0.1541
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0443	0.4485	0.4485
Echinococcus granulosus	Niemann Pick C1 protein	0.0402	0.406	0.4058
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1299	0.1299
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0054	0.0463	0.0406
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0106	0.1004	0.1
Echinococcus multilocularis	neuropeptides capa receptor	0.0012	0.0024	0.0019
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0188	0.1852	1
Brugia malayi	Serotonin receptor	0.0012	0.0024	0.0019
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0024	0.0019
Schistosoma mansoni	notch	0.0108	0.1024	0.1002
Trypanosoma cruzi	cytochrome P450, putative	0.0024	0.0155	0.0097
Mycobacterium ulcerans	tryptophan-rich sensory protein	0.0159	0.1545	0.1494
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Echinococcus granulosus	sodium:glucose cotransporter	0.0106	0.1004	0.1
Echinococcus granulosus	neural cadherin	0.0108	0.1024	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Echinococcus multilocularis	mitogen activated protein kinase	0.0054	0.0463	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0443	0.4485	0.4485
Brugia malayi	EGF-like domain containing protein	0.0108	0.1024	0.1019
Brugia malayi	Cytochrome P450 family protein	0.0024	0.0155	0.0151
Brugia malayi	Blistered cuticle protein 3	0.0443	0.4485	0.4482
Schistosoma mansoni	inositol transporter	0.0106	0.1004	0.0982
Schistosoma mansoni	peripheral-type benzodiazepine receptor	0.0159	0.1545	0.1525
Brugia malayi	hypothetical protein	0.0012	0.0024	0.0019
Brugia malayi	follicle stimulating hormone receptor	0.0012	0.0024	0.0019
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0426	0.0426
Echinococcus granulosus	cytochrome P450 2K1	0.0015	0.0059	0.0055
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0024	0.0019
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0108	0.1024	0.2241
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.0458	0.464	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0024	0.0019
Mycobacterium ulcerans	thymidylate synthase	0.0134	0.1288	0.1236
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0108	0.1024	0.1002
Echinococcus granulosus	neurogenic locus notch protein	0.0108	0.1024	0.1019
Echinococcus granulosus	expressed conserved protein	0.0045	0.0365	0.036
Onchocerca volvulus	Peroxidasin homolog	0.0443	0.4485	1
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0054	0.0463	0.0463
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.0976	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0024	0.0019
Echinococcus multilocularis	sex peptide receptor	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.018	0.0344
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0563	0.0563
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.0976	1	1
Brugia malayi	GCC2 and GCC3 family protein	0.0108	0.1024	0.1019
Brugia malayi	Delta serrate ligand family protein	0.0108	0.1024	0.1019
Schistosoma mansoni	hypothetical protein	0.0059	0.0514	0.0491
Leishmania major	hypothetical protein, conserved	0.0027	0.018	0.0122
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0298	0.0294
Schistosoma mansoni	high-affinity choline transporter	0.0027	0.0185	0.0161
Echinococcus multilocularis	protein jagged 1	0.0108	0.1024	0.1019
Entamoeba histolytica	hypothetical protein	0.0038	0.0298	0.5
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0055	0.0468	0.333
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0563	0.0541
Loa Loa (eye worm)	cytochrome P450 family protein	0.0024	0.0155	0.0155
Schistosoma mansoni	peroxidasin	0.0443	0.4485	0.4472
Brugia malayi	hypothetical protein	0.0012	0.0024	0.0019
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0024	0.0019
Echinococcus granulosus	protein jagged 2	0.0108	0.1024	0.1019
Loa Loa (eye worm)	MH2 domain-containing protein	0.0132	0.1266	0.1266
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0298	0.0275
Echinococcus multilocularis	neurogenic locus protein delta	0.0108	0.1024	0.1019
Brugia malayi	hypothetical protein	0.0012	0.0024	0.0019
Echinococcus multilocularis	neuropeptide s receptor	0.0361	0.3641	0.3638
Schistosoma mansoni	hypothetical protein	0.0015	0.0059	0.0035
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0125	0.12	0.1196
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0012	0.0024	0.0019
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0012	0.0024	0.0019
Loa Loa (eye worm)	notch protein	0.0108	0.1024	0.1024
Brugia malayi	Animal haem peroxidase family protein	0.0443	0.4485	0.4482
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Schistosoma mansoni	hypothetical protein	0.0108	0.1024	0.1002
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0086	0.0797	0.0792
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0054	0.0463	0.0406
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0028	0.0023
Echinococcus granulosus	biogenic amine 5HT receptor	0.0012	0.0024	0.0019
Brugia malayi	Animal haem peroxidase family protein	0.0443	0.4485	0.4482
Echinococcus multilocularis	fmrfamide receptor	0.0012	0.0024	0.0019
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0463	0.044
Echinococcus multilocularis	neurogenic locus notch protein	0.0108	0.1024	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1545	0.1545
Echinococcus multilocularis	neuropeptide Y receptor	0.0012	0.0024	0.0019
Onchocerca volvulus		0.0027	0.0185	0.036
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0012	0.0024	0.0019
Brugia malayi	notch-like transmembrane receptor	0.0108	0.1024	0.1019
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.0976	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0024	0.0019
Echinococcus granulosus	G protein coupled receptor 139	0.0012	0.0024	0.0019
Echinococcus multilocularis	protein jagged 1	0.0108	0.1024	0.1019
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0012	0.0024	0.0019
Schistosoma mansoni	notch	0.0108	0.1024	0.1002
Brugia malayi	hypothetical protein	0.0038	0.0298	0.0294
Brugia malayi	Serotonin receptor	0.0012	0.0024	0.0019
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0402	0.406	0.406
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0054	0.0463	0.225
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0188	0.1852	0.1804
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1545	0.1545
Schistosoma mansoni	hypothetical protein	0.0108	0.1024	0.1002
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0086	0.0797	0.0792
Brugia malayi	G-protein coupled receptor	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Echinococcus granulosus	notch	0.0108	0.1024	0.1019
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0012	0.0024	0.0019
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0134	0.1288	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0024	0.0019
Echinococcus multilocularis	neurogenic locus protein delta	0.0108	0.1024	0.1019
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0458	0.464	1
Onchocerca volvulus	Peroxidase homolog	0.0443	0.4485	1
Echinococcus granulosus	neuropeptide receptor A26	0.0361	0.3641	0.3638
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.0976	1	1
Brugia malayi	EGF-like domain containing protein	0.0108	0.1024	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Brugia malayi	hypothetical protein	0.0443	0.4485	0.4482
Echinococcus granulosus	neurogenic locus notch protein	0.0108	0.1024	0.1019
Echinococcus granulosus	biogenic amine 5HT receptor	0.0012	0.0024	0.0019
Echinococcus granulosus	microtubule associated protein 2	0.0761	0.7779	0.7778
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0012	0.0024	0.0019
Brugia malayi	Muscle positioning protein 4	0.0108	0.1024	0.1019
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0188	0.1852	0.1804
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0402	0.406	0.8612
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0024	0.0019
Brugia malayi	hypothetical protein	0.0012	0.0024	0.0019
Loa Loa (eye worm)	dihydrofolate reductase	0.0055	0.0468	0.0468
Brugia malayi	hypothetical protein	0.0012	0.0024	0.0019
Echinococcus multilocularis	RUN	0.0021	0.0121	0.0116
Echinococcus multilocularis	neuropeptide receptor	0.0012	0.0024	0.0019
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.018	0.0122
Echinococcus granulosus	thymidylate synthase	0.0134	0.1288	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Echinococcus multilocularis	GPCR, family 2	0.0027	0.0186	0.0182
Echinococcus multilocularis	notch	0.0108	0.1024	0.1019
Echinococcus multilocularis	neuropeptide receptor	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Echinococcus granulosus	neurogenic locus protein delta	0.0108	0.1024	0.1019
Onchocerca volvulus		0.0108	0.1024	0.2241
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0027	0.0186	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1545	0.1545
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0976	1	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0121	0.0116
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.018	0.0344
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0012	0.0024	0.0019
Loa Loa (eye worm)	G-protein coupled receptor	0.0012	0.0024	0.0024
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0426	0.0422
Brugia malayi	MAP kinase sur-1	0.0054	0.0463	0.0458
Onchocerca volvulus		0.0443	0.4485	1
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0563	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0443	0.4485	0.4485
Onchocerca volvulus		0.0021	0.0121	0.0217
Loa Loa (eye worm)	thymidylate synthase	0.0134	0.1288	0.1288
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0188	0.1852	0.1804
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0563	0.0559
Chlamydia trachomatis	dihydrofolate reductase	0.0055	0.0468	0.5
Loa Loa (eye worm)	hypothetical protein	0.0027	0.018	0.018
Loa Loa (eye worm)	hypothetical protein	0.0443	0.4485	0.4485
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.018	0.0676
Loa Loa (eye worm)	transcription factor SMAD2	0.0132	0.1266	0.1266
Echinococcus granulosus	dro:myosuppressin receptor	0.0012	0.0024	0.0019
Echinococcus granulosus	fmrfamide receptor	0.0012	0.0024	0.0019
Entamoeba histolytica	hypothetical protein	0.0038	0.0298	0.5
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0458	0.464	1
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0108	0.1024	0.1019
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0012	0.0024	0.0019
Trypanosoma cruzi	inositol 5-phosphatase 1, putative	0.0052	0.0447	0.039
Echinococcus granulosus	protein jagged 1	0.0108	0.1024	0.1019
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0054	0.0463	0.0406
Brugia malayi	Sodium:solute symporter family protein	0.0027	0.0185	0.018
Echinococcus multilocularis	solute carrier family 5	0.0106	0.1004	0.1
Brugia malayi	Cytochrome P450 family protein	0.0024	0.0155	0.0151
Echinococcus multilocularis	serotonin receptor	0.0012	0.0024	0.0019
Onchocerca volvulus	Dual oxidase homolog	0.0443	0.4485	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0024	0.0019
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0563	0.0563
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0563	0.0541
Schistosoma mansoni	sodium/solute symporter	0.0027	0.0185	0.0161
Brugia malayi	EGF-like domain containing protein	0.0108	0.1024	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Echinococcus granulosus	neuropeptide Y receptor	0.0012	0.0024	0.0019
Schistosoma mansoni	notch	0.0108	0.1024	0.1002
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Echinococcus multilocularis	g-protein coupled receptor	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0797	0.0797
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0402	0.406	0.4046
Brugia malayi	Cytochrome P450 family protein	0.0015	0.0059	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Brugia malayi	hypothetical protein	0.0064	0.0566	0.0562
Onchocerca volvulus	Peroxidase homolog	0.0443	0.4485	1
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0563	0.0541
Schistosoma mansoni	lipoxygenase	0.0125	0.12	0.1179
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0012	0.0024	0.0019
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0054	0.0463	0.0406
Echinococcus granulosus	neuropeptide receptor	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Brugia malayi	hypothetical protein	0.0027	0.018	0.0176
Echinococcus multilocularis	neurogenic locus notch protein	0.0108	0.1024	0.1019
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Schistosoma mansoni	rab6-interacting	0.0021	0.0121	0.0097
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0563	0.0559
Brugia malayi	hypothetical protein	0.0012	0.0024	0.0019
Echinococcus granulosus	high affinity choline transporter 1	0.0027	0.0185	0.018
Loa Loa (eye worm)	CYP4Cod1	0.0024	0.0155	0.0155
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0027	0.0186	0.0186
Schistosoma mansoni	hypothetical protein	0.0038	0.0298	0.0275
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0134	0.1288	0.1267
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0562	0.0239
Echinococcus granulosus	Polycystic kidney disease protein	0.0021	0.0121	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0443	0.4485	0.4485
Loa Loa (eye worm)	cytochrome P450 family protein	0.0035	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0426	0.0403
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0426	0.0422
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0024	0.0019
Schistosoma mansoni	patched 1	0.0402	0.406	0.4046
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0054	0.0463	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0012	0.0024	0.0024
Schistosoma mansoni	hypothetical protein	0.0012	0.0028	0.0004
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0976	1	1
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Schistosoma mansoni	septate junction protein	0.0108	0.1024	0.1002
Onchocerca volvulus		0.0443	0.4485	1
Brugia malayi	Dopamine receptor protein 2	0.0012	0.0024	0.0019
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0106	0.1004	0.1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0185	0.0185
Echinococcus granulosus	neuropeptides capa receptor	0.0012	0.0024	0.0019
Brugia malayi	EGF-like domain containing protein	0.0108	0.1024	0.1019
Brugia malayi	EGF-like domain containing protein	0.0108	0.1024	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0443	0.4485	0.4485
Trypanosoma brucei	cytochrome P450, putative	0.0024	0.0155	0.0097
Echinococcus granulosus	mitogen activated protein kinase 3	0.0054	0.0463	0.0458
Echinococcus granulosus	protein jagged 2	0.0108	0.1024	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Onchocerca volvulus	Putative cubilin	0.0108	0.1024	0.2241
Loa Loa (eye worm)	neuropeptide F receptor	0.0012	0.0024	0.0024
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0106	0.1004	0.1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Loa Loa (eye worm)	blistered cuticle protein 3	0.0443	0.4485	0.4485
Brugia malayi	hypothetical protein	0.0021	0.0121	0.0116
Brugia malayi	EGF-like domain containing protein	0.0108	0.1024	0.1019
Echinococcus multilocularis	peroxidasin	0.0443	0.4485	0.4482
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0121	0.0121
Echinococcus granulosus	7tm_1 domain containing protein	0.0012	0.0024	0.0019
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0134	0.1288	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0027	0.0186	0.0182
Echinococcus granulosus	somatostatin receptor	0.0012	0.0024	0.0019
Echinococcus multilocularis	thymidylate synthase	0.0134	0.1288	0.1284
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0012	0.0024	0.0019
Echinococcus granulosus	hypothetical protein	0.0012	0.0024	0.0019
Brugia malayi	neuropeptide F receptor	0.0012	0.0024	0.0019
Brugia malayi	dihydrofolate reductase family protein	0.0055	0.0468	0.0464
Brugia malayi	cytochrome P450	0.0015	0.0059	0.0055
Brugia malayi	Dihydrofolate reductase	0.0055	0.0468	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Loa Loa (eye worm)	hypothetical protein	0.0443	0.4485	0.4485
Brugia malayi	Animal haem peroxidase family protein	0.0443	0.4485	0.4482
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0054	0.0463	0.0458
Onchocerca volvulus	Neurogenic locus notch homolog	0.0108	0.1024	0.2241
Echinococcus multilocularis	neuropeptide Y receptor	0.0012	0.0024	0.0019
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0012	0.0024	0.0019
Echinococcus multilocularis	neural cadherin	0.0108	0.1024	0.1019
Echinococcus multilocularis	fibropellin Ia	0.0108	0.1024	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Echinococcus granulosus	neurogenic locus notch protein 4	0.0108	0.1024	0.1019
Echinococcus multilocularis	allatostatin A receptor	0.0012	0.0024	0.0019
Brugia malayi	GnHR receptor homolog	0.0012	0.0024	0.0019
Brugia malayi	Animal haem peroxidase family protein	0.0443	0.4485	0.4482
Echinococcus granulosus	orexin receptor type 2	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0443	0.4485	0.4485
Schistosoma mansoni	hypothetical protein	0.0045	0.0365	0.0342
Brugia malayi	putative neuropeptide receptor NPR1	0.0012	0.0024	0.0019
Brugia malayi	G protein-coupled receptor	0.0012	0.0024	0.0019
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.0976	1	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0012	0.0024	0.0024
Brugia malayi	hypothetical protein	0.0012	0.0024	0.0019
Echinococcus multilocularis	sterol regulatory element binding protein	0.0402	0.406	0.4058
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.0976	1	1
Echinococcus granulosus	dihydrofolate reductase	0.0055	0.0468	0.0464
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0024	0.0019
Echinococcus multilocularis	orexin receptor type 2	0.0012	0.0024	0.0019
Brugia malayi	hypothetical protein	0.0021	0.0121	0.0116
Echinococcus granulosus	peroxidasin	0.0443	0.4485	0.4482
Loa Loa (eye worm)	cytochrome P450 family protein	0.0024	0.0155	0.0155
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0024	0.0019
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0012	0.0024	0.0024
Onchocerca volvulus		0.0108	0.1024	0.2241
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0426	0.0422
Schistosoma mansoni	polycystin 1-related	0.0021	0.0121	0.0097
Brugia malayi	Dopamine receptor	0.0012	0.0024	0.0019
Echinococcus granulosus	delta-like protein 1	0.0108	0.1024	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Loa Loa (eye worm)	cytochrome P450	0.0015	0.0059	0.0059
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0563	0.0563
Echinococcus granulosus	slit 2 protein	0.0108	0.1024	0.1019
Toxoplasma gondii	EGF family domain-containing protein	0.0108	0.1024	0.5378
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0027	0.0185	0.018
Onchocerca volvulus	Peroxidasin homolog	0.0443	0.4485	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0012	0.0024	0.0019
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0024	0.0019
Brugia malayi	AKH receptor	0.0012	0.0024	0.0019
Echinococcus granulosus	serotonin receptor	0.0012	0.0024	0.0019
Brugia malayi	Dopamine receptor protein 1	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0443	0.4485	0.4485
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0012	0.0024	0.0019
Schistosoma mansoni	cytochrome P450	0.0015	0.0059	0.0035
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0055	0.0468	0.0412
Echinococcus granulosus	sex peptide receptor	0.0012	0.0024	0.0019
Loa Loa (eye worm)	animal heme peroxidase	0.0443	0.4485	0.4485
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Loa Loa (eye worm)	melatonin receptor type 1A	0.0012	0.0024	0.0024
Brugia malayi	MH2 domain containing protein	0.0132	0.1266	0.1262
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0012	0.0024	0.0019
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0012	0.0024	0.0019
Schistosoma mansoni	inositol transporter	0.0106	0.1004	0.0982
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0049	0.0414	0.041
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Schistosoma mansoni	hypothetical protein	0.0108	0.1024	0.1002
Loa Loa (eye worm)	G-protein coupled receptor	0.0012	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Brugia malayi	Animal haem peroxidase family protein	0.0443	0.4485	0.4482
Brugia malayi	Calcium binding EGF domain containing protein	0.0108	0.1024	0.1019
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0012	0.0024	0.0019
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0012	0.0024	0.0019
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Entamoeba histolytica	hypothetical protein	0.0038	0.0298	0.5
Echinococcus granulosus	sterol regulatory element binding protein	0.0402	0.406	0.4058
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0055	0.0468	0.333
Brugia malayi	sulfakinin receptor protein	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Brugia malayi	Cadherin domain containing protein	0.0108	0.1024	0.1019
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.018	0.0344
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0012	0.0024	0.0019
Echinococcus granulosus	neuropeptide FF receptor 2	0.0012	0.0024	0.0019
Brugia malayi	Latrophilin receptor protein 2	0.0027	0.0186	0.0182
Echinococcus multilocularis	protein jagged 2	0.0108	0.1024	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Brugia malayi	G protein-coupled receptor F59B2.13	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0108	0.1024	0.1019
Brugia malayi	CHE-14 protein	0.0402	0.406	0.4058
Echinococcus multilocularis		0.0015	0.0059	0.0055
Brugia malayi	Calcium binding EGF domain containing protein	0.0108	0.1024	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1024	0.1024
Onchocerca volvulus		0.0108	0.1024	0.2241
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0426	0.0422
Schistosoma mansoni	hypothetical protein	0.0108	0.1024	0.1002
Echinococcus granulosus	protein jagged 1	0.0108	0.1024	0.1019
Leishmania major	cytochrome p450-like protein	0.0024	0.0155	0.0097
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0027	0.0185	0.0699
Brugia malayi	Peroxidasin	0.0443	0.4485	0.4482
Trichomonas vaginalis	conserved hypothetical protein	0.0131	0.126	0.191
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0563	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0443	0.4485	0.4485
Brugia malayi	Calcium binding EGF domain containing protein	0.0108	0.1024	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0443	0.4485	0.4485
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0426	0.0403
Echinococcus granulosus	RUN	0.0021	0.0121	0.0116
Trypanosoma cruzi	cytochrome P450, putative	0.0024	0.0155	0.0097
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0188	0.1852	1
Onchocerca volvulus		0.0108	0.1024	0.2241
Echinococcus granulosus	mitogen activated protein kinase	0.0054	0.0463	0.0458
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0027	0.0185	0.018
Echinococcus granulosus	translocator protein	0.0159	0.1545	0.1541
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0125	0.12	0.1196
Echinococcus multilocularis	expressed conserved protein	0.0045	0.0365	0.036
Brugia malayi	RE15519p	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Schistosoma mansoni	hypothetical protein	0.0027	0.0186	0.0163
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0012	0.0024	0.0019
Echinococcus multilocularis	high affinity choline transporter 1	0.0027	0.0185	0.018
Schistosoma mansoni	cell polarity protein	0.0108	0.1024	0.1002
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0064	0.0562	0.0506
Onchocerca volvulus	Slit protein homolog	0.0108	0.1024	0.2241
Brugia malayi	hypothetical protein	0.0012	0.0024	0.0019
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0563	0.0541
Echinococcus multilocularis	neuropeptides capa receptor	0.0012	0.0024	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0443	0.4485	0.4485
Brugia malayi	EGF-like domain containing protein	0.0108	0.1024	0.1019

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 34 nM	inhibition of [3H]-Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes	ChEMBL.	12127505
IC50 (binding)	= 34 nM	inhibition of [3H]-Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes	ChEMBL.	12127505
IC50 (binding)	= 168 nM	Binding affinity of the compound was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO-cells expressing human recombinant Tachykinin receptor 2	ChEMBL.	12127505
IC50 (binding)	= 168 nM	Binding affinity of the compound was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO-cells expressing human recombinant Tachykinin receptor 2	ChEMBL.	12127505

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL63014

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 102577