TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 399.957 | Formula: C23H30ClN3O
H donors: 1 H acceptors: 1 LogP: 4.53 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)C(c1ccccc1C)N1CCN(CC1)C(=O)NC(C)(C)C
InChi: 1S/C23H30ClN3O/c1-17-7-5-6-8-20(17)21(18-9-11-19(24)12-10-18)26-13-15-27(16-14-26)22(28)25-23(2,3)4/h5-12,21H,13-16H2,1-4H3,(H,25,28)
InChiKey: XMHRIFZRYCUJAT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cannabinoid receptor 2 (macrophage)	Starlite/ChEMBL	References
Rattus norvegicus	Cannabinoid CB1 receptor	Starlite/ChEMBL	References
Homo sapiens	cannabinoid receptor 1 (brain)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0097	0.0582	0.1389
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0069	0.0289	0.0457
Loa Loa (eye worm)	cytochrome P450 family protein	0.0043	0.0031	0.0048
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0241	0.2044	0.3235
Brugia malayi	cathepsin L-like precursor	0.0307	0.2727	0.4315
Echinococcus granulosus	cathepsin l1	0.0451	0.419	0.6629
Echinococcus granulosus	cathepsin l1	0.0307	0.2727	0.4315
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.419	1
Brugia malayi	Cathepsin L-like precursor	0.0451	0.419	0.6629
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.419	1
Giardia lamblia	Cysteine protease	0.0097	0.0582	0.2469
Trypanosoma cruzi	cruzipain precursor, putative	0.0143	0.1051	0.1051
Giardia lamblia	Cathepsin B precursor	0.0271	0.2357	1
Entamoeba histolytica	cysteine protease, putative	0.0241	0.2044	0.488
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0097	0.0582	0.2469
Loa Loa (eye worm)	hypothetical protein	0.0659	0.632	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0069	0.0289	1
Leishmania major	cysteine peptidase A (CPA)	0.0451	0.419	0.419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0582	0.1389
Echinococcus multilocularis	cathepsin b	0.0659	0.632	1
Plasmodium falciparum	serine repeat antigen 8	0.0097	0.0582	0.1389
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0451	0.419	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0582	0.1389
Onchocerca volvulus		0.0451	0.419	1
Echinococcus multilocularis	cathepsin b	0.0659	0.632	1
Leishmania major	cathepsin L-like protease	0.102	1	1
Loa Loa (eye worm)	hypothetical protein	0.0307	0.2727	0.4315
Entamoeba histolytica	cysteine protease, putative	0.0241	0.2044	0.488
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0102	0.0629	0.0996
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0659	0.632	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0241	0.2044	0.2044
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0659	0.632	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0097	0.0582	0.2469
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.102	1	1
Giardia lamblia	Cathepsin L-like protease	0.0097	0.0582	0.2469
Giardia lamblia	Hypothetical protein	0.0097	0.0582	0.2469
Trypanosoma cruzi	cysteine peptidase, putative	0.0451	0.419	0.419
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0451	0.419	1
Schistosoma mansoni	cathepsin C	0.0097	0.0582	0.0921
Toxoplasma gondii	cathepsin CPC1	0.0097	0.0582	0.1389
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0451	0.419	0.6629
Trypanosoma cruzi	cysteine peptidase, putative	0.0241	0.2044	0.2044
Entamoeba histolytica	cysteine protease, putative	0.0097	0.0582	0.1389
Leishmania major	cathepsin L-like protease	0.0451	0.419	0.419
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0271	0.2357	0.2357
Leishmania major	cytochrome p450-like protein	0.0043	0.0031	0.0031
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0451	0.419	1
Brugia malayi	Cathepsin L-like precursor	0.0451	0.419	0.6629
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0451	0.419	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.419	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.102	1	1
Onchocerca volvulus		0.0451	0.419	1
Brugia malayi	Cathepsin L-like precursor	0.0307	0.2727	0.4315
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.102	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0451	0.419	1
Trypanosoma cruzi	cytochrome P450, putative	0.0043	0.0031	0.0031
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0097	0.0582	0.0921
Giardia lamblia	Cathepsin L precursor	0.0097	0.0582	0.2469
Giardia lamblia	Cathepsin B precursor	0.0271	0.2357	1
Plasmodium falciparum	serine repeat antigen 9	0.0097	0.0582	0.1389
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0451	0.419	1
Giardia lamblia	Cathepsin B precursor	0.0097	0.0582	0.2469
Giardia lamblia	Cathepsin B precursor	0.0097	0.0582	0.2469
Entamoeba histolytica	cysteine proteinase, putative	0.0451	0.419	1
Echinococcus multilocularis	cathepsin L	0.0241	0.2044	0.3235
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0102	0.0629	0.0996
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0097	0.0582	0.1389
Brugia malayi	Papain family cysteine protease containing protein	0.0241	0.2044	0.3235
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0241	0.2044	0.488
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.419	1
Entamoeba histolytica	cysteine protease, putative	0.0241	0.2044	0.488
Echinococcus multilocularis	cysteine protease	0.0451	0.419	0.6629
Trypanosoma cruzi	cysteine peptidase, putative	0.0143	0.1051	0.1051
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0097	0.0582	0.2469
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0451	0.419	0.6629
Plasmodium falciparum	serine repeat antigen 6	0.0097	0.0582	0.1389
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0307	0.2727	0.6509
Leishmania major	cathepsin L-like protease	0.102	1	1
Plasmodium falciparum	serine repeat antigen 2	0.0097	0.0582	0.1389
Giardia lamblia	Cathepsin L precursor	0.0097	0.0582	0.2469
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0097	0.0582	0.0921
Giardia lamblia	Cysteine protease	0.0097	0.0582	0.2469
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0097	0.0582	0.0921
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1051	0.1662
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.419	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0241	0.2044	0.488
Echinococcus multilocularis	cysteine protease	0.0451	0.419	0.6629
Entamoeba histolytica	cysteine protease, putative	0.0241	0.2044	0.488
Entamoeba histolytica	cysteine protease, putative	0.0241	0.2044	0.488
Entamoeba histolytica	cysteine protease, putative	0.0241	0.2044	0.488
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0241	0.2044	0.2044
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0582	0.0921
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0097	0.0582	0.0921
Plasmodium vivax	unspecified product	0.0143	0.1051	0.2507
Toxoplasma gondii	cathepsin B	0.0271	0.2357	0.5625
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0659	0.632	1
Entamoeba histolytica	cysteine protease, putative	0.0097	0.0582	0.1389
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.102	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0097	0.0582	0.1389
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0241	0.2044	0.3235
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.102	1	1
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1051	0.1662
Entamoeba histolytica	hypothetical protein	0.0097	0.0582	0.1389
Plasmodium vivax	vivapain-2	0.0451	0.419	1
Loa Loa (eye worm)	hypothetical protein	0.0307	0.2727	0.4315
Schistosoma mansoni	cathepsin S (C01 family)	0.0097	0.0582	0.0921
Plasmodium vivax	vivapain-2	0.0451	0.419	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0307	0.2727	0.4315
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0876	0.8537	0.8537
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0241	0.2044	0.2044
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.0582	0.0921
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.102	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0102	0.0629	0.0996
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.419	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0102	0.0629	0.0996
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.419	1
Entamoeba histolytica	cysteine proteinase, putative	0.0241	0.2044	0.488
Brugia malayi	Papain family cysteine protease containing protein	0.0241	0.2044	0.3235
Trypanosoma cruzi	cysteine proteinase, putative	0.0241	0.2044	0.2044
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0102	0.0629	0.0996
Echinococcus granulosus	cathepsin L cysteine protease	0.0241	0.2044	0.3235
Giardia lamblia	Cathepsin B precursor	0.0271	0.2357	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.0582	0.0921
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0097	0.0582	0.0921
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0582	0.1389
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0241	0.2044	0.488
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0451	0.419	0.6629
Echinococcus multilocularis	cathepsin L cysteine protease	0.0451	0.419	0.6629
Schistosoma mansoni	cathepsin s	0.0143	0.1051	0.1662
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0097	0.0582	0.2469
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.419	1
Entamoeba histolytica	cysteine protease, putative	0.0241	0.2044	0.488
Brugia malayi	Papain family cysteine protease containing protein	0.0097	0.0582	0.0921
Brugia malayi	cathepsin L-like cysteine proteinase	0.0097	0.0582	0.0921
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0097	0.0582	0.1389
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0097	0.0582	0.1389
Toxoplasma gondii	cathepsin CPC2	0.0097	0.0582	0.1389
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0097	0.0582	0.1389
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0102	0.0629	0.0996
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.0582	0.0921
Echinococcus granulosus	cathepsin L	0.0241	0.2044	0.3235
Brugia malayi	fibroinase precursor	0.0097	0.0582	0.0921
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0659	0.632	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0069	0.0289	0.0689
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0271	0.2357	0.3729
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0097	0.0582	0.1389
Loa Loa (eye worm)	hypothetical protein	0.0307	0.2727	0.4315
Trichomonas vaginalis	conserved hypothetical protein	0.0097	0.0582	0.1389
Schistosoma mansoni	hypothetical protein	0.0175	0.1379	0.2182
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0582	0.1389
Plasmodium falciparum	serine repeat antigen 4	0.0097	0.0582	0.1389
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0069	0.0289	0.0457
Entamoeba histolytica	cysteine protease, putative	0.0241	0.2044	0.488
Trypanosoma cruzi	major cysteine proteinase, putative	0.0097	0.0582	0.0582
Entamoeba histolytica	cysteine protease, putative	0.0097	0.0582	0.1389
Entamoeba histolytica	cysteine proteinase, putative	0.0241	0.2044	0.488
Schistosoma mansoni	cathepsin F (C01 family)	0.0451	0.419	0.6629
Onchocerca volvulus		0.0451	0.419	1
Onchocerca volvulus		0.0451	0.419	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0097	0.0582	0.1389
Giardia lamblia	Hypothetical protein	0.0097	0.0582	0.2469
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.004	0	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.419	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0307	0.2727	0.4315
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.419	1
Entamoeba histolytica	cysteine protease, putative	0.0097	0.0582	0.1389
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0241	0.2044	0.488
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0143	0.1051	0.1662
Plasmodium vivax	serine-repeat antigen (SERA)	0.0097	0.0582	0.1389
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0582	0.0921
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0097	0.0582	0.1389
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.419	1
Onchocerca volvulus	Cathepsin L homolog	0.0451	0.419	1
Onchocerca volvulus		0.0307	0.2727	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.102	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0451	0.419	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0097	0.0582	0.1389
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0097	0.0582	0.1389
Brugia malayi	Papain family cysteine protease containing protein	0.0097	0.0582	0.0921
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0097	0.0582	0.1389
Echinococcus multilocularis	geminin	0.0175	0.1379	0.2182
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0097	0.0582	0.0921
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0097	0.0582	0.1389
Loa Loa (eye worm)	CYP4Cod1	0.0043	0.0031	0.0048
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0097	0.0582	0.1389
Trypanosoma cruzi	major cysteine proteinase, putative	0.0666	0.6392	0.6392
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0097	0.0582	0.1389
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0451	0.419	1
Trypanosoma cruzi	cysteine peptidase, putative	0.102	1	1
Plasmodium falciparum	serine repeat antigen 5	0.0097	0.0582	0.1389
Entamoeba histolytica	cysteine protease, putative	0.0241	0.2044	0.488
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0097	0.0582	0.0921
Brugia malayi	Papain family cysteine protease containing protein	0.0097	0.0582	0.0921
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0097	0.0582	0.1389
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.0289	1
Entamoeba histolytica	cysteine protease, putative	0.0241	0.2044	0.488
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0451	0.419	0.6629
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0097	0.0582	0.1389
Giardia lamblia	Cysteine protease	0.0097	0.0582	0.2469
Trypanosoma brucei	cytochrome P450, putative	0.0043	0.0031	0.0031
Giardia lamblia	Cathepsin B precursor	0.0097	0.0582	0.2469
Entamoeba histolytica	cysteine proteinase, putative	0.0241	0.2044	0.488
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1051	0.1662
Trypanosoma cruzi	cysteine peptidase, putative	0.102	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.419	1
Giardia lamblia	Cathepsin L precursor	0.0097	0.0582	0.2469
Schistosoma mansoni	hypothetical protein	0.0175	0.1379	0.2182
Brugia malayi	cathepsin L precursor	0.0097	0.0582	0.0921
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.419	1
Entamoeba histolytica	cysteine protease, putative	0.0241	0.2044	0.488
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0582	0.0921
Onchocerca volvulus	Cathepsin L homolog	0.0451	0.419	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0582	0.0921
Loa Loa (eye worm)	hypothetical protein	0.0451	0.419	0.6629
Giardia lamblia	Cathepsin L precursor	0.0097	0.0582	0.2469
Entamoeba histolytica	cysteine proteinase, putative	0.0451	0.419	1
Onchocerca volvulus	Cathepsin F homolog	0.0451	0.419	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0097	0.0582	0.1389
Plasmodium vivax	vivapain-3	0.0241	0.2044	0.488
Brugia malayi	Cathepsin L-like precursor	0.0451	0.419	0.6629
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0271	0.2357	0.2357
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0451	0.419	1
Plasmodium vivax	vivapain-1	0.0241	0.2044	0.488
Schistosoma mansoni	aldehyde dehydrogenase	0.0069	0.0289	0.0457
Brugia malayi	Cytochrome P450 family protein	0.0088	0.0483	0.0764
Plasmodium falciparum	serine repeat antigen 7	0.0097	0.0582	0.1389
Entamoeba histolytica	cysteine protease, putative	0.0241	0.2044	0.488
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0097	0.0582	0.1389
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0097	0.0582	0.1389
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0271	0.2357	0.2357
Giardia lamblia	Cathepsin B precursor	0.0097	0.0582	0.2469
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.419	1
Echinococcus granulosus	cathepsin b	0.0659	0.632	1
Trypanosoma cruzi	cysteine protease, putative	0.0241	0.2044	0.2044
Entamoeba histolytica	cysteine protease, putative	0.0097	0.0582	0.1389
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0582	0.1389
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.102	1	1
Entamoeba histolytica	cysteine protease, putative	0.0451	0.419	1
Brugia malayi	Cathepsin L-like precursor	0.0451	0.419	0.6629
Entamoeba histolytica	cysteine protease, putative	0.0241	0.2044	0.488
Brugia malayi	Cathepsin L-like precursor	0.0451	0.419	0.6629
Giardia lamblia	Cathepsin B precursor	0.0097	0.0582	0.2469
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0097	0.0582	0.0921
Trypanosoma cruzi	cysteine peptidase, putative	0.102	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0451	0.419	0.6629
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.102	1	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0088	0.0483	0.0764
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0659	0.632	0.632
Trichomonas vaginalis	conserved hypothetical protein	0.0097	0.0582	0.1389
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0097	0.0582	0.1389
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0097	0.0582	0.1389
Brugia malayi	Papain family cysteine protease containing protein	0.0451	0.419	0.6629
Loa Loa (eye worm)	cytochrome P450 family protein	0.0043	0.0031	0.0048
Plasmodium vivax	unspecified product	0.0097	0.0582	0.1389
Giardia lamblia	Cathepsin L-like protease	0.0097	0.0582	0.2469
Echinococcus multilocularis	cathepsin L cysteine protease	0.0451	0.419	0.6629
Loa Loa (eye worm)	cathepsin B	0.0271	0.2357	0.3729
Plasmodium falciparum	serine repeat antigen 3	0.0097	0.0582	0.1389
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0102	0.0629	0.0996
Entamoeba histolytica	cysteine proteinase 2	0.0241	0.2044	0.488
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.0289	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0271	0.2357	0.5625
Loa Loa (eye worm)	fibroinase	0.0451	0.419	0.6629
Brugia malayi	Cytochrome P450 family protein	0.0043	0.0031	0.0048
Brugia malayi	Cytochrome P450 family protein	0.0043	0.0031	0.0048
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0451	0.419	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0097	0.0582	0.0921
Trypanosoma cruzi	cruzipain precursor, putative	0.102	1	1
Giardia lamblia	Encystation-specific protease	0.0097	0.0582	0.2469
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0582	0.0921
Schistosoma mansoni	cathepsin B (C01 family)	0.0097	0.0582	0.0921
Onchocerca volvulus		0.0451	0.419	1
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0043	0.0031	0.106
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.0582	0.0921
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0307	0.2727	0.6509
Brugia malayi	Cathepsin L-like precursor	0.0451	0.419	0.6629
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0582	0.0921
Brugia malayi	Cathepsin L-like precursor	0.0143	0.1051	0.1662
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0097	0.0582	0.1389
Leishmania major	cathepsin L-like protease	0.0451	0.419	0.419
Loa Loa (eye worm)	cysteine protease	0.0451	0.419	0.6629
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0451	0.419	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0097	0.0582	0.1389
Brugia malayi	Cathepsin L-like precursor	0.0307	0.2727	0.4315
Schistosoma mansoni	aldehyde dehydrogenase	0.0069	0.0289	0.0457
Toxoplasma gondii	cathepsin CPL	0.0451	0.419	1
Giardia lamblia	Cathepsin L precursor	0.0097	0.0582	0.2469
Entamoeba histolytica	cysteine proteinase, putative	0.0241	0.2044	0.488
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.102	1	1
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0097	0.0582	0.1389
Onchocerca volvulus		0.0451	0.419	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.0289	1
Echinococcus granulosus	cathepsin L	0.0097	0.0582	0.0921
Leishmania major	cathepsin L-like protease	0.0451	0.419	0.419
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0451	0.419	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0241	0.2044	0.3235
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.102	1	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0097	0.0582	0.1389
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0102	0.0629	0.0996
Plasmodium vivax	unspecified product	0.0241	0.2044	0.488
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0097	0.0582	0.1389
Brugia malayi	cathepsin F-like cysteine proteinase	0.0143	0.1051	0.1662
Leishmania major	cathepsin L-like protease	0.0451	0.419	0.419
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0451	0.419	1
Echinococcus multilocularis	cathepsin L	0.0097	0.0582	0.0921
Schistosoma mansoni	cathepsin F (C01 family)	0.0451	0.419	0.6629
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0069	0.0289	0.0289
Plasmodium vivax	serine-repeat antigen (SERA)	0.0097	0.0582	0.1389
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0102	0.0629	0.0996
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0097	0.0582	0.1389
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0451	0.419	1
Onchocerca volvulus		0.0451	0.419	1
Trypanosoma cruzi	cytochrome P450, putative	0.0043	0.0031	0.0031
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0143	0.1051	0.1662
Giardia lamblia	Cathepsin L precursor	0.0097	0.0582	0.2469
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0097	0.0582	0.0921
Echinococcus granulosus	geminin	0.0175	0.1379	0.2182
Treponema pallidum	exodeoxyribonuclease (exoA)	0.004	0	0.5
Trypanosoma cruzi	cysteine proteinase, putative	0.0241	0.2044	0.2044
Loa Loa (eye worm)	ctsf protein	0.0451	0.419	0.6629
Brugia malayi	cathepsin F-like cysteine proteinase	0.0097	0.0582	0.0921
Plasmodium falciparum	serine repeat antigen 1	0.0097	0.0582	0.1389
Entamoeba histolytica	cysteine proteinase, putative	0.0307	0.2727	0.6509
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0097	0.0582	0.0921
Brugia malayi	cathepsin B-like cysteine proteinase	0.0659	0.632	1
Leishmania major	cathepsin L-like protease	0.0451	0.419	0.419
Entamoeba histolytica	cysteine protease, putative	0.0097	0.0582	0.1389
Giardia lamblia	Cysteine protease	0.0097	0.0582	0.2469
Echinococcus granulosus	cysteine protease	0.0241	0.2044	0.3235
Echinococcus granulosus	cathepsin b	0.0659	0.632	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0451	0.419	0.6629

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 334 nM	Antagonist activity at human CB1 receptor expressed in CHOK1 cells by luciferase assay	ChEMBL.	18243711
IC50 (binding)	= 680 nM	Displacement of [3H]CP-55940 from CB1 receptor in Sprague-Dawley rat cerebella membrane	ChEMBL.	18243711
IC50 (binding)	> 10000 nM	Displacement of [3H]WIN-55212-2 from human CB2 receptor expressed in CHOK1 cells	ChEMBL.	18243711

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL528325

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1025805