Detailed information for compound 1025975

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 459.984 | Formula: C25H31ClFN3O2
  • H donors: 2 H acceptors: 2 LogP: 4.57 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN([C@@H]1CC[C@H](CC1)NC(=O)[C@@H](Cc1ccc(cc1)Cl)NC(=O)Cc1ccc(cc1)F)C
  • InChi: 1S/C25H31ClFN3O2/c1-30(2)22-13-11-21(12-14-22)28-25(32)23(15-17-3-7-19(26)8-4-17)29-24(31)16-18-5-9-20(27)10-6-18/h3-10,21-23H,11-16H2,1-2H3,(H,28,32)(H,29,31)/t21-,22-,23-/m1/s1
  • InChiKey: OUKGXVIBVLCUHQ-DNVJHFABSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens arginine vasopressin receptor 1A Starlite/ChEMBL References
Rattus norvegicus Vasopressin V1a receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Vasopressin V1a receptor   424 aa 400 aa 21.8 %
Onchocerca volvulus Vasopressin V1a receptor   424 aa 378 aa 21.4 %
Echinococcus multilocularis rhodopsin orphan GPCR Vasopressin V1a receptor   424 aa 370 aa 21.9 %
Loa Loa (eye worm) hypothetical protein Vasopressin V1a receptor   424 aa 382 aa 22.8 %
Onchocerca volvulus Vasopressin V1a receptor   424 aa 347 aa 21.9 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Vasopressin V1a receptor   424 aa 373 aa 24.9 %
Schistosoma mansoni biogenic amine (5HT) receptor Vasopressin V1a receptor   424 aa 347 aa 23.9 %
Echinococcus multilocularis neuropeptides capa receptor Vasopressin V1a receptor   424 aa 462 aa 19.5 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Vasopressin V1a receptor   424 aa 348 aa 21.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0217 0.1588 0.2141
Echinococcus granulosus mixed lineage leukemia protein mll 0.0068 0.0379 0.0538
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0336 0.255 0.3522
Brugia malayi Muscle positioning protein 4 0.0031 0.0083 0.0094
Loa Loa (eye worm) hypothetical protein 0.0871 0.6876 0.784
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0916 0.724 1
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.007 0.0397 0.0522
Echinococcus granulosus histone acetyltransferase KAT2B 0.0269 0.201 0.2858
Brugia malayi Bromodomain containing protein 0.0022 0.0013 0.0014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0336 0.255 0.3626
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0041 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0201 0.0189
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0315 0.2378 0.2368
Echinococcus multilocularis protein kinase C binding protein 1 0.0022 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0315 0.2378 0.3216
Brugia malayi Bromodomain containing protein 0.0022 0.0013 0.0014
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0041 0.0028
Giardia lamblia Kinase, PLK 0.0096 0.0605 0.1203
Trypanosoma cruzi DNA polymerase eta, putative 0.028 0.2093 0.2829
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0315 0.2378 0.3414
Onchocerca volvulus 0.0031 0.0083 0.007
Echinococcus multilocularis dna polymerase kappa 0.0315 0.2378 0.3284
Plasmodium vivax SET domain protein, putative 0.0163 0.1151 0.57
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.016 0.1123 0.1509
Loa Loa (eye worm) hypothetical protein 0.0107 0.0694 0.0791
Echinococcus multilocularis muscleblind protein 1 0.0156 0.109 0.1505
Schistosoma mansoni kinase 0.0049 0.0224 0.031
Brugia malayi Bromodomain containing protein 0.0022 0.0013 0.0014
Brugia malayi Bromodomain containing protein 0.0022 0.0013 0.0014
Schistosoma mansoni hypothetical protein 0.0033 0.0102 0.0141
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0263 0.03
Echinococcus granulosus histone acetyltransferase KAT2B 0.089 0.7032 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0114 0.0753 0.0859
Echinococcus granulosus PH interacting protein 0.0022 0.0013 0.0018
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0269 0.201 0.5184
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0871 0.6876 0.9498
Brugia malayi hypothetical protein 0.0042 0.0174 0.0199
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0101 0.0644 0.0735
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0101 0.0644 0.1282
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0916 0.724 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0044 0.0191 0.1042
Entamoeba histolytica hypothetical protein 0.0042 0.0174 0.0323
Schistosoma mansoni Smad4 0.0025 0.0036 0.005
Schistosoma mansoni cpg binding protein 0.0263 0.1961 0.2708
Echinococcus granulosus CREB binding protein 0.0022 0.0013 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0622 0.0828
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0056 0.0288 0.0275
Brugia malayi Bromodomain containing protein 0.0022 0.0013 0.0014
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0131 0.0891 0.1194
Echinococcus granulosus MAM 0.0033 0.0102 0.0145
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0013 0.00000026759
Mycobacterium ulcerans beta-lactamase 0.0114 0.0753 0.0414
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0642 0.5025 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0315 0.2378 0.2368
Echinococcus granulosus Niemann Pick C1 protein 0.0107 0.0694 0.0987
Mycobacterium tuberculosis Probable hydrolase 0.0114 0.0753 0.0214
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.0753 0.1007
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0029 0.016
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0931 0.7367 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0014
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.005 0.005
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0441 0.3398 0.4603
Giardia lamblia Hypothetical protein 0.0022 0.0013 0.0025
Trypanosoma brucei hypothetical protein, conserved 0.0098 0.0622 0.0828
Trypanosoma brucei DNA polymerase kappa, putative 0.0315 0.2378 0.3216
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.007 0.0397 0.2169
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0014
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0269 0.201 1
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.007 0.0397 0.0522
Trichomonas vaginalis bromodomain-containing protein, putative 0.0269 0.201 0.2
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0036 0.0041
Schistosoma mansoni ap endonuclease 0.0101 0.0644 0.089
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0101 0.0644 0.0916
Echinococcus multilocularis Bromodomain containing protein 0.0022 0.0013 0.0017
Leishmania major DNA polymerase kappa, putative 0.0315 0.2378 0.3216
Mycobacterium ulcerans hypothetical protein 0.0491 0.3801 1
Trypanosoma brucei chrX additional, unordered contigs 0.0098 0.0622 0.0828
Echinococcus granulosus bromodomain containing 2 0.0022 0.0013 0.0018
Loa Loa (eye worm) Smad1 0.0025 0.0036 0.0041
Echinococcus multilocularis Smad4 0.0025 0.0036 0.005
Schistosoma mansoni DNA polymerase eta 0.0497 0.385 0.5317
Brugia malayi Pre-SET motif family protein 0.0163 0.1151 0.1312
Loa Loa (eye worm) transcription factor SMAD2 0.0372 0.284 0.3238
Mycobacterium tuberculosis Probable lipase LipD 0.0114 0.0753 0.0214
Giardia lamblia Transcription regulatory protein SNF2 0.0022 0.0013 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0642 0.5025 0.5018
Trypanosoma brucei DNA polymerase kappa, putative 0.0315 0.2378 0.3216
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0163 0.1151 0.159
Brugia malayi MH2 domain containing protein 0.0025 0.0036 0.0041
Brugia malayi MH2 domain containing protein 0.0025 0.0036 0.0041
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0871 0.6876 0.9498
Echinococcus granulosus bloom syndrome protein 0.0051 0.024 0.0342
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0605 0.0593
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.0753 0.0742
Schistosoma mansoni bromodomain containing protein 0.0022 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.0255 0.1891 0.2156
Schistosoma mansoni transcription initiation factor tfiid 0.0022 0.0013 0.0017
Schistosoma mansoni polybromo-1 0.0022 0.0013 0.0017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0042 0.0167 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0288 0.0275
Echinococcus granulosus global transcription activator snf2l2 0.0022 0.0013 0.0018
Brugia malayi bromodomain containing protein 0.0022 0.0013 0.0014
Mycobacterium tuberculosis Conserved protein 0.0114 0.0753 0.0214
Echinococcus multilocularis Niemann Pick C1 protein 0.0152 0.1065 0.147
Brugia malayi acetyltransferase, GNAT family protein 0.0916 0.724 0.8255
Toxoplasma gondii bromodomain-containing protein 0.0022 0.0013 0.0033
Brugia malayi ImpB/MucB/SamB family protein 0.0315 0.2378 0.2711
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.0753 0.0742
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.008 0.0479 0.0953
Loa Loa (eye worm) beta-lactamase 0.0114 0.0753 0.0859
Loa Loa (eye worm) MH2 domain-containing protein 0.0372 0.284 0.3238
Echinococcus granulosus expressed conserved protein 0.01 0.0642 0.0913
Loa Loa (eye worm) hypothetical protein 0.0114 0.0753 0.0859
Plasmodium vivax hypothetical protein, conserved 0.0114 0.0753 0.3708
Trypanosoma brucei unspecified product 0.0315 0.2378 0.3216
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0931 0.7367 1
Giardia lamblia TCP-1 chaperonin subunit beta 0.0026 0.0041 0.0081
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.007 0.0397 0.1023
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0014
Giardia lamblia Hypothetical protein 0.0022 0.0013 0.0025
Trichomonas vaginalis hypothetical protein 0.003 0.0076 0.0063
Brugia malayi BRM protein 0.0022 0.0013 0.0014
Brugia malayi Pip kinase protein 1 0.007 0.0397 0.0452
Trypanosoma brucei hypothetical protein, conserved 0.0114 0.0753 0.1007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0163 0.1151 0.159
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0288 0.0275
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0014
Brugia malayi CHE-14 protein 0.0046 0.0201 0.023
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0083 0.0501 0.0713
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0127 0.0181
Schistosoma mansoni bromodomain containing protein 0.0037 0.0127 0.0176
Toxoplasma gondii ImpB/MucB/SamB family protein 0.028 0.2093 0.5399
Entamoeba histolytica acetyltransferase, GNAT family 0.0247 0.1828 0.3623
Echinococcus granulosus transcription initiation factor TFIID subunit 1 0.0022 0.0013 0.0018
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0441 0.3398 0.4603
Mycobacterium ulcerans DNA polymerase IV 0.0315 0.2378 0.5525
Loa Loa (eye worm) hypothetical protein 0.0497 0.385 0.4389
Loa Loa (eye worm) pip kinase 1 0.007 0.0397 0.0452
Schistosoma mansoni ap endonuclease 0.0101 0.0644 0.089
Brugia malayi ImpB/MucB/SamB family protein 0.0497 0.385 0.4389
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.008 0.0479 0.0634
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0029 0.0023
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0041 0.0056
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0034 0.0108 0.0476
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.007 0.0397 0.0548
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0116
Brugia malayi Niemann-Pick C1 protein precursor 0.0107 0.0694 0.0791
Trypanosoma cruzi DNA damage repair protein, putative 0.0098 0.0622 0.0828
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0076 0.0063
Brugia malayi polybromodomain protein 0.0022 0.0013 0.0014
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0083 0.0501 0.0692
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0013 0.0014
Schistosoma mansoni myst-related protein 0.0029 0.0069 0.0095
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0605 0.0805
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.007 0.0397 0.0522
Giardia lamblia DNA damage repair protein 0.0098 0.0622 0.1237
Schistosoma mansoni phd finger protein 0.0022 0.0013 0.0017
Schistosoma mansoni hypothetical protein 0.0352 0.2681 0.3703
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.007 0.0397 0.0452
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.007 0.0397 0.0548
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0163 0.1151 0.159
Loa Loa (eye worm) hypothetical protein 0.0031 0.0083 0.0094
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0029 0.016
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0336 0.255 0.2907
Echinococcus granulosus zinc finger protein 0.0037 0.0127 0.0181
Schistosoma mansoni hypothetical protein 0.0033 0.0102 0.0141
Trypanosoma brucei DNA damage repair protein, putative 0.0098 0.0622 0.0828
Loa Loa (eye worm) hypothetical protein 0.0114 0.0753 0.0859
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0036 0.005
Echinococcus multilocularis bromodomain containing 2 0.0022 0.0013 0.0017
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0041 0.0038
Schistosoma mansoni DNA polymerase IV / kappa 0.0098 0.0622 0.0858
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0036 0.0051
Onchocerca volvulus 0.0031 0.0083 0.007
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0314 0.2368 1
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.007 0.0397 0.0522
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0116
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.007 0.0397 0.0452
Trichomonas vaginalis helicase, putative 0.0056 0.0288 0.0275
Echinococcus multilocularis expressed conserved protein 0.01 0.0642 0.0886
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0336 0.255 0.3522
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0642 0.5025 0.5018
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0174 0.0241
Brugia malayi ATPase, AAA family protein 0.0022 0.0013 0.0014
Trypanosoma cruzi DNA polymerase eta, putative 0.0497 0.385 0.5217
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0041 0.0047
Onchocerca volvulus 0.0031 0.0083 0.007
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0315 0.2378 0.3284
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0056 0.0288 0.0275
Trypanosoma cruzi hypothetical protein, conserved 0.0098 0.0622 0.0828
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0114 0.0753 0.0214
Echinococcus granulosus peregrin 0.0022 0.0013 0.0018
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0041 0.0038
Brugia malayi Pip kinase protein 2 0.0871 0.6876 0.784
Trypanosoma brucei DNA polymerase kappa, putative 0.0315 0.2378 0.3216
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0126 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0288 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.0315 0.2378 0.3216
Trypanosoma brucei DNA polymerase IV, putative 0.0315 0.2378 0.3216
Trichomonas vaginalis esterase, putative 0.0114 0.0753 0.0742
Trichomonas vaginalis DNA helicase recq, putative 0.0051 0.024 0.0228
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0163 0.1151 0.159
Schistosoma mansoni hypothetical protein 0.0022 0.0013 0.0017
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0336 0.255 0.2907
Toxoplasma gondii histone lysine methyltransferase SET1 0.05 0.3877 1
Schistosoma mansoni hypothetical protein 0.0044 0.0188 0.026
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.007 0.0397 0.0384
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.008 0.0479 0.0546
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0174 0.0248
Echinococcus granulosus CREB binding protein 0.0022 0.0013 0.0018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0263 0.03
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0605 0.0593
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0214 0.0202
Echinococcus multilocularis PH interacting protein 0.0022 0.0013 0.0017
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.007 0.0397 0.0522
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0622 0.0828
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0056 0.0288 0.0275
Schistosoma mansoni cpg binding protein 0.0263 0.1961 0.2708
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0101 0.0644 0.3163
Echinococcus granulosus geminin 0.0352 0.2681 0.3813
Brugia malayi SET domain containing protein 0.0025 0.0037 0.0042
Echinococcus multilocularis bromodomain containing protein 8 0.0022 0.0013 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0288 0.0275
Echinococcus granulosus bromodomain containing protein 8 0.0022 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.008 0.0479 0.0546
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0163 0.1151 0.159
Giardia lamblia DINP protein human, muc B family 0.0315 0.2378 0.4733
Echinococcus granulosus dna polymerase eta 0.0497 0.385 0.5474
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.007 0.0397 0.0522
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0605 0.0593
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0605 0.0593
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0029 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0288 0.0275
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0605 0.0805
Mycobacterium ulcerans DNA polymerase IV 0.0315 0.2378 0.5525
Leishmania major mitochondrial DNA polymerase beta 0.0931 0.7367 1
Entamoeba histolytica hypothetical protein 0.0042 0.0174 0.0323
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0101 0.0644 0.0859
Loa Loa (eye worm) FYVE zinc finger family protein 0.007 0.0397 0.0452
Toxoplasma gondii hypothetical protein 0.0022 0.0013 0.0033
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0026 0.0041 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0288 0.0275
Schistosoma mansoni hypothetical protein 0.0352 0.2681 0.3703
Onchocerca volvulus 0.0114 0.0753 0.0742
Trypanosoma brucei DNA polymerase kappa, putative 0.0315 0.2378 0.3216
Echinococcus granulosus ubiquitin specific protease 41 0.008 0.0479 0.0681
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0041 0.0056
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0336 0.255 0.3626
Toxoplasma gondii exonuclease III APE 0.0101 0.0644 0.1662
Schistosoma mansoni zinc finger protein 0.0037 0.0127 0.0176
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0029 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0479 0.0467
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0022 0.0013 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.0753 0.0742
Loa Loa (eye worm) hypothetical protein 0.0037 0.0127 0.0145
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.008 0.0479 0.0467
Brugia malayi Bloom's syndrome protein homolog 0.0051 0.024 0.0274
Toxoplasma gondii hypothetical protein 0.015 0.1047 0.27
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.007 0.0397 0.0522
Echinococcus granulosus smad 0.0025 0.0036 0.0051
Trichomonas vaginalis lymphoid specific helicase, putative 0.0022 0.0013 0.000000000069741
Plasmodium falciparum zinc finger protein, putative 0.0029 0.0069 0.0376
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0642 0.5025 0.5018
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0642 0.5025 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0315 0.2378 0.3216
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0315 0.2378 0.3381
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.007 0.0397 0.0522
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0101 0.0644 0.3524
Echinococcus multilocularis muscleblind protein 0.0156 0.109 0.1505
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0605 0.0593
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0041 0.0047
Schistosoma mansoni terminal deoxycytidyl transferase 0.0315 0.2378 0.3284
Trypanosoma brucei DNA polymerase kappa, putative 0.0315 0.2378 0.3216
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.0605 0.0689
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0642 0.5025 0.5018
Mycobacterium tuberculosis Conserved hypothetical protein 0.0315 0.2378 0.3414
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.008 0.0479 0.0634
Echinococcus multilocularis protein dispatched 1 0.0052 0.0254 0.0351
Loa Loa (eye worm) hypothetical protein 0.0053 0.0263 0.03
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0101 0.0644 0.0859
Loa Loa (eye worm) hypothetical protein 0.0037 0.0127 0.0145
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0315 0.2378 0.3284
Brugia malayi Smad1 0.0025 0.0036 0.0041
Echinococcus granulosus beta LACTamase domain containing family member 0.0114 0.0753 0.1071
Mycobacterium ulcerans esterase/lipase LipP 0.0114 0.0753 0.0414
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0605 0.0593
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0314 0.2368 0.3395
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.005 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0315 0.2378 0.3216
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.0605 0.086
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.007 0.0397 0.0548
Schistosoma mansoni blooms syndrome DNA helicase 0.004 0.0154 0.0213
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0014
Entamoeba histolytica phosphoinositide kinase, putative 0.007 0.0397 0.0766
Onchocerca volvulus 0.0033 0.0102 0.0089
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.0753 0.104
Schistosoma mansoni cpg binding protein 0.0249 0.1846 0.255
Brugia malayi Pre-SET motif family protein 0.1105 0.8771 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0753 0.0859
Trypanosoma brucei DNA polymerase kappa, putative 0.0217 0.1588 0.2141
Schistosoma mansoni hypothetical protein 0.0044 0.0188 0.026
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0041 0.0038
Echinococcus multilocularis 0.0022 0.0013 0.0017
Schistosoma mansoni hypothetical protein 0.0022 0.0013 0.0017
Onchocerca volvulus 0.0114 0.0753 0.0742
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0642 0.5025 0.5018
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0026 0.0039 0.0026
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.005 0.005
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1105 0.8771 1
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0288 0.0275
Brugia malayi MH1 domain containing protein 0.0025 0.0036 0.0041
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0014
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0101 0.0644 0.0859
Toxoplasma gondii bromodomain-containing protein 0.0022 0.0013 0.0033
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0101 0.0644 0.0072
Brugia malayi exodeoxyribonuclease III family protein 0.0101 0.0644 0.0735
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0108 0.0708 0.0977
Trichomonas vaginalis ap endonuclease, putative 0.0101 0.0644 0.0633
Toxoplasma gondii histone acetyltransferase TAF1/250 0.0022 0.0013 0.0033
Onchocerca volvulus 0.0025 0.0037 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0642 0.5025 0.5018
Brugia malayi Bromodomain containing protein 0.0022 0.0013 0.0014
Echinococcus multilocularis beta LACTamase domain containing family member 0.0114 0.0753 0.104
Mycobacterium ulcerans lipase LipD 0.0114 0.0753 0.0414
Trypanosoma brucei unspecified product 0.0217 0.1588 0.2141
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0043 0.003
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0036 0.005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0056 0.0288 0.0275
Trypanosoma cruzi DNA polymerase kappa, putative 0.0315 0.2378 0.3216
Brugia malayi beta-lactamase family protein 0.0114 0.0753 0.0859
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0107 0.0694 0.136
Loa Loa (eye worm) TK/ALK protein kinase 0.0033 0.0102 0.0116
Brugia malayi hypothetical protein 0.0033 0.0102 0.0116
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0605 0.0593
Loa Loa (eye worm) RecQ helicase 0.0051 0.024 0.0274
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.007 0.0397 0.0522
Entamoeba histolytica hypothetical protein 0.0042 0.0174 0.0323
Echinococcus multilocularis CREB binding protein 0.0022 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.0098 0.0622 0.0709
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.007 0.0397 0.0548
Echinococcus granulosus Niemann Pick C1 protein 0.0152 0.1065 0.1514
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.007 0.0397 0.0548
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.008 0.0479 0.0681
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.0753 0.0742
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0336 0.255 0.3522
Echinococcus multilocularis zinc finger protein 0.0037 0.0127 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0288 0.0275
Schistosoma mansoni CREB-binding protein 2 0.0022 0.0013 0.0017
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0269 0.201 0.5184
Loa Loa (eye worm) DOMON domain-containing protein 0.0031 0.0083 0.0094
Schistosoma mansoni hypothetical protein 0.0044 0.0188 0.026
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.0605 0.1181
Brugia malayi beta-lactamase 0.0114 0.0753 0.0859
Brugia malayi Bromodomain containing protein 0.0037 0.0127 0.0145
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.007 0.0397 0.0522
Leishmania major DNA damage repair protein, putative 0.0098 0.0622 0.0828
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.008 0.0479 0.0661
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0201 0.0286
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0036 0.0041
Loa Loa (eye worm) hypothetical protein 0.0037 0.0126 0.0144
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0131 0.0891 0.1194
Schistosoma mansoni smad 0.0025 0.0036 0.005
Echinococcus multilocularis cpg binding protein 0.0263 0.1961 0.2708
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0043 0.003
Brugia malayi polybromodomain protein 0.0022 0.0013 0.0014
Plasmodium falciparum bromodomain protein 2, putative 0.0022 0.0013 0.0069
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0076 0.0063
Loa Loa (eye worm) histone methyltransferase 0.0083 0.0501 0.0572
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.007 0.0397 0.0564
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.007 0.0397 0.0384
Trypanosoma cruzi hypothetical protein, conserved 0.0098 0.0622 0.0828
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0201 0.0286
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0163 0.1151 0.159
Toxoplasma gondii bromodomain-containing protein 0.0022 0.0013 0.0033
Trypanosoma brucei ISWI complex protein 0.0026 0.0043 0.0041
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0029 0.0023
Leishmania major hypothetical protein, conserved 0.0114 0.0753 0.1007
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0114 0.0753 0.0214
Onchocerca volvulus 0.0033 0.0102 0.0089
Brugia malayi hypothetical protein 0.0024 0.0029 0.0033
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0036 0.005
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0101 0.0644 0.126
Entamoeba histolytica hypothetical protein 0.0042 0.0174 0.0323
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0101 0.0644 0.089
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0068 0.0379 0.0523
Echinococcus granulosus Smad4 0.0025 0.0036 0.0051
Trypanosoma brucei DNA polymerase IV, putative 0.0315 0.2378 0.3216
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0013 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0642 0.5025 0.5018
Trypanosoma cruzi DNA polymerase kappa, putative 0.0315 0.2378 0.3216
Plasmodium falciparum histone acetyltransferase GCN5 0.0247 0.1828 1
Schistosoma mansoni smad1 5 8 and 0.0025 0.0036 0.005
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.0605 0.0805
Trypanosoma brucei polo-like protein kinase 0.0096 0.0605 0.0805
Brugia malayi Bromodomain containing protein 0.0022 0.0013 0.0014
Schistosoma mansoni hypothetical protein 0.0022 0.0013 0.0017
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0036 0.0051
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0314 0.2368 0.5494
Loa Loa (eye worm) hypothetical protein 0.0156 0.109 0.1243
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0114 0.0753 0.0859
Trypanosoma cruzi DNA polymerase kappa, putative 0.0315 0.2378 0.3216
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.007 0.0397 0.1023
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0127 0.0176
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.007 0.0397 0.0522
Echinococcus granulosus muscleblind protein 0.0156 0.109 0.155
Echinococcus multilocularis dna polymerase eta 0.0497 0.385 0.5317
Loa Loa (eye worm) hypothetical protein 0.0163 0.1151 0.1312
Loa Loa (eye worm) hypothetical protein 0.0046 0.0201 0.023
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0131 0.0891 0.1194
Entamoeba histolytica hypothetical protein 0.0029 0.0069 0.0112
Mycobacterium tuberculosis Probable lipase LipE 0.0114 0.0753 0.0214
Echinococcus multilocularis protein patched 0.0046 0.0201 0.0278
Brugia malayi Bromodomain containing protein 0.0022 0.0013 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0217 0.1588 0.2141
Echinococcus multilocularis MAM 0.0033 0.0102 0.0141
Schistosoma mansoni SET domain protein 0.0025 0.0037 0.0051
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0174 0.0241
Leishmania major DNA polymerase eta, putative 0.0497 0.385 0.5217
Schistosoma mansoni hypothetical protein 0.0042 0.0174 0.0241
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.008 0.0479 0.0634
Entamoeba histolytica recQ family helicase, putative 0.0027 0.005 0.0074
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.008 0.0479 0.0467
Leishmania major DNA polymerase kappa, putative 0.0098 0.0622 0.0828
Schistosoma mansoni smad1 5 8 and 0.0025 0.0036 0.005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0068 0.0379 0.0523
Schistosoma mansoni patched 1 0.0046 0.0201 0.0278
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.0605 0.0835
Plasmodium vivax SET domain containing protein 0.0034 0.0104 0.0455
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.007 0.0397 0.1922
Giardia lamblia Histone acetyltransferase GCN5 0.0247 0.1828 0.3639
Plasmodium falciparum bromodomain protein, putative 0.0022 0.0013 0.0069
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0026 0.0039 0.0026
Echinococcus multilocularis geminin 0.0352 0.2681 0.3703
Brugia malayi MH1 domain containing protein 0.0025 0.0036 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0642 0.5025 0.5018
Loa Loa (eye worm) CBP-B 0.0022 0.0013 0.0014
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0114 0.0753 0.0859
Plasmodium falciparum bromodomain protein 1 0.0022 0.0013 0.0069
Trichomonas vaginalis DNA helicase recq1, putative 0.0051 0.024 0.0228
Trypanosoma brucei DNA polymerase IV, putative 0.0315 0.2378 0.3216
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.0753 0.0742
Toxoplasma gondii t-complex protein beta subunit 0.0026 0.0041 0.0105
Schistosoma mansoni smad1 5 8 and 0.0025 0.0036 0.005
Echinococcus multilocularis ubiquitin specific protease 41 0.008 0.0479 0.0661
Schistosoma mansoni helicase 0.0022 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.0056 0.0285 0.0325
Onchocerca volvulus 0.0871 0.6876 0.6872
Trypanosoma brucei unspecified product 0.0217 0.1588 0.2141
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.007 0.0397 0.1023
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0114 0.0753 0.0214
Brugia malayi Muscleblind-like protein 0.0156 0.109 0.1243
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.007 0.0397 0.0522
Trichomonas vaginalis set domain proteins, putative 0.1257 1 1
Loa Loa (eye worm) BRM protein 0.0022 0.0013 0.0014
Brugia malayi CXXC zinc finger family protein 0.0249 0.1846 0.2105
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.005 0.005
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0068 0.0379 0.0538
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0116
Onchocerca volvulus 0.0031 0.0083 0.007
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0101 0.0644 0.5
Plasmodium falciparum T-complex protein 1 subunit beta 0.0026 0.0041 0.0224
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.007 0.0397 0.0564
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.008 0.0479 0.0634
Loa Loa (eye worm) hypothetical protein 0.0156 0.109 0.1243
Trypanosoma brucei DNA polymerase kappa, putative 0.0315 0.2378 0.3216
Echinococcus multilocularis global transcription activator snf2l2 0.0022 0.0013 0.0017
Mycobacterium tuberculosis Conserved protein 0.0114 0.0753 0.0214
Toxoplasma gondii ABC1 family protein 0.0114 0.0753 0.1943
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0728 0.5723 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0029 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.0753 0.1007
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0101 0.0644 0.0859
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.007 0.0397 0.0522
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.008 0.0479 0.0681
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0114 0.0753 0.0414
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0152 0.106 0.1507
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0269 0.201 0.2
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.007 0.0397 0.0522
Mycobacterium ulcerans hypothetical protein 0.0114 0.0753 0.0414
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0441 0.3398 0.4603
Echinococcus granulosus dna polymerase kappa 0.0315 0.2378 0.3381
Trypanosoma brucei DNA polymerase kappa, putative 0.0315 0.2378 0.3216
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0022 0.0013 0.0017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0056 0.0288 0.0275
Treponema pallidum fructose-bisphosphate aldolase 0.0642 0.5025 1
Giardia lamblia Hypothetical protein 0.007 0.0397 0.0789
Trichomonas vaginalis chaperonin, putative 0.0026 0.0041 0.0028
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.0605 0.0689
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.007 0.0397 0.0522
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0022 0.0013 0.0018
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0029 0.0075
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.008 0.0479 0.0661
Echinococcus granulosus histone lysine methyltransferase setb 0.0163 0.1151 0.1637
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0379 0.0523
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0201 0.0278
Echinococcus multilocularis peregrin 0.0022 0.0013 0.0017
Mycobacterium tuberculosis Conserved protein 0.0114 0.0753 0.0214
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0041 0.0047
Echinococcus granulosus Bromodomain containing protein 0.0022 0.0013 0.0018
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0315 0.2378 0.2711
Echinococcus granulosus protein kinase C binding protein 1 0.0022 0.0013 0.0018
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.0605 0.0593
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.008 0.0479 0.0661
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.007 0.0397 0.0766
Brugia malayi TAZ zinc finger family protein 0.0022 0.0013 0.0014
Plasmodium vivax DNA repair protein REV1, putative 0.0098 0.0622 0.3049
Mycobacterium tuberculosis Probable esterase LipL 0.0114 0.0753 0.0214
Schistosoma mansoni hypothetical protein 0.0031 0.0083 0.0114
Trypanosoma brucei DNA damage repair protein, putative 0.0098 0.0622 0.0828
Toxoplasma gondii bromodomain-containing protein 0.0022 0.0013 0.0033
Schistosoma mansoni myst-related protein 0.0029 0.0069 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0288 0.0275
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0214 0.0202
Loa Loa (eye worm) CXXC zinc finger family protein 0.0249 0.1846 0.2105
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0871 0.6876 0.9498
Leishmania major hypothetical protein, conserved 0.0024 0.0029 0.0023
Trypanosoma brucei DNA polymerase eta, putative 0.0497 0.385 0.5217
Schistosoma mansoni bromodomain containing protein 0.0037 0.0127 0.0176
Giardia lamblia Kinase, putative 0.0022 0.0013 0.0025
Echinococcus multilocularis Niemann Pick C1 protein 0.0107 0.0694 0.0959
Onchocerca volvulus 0.0249 0.1846 0.1836
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0041 0.0056
Onchocerca volvulus 0.0163 0.1151 0.114
Trichomonas vaginalis ap endonuclease, putative 0.0101 0.0644 0.0633
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0056 0.0288 0.0275
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0931 0.7367 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.0753 0.104
Brugia malayi polk-prov protein 0.0098 0.0622 0.0709
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.008 0.0479 0.0661
Brugia malayi Protein kinase domain containing protein 0.0033 0.0102 0.0116
Trypanosoma brucei hypothetical protein, conserved 0.0098 0.0622 0.0828
Plasmodium falciparum DNA repair protein REV1, putative 0.0098 0.0622 0.3399
Loa Loa (eye worm) hypothetical protein 0.0031 0.0083 0.0094
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0022 0.0013 0.0017
Giardia lamblia Fructose-bisphosphate aldolase 0.0642 0.5025 1
Echinococcus multilocularis polybromo 1 0.0022 0.0013 0.0017
Leishmania major DNA polymerase eta, putative 0.028 0.2093 0.2829
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0336 0.255 0.3522
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.007 0.0397 0.0522
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0098 0.0622 0.1603
Brugia malayi F/Y-rich N-terminus family protein 0.0082 0.0493 0.0563
Onchocerca volvulus 0.0114 0.0753 0.0742
Toxoplasma gondii bromodomain-containing protein 0.0022 0.0013 0.0033
Brugia malayi Bromodomain containing protein 0.0022 0.0013 0.0014
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0201 0.023
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.007 0.0397 0.0548
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0098 0.0622 0.1603
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0534 0.4152 0.5734
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0871 0.6876 0.9778
Schistosoma mansoni hypothetical protein 0.0037 0.0126 0.0175
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0315 0.2378 0.3216
Trypanosoma cruzi DNA damage repair protein, putative 0.0098 0.0622 0.0828
Mycobacterium tuberculosis Conserved hypothetical protein 0.0491 0.3801 0.6215
Schistosoma mansoni hypothetical protein 0.0022 0.0013 0.0017
Plasmodium vivax hypothetical protein, conserved 0.007 0.0397 0.1924
Schistosoma mansoni bromodomain containing 0.0022 0.0013 0.0017
Echinococcus granulosus Bromodomain containing protein 0.0022 0.0013 0.0018
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0041 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0043 0.003
Loa Loa (eye worm) acetyltransferase 0.0916 0.724 0.8255
Echinococcus multilocularis bloom syndrome protein 0.0051 0.024 0.0332
Loa Loa (eye worm) hypothetical protein 0.0114 0.0753 0.0859
Entamoeba histolytica deoxycytidyl transferase, putative 0.0315 0.2378 0.4719
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0034 0.0104 0.027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0056 0.0288 0.0275
Brugia malayi beta-lactamase family protein 0.0114 0.0753 0.0859
Loa Loa (eye worm) hypothetical protein 0.0114 0.0753 0.0859
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0056 0.0288 0.0275
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0041 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0605 0.0835
Echinococcus granulosus polybromo 1 0.0022 0.0013 0.0018
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.007 0.0397 0.0789
Echinococcus multilocularis smad 0.0025 0.0036 0.005
Brugia malayi MH2 domain containing protein 0.0372 0.284 0.3238
Echinococcus multilocularis Bromodomain containing protein 0.0022 0.0013 0.0017
Schistosoma mansoni hypothetical protein 0.0044 0.0188 0.026
Onchocerca volvulus 0.0031 0.0083 0.007
Echinococcus granulosus cpg binding protein 0.0263 0.1961 0.2788
Entamoeba histolytica ankyrin repeat protein, putative 0.0022 0.0013 0.00000010663
Brugia malayi SEA domain containing protein 0.0031 0.0083 0.0094
Loa Loa (eye worm) pip kinase 2 0.0871 0.6876 0.784
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0263 0.03
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0022 0.0013 0.0017
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0131 0.0891 0.1194
Trypanosoma cruzi ISWI complex protein 0.0026 0.0043 0.0041
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0163 0.1151 0.2969
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0336 0.255 0.3522
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.008 0.0479 0.093
Brugia malayi PHD-finger family protein 0.0037 0.0127 0.0145

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 7.16 Displacement of [3H]AVP from rat V1A receptor expressed in CHO cells ChEMBL. 21700453
Ki (binding) = 8.95 Displacement of [3H]AVP from human V1A receptor expressed in CHO cells ChEMBL. 21700453
Papp (ADMET) < 100 nm/s Apparent permeability of the compound from apical to basolateral side of human Caco2 cells ChEMBL. 21700453

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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