Detailed information for compound 1026192

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 436.497 | Formula: C25H26F2N4O
  • H donors: 1 H acceptors: 2 LogP: 4.43 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)CN(C1CCN(CC1)c1nccc(c1)NC(=O)c1cccc(c1)F)C
  • InChi: 1S/C25H26F2N4O/c1-30(17-18-4-2-6-20(26)14-18)23-9-12-31(13-10-23)24-16-22(8-11-28-24)29-25(32)19-5-3-7-21(27)15-19/h2-8,11,14-16,23H,9-10,12-13,17H2,1H3,(H,28,29,32)
  • InChiKey: CJKRXRGCBDILIZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0326 0.0319
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0312 0.03
Echinococcus multilocularis geminin 0.0697 0.8175 0.8166
Schistosoma mansoni cpg binding protein 0.0088 0.0883 0.0875
Mycobacterium ulcerans glutaminase 0.0558 0.6506 0.8673
Loa Loa (eye worm) CHromoDomain protein family member 0.0018 0.0046 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0163 0.0098
Mycobacterium ulcerans hypothetical protein 0.0041 0.0326 0.0319
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0568 0.0759
Giardia lamblia DINP protein human, muc B family 0.004 0.0312 0.0585
Brugia malayi beta-lactamase 0.0041 0.0326 0.0436
Entamoeba histolytica hypothetical protein 0.0026 0.0143 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0205 0.0182
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0114 0.0033
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0233 0.2619 0.3498
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0568 0.056
Brugia malayi Importin beta-1 subunit 0.0032 0.0216 0.0288
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0233 0.2619 0.2585
Schistosoma mansoni hypothetical protein 0.0163 0.1779 0.1771
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0326 0.0814
Brugia malayi RNA binding protein 0.0061 0.0568 0.0759
Brugia malayi Isocitrate dehydrogenase 0.0051 0.0439 0.0586
Echinococcus multilocularis cpg binding protein 0.0093 0.0943 0.0901
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0312 0.03
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0233 0.2619 0.3498
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0224 0.0207
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0326 0.0319
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0138 0.0184
Schistosoma mansoni DNA polymerase eta 0.004 0.0312 0.0303
Schistosoma mansoni cpg binding protein 0.0093 0.0943 0.0935
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0326 0.0345
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.064 0.7488 1
Echinococcus granulosus lamin 0.0026 0.0145 0.01
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0399 0.1008
Mycobacterium ulcerans beta-lactamase 0.0041 0.0326 0.0319
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0568 0.056
Leishmania major DNA polymerase kappa, putative 0.004 0.0312 0.03
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0114 0.0069
Schistosoma mansoni importin beta-1 0.0032 0.0216 0.0207
Loa Loa (eye worm) hypothetical protein 0.0048 0.0413 0.0551
Entamoeba histolytica Ran family GTPase 0.0024 0.0114 0.0033
Echinococcus granulosus dna polymerase eta 0.004 0.0312 0.0267
Loa Loa (eye worm) hypothetical protein 0.0163 0.1779 0.2375
Schistosoma mansoni ap endonuclease 0.0022 0.009 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0359 0.0389
Brugia malayi latrophilin 2 splice variant baaae 0.0351 0.4037 0.5392
Echinococcus granulosus smad 0.0026 0.0138 0.0092
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0128 0.01
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0326 0.0282
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0312 0.0417
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0439 0.0394
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0338 0.3879 0.5121
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0326 0.0814
Loa Loa (eye worm) hypothetical protein 0.0338 0.3879 0.518
Brugia malayi ERG2 and Sigma1 receptor like protein 0.036 0.4141 0.5531
Schistosoma mansoni hypothetical protein 0.0163 0.1779 0.1771
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0114 0.0069
Brugia malayi Latrophilin receptor protein 2 0.0163 0.1779 0.2375
Loa Loa (eye worm) isocitrate dehydrogenase 0.0051 0.0439 0.0586
Leishmania major hypothetical protein, conserved 0.0041 0.0326 0.0319
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0439 0.0394
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0538 0.0605
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.009 0.0044
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0053 0.0463 0.0419
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0093 0.0048
Trypanosoma brucei unspecified product 0.0028 0.0163 0.0098
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.009 0.012
Schistosoma mansoni hypothetical protein 0.0351 0.4037 0.4032
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0439 0.0471
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0128 0.0051
Loa Loa (eye worm) hypothetical protein 0.0032 0.0216 0.0288
Echinococcus granulosus synaptic glycoprotein sc2 0.0338 0.3879 0.385
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0233 0.2619 0.2585
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0568 0.056
Onchocerca volvulus 0.0026 0.0145 0.0353
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0568 0.0759
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0143 0.0098
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0312 0.0303
Brugia malayi Calcitonin receptor-like protein seb-1 0.0514 0.5984 0.7991
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0326 0.0814
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0538 0.0529
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0326 0.0319
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0338 0.3879 0.5134
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0399 0.0443
Leishmania major DNA polymerase eta, putative 0.004 0.0312 0.03
Loa Loa (eye worm) glutaminase 0.0558 0.6506 0.8689
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0338 0.3879 0.5134
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0326 0.0317
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0163 0.1779 0.1741
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0312 0.03
Toxoplasma gondii ABC1 family protein 0.0041 0.0326 0.0319
Plasmodium vivax importin-beta 2, putative 0.0032 0.0216 0.0331
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0143 0.0072
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0224 0.0207
Echinococcus granulosus GPCR family 2 0.0163 0.1779 0.1741
Brugia malayi Synaptic glycoprotein SC2 0.0338 0.3879 0.518
Mycobacterium ulcerans hypothetical protein 0.064 0.7488 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0359 0.048
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.064 0.7488 1
Loa Loa (eye worm) hypothetical protein 0.064 0.7488 1
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0338 0.3879 0.3873
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0128 0.0051
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0312 0.0417
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0312 0.0267
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0128 0.01
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0538 0.0605
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.064 0.7488 1
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0053 0.0463 0.0503
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0145 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.3879 0.5134
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0326 0.0623
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0338 0.3879 0.5134
Brugia malayi intermediate filament protein 0.0026 0.0145 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0163 0.0098
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0053 0.0463 0.0983
Mycobacterium leprae Probable lipase LipE 0.0041 0.0326 0.5
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0053 0.0463 0.0529
Echinococcus granulosus chromobox protein 1 0.0079 0.0772 0.073
Echinococcus multilocularis chromobox protein 1 0.0079 0.0772 0.073
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0051 0.0439 0.0394
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0114 0.0153
Echinococcus multilocularis isocitrate dehydrogenase 0.0051 0.0439 0.0394
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.2619 0.2613
Loa Loa (eye worm) hypothetical protein 0.0338 0.3879 0.518
Trypanosoma brucei unspecified product 0.004 0.0312 0.03
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0439 0.0394
Trichomonas vaginalis chaperonin, putative 0.0053 0.0463 0.0529
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.2619 0.2613
Echinococcus granulosus geminin 0.0697 0.8175 0.8166
Schistosoma mansoni hypothetical protein 0.0697 0.8175 0.8173
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0312 0.0267
Echinococcus multilocularis synaptic glycoprotein sc2 0.0338 0.3879 0.385
Echinococcus multilocularis GPCR, family 2 0.0163 0.1779 0.1741
Loa Loa (eye worm) hypothetical protein 0.0184 0.2035 0.2717
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0338 0.3879 1
Schistosoma mansoni Smad4 0.0026 0.0138 0.0129
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0264 0.2988 1
Brugia malayi glutaminase DH11.1 0.0558 0.6506 0.8689
Loa Loa (eye worm) hypothetical protein 0.0351 0.4037 0.5392
Schistosoma mansoni hypothetical protein 0.0163 0.1779 0.1771
Brugia malayi T-complex protein 1, beta subunit 0.0053 0.0463 0.0618
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0224 0.0207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0096 0.0035
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0312 0.03
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.009 0.0027
Trypanosoma brucei unspecified product 0.0028 0.0163 0.0098
Brugia malayi RNA, U transporter 1 0.0091 0.0923 0.1232
Plasmodium falciparum importin beta, putative 0.0032 0.0216 0.0331
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0224 0.0207
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0114 0.0064
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0326 0.0282
Leishmania major GTP-binding protein, putative 0.0024 0.0114 0.0033
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0114 0.0064
Schistosoma mansoni chromobox protein 0.0079 0.0772 0.0764
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.009 0.5
Echinococcus granulosus importin subunit beta 1 0.0032 0.0216 0.017
Brugia malayi T-complex protein 1, beta subunit 0.0053 0.0463 0.0618
Mycobacterium tuberculosis Conserved protein 0.0041 0.0326 0.0814
Loa Loa (eye worm) latrophilin receptor protein 2 0.0163 0.1779 0.2375
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0326 0.5
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0018 0.0046 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0359 0.0389
Brugia malayi beta-lactamase family protein 0.0041 0.0326 0.0436
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0216 0.017
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Echinococcus multilocularis tumor protein p63 0.0331 0.3797 0.3769
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.009 0.0027
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0051 0.0439 0.0471
Echinococcus granulosus lamin dm0 0.0026 0.0145 0.01
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0399 0.0443
Giardia lamblia TCP-1 chaperonin subunit beta 0.0053 0.0463 0.0983
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0233 0.2619 0.2585
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0312 0.03
Brugia malayi isocitrate dehydrogenase 0.0051 0.0439 0.0586
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Leishmania major C-8 sterol isomerase-like protein 0.036 0.4141 0.5476
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0538 0.0494
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0312 0.03
Trypanosoma brucei C-8 sterol isomerase, putative 0.036 0.4141 0.5476
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0312 0.03
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0338 0.3879 0.385
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0338 0.3879 0.5121
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0163 0.1779 0.1741
Schistosoma mansoni hypothetical protein 0.0849 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0312 0.03
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0538 0.0605
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0053 0.0463 0.0503
Onchocerca volvulus 0.0041 0.0326 0.082
Echinococcus granulosus intermediate filament protein 0.0026 0.0145 0.01
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0312 0.03
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0143 0.0098
Schistosoma mansoni hypothetical protein 0.0163 0.1779 0.1771
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0312 0.0417
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0338 0.3879 0.5121
Onchocerca volvulus 0.0338 0.3879 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Loa Loa (eye worm) hypothetical protein 0.0025 0.0128 0.0171
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0312 0.0303
Brugia malayi MH2 domain containing protein 0.0026 0.0138 0.0184
Echinococcus granulosus tar DNA binding protein 0.0061 0.0568 0.0524
Plasmodium vivax polyprenol reductase, putative 0.0338 0.3879 1
Echinococcus multilocularis lamin dm0 0.0026 0.0145 0.01
Echinococcus granulosus Smad4 0.0026 0.0138 0.0092
Schistosoma mansoni ap endonuclease 0.0022 0.009 0.0081
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0312 0.0326
Onchocerca volvulus 0.0041 0.0326 0.082
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0338 0.3879 1
Loa Loa (eye worm) heterochromatin protein 1 0.0079 0.0772 0.1031
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0216 0.017
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0051 0.0439 0.0394
Echinococcus granulosus cpg binding protein 0.0093 0.0943 0.0901
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0436
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0436
Brugia malayi CHD4 protein 0.0018 0.0046 0.0061
Giardia lamblia Synaptic glycoprotein SC2 0.0338 0.3879 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0436
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0312 0.03
Schistosoma mansoni smad1 5 8 and 0.0026 0.0138 0.0129
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0312 0.03
Brugia malayi MH1 domain containing protein 0.0014 0.0001 0.0002
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.064 0.7488 1
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0053 0.0463 0.0419
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0053 0.0463 0.0454
Echinococcus multilocularis lamin 0.0026 0.0145 0.01
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0326 0.0317
Echinococcus granulosus chromobox protein 1 0.0079 0.0772 0.073
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0093 0.0084
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0233 0.2619 0.2585
Loa Loa (eye worm) T-complex protein 1 0.0053 0.0463 0.0618
Brugia malayi TAR-binding protein 0.0061 0.0568 0.0759
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0138 0.0092
Brugia malayi SET domain containing protein 0.0015 0.0009 0.0012
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0568 0.0524
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0138 0.0092
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0224 0.0207
Plasmodium falciparum polyprenol reductase, putative 0.0338 0.3879 1
Loa Loa (eye worm) beta-lactamase 0.0041 0.0326 0.0436
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0051 0.0439 0.0919
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.3879 0.5134
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0326 0.0345
Leishmania major T-complex protein 1, beta subunit, putative 0.0053 0.0463 0.0503
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0138 0.0092
Loa Loa (eye worm) hypothetical protein 0.0026 0.0145 0.0194
Schistosoma mansoni hypothetical protein 0.0697 0.8175 0.8173
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0114 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Echinococcus multilocularis snurportin 1 0.0342 0.3926 0.3898
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.009 0.0044
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0157 0.0112
Loa Loa (eye worm) hypothetical protein 0.0514 0.5984 0.7991
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0053 0.0463 0.0454
Loa Loa (eye worm) hypothetical protein 0.036 0.4141 0.5531
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.064 0.7488 1
Onchocerca volvulus 0.0048 0.0413 0.1043
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0093 0.0048
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0568 0.056
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0224 0.0207
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.064 0.7488 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0436
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0216 0.017
Schistosoma mansoni intermediate filament proteins 0.0026 0.0145 0.0137
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0326 0.0814
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0157 0.021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0514 0.5984 0.7991
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0312 0.0765
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0326 0.0345
Onchocerca volvulus 0.0035 0.0245 0.0611
Trichomonas vaginalis esterase, putative 0.0041 0.0326 0.0345
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0051 0.0439 0.0471
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0326 0.0319
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0114 0.0059
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0538 0.1543
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0326 0.0345
Brugia malayi hypothetical protein 0.0016 0.0023 0.0031
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0359 0.0905
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0114 0.0059
Mycobacterium tuberculosis Conserved protein 0.0041 0.0326 0.0814
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0326 0.0814
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.009 0.012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0157 0.0112
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0338 0.3879 0.5121
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0772 0.0946
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0153 0.0205
Brugia malayi MH1 domain containing protein 0.0014 0.0001 0.0002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0514 0.5984 0.7991
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0114 0.0064
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.064 0.7488 1
Onchocerca volvulus 0.0026 0.0145 0.0353
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0436
Schistosoma mansoni glutaminase 0.0558 0.6506 0.6503
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0216 0.017
Schistosoma mansoni lamin 0.0026 0.0145 0.0137
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0053 0.0463 0.0454
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0338 0.3879 0.5134
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0326 0.0814
Onchocerca volvulus 0.0088 0.0883 0.2259
Echinococcus multilocularis Smad4 0.0026 0.0138 0.0092
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0128 0.0051
Schistosoma mansoni ran 0.0024 0.0114 0.0106
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0163 0.1779 0.1741
Echinococcus multilocularis chromobox protein 1 0.0079 0.0772 0.073
Schistosoma mansoni lamin 0.0026 0.0145 0.0137
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0224 0.0207
Loa Loa (eye worm) nuclear factor I 0.0014 0.0001 0.0002
Echinococcus multilocularis smad 0.0026 0.0138 0.0092
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0128 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.2619 0.2613
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0342 0.3926 0.5243
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0538 0.0494
Loa Loa (eye worm) Smad1 0.0026 0.0138 0.0184
Echinococcus granulosus dna polymerase kappa 0.004 0.0312 0.0267
Mycobacterium tuberculosis Conserved protein 0.0041 0.0326 0.0814
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0326 0.0345
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.064 0.7488 1
Plasmodium falciparum T-complex protein 1 subunit beta 0.0053 0.0463 0.0983
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0439 0.0471
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0326 0.0319
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.009 0.5
Toxoplasma gondii t-complex protein beta subunit 0.0053 0.0463 0.0503
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0205 0.0182
Loa Loa (eye worm) transcription factor SMAD2 0.0375 0.4321 0.577
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0538 0.0529
Loa Loa (eye worm) CXXC zinc finger family protein 0.0088 0.0883 0.118
Echinococcus multilocularis dnaJ subfamily B 0.0849 1 1
Schistosoma mansoni cpg binding protein 0.0093 0.0943 0.0935
Mycobacterium ulcerans lipase LipD 0.0041 0.0326 0.0319
Brugia malayi MH1 domain containing protein 0.0026 0.0138 0.0184
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0772 0.0946
Schistosoma mansoni hypothetical protein 0.0342 0.3926 0.392
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0186 0.2061 0.2054
Brugia malayi Heterochromatin protein 1 0.0079 0.0772 0.1031
Echinococcus multilocularis dna polymerase kappa 0.004 0.0312 0.0267
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0128 0.01
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0338 0.3879 0.3873
Loa Loa (eye worm) hypothetical protein 0.0026 0.014 0.0187
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0138 0.0184
Brugia malayi hypothetical protein 0.0025 0.0128 0.0171
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0051 0.0439 0.0919
Schistosoma mansoni smad1 5 8 and 0.0026 0.0138 0.0129
Echinococcus multilocularis dna polymerase eta 0.004 0.0312 0.0267
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0326 0.0436
Onchocerca volvulus 0.0041 0.0326 0.082
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0439 0.0471
Brugia malayi MH2 domain containing protein 0.0375 0.4321 0.577
Loa Loa (eye worm) glutaminase 2 0.0558 0.6506 0.8689
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0338 0.3879 0.5121
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0051 0.0439 0.043
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0326 0.0436
Loa Loa (eye worm) hypothetical protein 0.0035 0.0245 0.0328
Schistosoma mansoni ran 0.0024 0.0114 0.0106
Schistosoma mansoni smad1 5 8 and 0.0026 0.0138 0.0129
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0413 0.0404
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0114 0.0153
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0312 0.0765
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0439 0.0471
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0138 0.0129
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0338 0.3879 0.5121
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0312 0.03
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0224 0.0207
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0436
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0338 0.3879 0.385
Trypanosoma cruzi C-8 sterol isomerase, putative 0.036 0.4141 0.5476
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Echinococcus granulosus tumor protein p63 0.0331 0.3797 0.3769
Leishmania major hypothetical protein, conserved 0.0025 0.0128 0.0051
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.064 0.7488 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0114 0.0033
Entamoeba histolytica hypothetical protein 0.0338 0.3879 0.5121
Brugia malayi beta-lactamase family protein 0.0041 0.0326 0.0436
Brugia malayi chromobox protein homolog 3 0.0044 0.0359 0.048
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0138 0.0092
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0312 0.0326
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0143 0.0098
Loa Loa (eye worm) hypothetical protein 0.004 0.0312 0.0417
Leishmania major importin beta-1 subunit, putative 0.0026 0.0143 0.0072
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0163 0.1779 0.1741
Entamoeba histolytica steroid 5-alpha reductase, putative 0.064 0.7488 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0145 0.0194
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0568 0.056
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0538 0.0605
Toxoplasma gondii histone lysine methyltransferase SET1 0.0166 0.1823 0.2343
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0163 0.1779 0.2375
Loa Loa (eye worm) RNA binding protein 0.0061 0.0568 0.0759
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0326 0.0814
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0538 0.0605
Brugia malayi Smad1 0.0026 0.0138 0.0184
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0163 0.0098
Echinococcus granulosus snurportin 1 0.0342 0.3926 0.3898
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0114 0.0033
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0051 0.0439 0.1202
Schistosoma mansoni chromobox protein 0.0079 0.0772 0.0764
Brugia malayi CXXC zinc finger family protein 0.0088 0.0883 0.118
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0439 0.0471
Schistosoma mansoni smad 0.0026 0.0138 0.0129
Loa Loa (eye worm) MH2 domain-containing protein 0.0375 0.4321 0.577
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0312 0.03
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0093 0.0048
Brugia malayi MH1 domain containing protein 0.0026 0.0138 0.0184
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0568 0.0759
Trichomonas vaginalis ran, putative 0.0024 0.0114 0.0059
Brugia malayi MH2 domain containing protein 0.0026 0.0138 0.0184
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0053 0.0463 0.0503
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0093 0.0048
Echinococcus multilocularis musashi 0.0026 0.0145 0.01
Trichomonas vaginalis glutaminase, putative 0.0558 0.6506 0.8677
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0145 0.0194

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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