Detailed information for compound 1026455

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 418.506 | Formula: C25H27FN4O
  • H donors: 1 H acceptors: 2 LogP: 4.33 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)C(=O)Nc1ccnc(c1)N1CCC(CC1)N(Cc1ccccc1)C
  • InChi: 1S/C25H27FN4O/c1-29(18-19-6-3-2-4-7-19)23-11-14-30(15-12-23)24-17-22(10-13-27-24)28-25(31)20-8-5-9-21(26)16-20/h2-10,13,16-17,23H,11-12,14-15,18H2,1H3,(H,27,28,31)
  • InChiKey: RZGYRTOVNBTZMJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.064 0.7488 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0093 0.0048
Onchocerca volvulus 0.0048 0.0413 0.1043
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0053 0.0463 0.0454
Loa Loa (eye worm) hypothetical protein 0.036 0.4141 0.5531
Loa Loa (eye worm) hypothetical protein 0.0514 0.5984 0.7991
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0157 0.0112
Echinococcus multilocularis snurportin 1 0.0342 0.3926 0.3898
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.009 0.0044
Loa Loa (eye worm) hypothetical protein 0.0026 0.0145 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Schistosoma mansoni hypothetical protein 0.0697 0.8175 0.8173
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0114 0.0033
Loa Loa (eye worm) beta-lactamase 0.0041 0.0326 0.0436
Plasmodium falciparum polyprenol reductase, putative 0.0338 0.3879 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0224 0.0207
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0138 0.0092
Leishmania major T-complex protein 1, beta subunit, putative 0.0053 0.0463 0.0503
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0051 0.0439 0.0919
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0326 0.0345
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.3879 0.5134
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0138 0.0092
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0568 0.0524
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0138 0.0092
Brugia malayi TAR-binding protein 0.0061 0.0568 0.0759
Brugia malayi SET domain containing protein 0.0015 0.0009 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0233 0.2619 0.2585
Loa Loa (eye worm) T-complex protein 1 0.0053 0.0463 0.0618
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0093 0.0084
Echinococcus multilocularis lamin 0.0026 0.0145 0.01
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0053 0.0463 0.0454
Echinococcus granulosus chromobox protein 1 0.0079 0.0772 0.073
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0326 0.0317
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0312 0.03
Schistosoma mansoni smad1 5 8 and 0.0026 0.0138 0.0129
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0053 0.0463 0.0419
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.064 0.7488 1
Brugia malayi MH1 domain containing protein 0.0014 0.0001 0.0002
Giardia lamblia Synaptic glycoprotein SC2 0.0338 0.3879 1
Brugia malayi CHD4 protein 0.0018 0.0046 0.0061
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0312 0.03
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0436
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0436
Echinococcus multilocularis smad 0.0026 0.0138 0.0092
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0128 0.0051
Loa Loa (eye worm) nuclear factor I 0.0014 0.0001 0.0002
Schistosoma mansoni lamin 0.0026 0.0145 0.0137
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0163 0.1779 0.1741
Echinococcus multilocularis chromobox protein 1 0.0079 0.0772 0.073
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0224 0.0207
Echinococcus multilocularis Smad4 0.0026 0.0138 0.0092
Schistosoma mansoni ran 0.0024 0.0114 0.0106
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0128 0.0051
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0338 0.3879 0.5134
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0326 0.0814
Onchocerca volvulus 0.0088 0.0883 0.2259
Schistosoma mansoni glutaminase 0.0558 0.6506 0.6503
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0436
Onchocerca volvulus 0.0026 0.0145 0.0353
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0053 0.0463 0.0454
Schistosoma mansoni lamin 0.0026 0.0145 0.0137
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0216 0.017
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0514 0.5984 0.7991
Brugia malayi MH1 domain containing protein 0.0014 0.0001 0.0002
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0114 0.0064
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.064 0.7488 1
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0338 0.3879 0.5121
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0157 0.0112
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.009 0.012
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0153 0.0205
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0772 0.0946
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Mycobacterium tuberculosis Conserved protein 0.0041 0.0326 0.0814
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0326 0.0814
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0359 0.0905
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0114 0.0059
Brugia malayi hypothetical protein 0.0016 0.0023 0.0031
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0538 0.1543
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0326 0.0345
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0114 0.0059
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0326 0.0319
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0051 0.0439 0.0471
Onchocerca volvulus 0.0035 0.0245 0.0611
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0326 0.0345
Trichomonas vaginalis esterase, putative 0.0041 0.0326 0.0345
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0157 0.021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0514 0.5984 0.7991
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0312 0.0765
Schistosoma mansoni intermediate filament proteins 0.0026 0.0145 0.0137
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0326 0.0814
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0224 0.0207
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0568 0.056
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0436
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.064 0.7488 1
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0216 0.017
Trypanosoma cruzi C-8 sterol isomerase, putative 0.036 0.4141 0.5476
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0224 0.0207
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0338 0.3879 0.385
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0436
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.064 0.7488 1
Echinococcus granulosus tumor protein p63 0.0331 0.3797 0.3769
Leishmania major hypothetical protein, conserved 0.0025 0.0128 0.0051
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0312 0.0765
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0439 0.0471
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0138 0.0129
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0312 0.03
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0338 0.3879 0.5121
Schistosoma mansoni smad1 5 8 and 0.0026 0.0138 0.0129
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0114 0.0153
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0413 0.0404
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0051 0.0439 0.043
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Schistosoma mansoni ran 0.0024 0.0114 0.0106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0245 0.0328
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0326 0.0436
Brugia malayi MH2 domain containing protein 0.0375 0.4321 0.577
Loa Loa (eye worm) glutaminase 2 0.0558 0.6506 0.8689
Onchocerca volvulus 0.0041 0.0326 0.082
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0326 0.0436
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0439 0.0471
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0338 0.3879 0.5121
Schistosoma mansoni smad1 5 8 and 0.0026 0.0138 0.0129
Echinococcus multilocularis dna polymerase eta 0.004 0.0312 0.0267
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0051 0.0439 0.0919
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0338 0.3879 0.3873
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0138 0.0184
Loa Loa (eye worm) hypothetical protein 0.0026 0.014 0.0187
Brugia malayi hypothetical protein 0.0025 0.0128 0.0171
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0186 0.2061 0.2054
Brugia malayi Heterochromatin protein 1 0.0079 0.0772 0.1031
Echinococcus multilocularis dna polymerase kappa 0.004 0.0312 0.0267
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0128 0.01
Brugia malayi MH1 domain containing protein 0.0026 0.0138 0.0184
Mycobacterium ulcerans lipase LipD 0.0041 0.0326 0.0319
Echinococcus multilocularis dnaJ subfamily B 0.0849 1 1
Schistosoma mansoni cpg binding protein 0.0093 0.0943 0.0935
Schistosoma mansoni hypothetical protein 0.0342 0.3926 0.392
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0772 0.0946
Loa Loa (eye worm) transcription factor SMAD2 0.0375 0.4321 0.577
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0205 0.0182
Loa Loa (eye worm) CXXC zinc finger family protein 0.0088 0.0883 0.118
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0538 0.0529
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0439 0.0471
Toxoplasma gondii t-complex protein beta subunit 0.0053 0.0463 0.0503
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0326 0.0319
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.009 0.5
Plasmodium falciparum T-complex protein 1 subunit beta 0.0053 0.0463 0.0983
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.064 0.7488 1
Echinococcus granulosus dna polymerase kappa 0.004 0.0312 0.0267
Loa Loa (eye worm) Smad1 0.0026 0.0138 0.0184
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0326 0.0345
Mycobacterium tuberculosis Conserved protein 0.0041 0.0326 0.0814
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0342 0.3926 0.5243
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0538 0.0494
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.2619 0.2613
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0145 0.0194
Trichomonas vaginalis glutaminase, putative 0.0558 0.6506 0.8677
Echinococcus multilocularis musashi 0.0026 0.0145 0.01
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0093 0.0048
Trichomonas vaginalis ran, putative 0.0024 0.0114 0.0059
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0053 0.0463 0.0503
Brugia malayi MH2 domain containing protein 0.0026 0.0138 0.0184
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0093 0.0048
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0568 0.0759
Brugia malayi MH1 domain containing protein 0.0026 0.0138 0.0184
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0312 0.03
Schistosoma mansoni chromobox protein 0.0079 0.0772 0.0764
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0439 0.0471
Brugia malayi CXXC zinc finger family protein 0.0088 0.0883 0.118
Loa Loa (eye worm) MH2 domain-containing protein 0.0375 0.4321 0.577
Schistosoma mansoni smad 0.0026 0.0138 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0163 0.0098
Echinococcus granulosus snurportin 1 0.0342 0.3926 0.3898
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0114 0.0033
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0051 0.0439 0.1202
Brugia malayi Smad1 0.0026 0.0138 0.0184
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0538 0.0605
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0326 0.0814
Loa Loa (eye worm) RNA binding protein 0.0061 0.0568 0.0759
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0163 0.1779 0.2375
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0538 0.0605
Toxoplasma gondii histone lysine methyltransferase SET1 0.0166 0.1823 0.2343
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0145 0.0194
Entamoeba histolytica steroid 5-alpha reductase, putative 0.064 0.7488 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0163 0.1779 0.1741
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0568 0.056
Loa Loa (eye worm) hypothetical protein 0.004 0.0312 0.0417
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0143 0.0098
Leishmania major importin beta-1 subunit, putative 0.0026 0.0143 0.0072
Brugia malayi chromobox protein homolog 3 0.0044 0.0359 0.048
Brugia malayi beta-lactamase family protein 0.0041 0.0326 0.0436
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0312 0.0326
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0138 0.0092
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0114 0.0033
Entamoeba histolytica hypothetical protein 0.0338 0.3879 0.5121
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0359 0.0389
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0128 0.01
Brugia malayi latrophilin 2 splice variant baaae 0.0351 0.4037 0.5392
Echinococcus granulosus smad 0.0026 0.0138 0.0092
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0326 0.0282
Echinococcus granulosus dna polymerase eta 0.004 0.0312 0.0267
Schistosoma mansoni ap endonuclease 0.0022 0.009 0.0081
Loa Loa (eye worm) hypothetical protein 0.0163 0.1779 0.2375
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0114 0.0069
Schistosoma mansoni importin beta-1 0.0032 0.0216 0.0207
Leishmania major DNA polymerase kappa, putative 0.004 0.0312 0.03
Entamoeba histolytica Ran family GTPase 0.0024 0.0114 0.0033
Loa Loa (eye worm) hypothetical protein 0.0048 0.0413 0.0551
Mycobacterium ulcerans beta-lactamase 0.0041 0.0326 0.0319
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0399 0.1008
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0568 0.056
Schistosoma mansoni DNA polymerase eta 0.004 0.0312 0.0303
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.064 0.7488 1
Schistosoma mansoni cpg binding protein 0.0093 0.0943 0.0935
Echinococcus granulosus lamin 0.0026 0.0145 0.01
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0326 0.0345
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0138 0.0184
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0233 0.2619 0.3498
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0224 0.0207
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0326 0.0319
Brugia malayi RNA binding protein 0.0061 0.0568 0.0759
Echinococcus multilocularis cpg binding protein 0.0093 0.0943 0.0901
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0312 0.03
Brugia malayi Isocitrate dehydrogenase 0.0051 0.0439 0.0586
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0326 0.0814
Brugia malayi Importin beta-1 subunit 0.0032 0.0216 0.0288
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0233 0.2619 0.2585
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0568 0.056
Schistosoma mansoni hypothetical protein 0.0163 0.1779 0.1771
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0205 0.0182
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0114 0.0033
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0233 0.2619 0.3498
Entamoeba histolytica hypothetical protein 0.0026 0.0143 0.0072
Brugia malayi beta-lactamase 0.0041 0.0326 0.0436
Giardia lamblia DINP protein human, muc B family 0.004 0.0312 0.0585
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0568 0.0759
Mycobacterium ulcerans hypothetical protein 0.0041 0.0326 0.0319
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0163 0.0098
Loa Loa (eye worm) CHromoDomain protein family member 0.0018 0.0046 0.0061
Mycobacterium ulcerans glutaminase 0.0558 0.6506 0.8673
Schistosoma mansoni cpg binding protein 0.0088 0.0883 0.0875
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0312 0.03
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0326 0.0319
Echinococcus multilocularis geminin 0.0697 0.8175 0.8166
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0326 0.0623
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.3879 0.5134
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0053 0.0463 0.0503
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0145 0.0194
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.064 0.7488 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0538 0.0605
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0128 0.01
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0312 0.0417
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0312 0.0267
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0338 0.3879 0.3873
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.064 0.7488 1
Loa Loa (eye worm) hypothetical protein 0.064 0.7488 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0128 0.0051
Brugia malayi Synaptic glycoprotein SC2 0.0338 0.3879 0.518
Echinococcus granulosus GPCR family 2 0.0163 0.1779 0.1741
Loa Loa (eye worm) hypothetical protein 0.0044 0.0359 0.048
Mycobacterium ulcerans hypothetical protein 0.064 0.7488 1
Plasmodium vivax importin-beta 2, putative 0.0032 0.0216 0.0331
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0224 0.0207
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0143 0.0072
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0326 0.0317
Toxoplasma gondii ABC1 family protein 0.0041 0.0326 0.0319
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0312 0.03
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0163 0.1779 0.1741
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0399 0.0443
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0538 0.0529
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0338 0.3879 0.5134
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0326 0.0319
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0338 0.3879 0.5134
Loa Loa (eye worm) glutaminase 0.0558 0.6506 0.8689
Leishmania major DNA polymerase eta, putative 0.004 0.0312 0.03
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0143 0.0098
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0568 0.0759
Onchocerca volvulus 0.0026 0.0145 0.0353
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0326 0.0814
Brugia malayi Calcitonin receptor-like protein seb-1 0.0514 0.5984 0.7991
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0312 0.0303
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0233 0.2619 0.2585
Echinococcus granulosus synaptic glycoprotein sc2 0.0338 0.3879 0.385
Loa Loa (eye worm) hypothetical protein 0.0032 0.0216 0.0288
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0568 0.056
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0439 0.0471
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.009 0.012
Schistosoma mansoni hypothetical protein 0.0351 0.4037 0.4032
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0128 0.0051
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.009 0.0044
Trypanosoma brucei unspecified product 0.0028 0.0163 0.0098
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0093 0.0048
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0053 0.0463 0.0419
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0439 0.0394
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0538 0.0605
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0114 0.0069
Brugia malayi ERG2 and Sigma1 receptor like protein 0.036 0.4141 0.5531
Schistosoma mansoni hypothetical protein 0.0163 0.1779 0.1771
Leishmania major hypothetical protein, conserved 0.0041 0.0326 0.0319
Brugia malayi Latrophilin receptor protein 2 0.0163 0.1779 0.2375
Loa Loa (eye worm) isocitrate dehydrogenase 0.0051 0.0439 0.0586
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0439 0.0394
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0312 0.0417
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0326 0.0814
Loa Loa (eye worm) hypothetical protein 0.0338 0.3879 0.518
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0338 0.3879 0.5121
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0018 0.0046 0.0037
Brugia malayi beta-lactamase family protein 0.0041 0.0326 0.0436
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0359 0.0389
Loa Loa (eye worm) latrophilin receptor protein 2 0.0163 0.1779 0.2375
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0326 0.5
Mycobacterium tuberculosis Conserved protein 0.0041 0.0326 0.0814
Brugia malayi T-complex protein 1, beta subunit 0.0053 0.0463 0.0618
Echinococcus granulosus importin subunit beta 1 0.0032 0.0216 0.017
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0114 0.0064
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.009 0.5
Schistosoma mansoni chromobox protein 0.0079 0.0772 0.0764
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0326 0.0282
Leishmania major GTP-binding protein, putative 0.0024 0.0114 0.0033
Brugia malayi RNA, U transporter 1 0.0091 0.0923 0.1232
Trypanosoma brucei unspecified product 0.0028 0.0163 0.0098
Plasmodium falciparum importin beta, putative 0.0032 0.0216 0.0331
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0114 0.0064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0224 0.0207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0224 0.0207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0096 0.0035
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0312 0.03
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.009 0.0027
Loa Loa (eye worm) hypothetical protein 0.0351 0.4037 0.5392
Brugia malayi glutaminase DH11.1 0.0558 0.6506 0.8689
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0264 0.2988 1
Brugia malayi T-complex protein 1, beta subunit 0.0053 0.0463 0.0618
Schistosoma mansoni hypothetical protein 0.0163 0.1779 0.1771
Loa Loa (eye worm) hypothetical protein 0.0184 0.2035 0.2717
Schistosoma mansoni Smad4 0.0026 0.0138 0.0129
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0338 0.3879 1
Schistosoma mansoni hypothetical protein 0.0697 0.8175 0.8173
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0312 0.0267
Echinococcus granulosus geminin 0.0697 0.8175 0.8166
Echinococcus multilocularis GPCR, family 2 0.0163 0.1779 0.1741
Echinococcus multilocularis synaptic glycoprotein sc2 0.0338 0.3879 0.385
Trichomonas vaginalis chaperonin, putative 0.0053 0.0463 0.0529
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0439 0.0394
Trypanosoma brucei unspecified product 0.004 0.0312 0.03
Loa Loa (eye worm) hypothetical protein 0.0338 0.3879 0.518
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.2619 0.2613
Echinococcus multilocularis isocitrate dehydrogenase 0.0051 0.0439 0.0394
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0051 0.0439 0.0394
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0114 0.0153
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.2619 0.2613
Echinococcus granulosus chromobox protein 1 0.0079 0.0772 0.073
Echinococcus multilocularis chromobox protein 1 0.0079 0.0772 0.073
Mycobacterium leprae Probable lipase LipE 0.0041 0.0326 0.5
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0053 0.0463 0.0983
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0163 0.0098
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0053 0.0463 0.0529
Brugia malayi intermediate filament protein 0.0026 0.0145 0.0194
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0338 0.3879 0.5134
Echinococcus granulosus cpg binding protein 0.0093 0.0943 0.0901
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0436
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0051 0.0439 0.0394
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0216 0.017
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0338 0.3879 1
Onchocerca volvulus 0.0041 0.0326 0.082
Loa Loa (eye worm) heterochromatin protein 1 0.0079 0.0772 0.1031
Schistosoma mansoni ap endonuclease 0.0022 0.009 0.0081
Echinococcus granulosus Smad4 0.0026 0.0138 0.0092
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0312 0.0326
Plasmodium vivax polyprenol reductase, putative 0.0338 0.3879 1
Echinococcus multilocularis lamin dm0 0.0026 0.0145 0.01
Loa Loa (eye worm) hypothetical protein 0.0025 0.0128 0.0171
Echinococcus granulosus tar DNA binding protein 0.0061 0.0568 0.0524
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0312 0.0303
Brugia malayi MH2 domain containing protein 0.0026 0.0138 0.0184
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Onchocerca volvulus 0.0338 0.3879 1
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0312 0.0417
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0338 0.3879 0.5121
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0312 0.03
Schistosoma mansoni hypothetical protein 0.0163 0.1779 0.1771
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0143 0.0098
Onchocerca volvulus 0.0041 0.0326 0.082
Echinococcus granulosus intermediate filament protein 0.0026 0.0145 0.01
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0538 0.0605
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0053 0.0463 0.0503
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0312 0.03
Trypanosoma brucei C-8 sterol isomerase, putative 0.036 0.4141 0.5476
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0312 0.03
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0338 0.3879 0.5121
Schistosoma mansoni hypothetical protein 0.0849 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0163 0.1779 0.1741
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0312 0.03
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0338 0.3879 0.385
Leishmania major C-8 sterol isomerase-like protein 0.036 0.4141 0.5476
Brugia malayi isocitrate dehydrogenase 0.0051 0.0439 0.0586
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0538 0.0494
Giardia lamblia TCP-1 chaperonin subunit beta 0.0053 0.0463 0.0983
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0399 0.0443
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0233 0.2619 0.2585
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0312 0.03
Echinococcus granulosus lamin dm0 0.0026 0.0145 0.01
Echinococcus multilocularis tumor protein p63 0.0331 0.3797 0.3769
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0051 0.0439 0.0471
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.009 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0312 0.03
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0216 0.017

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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