Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0045 | 0.6045 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.6045 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0045 | 0.6045 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0018 | 0.0479 | 0.0792 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0064 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0045 | 0.6045 | 0.5 |
Loa Loa (eye worm) | doublecortin family protein | 0.0023 | 0.1456 | 0.3857 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0023 | 0.1456 | 0.1456 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.6045 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.6045 | 1 |
Echinococcus multilocularis | RUN | 0.0023 | 0.1456 | 0.1456 |
Echinococcus multilocularis | dna polymerase kappa | 0.0045 | 0.6045 | 0.6045 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0023 | 0.1456 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1456 | 0.3857 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0023 | 0.1456 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.6045 | 1 |
Onchocerca volvulus | 0.0023 | 0.1456 | 0.5 | |
Mycobacterium ulcerans | DNA polymerase IV | 0.0045 | 0.6045 | 0.5 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0023 | 0.1456 | 0.1456 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0.15 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0016 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.15 | 0.2481 |
Brugia malayi | hypothetical protein | 0.0023 | 0.1456 | 0.3857 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0023 | 0.1456 | 0.1456 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0045 | 0.6045 | 0.5 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0023 | 0.1456 | 0.1456 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0045 | 0.6045 | 1 |
Brugia malayi | hypothetical protein | 0.0023 | 0.1456 | 0.3857 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.6045 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0045 | 0.6045 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0045 | 0.6045 | 1 |
Schistosoma mansoni | loxhd1 | 0.0023 | 0.1456 | 0.1456 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0.15 | 1 |
Echinococcus granulosus | RUN | 0.0023 | 0.1456 | 0.1456 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0034 | 0.3776 | 0.6246 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.15 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.1456 | 0.1456 |
Schistosoma mansoni | polycystin 1-related | 0.0023 | 0.1456 | 0.1456 |
Trypanosoma brucei | unspecified product | 0.0038 | 0.4545 | 0.7519 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.6045 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0045 | 0.6045 | 0.6045 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0038 | 0.4545 | 0.7519 |
Brugia malayi | polk-prov protein | 0.0034 | 0.3776 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0023 | 0.1456 | 0.1456 |
Brugia malayi | Doublecortin family protein | 0.0023 | 0.1456 | 0.3857 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.15 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.6045 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3776 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0064 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0018 | 0.0479 | 0.0792 |
Schistosoma mansoni | rab6-interacting | 0.0023 | 0.1456 | 0.1456 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1456 | 0.3857 |
Schistosoma mansoni | rab6-interacting | 0.0023 | 0.1456 | 0.1456 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0018 | 0.0479 | 0.0792 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0045 | 0.6045 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.6045 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0023 | 0.1456 | 0.1456 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0023 | 0.1456 | 0.1456 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0045 | 0.6045 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0045 | 0.6045 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0034 | 0.3776 | 0.6246 |
Onchocerca volvulus | 0.0023 | 0.1456 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.03 ug ml-1 | In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 6538 | ChEMBL. | 9873483 |
MIC (functional) | = 0.03 ug ml-1 | In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 25923 | ChEMBL. | 9873483 |
MIC (functional) | = 0.03 ug ml-1 | In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 29213 | ChEMBL. | 9873483 |
MIC (functional) | = 0.03 ug ml-1 | In vitro inhibitory activity in iso sensitest agar against Staphylococcus hyicus strain ATCC 9621 | ChEMBL. | 9873483 |
MIC (functional) | = 0.03 ug ml-1 | In vitro inhibitory activity in iso sensitest agar against Staphylococcus hyicus strain ATCC 9622 | ChEMBL. | 9873483 |
MIC (functional) | = 0.5 ug ml-1 | In vitro inhibitory activity in iso sensitest agar against Staphylococcus intermedius strain ATCC 9503 | ChEMBL. | 9873483 |
MIC (functional) | = 2 ug ml-1 | In vitro inhibitory activity in iso sensitest agar against Staphylococcus intermedius strain ATCC 29663 | ChEMBL. | 9873483 |
MIC (functional) | = 16 ug ml-1 | In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 25923 in addition with 5%serum | ChEMBL. | 9873483 |
MIC (functional) | = 16 ug ml-1 | In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 29213 in addition with 5%serum | ChEMBL. | 9873483 |
MIC (functional) | = 16 ug ml-1 | In vitro inhibitory activity in iso sensitest agar against Staphylococcus intermedius strain ATCC 29663 in addition with 5%serum | ChEMBL. | 9873483 |
MIC (functional) | = 32 ug ml-1 | In vitro inhibitory activity in iso sensitest agar against Staphylococcus intermedius strain ATCC 9503 in addition with 5%serum | ChEMBL. | 9873483 |
MIC (functional) | > 64 ug ml-1 | In vitro inhibitory activity in iso sensitest agar against Staphylococcus aureus strain ATCC 6538 in addition with 5%serum | ChEMBL. | 9873483 |
MIC (functional) | > 64 ug ml-1 | In vitro inhibitory activity in iso sensitest agar against Staphylococcus hyicus strain ATCC 9621 in addition with 5%serum | ChEMBL. | 9873483 |
MIC (functional) | > 64 ug ml-1 | In vitro inhibitory activity in iso sensitest agar against Staphylococcus hyicus strain ATCC 9622 in addition with 5%serum | ChEMBL. | 9873483 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.