Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 0.4699 | 0.4699 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0017 | 0.0015 | 0.0015 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0032 | 0.0658 | 0.0658 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0032 | 0.0658 | 0.0658 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1064 | 0.1064 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.1478 | 0.2171 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0032 | 0.0658 | 0.0658 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0923 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0032 | 0.0658 | 0.0658 |
Brugia malayi | ecdysteroid receptor | 0.0032 | 0.0658 | 0.0658 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0032 | 0.0658 | 0.0658 |
Onchocerca volvulus | 0.0051 | 0.1478 | 1 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.2043 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0658 | 0.0658 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0032 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0032 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1276 | 0.1276 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0127 | 0.4726 | 0.4726 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.1478 | 0.1478 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0032 | 0.0658 | 0.0658 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0249 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 0.4699 | 0.4699 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0032 | 0.0658 | 0.0966 |
Brugia malayi | nuclear receptor RXR | 0.0017 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.4083 | 0.4083 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0032 | 0.0658 | 0.0658 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0017 | 0.0015 | 0.0015 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.2043 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0782 | 0.0782 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1064 | 0.1064 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0032 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0782 | 0.0782 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.057 | 0.057 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0923 | 0.1356 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.6808 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0032 | 0.0658 | 0.0658 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0032 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1276 | 0.1276 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0017 | 0.0015 | 0.0015 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.2043 | 0.3002 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0032 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1064 | 0.1064 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.057 | 0.057 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.2043 | 0.2043 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.057 | 0.057 |
Trichomonas vaginalis | cation chloride cotransporter, putative | 0.0016 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0032 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0032 | 0.0658 | 0.0658 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.2043 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0126 | 0.4699 | 0.4699 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0032 | 0.0658 | 0.0658 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0032 | 0.0658 | 0.0966 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0032 | 0.0658 | 0.0966 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0032 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0032 | 0.0658 | 0.0658 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0032 | 0.0658 | 0.0658 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.6808 | 1 |
Echinococcus granulosus | geminin | 0.0175 | 0.6808 | 0.6808 |
Echinococcus multilocularis | geminin | 0.0175 | 0.6808 | 0.6808 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0127 | 0.4726 | 0.4726 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.2043 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0032 | 0.0658 | 0.0658 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0017 | 0.0015 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0015 | 0.0015 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0032 | 0.0658 | 0.0966 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0032 | 0.0658 | 0.0658 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0032 | 0.0658 | 0.0658 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0016 | 0 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.2043 | 0.5 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0015 | 0.0015 |
Schistosoma mansoni | solute carrier family 12 electroneutral k-cl cotransporter | 0.0046 | 0.1276 | 0.1874 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0016 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | solute carrier family 12 | 0.0046 | 0.1276 | 0.1276 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0782 | 0.0782 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0015 | 0.0015 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0032 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0015 | 0.0015 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0032 | 0.0658 | 0.0966 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0658 | 0.0658 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.011 | 0.4006 | 0.4006 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.2043 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.057 | 0.057 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0032 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1276 | 0.1276 |
Loa Loa (eye worm) | amino acid permease | 0.0035 | 0.0782 | 0.0782 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0923 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0923 | 0.1356 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0032 | 0.0658 | 0.0966 |
Schistosoma mansoni | thyroid hormone receptor | 0.0032 | 0.0658 | 0.0966 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0017 | 0.0015 | 0.0015 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0032 | 0.0658 | 0.0658 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1478 | 0.2171 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0032 | 0.0658 | 0.0966 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0032 | 0.0658 | 0.0658 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0017 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0032 | 0.0658 | 0.0658 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0923 | 0.0923 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0032 | 0.0658 | 0.0658 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0032 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0658 | 0.0658 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0032 | 0.0658 | 0.0658 |
Echinococcus granulosus | FTZ F1 alpha | 0.0032 | 0.0658 | 0.0658 |
Schistosoma mansoni | nuclear hormone receptor | 0.0032 | 0.0658 | 0.0966 |
Brugia malayi | nuclear receptor NHR-88 | 0.0032 | 0.0658 | 0.0658 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0032 | 0.0658 | 0.0658 |
Schistosoma mansoni | coup transcription factor | 0.0032 | 0.0658 | 0.0966 |
Brugia malayi | nuclear hormone receptor | 0.0032 | 0.0658 | 0.0658 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0016 | 0 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0032 | 0.0658 | 0.0658 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0923 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0015 | 0.0015 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0016 | 0 | 0.5 |
Brugia malayi | Amino acid permease family protein | 0.0046 | 0.1276 | 0.1276 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0032 | 0.0658 | 0.0966 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0017 | 0.0015 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0658 | 0.0658 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0249 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0032 | 0.0658 | 0.0658 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.2043 | 0.3002 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0032 | 0.0658 | 0.0658 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.2043 | 0.2043 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0923 | 0.5 |
Trichomonas vaginalis | cation chloride cotransporter, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0782 | 0.0782 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0032 | 0.0658 | 0.0658 |
Schistosoma mansoni | thyroid hormone receptor | 0.0032 | 0.0658 | 0.0966 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0032 | 0.0658 | 0.0658 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0032 | 0.0658 | 0.0966 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0032 | 0.0658 | 0.0658 |
Brugia malayi | Hypothetical 112.3 kDa protein K02A2.3 in chromosome II | 0.0046 | 0.1276 | 0.1276 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0032 | 0.0658 | 0.0658 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0127 | 0.4726 | 0.4726 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0032 | 0.0658 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0015 | 0.0015 |
Echinococcus multilocularis | solute carrier family 12 | 0.0046 | 0.1276 | 0.1276 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.