TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 415.256 | Formula: C20H16BrFN2O2
H donors: 2 H acceptors: 2 LogP: 4.6 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc(c(c1)CN(c1ccccc1F)C(=O)Nc1ccccc1)O
InChi: 1S/C20H16BrFN2O2/c21-15-10-11-19(25)14(12-15)13-24(18-9-5-4-8-17(18)22)20(26)23-16-6-2-1-3-7-16/h1-12,25H,13H2,(H,23,26)
InChiKey: IVPSFAAKNGILAC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	3-oxoacyl-[acyl-carrier-protein] synthase III	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Chlamydia trachomatis	oxoacyl-ACP synthase III	Get druggable targets OG5_129509	All targets in OG5_129509
Mycobacterium tuberculosis	3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III)	Get druggable targets OG5_129509	All targets in OG5_129509
Plasmodium knowlesi	beta-ketoacyl-acyl carrier protein synthase III precursor, putative	Get druggable targets OG5_129509	All targets in OG5_129509
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	Get druggable targets OG5_129509	All targets in OG5_129509
Plasmodium vivax	beta-ketoacyl-acyl carrier protein synthase III precursor, putative	Get druggable targets OG5_129509	All targets in OG5_129509
Neospora caninum	3-oxoacyl-(acyl-carrier-protein) synthase III family protein, putative	Get druggable targets OG5_129509	All targets in OG5_129509
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	Get druggable targets OG5_129509	All targets in OG5_129509
Mycobacterium ulcerans	beta-ketoacyl synthase-like protein	Get druggable targets OG5_129509	All targets in OG5_129509
Plasmodium falciparum	beta-ketoacyl-ACP synthase III	Get druggable targets OG5_129509	All targets in OG5_129509
Wolbachia endosymbiont of Brugia malayi	3-oxoacyl-ACP synthase	Get druggable targets OG5_129509	All targets in OG5_129509
Plasmodium berghei	apicoplast beta-ketoacyl-acyl carrier protein synthase III precursor, putative	Get druggable targets OG5_129509	All targets in OG5_129509

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Conserved hypothetical protein	3-oxoacyl-[acyl-carrier-protein] synthase III	317 aa	265 aa	26.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.02	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0549	0.3211
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0042	0.0402	0.0473
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.001	0.0027	0.0157
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0067	0.0079
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0402	0.7451
Schistosoma mansoni	nuclear receptor	0.001	0.0027	0.0032
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0402	0.7451
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0163	0.0192
Leishmania major	DNA polymerase kappa, putative	0.0013	0.0059	0.0886
Leishmania major	DNA damage repair protein, putative	0.0013	0.0059	0.0886
Loa Loa (eye worm)	hypothetical protein	0.0025	0.02	0.117
Echinococcus multilocularis	expressed conserved protein	0.0098	0.1056	0.1056
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0126	0.0734
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.02	0.117
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.004	0.0376	0.6963
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0668	0.1399
Plasmodium falciparum	histone acetyltransferase GCN5	0.0041	0.0392	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0163	0.0954
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0126	0.0734
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.02	0.0324
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.001	0.0027	0.0032
Leishmania major	DNA polymerase eta, putative	0.0013	0.0059	0.0886
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0376	0.0443
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0042	0.0402	0.0402
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0402	0.7451
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.02	0.117
Brugia malayi	ImpB/MucB/SamB family protein	0.0042	0.0402	0.2349
Brugia malayi	tailless protein	0.001	0.0027	0.0157
Loa Loa (eye worm)	Smad1	0.0009	0.0007	0.0043
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0402	0.7451
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0241	0.1407
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0539	0.0635
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0059	0.1098
Echinococcus multilocularis	sterol regulatory element binding protein	0.0045	0.0431	0.0431
Entamoeba histolytica	fatty acid elongase, putative	0.005	0.049	0.4337
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0163	0.0954
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.02	0.177
Schistosoma mansoni	hypothetical protein	0.0043	0.0412	0.0485
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0163	0.0192
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0163	0.0192
Trypanosoma brucei	chrX additional, unordered contigs	0.0013	0.0059	0.1098
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0059	0.1098
Brugia malayi	nuclear receptor RXR	0.001	0.0027	0.0157
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0065	0.0668	0.0787
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0163	0.0954
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.004	0.0376	0.3321
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.0163	0.0954
Echinococcus granulosus	geminin	0.0179	0.2015	0.2371
Trypanosoma brucei	hypothetical protein, conserved	0.0013	0.0059	0.1098
Brugia malayi	MAP kinase sur-1	0.0054	0.0539	0.3153
Loa Loa (eye worm)	hypothetical protein	0.001	0.0027	0.0157
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0402	0.7451
Brugia malayi	nuclear hormone receptor	0.0022	0.0163	0.0954
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.02	0.177
Entamoeba histolytica	acetyltransferase, GNAT family	0.0041	0.0392	0.3465
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0054	0.0539	1
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0389	0.5817
Plasmodium vivax	beta-ketoacyl-acyl carrier protein synthase III precursor, putative	0.0383	0.4412	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0668	0.1399
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0037	0.0338	1
Schistosoma mansoni	hypothetical protein	0.0179	0.2015	0.2371
Echinococcus granulosus	neuropeptide s receptor	0.0476	0.5507	0.6482
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0241	0.1407
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0061	0.0356
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0163	0.0192
Trypanosoma brucei	unspecified product	0.0029	0.0248	0.4592
Leishmania major	pantothenate kinase subunit, putative	0.0009	0.0012	0.018
Schistosoma mansoni	nuclear receptor nhr-48	0.001	0.0027	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0163	0.0954
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0539	1
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0007	0.0009
Leishmania major	DNA polymerase eta, putative	0.0042	0.0402	0.6014
Mycobacterium ulcerans	DNA polymerase IV	0.0042	0.0402	0.0787
Trypanosoma cruzi	hypothetical protein, conserved	0.0013	0.0059	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0163	0.0954
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0041	0.0389	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0163	0.0954
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0163	0.0954
Brugia malayi	hypothetical protein	0.004	0.0376	0.2199
Schistosoma mansoni	DNA polymerase IV / kappa	0.0013	0.0059	0.007
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.004	0.0376	0.6963
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1131	0.6609
Loa Loa (eye worm)	hypothetical protein	0.001	0.0027	0.0157
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0149	0.166	0.1954
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0376	0.0376
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0126	0.0285
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0402	0.7451
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.02	0.0324
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0013	0.0059	0.0886
Trypanosoma brucei	DNA damage repair protein, putative	0.0013	0.0059	0.1098
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0041	0.0389	0.3438
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.0163	0.0954
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.0163	0.0954
Brugia malayi	nuclear hormone receptor family member nhr-6	0.001	0.0027	0.0157
Echinococcus granulosus	sterol regulatory element binding protein	0.0045	0.0431	0.0507
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0013	0.0059	0.0886
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0539	1
Schistosoma mansoni	lamin	0.0029	0.0241	0.0283
Echinococcus multilocularis	dna polymerase kappa	0.0042	0.0402	0.0402
Loa Loa (eye worm)	hypothetical protein	0.001	0.0027	0.0157
Brugia malayi	Smad1	0.0009	0.0007	0.0043
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0163	0.0192
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.048	0.0565
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0054	0.0539	0.8071
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.004	0.0376	0.0442
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.0027	0.0032
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0054	0.0539	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0042	0.0402	0.7451
Schistosoma mansoni	zinc finger protein	0.001	0.0027	0.0032
Schistosoma mansoni	hypothetical protein	0.0043	0.0412	0.0485
Echinococcus multilocularis	musashi	0.0029	0.0241	0.0241
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0402	0.7451
Echinococcus multilocularis	lamin	0.0029	0.0241	0.0241
Schistosoma mansoni	hypothetical protein	0.0043	0.0412	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0126	0.0734
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0042	0.0402	0.0911
Loa Loa (eye worm)	hypothetical protein	0.001	0.0027	0.0157
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0163	0.0954
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.0163	0.0192
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0027	0.0032
Trypanosoma cruzi	hypothetical protein, conserved	0.0013	0.0059	0.1098
Echinococcus multilocularis	protein patched	0.0045	0.0431	0.0431
Mycobacterium tuberculosis	3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III)	0.0383	0.4412	1
Trypanosoma cruzi	DNA damage repair protein, putative	0.0013	0.0059	0.1098
Brugia malayi	CHE-14 protein	0.0045	0.0431	0.2519
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0114	0.0257
Schistosoma mansoni	inositol monophosphatase	0.0041	0.0389	0.0458
Schistosoma mansoni	inositol monophosphatase	0.0041	0.0389	0.0458
Echinococcus granulosus	lamin dm0	0.0029	0.0241	0.0283
Echinococcus granulosus	Smad4	0.0009	0.0007	0.0009
Brugia malayi	steroid hormone receptor	0.0022	0.0163	0.0954
Loa Loa (eye worm)	hypothetical protein	0.001	0.0027	0.0157
Trypanosoma cruzi	pantothenate kinase subunit, putative	0.0009	0.0012	0.0223
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0163	0.0163
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.004	0.0376	0.2195
Schistosoma mansoni	coup transcription factor	0.0022	0.0163	0.0192
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.004	0.0376	0.6963
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0163	0.0192
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0042	0.0402	0.7451
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.048	0.2806
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0045	0.0436	0.8084
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0242
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.0668	0.0787
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0054	0.0539	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.02	0.0454
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.0163	0.0954
Brugia malayi	Nuclear hormone receptor E75	0.001	0.0027	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0025	0.02	0.117
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0163	0.0954
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0027	0.0032
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.0163	0.0163
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0065	0.0668	0.1514
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.0383	0.4412	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0402	0.7451
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0163	0.0192
Loa Loa (eye worm)	acetyltransferase	0.0153	0.1711	1
Schistosoma mansoni	Smad4	0.0009	0.0007	0.0009
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0402	0.7451
Trypanosoma brucei	unspecified product	0.0042	0.0402	0.7451
Loa Loa (eye worm)	hypothetical protein	0.001	0.0027	0.0157
Plasmodium falciparum	beta-ketoacyl-ACP synthase III	0.0383	0.4412	1
Trypanosoma brucei	unspecified product	0.0029	0.0248	0.4592
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0065	0.0668	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0126	0.0734
Echinococcus multilocularis	protein dispatched 1	0.0051	0.0505	0.0505
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.0027	0.0032
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0163	0.0954
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.0163	0.0954
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0061	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0025	0.02	0.117
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0013	0.0059	0.0886
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.001	0.0027	0.1113
Echinococcus granulosus	Niemann Pick C1 protein	0.0149	0.1657	0.195
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.02	0.177
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0085	0.0496
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0163	0.0954
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0041	0.0389	0.7207
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0163	0.0954
Onchocerca volvulus		0.001	0.0027	0.1113
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.001	0.0027	0.0027
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0241	0.0283
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0163	0.0954
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0242
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0054	0.0539	0.8071
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0027	0.0027
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0668	0.1399
Schistosoma mansoni	lamin	0.0029	0.0241	0.0283
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0042	0.0402	0.0911
Toxoplasma gondii	exonuclease III APE	0.004	0.0376	0.562
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.02	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0242
Schistosoma mansoni	hypothetical protein	0.0179	0.2015	0.2371
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0163	0.0954
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.048	0.048
Plasmodium vivax	DNA repair protein REV1, putative	0.0013	0.0059	0.0134
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0007	0.0009
Brugia malayi	nuclear receptor RXR	0.0012	0.0041	0.0242
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0012	0.0041	0.0242
Brugia malayi	nuclear receptor NHR-67	0.001	0.0027	0.0157
Echinococcus multilocularis	nuclear receptor nhr 48	0.001	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.001	0.0027	0.0157
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0054	0.0539	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0235	0.1371
Echinococcus granulosus	microtubule associated protein 2	0.073	0.8496	1
Schistosoma mansoni	patched 1	0.0045	0.0431	0.0507
Onchocerca volvulus		0.0029	0.0241	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.004	0.0376	0.0851
Echinococcus granulosus	dna polymerase eta	0.0042	0.0402	0.0473
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0163	0.0163
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0163	0.0192
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0007	0.0043
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0042	0.0402	0.3554
Trypanosoma cruzi	DNA polymerase eta, putative	0.0042	0.0402	0.7451
Brugia malayi	MH2 domain containing protein	0.0009	0.0007	0.0043
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0163	0.0192
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0163	0.0192
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0163	0.0954
Schistosoma mansoni	microtubule-associated protein tau	0.073	0.8496	1
Schistosoma mansoni	DNA polymerase eta	0.0042	0.0402	0.0473
Trypanosoma brucei	DNA polymerase kappa, putative	0.0029	0.0248	0.4592
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.02	0.0324
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0114	0.0257
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0041	0.0242
Brugia malayi	nuclear hormone receptor	0.001	0.0027	0.0157
Echinococcus multilocularis	geminin	0.0179	0.2015	0.2015
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0126	0.0285
Mycobacterium ulcerans	hypothetical protein	0.0025	0.02	0.0324
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0402	0.7451
Trypanosoma brucei	DNA polymerase IV, putative	0.0042	0.0402	0.7451
Brugia malayi	MH1 domain containing protein	0.0009	0.0007	0.0043
Echinococcus granulosus	Niemann Pick C1 protein	0.0104	0.1131	0.1331
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0402	0.7451
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0163	0.0192
Echinococcus granulosus	thyroid hormone receptor alpha	0.001	0.0027	0.0032
Brugia malayi	Nuclear hormone receptor E75	0.001	0.0027	0.0157
Echinococcus granulosus	smad	0.0009	0.0007	0.0009
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.004	0.0376	0.0851
Brugia malayi	acetyltransferase, GNAT family protein	0.0153	0.1711	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0241	0.1407
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.02	0.2995
Giardia lamblia	DNA damage repair protein	0.0013	0.0059	0.1098
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0163	0.0192
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0042	0.0402	0.6014
Brugia malayi	ecdysteroid receptor	0.0022	0.0163	0.0954
Schistosoma mansoni	smad	0.0009	0.0007	0.0009
Echinococcus multilocularis	Smad4	0.0009	0.0007	0.0007
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0007	0.0009
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0163	0.0954
Trichomonas vaginalis	ap endonuclease, putative	0.004	0.0376	0.6963
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0402	0.7451
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0242
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0054	0.0539	0.3153
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0163	0.0163
Entamoeba histolytica	fatty acid elongase, putative	0.005	0.049	0.4337
Brugia malayi	hypothetical protein	0.001	0.0027	0.0157
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0163	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0163	0.0954
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.02	0.2995
Treponema pallidum	exodeoxyribonuclease (exoA)	0.004	0.0376	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0007	0.0009
Brugia malayi	MH2 domain containing protein	0.0128	0.1406	0.8218
Schistosoma mansoni	ap endonuclease	0.004	0.0376	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0163	0.0954
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0027	0.0032
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0042	0.0402	0.0473
Entamoeba histolytica	hypothetical protein	0.004	0.0376	0.3327
Echinococcus multilocularis	Niemann Pick C1 protein	0.0104	0.1131	0.1131
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.004	0.0376	0.0376
Echinococcus granulosus	inositol monophosphatase 1	0.0041	0.0389	0.0458
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0163	0.0163
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0376	0.0443
Brugia malayi	nuclear receptor NHR-88	0.001	0.0027	0.0157
Entamoeba histolytica	hypothetical protein	0.004	0.0376	0.3327
Brugia malayi	ecdysone receptor	0.001	0.0027	0.0157
Brugia malayi	MH2 domain containing protein	0.0009	0.0007	0.0043
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0007	0.0043
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0045	0.0436	0.0988
Schistosoma mansoni	ap endonuclease	0.004	0.0376	0.0442
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0012	0.0041	0.0049
Echinococcus multilocularis	mitogen activated protein kinase	0.0054	0.0539	0.0539
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.004	0.0376	0.0727
Brugia malayi	ImpB/MucB/SamB family protein	0.0042	0.0402	0.2349
Schistosoma mansoni	hypothetical protein	0.004	0.0376	0.0443
Echinococcus multilocularis	microtubule associated protein 2	0.073	0.8496	0.8496
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0114	0.0257
Brugia malayi	Niemann-Pick C1 protein precursor	0.0104	0.1131	0.6609
Trypanosoma brucei	DNA polymerase eta, putative	0.0042	0.0402	0.7451
Echinococcus granulosus	expressed conserved protein	0.0098	0.1056	0.1243
Loa Loa (eye worm)	hypothetical protein	0.001	0.0027	0.0157
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.02	0.2995
Echinococcus granulosus	intermediate filament protein	0.0029	0.0241	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0402	0.2349
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.048	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0067	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0059	0.0346
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0163	0.0163
Leishmania major	DNA polymerase kappa, putative	0.0042	0.0402	0.6014
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.0163	0.0192
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.048	0.2806
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0054	0.0539	0.8071
Onchocerca volvulus	Protein ultraspiracle homolog	0.0022	0.0163	0.6778
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.048	0.048
Loa Loa (eye worm)	MH2 domain-containing protein	0.0128	0.1406	0.8218
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0163	0.0192
Trypanosoma cruzi	DNA damage repair protein, putative	0.0013	0.0059	0.1098
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0402	0.7451
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0402	0.7451
Trypanosoma brucei	DNA polymerase IV, putative	0.0042	0.0402	0.7451
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0045	0.0436	0.0513
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0431	0.7991
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0126	0.0734
Brugia malayi	MH1 domain containing protein	0.0009	0.0007	0.0043
Loa Loa (eye worm)	hypothetical protein	0.001	0.0027	0.0157
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0163	0.0192
Loa Loa (eye worm)	hypothetical protein	0.001	0.0027	0.0157
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0163	0.0954
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0389	0.7207
Trichomonas vaginalis	inositol monophosphatase, putative	0.0041	0.0389	0.7207
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0007	0.0009
Echinococcus granulosus	nuclear receptor nhr 48	0.001	0.0027	0.0032
Onchocerca volvulus		0.0025	0.02	0.8315
Echinococcus multilocularis	inositol monophosphatase 1	0.0041	0.0389	0.0389
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0153	0.1711	0.1711
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.001	0.0027	0.1113
Entamoeba histolytica	fatty acid elongase, putative	0.005	0.049	0.4337
Brugia malayi	exodeoxyribonuclease III family protein	0.004	0.0376	0.2195
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0041	0.0389	0.5817
Chlamydia trachomatis	oxoacyl-ACP synthase III	0.0383	0.4412	1
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0007	0.0009
Loa Loa (eye worm)	transcription factor SMAD2	0.0128	0.1406	0.8218
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0163	0.0192
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.0383	0.4412	1
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0163	0.0163
Brugia malayi	nuclear hormone receptor family member odr-7	0.001	0.0027	0.0157
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.004	0.0376	0.0851
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.004	0.0376	0.6963
Trichomonas vaginalis	DNA polymerase eta, putative	0.0042	0.0402	0.7451
Echinococcus multilocularis	neuropeptide s receptor	0.0476	0.5507	0.5507
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.02	0.117
Entamoeba histolytica	fatty acid elongase, putative	0.005	0.049	0.4337
Onchocerca volvulus		0.0029	0.0241	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0054	0.0539	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0022	0.0163	0.6778
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0042	0.0402	0.2349
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0065	0.0668	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0041	0.0049
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0163	0.0163
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0045	0.0436	0.8084
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.02	0.0324
Loa Loa (eye worm)	DR-78	0.001	0.0027	0.0157
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0104	0.1131	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.001	0.0027	0.0157
Giardia lamblia	Histone acetyltransferase GCN5	0.0041	0.0392	0.7264
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0045	0.0436	0.6525
Schistosoma mansoni	hypothetical protein	0.0043	0.0412	0.0485
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0085	0.0496
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.0163	0.0954
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.001	0.0027	0.0027
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0037	0.0338	0.0766
Entamoeba histolytica	hypothetical protein	0.004	0.0376	0.3327
Brugia malayi	hypothetical protein	0.001	0.0027	0.0157
Giardia lamblia	DINP protein human, muc B family	0.0042	0.0402	0.7451
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.048	0.0565
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0163	0.0192
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0041	0.0389	0.0757
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.001	0.0027	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0163	0.0954
Trypanosoma brucei	protein kinase, putative	0.0054	0.0539	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0126	0.0285
Trichomonas vaginalis	ap endonuclease, putative	0.004	0.0376	0.6963
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0007	0.0007
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0012	0.0041	0.0041
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0114	0.0257
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0106	0.115	0.1353
Brugia malayi	orphan nuclear receptor NR2E1	0.001	0.0027	0.0157
Echinococcus granulosus	dna polymerase kappa	0.0042	0.0402	0.0473
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.001	0.0027	0.0157
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.0163	0.0954
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0126	0.0152
Giardia lamblia	Kinase, CMGC MAPK	0.0054	0.0539	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0163	0.0954
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0007	0.0007
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.048	0.0565
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0163	0.0954
Onchocerca volvulus	Bile acid receptor homolog	0.0022	0.0163	0.6778
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0431	0.2519
Echinococcus granulosus	mitogen activated protein kinase 3	0.0054	0.0539	0.0635
Brugia malayi	hypothetical protein	0.0012	0.0041	0.0242
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.0668	0.0787
Loa Loa (eye worm)	nuclear hormone receptor	0.001	0.0027	0.0157
Loa Loa (eye worm)	hypothetical protein	0.001	0.0027	0.0157
Echinococcus granulosus	neuropeptide receptor A26	0.0476	0.5507	0.6482
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0241	0.1407
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.0163	0.0954
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0012	0.0041	0.0049
Echinococcus granulosus	Protein patched homolog 1	0.0045	0.0431	0.0507
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.02	0.0324
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.048	0.0565
Onchocerca volvulus		0.0022	0.0163	0.6778
Plasmodium falciparum	DNA repair protein REV1, putative	0.0013	0.0059	0.0134
Brugia malayi	conserved hypotetical protein	0.001	0.0027	0.0157
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0389	0.7207
Echinococcus granulosus	mitogen activated protein kinase	0.0054	0.0539	0.0635
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.0027	0.0027
Brugia malayi	intermediate filament protein	0.0029	0.0241	0.1407
Loa Loa (eye worm)	hypothetical protein	0.001	0.0027	0.0157
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.004	0.0376	0.562
Wolbachia endosymbiont of Brugia malayi	3-oxoacyl-ACP synthase	0.0383	0.4412	1
Entamoeba histolytica	fatty acid elongase, putative	0.005	0.049	0.4337
Brugia malayi	polk-prov protein	0.0013	0.0059	0.0346
Brugia malayi	Inositol-1	0.0041	0.0389	0.2272
Trypanosoma brucei	DNA damage repair protein, putative	0.0013	0.0059	0.1098
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0163	0.0192
Echinococcus multilocularis	Niemann Pick C1 protein	0.0149	0.1657	0.1657
Echinococcus multilocularis	lamin dm0	0.0029	0.0241	0.0241
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0054	0.0539	1
Trypanosoma brucei	hypothetical protein, conserved	0.0013	0.0059	0.1098
Toxoplasma gondii	aldehyde dehydrogenase	0.0065	0.0668	1
Echinococcus multilocularis	dna polymerase eta	0.0042	0.0402	0.0402
Trypanosoma cruzi	DNA polymerase eta, putative	0.0013	0.0059	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0163	0.0954
Trypanosoma brucei	DNA polymerase kappa, putative	0.0029	0.0248	0.4592
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0041	0.0242
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0042	0.0402	0.0473
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.02	0.0324
Brugia malayi	hypothetical protein	0.0012	0.0041	0.0242
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0045	0.0431	0.2519
Mycobacterium ulcerans	beta-ketoacyl synthase-like protein	0.0383	0.4412	1
Entamoeba histolytica	hypothetical protein	0.004	0.0376	0.3327
Mycobacterium ulcerans	DNA polymerase IV	0.0042	0.0402	0.0787
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0389	0.7207
Trypanosoma brucei	DNA polymerase kappa, putative	0.0029	0.0248	0.4592
Onchocerca volvulus		0.001	0.0027	0.1113
Echinococcus multilocularis	smad	0.0009	0.0007	0.0007
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.0163	0.0954
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.001	0.0027	0.0032
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0045	0.0436	0.6525
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0163	0.0954
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0539	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0476	0.5507	0.5507
Loa Loa (eye worm)	hypothetical protein	0.001	0.0027	0.0157
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0153	0.1711	0.2014
Schistosoma mansoni	nuclear receptor	0.001	0.0027	0.0032
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0067	0.0067
Echinococcus granulosus	lamin	0.0029	0.0241	0.0283
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0041	0.0389	0.7207
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0539	1
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0163	0.0192
Loa Loa (eye worm)	inositol-1	0.0041	0.0389	0.2272

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 37.4 uM	Inhibition of Escherichia coli FabH expressed in Escherichia coli DH10B cells assessed as incorporation of 3H signal in the product after 25 mins by liquid scintillation	ChEMBL.	21752655
Ki (binding)	= 38.36 fM	Inhibition of Escherichia coli FabH expressed in Escherichia coli DH10B cells assessed as incorporation of 3H signal in the product after 25 mins by liquid scintillation	ChEMBL.	21752655
MIC (functional)	= 12.5 ug ml-1	Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay	ChEMBL.	21752655

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1808846

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1027881