Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.2675 | 0.2656 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0014 | 0.0052 | 0.0011 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0051 | 0.122 | 0.1924 |
Schistosoma mansoni | zinc finger protein | 0.0048 | 0.1133 | 0.1109 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0026 | 0.0042 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.1801 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.044 | 0.0641 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0069 | 0.1801 | 1 |
Trypanosoma brucei | ISWI complex protein | 0.0035 | 0.0696 | 0.5 |
Echinococcus multilocularis | lamin | 0.0027 | 0.044 | 0.0695 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0054 | 0.1302 | 0.1279 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0047 | 0.1082 | 0.1742 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0014 | 0.0052 | 0.0084 |
Schistosoma mansoni | zinc finger protein | 0.0035 | 0.0696 | 0.0671 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0211 | 0.6338 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0014 | 0.0052 | 0.0026 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.1801 | 0.1779 |
Onchocerca volvulus | 0.0054 | 0.1302 | 0.203 | |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0014 | 0.0052 | 0.0082 |
Onchocerca volvulus | 0.0027 | 0.044 | 0.0631 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0014 | 0.0052 | 0.0084 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0045 | 0.0073 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0014 | 0.0052 | 0.0084 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0014 | 0.0052 | 0.0026 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.2675 | 0.4221 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0097 | 0.2675 | 0.4267 |
Brugia malayi | nuclear receptor NHR-88 | 0.0014 | 0.0052 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0052 | 0.0084 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0061 | 0.1539 | 0.2428 |
Brugia malayi | nuclear hormone receptor | 0.0014 | 0.0052 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.3988 | 0.6423 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0014 | 0.0052 | 0.0082 |
Brugia malayi | steroid hormone receptor | 0.0014 | 0.0052 | 0.0011 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0039 | 0.0823 | 0.1298 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.2801 | 0.4512 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0014 | 0.0052 | 0.0082 |
Brugia malayi | PHD-finger family protein | 0.006 | 0.1518 | 0.239 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0061 | 0.1539 | 0.2428 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.2663 | 0.4289 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0014 | 0.0052 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0425 | 0.0684 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0014 | 0.0052 | 0.0011 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0039 | 0.0823 | 0.0799 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0014 | 0.0052 | 0.0082 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0014 | 0.0052 | 0.0011 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0054 | 0.1302 | 0.1279 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.4704 | 0.7577 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0014 | 0.0052 | 0.0011 |
Echinococcus multilocularis | musashi | 0.0027 | 0.044 | 0.0695 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0014 | 0.0052 | 0.0026 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.2675 | 0.4221 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0039 | 0.0823 | 0.0799 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.044 | 0.0709 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0014 | 0.0052 | 0.0011 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0069 | 0.1801 | 0.2841 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0061 | 0.1539 | 0.2423 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0014 | 0.0052 | 0.0011 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0044 | 0.0992 | 0.5 |
Trypanosoma cruzi | ISWI complex protein | 0.0035 | 0.0696 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.2364 | 0.3808 |
Schistosoma mansoni | thyroid hormone receptor | 0.0014 | 0.0052 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0052 | 0.0084 |
Echinococcus granulosus | FTZ F1 alpha | 0.0014 | 0.0052 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0052 | 0.0084 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0061 | 0.1539 | 0.2428 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0014 | 0.0052 | 0.0082 |
Schistosoma mansoni | coup transcription factor | 0.0014 | 0.0052 | 0.0026 |
Echinococcus granulosus | geminin | 0.0194 | 0.5802 | 0.9155 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.044 | 0.0709 |
Schistosoma mansoni | lamin | 0.0027 | 0.044 | 0.0415 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0014 | 0.0052 | 0.0084 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0014 | 0.0052 | 0.0011 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.044 | 0.0641 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0039 | 0.0823 | 0.0799 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.044 | 0.0695 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0823 | 0.1325 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0039 | 0.0823 | 0.0799 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0052 | 0.0084 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0696 | 0.0671 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.044 | 0.0709 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0014 | 0.0052 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1302 | 0.2097 |
Schistosoma mansoni | bromodomain containing protein | 0.0147 | 0.4294 | 0.4279 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0014 | 0.0052 | 0.0084 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0054 | 0.1302 | 0.1279 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0139 | 0.4035 | 0.6366 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0014 | 0.0052 | 0.0082 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.1801 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.2487 | 0.3961 |
Brugia malayi | ecdysteroid receptor | 0.0014 | 0.0052 | 0.0011 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1082 | 0.1058 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0053 | 0.1291 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0014 | 0.0052 | 0.0011 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0211 | 0.6338 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0168 | 0.4964 | 0.7981 |
Loa Loa (eye worm) | acetyltransferase | 0.0168 | 0.4964 | 0.7996 |
Schistosoma mansoni | lamin | 0.0027 | 0.044 | 0.0415 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0014 | 0.0052 | 0.0011 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0054 | 0.1302 | 0.2054 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0052 | 0.0084 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0014 | 0.0052 | 0.0011 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0158 | 0.4647 | 0.7332 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0044 | 0.0992 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.2675 | 0.2656 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0054 | 0.1302 | 0.2054 |
Brugia malayi | Bromodomain containing protein | 0.0174 | 0.5141 | 0.8268 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0014 | 0.0052 | 0.0026 |
Brugia malayi | N-terminal motif family protein | 0.0207 | 0.6209 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.2675 | 0.4221 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0044 | 0.0994 | 0.1602 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0014 | 0.0052 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.1539 | 0.2478 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.1801 | 0.1779 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0207 | 0.6209 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0014 | 0.0052 | 0.0082 |
Loa Loa (eye worm) | MBCTL1 | 0.0061 | 0.1539 | 0.2478 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0081 | 0.2188 | 0.3452 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0061 | 0.1539 | 0.1517 |
Schistosoma mansoni | thyroid hormone receptor | 0.0014 | 0.0052 | 0.0026 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0168 | 0.4964 | 0.4951 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0053 | 0.1291 | 0.2036 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0014 | 0.0052 | 0.0082 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0014 | 0.0052 | 0.0011 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0069 | 0.1801 | 0.2841 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0014 | 0.0052 | 0.0082 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0014 | 0.0052 | 0.0082 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0039 | 0.0823 | 0.1298 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0052 | 0.0084 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0069 | 0.1801 | 1 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0054 | 0.1302 | 0.2054 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.1801 | 0.5 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0044 | 0.0992 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0014 | 0.0052 | 0.0084 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0054 | 0.1302 | 0.2054 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0097 | 0.2675 | 0.4309 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0061 | 0.1539 | 0.2428 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0051 | 0.122 | 0.1924 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0139 | 0.4035 | 0.6366 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.044 | 0.0695 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0052 | 0.0084 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.2675 | 0.2656 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0069 | 0.1801 | 0.5 |
Brugia malayi | mbt repeat family protein | 0.0054 | 0.1302 | 0.2039 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0052 | 0.0084 |
Schistosoma mansoni | nuclear hormone receptor | 0.0014 | 0.0052 | 0.0026 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0014 | 0.0052 | 0.0082 |
Echinococcus multilocularis | zinc finger protein | 0.0048 | 0.1133 | 0.1787 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0014 | 0.0052 | 0.0011 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0039 | 0.0823 | 0.1298 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0168 | 0.4964 | 0.7833 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0054 | 0.1302 | 0.203 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0014 | 0.0052 | 0.0084 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0014 | 0.0052 | 0.0026 |
Trypanosoma cruzi | ISWI complex protein | 0.0035 | 0.0696 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0051 | 0.122 | 0.1197 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0053 | 0.1291 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0014 | 0.0052 | 0.0011 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0014 | 0.0052 | 0.0026 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0014 | 0.0052 | 0.0082 |
Onchocerca volvulus | Huntingtin homolog | 0.0138 | 0.3988 | 0.6393 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.044 | 0.0695 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0039 | 0.0823 | 0.1298 |
Echinococcus granulosus | lamin | 0.0027 | 0.044 | 0.0695 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0053 | 0.1291 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.6209 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.5802 | 0.5791 |
Echinococcus multilocularis | geminin | 0.0194 | 0.5802 | 0.9155 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.5802 | 0.5791 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.2675 | 0.4221 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0014 | 0.0052 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.3988 | 0.6423 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0014 | 0.0052 | 0.0082 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0014 | 0.0052 | 0.0026 |
Brugia malayi | mbt repeat family protein | 0.0054 | 0.1302 | 0.2039 |
Onchocerca volvulus | 0.0027 | 0.044 | 0.0631 | |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0014 | 0.0052 | 0.0026 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0014 | 0.0052 | 0.0026 |
Echinococcus granulosus | zinc finger protein | 0.0048 | 0.1133 | 0.1787 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0014 | 0.0052 | 0.0082 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0014 | 0.0052 | 0.0082 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0054 | 0.1302 | 0.2097 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.044 | 0.0415 |
Onchocerca volvulus | Huntingtin homolog | 0.0138 | 0.3988 | 0.6393 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0014 | 0.0052 | 0.0011 |
Brugia malayi | hypothetical protein | 0.0138 | 0.3988 | 0.6397 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0081 | 0.2188 | 0.3452 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0014 | 0.0052 | 0.0011 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.