TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 444.187 | Formula: C15H16Br2N4S
H donors: 3 H acceptors: 1 LogP: 5.21 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Brc1cc(sc1Br)CNCCCNc1nc2c([nH]1)cccc2
InChi: 1S/C15H16Br2N4S/c16-11-8-10(22-14(11)17)9-18-6-3-7-19-15-20-12-4-1-2-5-13(12)21-15/h1-2,4-5,8,18H,3,6-7,9H2,(H2,19,20,21)
InChiKey: NAPURCVWDONFRP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0051	0.0177	0.1033
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0046	0.0142	0.0716
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0032	0.0045	0.0166
Echinococcus granulosus	cathepsin L	0.0039	0.0098	0.0084
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.0347	0.2024
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0291	0.179	0.9148
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0149	0.0835	0.404
Schistosoma mansoni	intermediate filament proteins	0.0086	0.0411	0.152
Brugia malayi	Cathepsin L-like precursor	0.0076	0.0347	0.135
Leishmania major	cathepsin L-like protease	0.0291	0.179	0.9148
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0035	0.0066	0.0051
Schistosoma mansoni	smad1 5 8 and	0.0027	0.0018	0.0057
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0032	0.0045	0.0166
Brugia malayi	Cathepsin L-like precursor	0.0076	0.0347	0.135
Onchocerca volvulus		0.0086	0.0411	0.2652
Entamoeba histolytica	hypothetical protein	0.0042	0.0115	0.0709
Echinococcus granulosus	tumor protein p63	0.143	0.9455	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0046	0.0142	0.0337
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0032	0.0045	0.0166
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0131	0.0656
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.0045	0.0029
Leishmania major	cathepsin L-like protease	0.0291	0.179	0.9148
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0079	0.0461
Onchocerca volvulus	Cathepsin L homolog	0.0076	0.0347	0.2186
Plasmodium vivax	vivapain-2	0.0076	0.0347	0.2418
Brugia malayi	photoreceptor-specific nuclear receptor	0.0032	0.0045	0.0166
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0149	0.0835	0.404
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0131	0.0656
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.0066	0.0248
Echinococcus granulosus	cathepsin l1	0.0076	0.0347	0.0348
Echinococcus granulosus	intermediate filament protein	0.0086	0.0411	0.0416
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0076	0.0347	0.0348
Schistosoma mansoni	glutaminase	0.0279	0.1713	0.6372
Brugia malayi	Papain family cysteine protease containing protein	0.0039	0.0098	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0177	0.0683
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0063	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0112	0.0428
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0076	0.0347	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0016	0.0093
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0291	0.179	0.9148
Echinococcus multilocularis	cysteine protease	0.0076	0.0347	0.0348
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.0347	0.2024
Loa Loa (eye worm)	hypothetical protein	0.0236	0.1424	0.5582
Schistosoma mansoni	Smad4	0.0027	0.0018	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0236	0.1424	0.5582
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0045	0.0166
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.0066	0.0248
Entamoeba histolytica	hypothetical protein	0.0042	0.0115	0.0709
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0109	0.057	0.2225
Echinococcus granulosus	GPCR family 2	0.0035	0.0066	0.0051
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0347	0.2024
Onchocerca volvulus		0.0236	0.1424	1
Leishmania major	hypothetical protein, conserved	0.0236	0.1424	0.7194
Brugia malayi	beta-lactamase family protein	0.0236	0.1424	0.5582
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0039	0.0098	0.0353
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0039	0.0098	0.0353
Echinococcus granulosus	lamin	0.0086	0.0411	0.0416
Brugia malayi	Intermediate filament tail domain containing protein	0.0086	0.0411	0.1602
Loa Loa (eye worm)	hypothetical protein	0.0084	0.04	0.1561
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0035	0.0066	0.0051
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0291	0.179	0.9148
Echinococcus granulosus	FTZ F1 alpha	0.0032	0.0045	0.0029
Giardia lamblia	GTOR	0.0046	0.0142	0.5
Loa Loa (eye worm)	hypothetical protein	0.0109	0.057	0.2225
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0177	0.0683
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0086	0.0411	0.1602
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0291	0.179	0.9148
Mycobacterium ulcerans	glutaminase	0.0279	0.1713	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0032	0.0045	0.0029
Trypanosoma cruzi	cysteine proteinase, putative	0.0039	0.0098	0.0487
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0032	0.0045	0.0157
Onchocerca volvulus		0.0236	0.1424	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0236	0.1424	0.8315
Onchocerca volvulus		0.0076	0.0347	0.2186
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0424	0.2687	0.2828
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0347	0.2024
Echinococcus multilocularis	FTZ F1 alpha	0.0032	0.0045	0.0029
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0032	0.0045	0.0166
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0347	0.2024
Toxoplasma gondii	ABC1 family protein	0.0236	0.1424	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0347	0.2024
Leishmania major	cathepsin L-like protease	0.0076	0.0347	0.1431
Echinococcus multilocularis	cysteine protease	0.0076	0.0347	0.0348
Schistosoma mansoni	smad1 5 8 and	0.0027	0.0018	0.0057
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0079	0.0461
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.0347	0.2024
Loa Loa (eye worm)	cysteine protease	0.0076	0.0347	0.135
Brugia malayi	Smad1	0.0027	0.0018	0.006
Loa Loa (eye worm)	steroid hormone receptor	0.0032	0.0045	0.0166
Leishmania major	cysteine peptidase A (CPA)	0.0076	0.0347	0.1431
Brugia malayi	nuclear hormone receptor	0.0032	0.0045	0.0166
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0314	0.1949	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0076	0.0347	1
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.161	0.5987
Brugia malayi	Cathepsin L-like precursor	0.0076	0.0347	0.135
Onchocerca volvulus		0.0076	0.0347	0.2186
Loa Loa (eye worm)	transcription factor SMAD2	0.0404	0.2549	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0046	0.0142	0.0547
Mycobacterium leprae	conserved hypothetical protein	0.0236	0.1424	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0018	0.0104
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0347	0.2024
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0046	0.0142	0.0131
Leishmania major	cathepsin L-like protease	0.0291	0.179	0.9148
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0392	0.2475	0.2603
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0291	0.179	0.9148
Schistosoma mansoni	cathepsin F (C01 family)	0.0076	0.0347	0.1281
Mycobacterium ulcerans	hypothetical protein	0.0236	0.1424	0.6229
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0347	0.2024
Brugia malayi	Papain family cysteine protease containing protein	0.0039	0.0098	0.0372
Entamoeba histolytica	cysteine proteinase, putative	0.0076	0.0347	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0347	0.135
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0032	0.0045	0.0166
Trichomonas vaginalis	penicillin-binding protein, putative	0.0236	0.1424	0.8315
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0109	0.057	0.2225
Loa Loa (eye worm)	hypothetical protein	0.0236	0.1424	0.5582
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0079	0.0461
Schistosoma mansoni	hypothetical protein	0.0042	0.0115	0.0419
Loa Loa (eye worm)	Smad1	0.0027	0.0018	0.006
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0076	0.0347	0.135
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0039	0.0098	0.0487
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0347	0.2024
Loa Loa (eye worm)	hypothetical protein	0.0236	0.1424	0.5582
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.0045	0.0029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0347	0.2024
Onchocerca volvulus		0.0236	0.1424	1
Brugia malayi	MH1 domain containing protein	0.0027	0.0018	0.006
Onchocerca volvulus		0.0076	0.0347	0.2186
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0236	0.1424	0.0527
Trypanosoma cruzi	major cysteine proteinase, putative	0.0229	0.1371	0.703
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0032	0.0045	0.0029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0347	0.2024
Entamoeba histolytica	hypothetical protein	0.0042	0.0115	0.0709
Toxoplasma gondii	cathepsin CPL	0.0076	0.0347	0.2084
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0032	0.0045	0.0166
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0266	0.162	0.8309
Entamoeba histolytica	hypothetical protein	0.0042	0.0115	0.0709
Onchocerca volvulus	Cathepsin L homolog	0.0076	0.0347	0.2186
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0177	0.0683
Loa Loa (eye worm)	glutaminase 2	0.0279	0.1713	0.6716
Schistosoma mansoni	hypothetical protein	0.0035	0.0066	0.0236
Trypanosoma cruzi	hypothetical protein, conserved	0.0236	0.1424	0.7304
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0063	0.0368
Trichomonas vaginalis	D-aminoacylase, putative	0.0236	0.1424	0.8315
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.004	0.0236
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0046	0.0142	0.1787
Schistosoma mansoni	thyroid hormone receptor	0.0424	0.2687	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0051	0.0177	0.1033
Mycobacterium tuberculosis	Conserved protein	0.0236	0.1424	0.0527
Loa Loa (eye worm)	hypothetical protein	0.004	0.0101	0.0387
Mycobacterium leprae	Probable lipase LipE	0.0236	0.1424	0.5
Brugia malayi	RNA binding protein	0.0264	0.161	0.6309
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0032	0.0045	0.0166
Echinococcus multilocularis	cathepsin L	0.0039	0.0098	0.0084
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0236	0.1424	0.149
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0041	0.0112	0.0099
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0291	0.179	0.9148
Schistosoma mansoni	lamin	0.0086	0.0411	0.152
Schistosoma mansoni	smad1 5 8 and	0.0027	0.0018	0.0057
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0032	0.0045	0.0166
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0032	0.0045	0.0029
Echinococcus multilocularis	tar DNA binding protein	0.0264	0.161	0.1686
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0032	0.0045	0.0166
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0079	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0045	0.0166
Echinococcus granulosus	tar DNA binding protein	0.0264	0.161	0.1686
Entamoeba histolytica	cysteine proteinase, putative	0.0051	0.0177	0.3182
Brugia malayi	latrophilin 2 splice variant baaae	0.0075	0.0337	0.131
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.161	0.5987
Schistosoma mansoni	lamin	0.0086	0.0411	0.152
Loa Loa (eye worm)	hypothetical protein	0.004	0.0101	0.0387
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0032	0.0045	0.0157
Echinococcus multilocularis	cathepsin L cysteine protease	0.0076	0.0347	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0045	0.0166
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0032	0.0045	0.0157
Trypanosoma cruzi	cysteine peptidase, putative	0.0039	0.0098	0.0487
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0291	0.179	0.9148
Schistosoma mansoni	cathepsin F (C01 family)	0.0051	0.0177	0.0648
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0018	0.0104
Mycobacterium ulcerans	esterase/lipase LipP	0.0236	0.1424	0.6229
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0392	0.2475	0.2603
Mycobacterium ulcerans	beta-lactamase	0.0236	0.1424	0.6229
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	0.0347	0.1766
Brugia malayi	hypothetical protein	0.0042	0.0115	0.0442
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0032	0.0045	0.0157
Trypanosoma brucei	hypothetical protein, conserved	0.0236	0.1424	0.7194
Loa Loa (eye worm)	fibroinase	0.0076	0.0347	0.135
Schistosoma mansoni	hypothetical protein	0.0075	0.0337	0.1243
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0032	0.0045	0.0157
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0079	0.0461
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0347	0.2024
Entamoeba histolytica	cysteine protease, putative	0.0076	0.0347	1
Loa Loa (eye worm)	RNA binding protein	0.0264	0.161	0.6309
Mycobacterium ulcerans	lipase LipD	0.0236	0.1424	0.6229
Plasmodium vivax	unspecified product	0.0039	0.0098	0.0667
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0016	0.0093
Loa Loa (eye worm)	MH2 domain-containing protein	0.0404	0.2549	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0291	0.179	0.9182
Onchocerca volvulus		0.0051	0.0177	0.0955
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0076	0.0347	0.135
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0018	0.0104
Trypanosoma cruzi	cysteine protease, putative	0.0039	0.0098	0.0487
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0236	0.1424	0.5297
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0032	0.0045	0.0166
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0046	0.0142	0.0547
Brugia malayi	Nuclear hormone receptor-like 1	0.0032	0.0045	0.0166
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0076	0.0347	0.0348
Onchocerca volvulus		0.0076	0.0347	0.2186
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0076	0.0347	0.0348
Mycobacterium tuberculosis	Probable hydrolase	0.0236	0.1424	0.0527
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0314	0.1949	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0097	0.0566
Brugia malayi	nuclear receptor NHR-88	0.0032	0.0045	0.0166
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.0347	0.2024
Trichomonas vaginalis	glutaminase, putative	0.0279	0.1713	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.0347	0.2024
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0032	0.0045	0.0029
Brugia malayi	cytoplasmic intermediate filament protein	0.0046	0.0143	0.0549
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0063	0.0368
Echinococcus granulosus	lamin dm0	0.0086	0.0411	0.0416
Loa Loa (eye worm)	glutaminase	0.0279	0.1713	0.6716
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0032	0.0045	0.0029
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0032	0.0045	0.0166
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0046	0.0142	0.1787
Onchocerca volvulus		0.0086	0.0411	0.2652
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0142	0.083
Brugia malayi	TAR-binding protein	0.0264	0.161	0.6309
Brugia malayi	MH2 domain containing protein	0.0027	0.0018	0.006
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0109	0.057	0.2225
Schistosoma mansoni	RAR-like nuclear receptor	0.0032	0.0045	0.0157
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.0045	0.0029
Schistosoma mansoni	nuclear hormone receptor	0.0032	0.0045	0.0157
Echinococcus multilocularis	GPCR, family 2	0.0035	0.0066	0.0051
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0236	0.1424	0.0527
Plasmodium vivax	hypothetical protein, conserved	0.0236	0.1424	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0045	0.0166
Brugia malayi	Steroid receptor seven-up type 2	0.0032	0.0045	0.0166
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0035	0.0066	0.0051
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0046	0.0142	0.0131
Mycobacterium tuberculosis	Conserved protein	0.0236	0.1424	0.0527
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.0347	0.2024
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0034	0.0197
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0142	0.083
Onchocerca volvulus		0.0076	0.0347	0.2186
Loa Loa (eye worm)	hypothetical protein	0.0236	0.1424	0.5582
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0054	0.0196	0.0991
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0046	0.0142	0.0337
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0027	0.0018	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0045	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0045	0.0166
Entamoeba histolytica	cysteine proteinase, putative	0.0076	0.0347	1
Loa Loa (eye worm)	intermediate filament protein	0.0086	0.0411	0.1602
Brugia malayi	Cathepsin L-like precursor	0.0076	0.0347	0.135
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0236	0.1424	0.6229
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0098	0.057
Echinococcus multilocularis	musashi	0.0086	0.0411	0.0416
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0076	0.0347	0.0348
Leishmania major	cathepsin L-like protease	0.0076	0.0347	0.1431
Leishmania major	cathepsin L-like protease	0.0076	0.0347	0.1431
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.161	0.5987
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0347	0.2024
Leishmania major	mitochondrial DNA polymerase beta	0.0314	0.1949	1
Schistosoma mansoni	thyroid hormone receptor	0.0424	0.2687	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0291	0.179	0.9182
Brugia malayi	Cathepsin L-like precursor	0.0051	0.0177	0.0683
Loa Loa (eye worm)	MH1 domain-containing protein	0.0027	0.0018	0.006
Echinococcus granulosus	ecdysone induced protein 78C	0.0032	0.0045	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0066	0.0248
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0032	0.0045	0.0166
Brugia malayi	beta-lactamase family protein	0.0236	0.1424	0.5582
Onchocerca volvulus		0.0209	0.1241	0.8673
Trichomonas vaginalis	D-aminoacylase, putative	0.0236	0.1424	0.8315
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0044	0.0131	0.0656
Schistosoma mansoni	hypothetical protein	0.0035	0.0066	0.0236
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.0347	0.2024
Loa Loa (eye worm)	TAR-binding protein	0.0264	0.161	0.6309
Echinococcus granulosus	cysteine protease	0.0039	0.0098	0.0084
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0076	0.0347	0.2024
Trypanosoma cruzi	cysteine peptidase, putative	0.0291	0.179	0.9182
Echinococcus granulosus	cathepsin L cysteine protease	0.0039	0.0098	0.0084
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0063	0.0368
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0032	0.0045	0.0029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0347	0.2024
Loa Loa (eye worm)	hypothetical protein	0.0236	0.1424	0.5582
Brugia malayi	cathepsin L-like precursor	0.0051	0.0177	0.0683
Mycobacterium tuberculosis	Conserved protein	0.0236	0.1424	0.0527
Schistosoma mansoni	retinoic acid receptor RXR	0.0032	0.0045	0.0157
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0115	0.0419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0291	0.179	0.9148
Brugia malayi	Cathepsin L-like precursor	0.0076	0.0347	0.135
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.0045	0.0029
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0032	0.0045	0.0029
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0046	0.0142	0.0337
Schistosoma mansoni	cellular tumor antigen P53	0.0209	0.1241	0.4615
Leishmania major	cathepsin L-like protease	0.0076	0.0347	0.1431
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0032	0.0045	0.0166
Brugia malayi	Papain family cysteine protease containing protein	0.0076	0.0347	0.135
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0291	0.179	0.9148
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0115	0.0103
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0032	0.0045	0.0166
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0039	0.0098	0.0099
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0039	0.0098	0.0099
Loa Loa (eye worm)	ctsf protein	0.0076	0.0347	0.135
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0115	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0411	0.1602
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0032	0.0045	0.0166
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0236	0.1424	0.0527
Plasmodium vivax	vivapain-3	0.0039	0.0098	0.0667
Loa Loa (eye worm)	hypothetical protein	0.0209	0.1241	0.4863
Brugia malayi	MH2 domain containing protein	0.0027	0.0018	0.006
Echinococcus granulosus	cathepsin l1	0.0051	0.0177	0.0168
Brugia malayi	intermediate filament protein	0.0086	0.0411	0.1602
Toxoplasma gondii	hypothetical protein	0.0051	0.0174	0.0818
Mycobacterium tuberculosis	Probable esterase LipL	0.0236	0.1424	0.0527
Echinococcus multilocularis	ecdysone induced protein 78C	0.0032	0.0045	0.0029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0347	0.2024
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.0347	0.2024
Loa Loa (eye worm)	beta-lactamase	0.0236	0.1424	0.5582
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.161	0.5987
Trypanosoma cruzi	target of rapamycin kinase 3	0.0037	0.0079	0.0392
Trichomonas vaginalis	penicillin-binding protein, putative	0.0236	0.1424	0.8315
Echinococcus multilocularis	lamin	0.0086	0.0411	0.0416
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0039	0.0098	0.0353
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0098	0.057
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.161	0.5987
Schistosoma mansoni	hypothetical protein	0.0392	0.2475	0.921
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0032	0.0045	0.0166
Brugia malayi	steroid hormone receptor	0.0032	0.0045	0.0166
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0236	0.1424	0.5582
Brugia malayi	RNA recognition motif domain containing protein	0.0264	0.161	0.6309
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0046	0.0142	0.0519
Mycobacterium tuberculosis	Probable lipase LipE	0.0236	0.1424	0.0527
Mycobacterium tuberculosis	Probable lipase LipD	0.0236	0.1424	0.0527
Schistosoma mansoni	smad	0.0027	0.0018	0.0057
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0142	0.083
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0044	0.0131	0.0275
Schistosoma mansoni	hypothetical protein	0.0035	0.0066	0.0236
Onchocerca volvulus		0.0076	0.0347	0.2186
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0063	0.0368
Plasmodium vivax	vivapain-1	0.0039	0.0098	0.0667
Leishmania major	cathepsin L-like protease	0.0076	0.0347	0.1431
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0076	0.0347	0.2024
Brugia malayi	ecdysteroid receptor	0.0032	0.0045	0.0166
Onchocerca volvulus	Cathepsin F homolog	0.0076	0.0347	0.2186
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0076	0.0347	0.2024
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0032	0.0045	0.0029
Brugia malayi	MH2 domain containing protein	0.0404	0.2549	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0236	0.1424	0.149
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0032	0.0045	0.0029
Schistosoma mansoni	cathepsin F (C01 family)	0.0076	0.0347	0.1281
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0046	0.0142	0.0716
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0032	0.0045	0.0157
Trypanosoma cruzi	cysteine proteinase, putative	0.0039	0.0098	0.0487
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0041	0.0112	0.0099
Echinococcus multilocularis	cathepsin L cysteine protease	0.0076	0.0347	0.0348
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0063	0.0368
Brugia malayi	Cathepsin L-like precursor	0.0051	0.0177	0.0683
Loa Loa (eye worm)	MH2 domain-containing protein	0.0027	0.0018	0.006
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0032	0.0045	0.0166
Brugia malayi	MH1 domain containing protein	0.0027	0.0018	0.006
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0291	0.179	0.9148
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0046	0.0142	0.0337
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0032	0.0045	0.0157
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0032	0.0045	0.0166
Trichomonas vaginalis	esterase, putative	0.0236	0.1424	0.8315
Brugia malayi	glutaminase DH11.1	0.0279	0.1713	0.6716
Schistosoma mansoni	hypothetical protein	0.0035	0.0066	0.0236
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.0066	0.0248
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0149	0.0835	0.4273
Echinococcus multilocularis	lamin dm0	0.0086	0.0411	0.0416
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0035	0.0066	0.0051
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0291	0.179	0.9148
Onchocerca volvulus		0.0076	0.0347	0.2186
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0076	0.0347	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0314	0.1949	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0051	0.0177	0.0683
Brugia malayi	beta-lactamase	0.0236	0.1424	0.5582
Echinococcus multilocularis	tumor protein p63	0.143	0.9455	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0236	0.1424	0.7304
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0337	0.131
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0032	0.0045	0.0166
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0032	0.0045	0.0166
Trypanosoma cruzi	cysteine peptidase, putative	0.0291	0.179	0.9182
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0045	0.0166
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0046	0.0143	0.0549
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0236	0.1424	0.5297
Schistosoma mansoni	coup transcription factor	0.0032	0.0045	0.0157
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0063	0.0368
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0076	0.0347	0.2024
Plasmodium vivax	vivapain-2	0.0076	0.0347	0.2418
Brugia malayi	Cathepsin L-like precursor	0.0076	0.0347	0.135
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0045	0.0166
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0236	0.1424	0.5582
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0264	0.161	0.6309

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL531465

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1028130