Detailed information for compound 102823

Basic information

Technical information
  • TDR Targets ID: 102823
  • Name: 1-(4-benzylpiperazin-1-yl)-3-quinolin-5-yloxy propan-2-ol
  • MW: 377.479 | Formula: C23H27N3O2
  • H donors: 1 H acceptors: 2 LogP: 2.89 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(CN1CCN(CC1)Cc1ccccc1)COc1cccc2c1cccn2
  • InChi: 1S/C23H27N3O2/c27-20(18-28-23-10-4-9-22-21(23)8-5-11-24-22)17-26-14-12-25(13-15-26)16-19-6-2-1-3-7-19/h1-11,20,27H,12-18H2
  • InChiKey: HXDJWAVEZFAPDV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-benzylpiperazin-1-yl)-3-(5-quinolyloxy)propan-2-ol
  • 1-(4-benzyl-1-piperazinyl)-3-(5-quinolyloxy)-2-propanol
  • 1-[4-(phenylmethyl)piperazin-1-yl]-3-quinolin-5-yloxy-propan-2-ol
  • 1-(4-benzylpiperazino)-3-(5-quinolyloxy)propan-2-ol
  • 1-[4-(phenylmethyl)piperazin-1-yl]-3-quinolin-5-yloxypropan-2-ol
  • 1-[4-(phenylmethyl)piperazin-1-yl]-3-(5-quinolyloxy)propan-2-ol
  • 1-[4-(phenylmethyl)-1-piperazinyl]-3-(5-quinolyloxy)propan-2-ol
  • 1-[4-(benzyl)piperazin-1-yl]-3-(5-quinolyloxy)propan-2-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi steroid hormone receptor 0.0031 0.0089 0.0147
Loa Loa (eye worm) hypothetical protein 0.0319 0.1789 0.2965
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0147 0.0773 0.1081
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0089 0.0147
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0259 0.0429
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0773 0.2416
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0089 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0089 0.0147
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0304 0.17 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.028 0.0465
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1038 0.6036 1
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.017 0.0201
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0147
Loa Loa (eye worm) hypothetical protein 0.0077 0.0361 0.0598
Brugia malayi ecdysteroid receptor 0.0031 0.0089 0.0147
Leishmania major hypothetical protein, conserved 0.0147 0.0773 0.7589
Giardia lamblia Fructose-bisphosphate aldolase 0.0304 0.17 1
Echinococcus multilocularis Excitatory amino acid transporter 0.1038 0.6036 0.6036
Mycobacterium ulcerans hypothetical protein 0.0147 0.0773 0.7218
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0089 0.0089
Schistosoma mansoni alpha-glucosidase 0.0139 0.0725 0.1201
Echinococcus multilocularis sodium:dicarboxylate symporter 0.046 0.2622 0.2622
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0136 0.013
Loa Loa (eye worm) hypothetical protein 0.0147 0.0773 0.1281
Echinococcus granulosus Niemann Pick C1 protein 0.0105 0.0524 0.0869
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0089 0.0147
Schistosoma mansoni hypothetical protein 0.0043 0.016 0.0266
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0089 0.0147
Schistosoma mansoni hypothetical protein 0.0033 0.0099 0.0165
Loa Loa (eye worm) hypothetical protein 0.0147 0.0773 0.1281
Schistosoma mansoni hypothetical protein 0.0072 0.0327 0.0541
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0089 0.0089
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0059 0.0757
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0089 0.0089
Echinococcus granulosus neuropeptide receptor A26 0.0483 0.2755 0.4564
Echinococcus granulosus ubiquitin specific protease 41 0.0077 0.0361 0.0598
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0047 0.0179 0.2317
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0278 0.3595
Brugia malayi nuclear receptor RXR 0.0017 0.0002 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.1027 0.1027
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0089 0.0147
Toxoplasma gondii ABC1 family protein 0.0147 0.0773 0.7589
Mycobacterium tuberculosis Probable oxidoreductase 0.0101 0.05 0.0617
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0047 0.0179 0.0297
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0207 0.268
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0047 0.0179 0.0297
Mycobacterium ulcerans beta-lactamase 0.0147 0.0773 0.7218
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0136 0.0075
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0147
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.0773 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0089 0.0147
Mycobacterium tuberculosis Probable dehydrogenase 0.0091 0.044 0.0516
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Schistosoma mansoni cpg binding protein 0.0064 0.0279 0.0462
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0857 0.0857
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0091 0.044 0.0516
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0265 0.0439
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0142 0.0142
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.0178 0.0955 0.1583
Mycobacterium tuberculosis Probable esterase LipL 0.0147 0.0773 0.1081
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0147
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.002 0.0034
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0147 0.0773 0.1281
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0005 0.0005
Brugia malayi CXXC zinc finger family protein 0.006 0.0259 0.0429
Toxoplasma gondii thioredoxin reductase 0.004 0.0139 0.1362
Leishmania major GTP-binding protein, putative 0.0047 0.0179 0.1758
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0059 0.2104
Mycobacterium leprae Probable lipase LipE 0.0147 0.0773 0.9779
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.0857 0.1421
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0077 0.0361 0.0901
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0005 0.0009
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0077 0.0361 0.1439
Brugia malayi Pre-SET motif family protein 0.0437 0.2484 0.4116
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0089 0.0147
Loa Loa (eye worm) beta-lactamase 0.0147 0.0773 0.1281
Echinococcus granulosus microtubule associated protein 2 0.0725 0.4186 0.6936
Onchocerca volvulus 0.0147 0.0773 0.1151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.1027 0.1702
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0115 0.1131
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.17 0.5816
Plasmodium vivax importin-beta 2, putative 0.0063 0.0278 0.3595
Brugia malayi Thioredoxin reductase 0.004 0.0139 0.023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.0773 0.1281
Entamoeba histolytica Ran family GTPase 0.0047 0.0179 0.0404
Trichomonas vaginalis ran, putative 0.0047 0.0179 0.0235
Toxoplasma gondii exonuclease III APE 0.0039 0.0136 0.1332
Echinococcus granulosus GPCR family 2 0.0033 0.0099 0.0165
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0147
Treponema pallidum glutamate transporter 0.046 0.2622 1
Echinococcus multilocularis muscleblind protein 0.0319 0.1789 0.1789
Loa Loa (eye worm) glutathione reductase 0.004 0.0139 0.023
Loa Loa (eye worm) hypothetical protein 0.0063 0.0278 0.0461
Brugia malayi Pre-SET motif family protein 0.0064 0.028 0.0465
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.1027 0.1702
Echinococcus granulosus neuropeptide s receptor 0.0483 0.2755 0.4564
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0089 0.0147
Onchocerca volvulus 0.005 0.02 0.0187
Onchocerca volvulus 0.006 0.0259 0.0285
Schistosoma mansoni hypothetical protein 0.0677 0.3901 0.6463
Echinococcus multilocularis excitatory amino acid transporter 3 0.1038 0.6036 0.6036
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0136 0.0075
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0115 0.0115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.1027 0.1702
Leishmania major trypanothione reductase 0.004 0.0139 0.1362
Loa Loa (eye worm) hypothetical protein 0.0105 0.0524 0.0869
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0077 0.0361 0.354
Schistosoma mansoni hypothetical protein 0.0178 0.0955 0.1583
Loa Loa (eye worm) hypothetical protein 0.0147 0.0773 0.1281
Trypanosoma brucei hypothetical protein, conserved 0.0147 0.0773 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0089 0.0147
Schistosoma mansoni aldehyde dehydrogenase 0.0189 0.1019 0.1689
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0136 0.1756
Brugia malayi hypothetical protein 0.0026 0.0059 0.0097
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0189 0.1019 0.1019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.17 0.5816
Schistosoma mansoni cpg binding protein 0.0064 0.0279 0.0462
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0089 0.0147
Onchocerca volvulus 0.0497 0.284 0.4626
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0027 0.0027
Echinococcus multilocularis neuropeptide s receptor 0.0483 0.2755 0.2755
Loa Loa (eye worm) hypothetical protein 0.0147 0.0773 0.1281
Echinococcus granulosus expressed conserved protein 0.0099 0.0487 0.0806
Brugia malayi Niemann-Pick C1 protein precursor 0.0105 0.0524 0.0869
Mycobacterium tuberculosis Probable lipase LipE 0.0147 0.0773 0.1081
Trypanosoma brucei trypanothione reductase 0.004 0.0139 0.1795
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0077 0.0361 0.0361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0089 0.0147
Echinococcus multilocularis expressed conserved protein 0.0099 0.0487 0.0487
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0089 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0089 0.0147
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.0857 0.1421
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0059 0.0757
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.17 0.5816
Mycobacterium ulcerans esterase/lipase LipP 0.0147 0.0773 0.7218
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.028 0.0465
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0207 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0089 0.0147
Schistosoma mansoni hypothetical protein 0.0033 0.0099 0.0165
Echinococcus granulosus excitatory amino acid transporter 2 0.1038 0.6036 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0089 0.0089
Brugia malayi MH2 domain containing protein 0.0118 0.0603 0.0998
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0089 0.0147
Loa Loa (eye worm) excitatory amino acid transporter 0.1038 0.6036 1
Echinococcus granulosus Niemann Pick C1 protein 0.015 0.0791 0.131
Echinococcus multilocularis cpg binding protein 0.0064 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0319 0.1789 0.2965
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.0534 0.0885
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0033 0.0099 0.0165
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.046 0.2622 0.2622
Entamoeba histolytica hypothetical protein 0.0051 0.0207 0.0581
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.0857 0.1421
Schistosoma mansoni survival motor neuron protein 0.005 0.02 0.0331
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.02 0.0331
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0677 0.3901 0.6463
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.017 0.017
Plasmodium vivax glutathione reductase, putative 0.004 0.0139 0.1795
Brugia malayi hypothetical protein 0.0017 0.0004 0.0006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.0522 0.0866
Brugia malayi beta-lactamase family protein 0.0147 0.0773 0.1281
Brugia malayi jmjC domain containing protein 0.0065 0.0285 0.0473
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.0522 0.0866
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0089 0.0147
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0077 0.0361 0.0598
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0091 0.044 0.0516
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0179 0.2317
Echinococcus granulosus GTP binding nuclear protein Ran 0.0047 0.0179 0.0297
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1038 0.6036 1
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.0773 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0136 0.0136
Echinococcus granulosus beta LACTamase domain containing family member 0.0147 0.0773 0.1281
Schistosoma mansoni alpha-glucosidase 0.0139 0.0725 0.1201
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0099 0.0165
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.0773 0.2416
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0147 0.0773 0.1081
Mycobacterium tuberculosis Probable lipase LipD 0.0147 0.0773 0.1081
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0603 0.0998
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.028 0.2751
Brugia malayi jmjC domain containing protein 0.0061 0.0265 0.0439
Plasmodium falciparum glutathione reductase 0.004 0.0139 0.4991
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0139 0.1795
Echinococcus granulosus importin subunit beta 1 0.0063 0.0278 0.0461
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0089 0.0147
Leishmania major hypothetical protein, conserved 0.0026 0.0059 0.0574
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.1027 0.1702
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0047 0.0179 0.0179
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0089 0.0147
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.1357 0.1357
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1038 0.6036 0.6036
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0136 0.0225
Echinococcus granulosus snurportin 1 0.0677 0.3901 0.6463
Loa Loa (eye worm) hypothetical protein 0.0055 0.023 0.0381
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0097
Brugia malayi hypothetical protein 0.0017 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0043 0.016 0.0266
Onchocerca volvulus 0.0093 0.0455 0.0616
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0089 0.0147
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.017 0.0282
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0285 0.0473
Treponema pallidum glutamate/aspartate transporter 0.046 0.2622 1
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0265 0.0439
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0115 0.1131
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0147 0.0773 0.7218
Echinococcus granulosus geminin 0.0178 0.0955 0.1583
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0005 0.0009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.1027 0.1027
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0089 0.0147
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0089 0.0147
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0047 0.0179 0.1758
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0005 0.0009
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0139 0.023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0089 0.0147
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0136 0.1756
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.17 0.5816
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0089 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.028 0.0465
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0089 0.0089
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0101 0.05 0.0617
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.028 0.028
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0105 0.0524 0.2582
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.067 0.1111
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0361 0.4664
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.17 0.5816
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0101 0.05 0.0617
Echinococcus multilocularis snurportin 1 0.0677 0.3901 0.3901
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.028 0.0465
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0115 0.149
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.028 0.028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.028 0.0465
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0089 0.0089
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0136 0.1332
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0089 0.0147
Brugia malayi Importin beta-1 subunit 0.0063 0.0278 0.0461
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0089 0.0147
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0361 0.4664
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0089 0.0089
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.1027 0.1702
Chlamydia trachomatis glutamate symporter 0.1038 0.6036 1
Echinococcus granulosus Protein patched homolog 1 0.0045 0.017 0.0282
Mycobacterium tuberculosis Conserved protein 0.0147 0.0773 0.1081
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0101 0.05 0.1756
Schistosoma mansoni ran 0.0047 0.0179 0.0297
Echinococcus granulosus Excitatory amino acid transporter 0.1038 0.6036 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.17 0.5816
Echinococcus multilocularis neuropeptide receptor A26 0.0483 0.2755 0.2755
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0089 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0089 0.0147
Brugia malayi beta-lactamase 0.0147 0.0773 0.1281
Mycobacterium tuberculosis Conserved protein 0.0147 0.0773 0.1081
Loa Loa (eye worm) hypothetical protein 0.0033 0.0099 0.0165
Loa Loa (eye worm) hypothetical protein 0.0064 0.028 0.0465
Echinococcus granulosus neutral amino acid transporter A 0.1038 0.6036 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0179 0.2317
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0089 0.0147
Brugia malayi Muscleblind-like protein 0.0319 0.1789 0.2965
Echinococcus multilocularis neutral amino acid transporter A 0.1038 0.6036 0.6036
Echinococcus multilocularis excitatory amino acid transporter 2 0.1038 0.6036 0.6036
Mycobacterium tuberculosis Probable hydrolase 0.0147 0.0773 0.1081
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.1019 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.017 0.0282
Brugia malayi follicle stimulating hormone receptor 0.0232 0.1274 0.2111
Toxoplasma gondii HEAT repeat-containing protein 0.0063 0.0278 0.2728
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0077 0.0361 0.0901
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0147
Echinococcus multilocularis neutral amino acid transporter A 0.1038 0.6036 0.6036
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.0773 0.2416
Mycobacterium tuberculosis Probable reductase 0.0091 0.044 0.0516
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0089 0.0147
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0285 0.0473
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.0522 0.0866
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0089 0.0147
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0089 0.0147
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0147 0.0773 0.1281
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0005 0.0005
Echinococcus multilocularis beta LACTamase domain containing family member 0.0147 0.0773 0.0773
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0043 0.016 0.0266
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.0781 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0189 0.1019 0.1497
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0147 0.0773 0.1081
Echinococcus granulosus cpg binding protein 0.0064 0.0279 0.0462
Onchocerca volvulus 0.0147 0.0773 0.1151
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0089 0.0147
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0059 0.2104
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0115 0.0191
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0091 0.044 0.0516
Schistosoma mansoni hypothetical protein 0.0043 0.016 0.0266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0089 0.0147
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0285 0.0473
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0189 0.1019 0.1689
Schistosoma mansoni ap endonuclease 0.0039 0.0136 0.0225
Echinococcus multilocularis importin subunit beta 1 0.0063 0.0278 0.0278
Mycobacterium leprae conserved hypothetical protein 0.0147 0.0773 0.9779
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0285 0.0473
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0115 0.0191
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0207 0.0338
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0136 0.0225
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1038 0.6036 0.6036
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.0773 0.1281
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0089 0.0147
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0099 0.0165
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0327 0.0541
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0027 0.0045
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0089 0.0089
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.17 0.5816
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0026 0.0042
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.0781 0.7304
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0361 0.0901
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0059 0.0757
Brugia malayi glutathione reductase 0.004 0.0139 0.023
Loa Loa (eye worm) hypothetical protein 0.0072 0.0327 0.0541
Echinococcus multilocularis excitatory amino acid transporter 2 0.1038 0.6036 0.6036
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0139 0.0005
Echinococcus multilocularis dnaJ subfamily B 0.0856 0.496 0.496
Schistosoma mansoni alpha glucosidase 0.0036 0.0115 0.0191
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0047 0.0179 0.0278
Echinococcus granulosus excitatory amino acid transporter 2 0.1038 0.6036 1
Brugia malayi hypothetical protein 0.0246 0.1357 0.2248
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0089 0.0147
Brugia malayi RNA, U transporter 1 0.018 0.0968 0.1605
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0089 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0089 0.0147
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0059 0.0757
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1038 0.6036 1
Toxoplasma gondii aldehyde dehydrogenase 0.0189 0.1019 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0147
Echinococcus multilocularis GPCR, family 2 0.0033 0.0099 0.0099
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0189 0.1019 1
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.1357 0.2248
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.1274 0.2111
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0089 0.0147
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0136 0.0225
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0047 0.0179 0.6445
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.0781 0.1094
Echinococcus multilocularis Niemann Pick C1 protein 0.0105 0.0524 0.0524
Mycobacterium ulcerans lipase LipD 0.0147 0.0773 0.7218
Echinococcus multilocularis protein patched 0.0045 0.017 0.017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.1019 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0147
Brugia malayi beta-lactamase family protein 0.0147 0.0773 0.1281
Brugia malayi Excitatory amino acid transporter 0.1038 0.6036 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0077 0.0361 0.0598
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0136 0.4884
Onchocerca volvulus 0.0147 0.0773 0.1151
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.059 0.5787
Echinococcus multilocularis Niemann Pick C1 protein 0.015 0.0791 0.0791
Echinococcus multilocularis protein dispatched 1 0.0051 0.0208 0.0208
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0207 0.0338
Echinococcus granulosus excitatory amino acid transporter 3 0.1038 0.6036 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0002 0.0002
Schistosoma mansoni coup transcription factor 0.0031 0.0089 0.0147
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.17 0.5816
Brugia malayi nuclear receptor NHR-88 0.0031 0.0089 0.0147
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0136 0.1756
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0027 0.0045
Mycobacterium tuberculosis Conserved protein 0.0147 0.0773 0.1081
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0142 0.0235
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0089 0.0147
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0099 0.0165
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0089 0.0147
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0265 0.0265
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0136 0.1756
Trypanosoma brucei glucosidase, putative 0.0036 0.0115 0.149
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0115 0.149
Trichomonas vaginalis set domain proteins, putative 0.0497 0.284 1
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0139 0.1795
Brugia malayi hypothetical protein 0.0017 0.0002 0.0002
Schistosoma mansoni patched 1 0.0045 0.017 0.0282
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0089 0.0147
Schistosoma mansoni cpg binding protein 0.006 0.0259 0.0429
Plasmodium vivax SET domain protein, putative 0.0064 0.028 0.3625
Echinococcus granulosus neutral amino acid transporter A 0.1038 0.6036 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0077 0.0361 0.0598
Loa Loa (eye worm) hypothetical protein 0.0147 0.0773 0.1281
Echinococcus multilocularis microtubule associated protein 2 0.0725 0.4186 0.4186
Schistosoma mansoni hypothetical protein 0.0033 0.0099 0.0165
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0603 0.0998
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.002 0.002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.1019 1
Echinococcus granulosus sodium:dicarboxylate symporter 0.1038 0.6036 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0278 0.3595
Echinococcus multilocularis muscleblind protein 1 0.0319 0.1789 0.1789
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.1027 0.1702
Schistosoma mansoni ap endonuclease 0.0039 0.0136 0.0225
Schistosoma mansoni microtubule-associated protein tau 0.0725 0.4186 0.6936
Echinococcus multilocularis neutral amino acid transporter A 0.1038 0.6036 0.6036
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0099 0.0165
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0304 0.17 1
Echinococcus granulosus muscleblind protein 0.0319 0.1789 0.2965
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0099 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0089 0.0147
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0089 0.0147
Plasmodium vivax hypothetical protein, conserved 0.0147 0.0773 1
Brugia malayi CHE-14 protein 0.0045 0.017 0.0282
Onchocerca volvulus 0.0064 0.028 0.0322
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0091 0.044 0.0516
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.1027 0.1702
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1038 0.6036 1
Echinococcus multilocularis geminin 0.0178 0.0955 0.0955
Schistosoma mansoni ran 0.0047 0.0179 0.0297
Plasmodium falciparum importin beta, putative 0.0063 0.0278 1
Plasmodium falciparum thioredoxin reductase 0.004 0.0139 0.4991
Schistosoma mansoni hypothetical protein 0.0856 0.496 0.8218
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0002 0.0002
Echinococcus granulosus Excitatory amino acid transporter 0.1038 0.6036 1
Echinococcus multilocularis Excitatory amino acid transporter 0.1038 0.6036 0.6036
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0147
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0002 0.0002
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0857 0.0857
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0077 0.0361 0.0598
Loa Loa (eye worm) hypothetical protein 0.0105 0.0522 0.0866
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0077 0.0361 0.1549
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0773 0.2416
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0437 0.2484 0.4116
Loa Loa (eye worm) hypothetical protein 0.0246 0.1357 0.2248
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0089 0.0147
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0115 0.0191
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0361 0.4664
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.046 0.2622 0.4343
Trichomonas vaginalis esterase, putative 0.0147 0.0773 0.2416
Treponema pallidum fructose-bisphosphate aldolase 0.0304 0.17 0.6291
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0002 0.0002
Echinococcus granulosus neutral amino acid transporter 0.1038 0.6036 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0077 0.0361 0.0598
Schistosoma mansoni hypothetical protein 0.005 0.02 0.0331
Schistosoma mansoni importin beta-1 0.0063 0.0278 0.0461
Echinococcus multilocularis ubiquitin specific protease 41 0.0077 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0147 0.0773 0.1281
Echinococcus granulosus dnaJ subfamily B 0.0856 0.496 0.8218
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.046 0.2622 0.4343
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.017 0.0282
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0077 0.0361 0.0361
Schistosoma mansoni aldehyde dehydrogenase 0.0189 0.1019 0.1689
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0089 0.0147
Brugia malayi nuclear hormone receptor 0.0031 0.0089 0.0147
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0259 0.0429
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0047 0.0179 0.2317
Leishmania major importin beta-1 subunit, putative 0.0051 0.0207 0.2034
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0099 0.0099
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0941 0.5461 0.9026
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0002 0.0002
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0059 0.0574
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0773 0.2416
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0099 0.0165

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 123 % MDR-reversing activity in K562/ADM cells at 1 microM concentration of [3H]-VCR (vincristine), activity expressed relative to verapamil. ChEMBL. 9207946
Activity (functional) = 123 % MDR-reversing activity in K562/ADM cells at 1 microM concentration of [3H]-VCR (vincristine), activity expressed relative to verapamil. ChEMBL. 9207946

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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