Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Endothelin receptor ET-B | Starlite/ChEMBL | References |
Rattus norvegicus | Endothelin receptor ET-A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Endothelin receptor ET-B | 443 aa | 371 aa | 20.5 % | |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | Endothelin receptor ET-A | 426 aa | 412 aa | 20.1 % |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | Endothelin receptor ET-A | 426 aa | 412 aa | 21.1 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Endothelin receptor ET-B | 443 aa | 392 aa | 23.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.4066 | 0.3982 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0044 | 0.7396 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0139 | 0.0139 |
Echinococcus granulosus | lamin | 0.0031 | 0.4066 | 0.3982 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 1 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0044 | 0.7396 | 0.5 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.004 | 0.6252 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0044 | 0.7396 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0044 | 0.7396 | 0.736 |
Onchocerca volvulus | 0.0031 | 0.4066 | 0.5 | |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0044 | 0.7396 | 0.736 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0044 | 0.7396 | 0.7396 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.4066 | 0.4066 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.3927 | 0.3927 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0044 | 0.7396 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.4066 | 0.4066 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 1 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.7396 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0044 | 0.7396 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.4066 | 0.3982 |
Schistosoma mansoni | inositol monophosphatase | 0.0044 | 0.7396 | 0.5612 |
Echinococcus multilocularis | lamin | 0.0031 | 0.4066 | 0.3982 |
Echinococcus multilocularis | musashi | 0.0031 | 0.4066 | 0.3982 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0542 | 0.0542 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.004 | 0.6252 | 0.5 |
Onchocerca volvulus | 0.0031 | 0.4066 | 0.5 | |
Brugia malayi | intermediate filament protein | 0.0031 | 0.4066 | 0.3726 |
Brugia malayi | Inositol-1 | 0.0044 | 0.7396 | 0.7247 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.4066 | 0.4066 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0044 | 0.7396 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0044 | 0.7396 | 0.5612 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.7396 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0044 | 0.7396 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.7396 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.4066 | 0.3726 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.7396 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.4066 | 0.3982 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 74 nM | Binding affinity for endothelin A receptor by inhibition of [125I]-ET-1 binding in rat aorta smooth muscle cells | ChEMBL. | 11985472 |
IC50 (binding) | = 74 nM | Ability to displace [125I]-ET-1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells. | ChEMBL. | 15139753 |
IC50 (binding) | = 74 nM | Binding affinity for endothelin A receptor by inhibition of [125I]-ET-1 binding in rat aorta smooth muscle cells | ChEMBL. | 11985472 |
IC50 (binding) | = 74 nM | Ability to displace [125I]-ET-1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells. | ChEMBL. | 15139753 |
IC50 (binding) | = 540 nM | Binding affinity to endothelin B receptor measured by inhibition of [125I]-ET-3 binding recombinant pig ET-B receptor expressed in COS-7 cells | ChEMBL. | 11985472 |
IC50 (binding) | = 540 nM | Binding affinity to endothelin B receptor measured by inhibition of [125I]-ET-3 binding recombinant pig ET-B receptor expressed in COS-7 cells | ChEMBL. | 11985472 |
Ratio (binding) | = 7.3 | Ratio of inhibitory concentrations at ET-B receptor relative to that of ET-A receptor | ChEMBL. | 11985472 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.