Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0138 | 0.4694 | 0.5536 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.4694 | 0.4694 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0162 | 0.8478 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.4694 | 0.4694 |
Brugia malayi | thymidylate synthase | 0.0162 | 0.8478 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0162 | 0.8478 | 0.8478 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0159 | 0.8047 | 0.9491 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.4694 | 0.4694 |
Brugia malayi | TAR-binding protein | 0.0138 | 0.4694 | 0.5536 |
Echinococcus multilocularis | geminin | 0.0172 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0162 | 0.8478 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.8047 | 0.9491 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0159 | 0.8047 | 0.9491 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0162 | 0.8478 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0162 | 0.8478 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0162 | 0.8478 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0162 | 0.8478 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0162 | 0.8478 | 0.7132 |
Onchocerca volvulus | 0.0162 | 0.8478 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.4694 | 0.4694 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.4694 | 0.4694 |
Brugia malayi | RNA binding protein | 0.0138 | 0.4694 | 0.5536 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0162 | 0.8478 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0138 | 0.4694 | 0.5536 |
Echinococcus granulosus | thymidylate synthase | 0.0162 | 0.8478 | 0.7132 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0159 | 0.8047 | 0.9491 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0162 | 0.8478 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0138 | 0.4694 | 0.5536 |
Loa Loa (eye worm) | TAR-binding protein | 0.0138 | 0.4694 | 0.5536 |
Loa Loa (eye worm) | thymidylate synthase | 0.0162 | 0.8478 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0162 | 0.8478 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4800 uM | Inhibition of [3H]GABA uptake at mouse GAT1 expressed in D8 cells | ChEMBL. | 17517506 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.