Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MET proto-oncogene, receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.7429 | 0.7429 |
Schistosoma mansoni | plexin | 0.0021 | 0.2846 | 0.2846 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.7429 | 0.5 |
Schistosoma mansoni | plexin | 0.0012 | 0.0803 | 0.0803 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.7429 | 0.5 |
Brugia malayi | hypothetical protein | 0.004 | 0.7429 | 0.7429 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.7429 | 0.5 |
Brugia malayi | Plexin repeat family protein | 0.0021 | 0.2846 | 0.2846 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0803 | 0.0803 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.7429 | 0.7429 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 1 | 1 |
Echinococcus granulosus | plexin a4 | 0.0025 | 0.3741 | 0.3741 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0803 | 0.0803 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.7429 | 0.7429 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.7429 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | plexin A | 0.0025 | 0.3741 | 0.3741 |
Onchocerca volvulus | 0.0021 | 0.2846 | 1 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.7429 | 0.7429 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 1 | 1 |
Echinococcus multilocularis | plexin a4 | 0.0025 | 0.3741 | 0.3741 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.2846 | 0.2846 |
Brugia malayi | plexin A | 0.0025 | 0.3741 | 0.3741 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 nM | Inhibition of human c-MET | ChEMBL. | 21641696 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.