Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.089 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0041 | 0.0886 | 0.3814 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0068 | 0.2002 | 0.8615 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.1251 | 0.5382 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.0951 | 0.2714 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0258 | 0.1109 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1202 | 0.4769 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.089 | 0.3828 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.1251 | 0.3751 |
Echinococcus granulosus | chromobox protein 1 | 0.0076 | 0.2324 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.1084 | 0.3419 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0041 | 0.0886 | 0.3814 |
Echinococcus multilocularis | chromobox protein 1 | 0.0076 | 0.2324 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1251 | 0.5382 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.089 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.252 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0068 | 0.2002 | 0.8615 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.089 | 0.3828 |
Onchocerca volvulus | 0.0041 | 0.089 | 0.6202 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.089 | 0.2389 |
Brugia malayi | Heterochromatin protein 1 | 0.0076 | 0.2324 | 0.8315 |
Loa Loa (eye worm) | bromodomain containing protein | 0.002 | 0.0029 | 0.0114 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.089 | 0.3828 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.089 | 0.3531 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0118 | 0.051 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.1251 | 0.5382 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.1251 | 0.4965 |
Schistosoma mansoni | bromodomain containing protein | 0.0072 | 0.2171 | 0.9338 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.089 | 0.3828 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.089 | 0.2389 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.089 | 0.2215 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.089 | 0.3531 |
Trichomonas vaginalis | chromobox protein, putative | 0.0076 | 0.2324 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0076 | 0.2324 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.089 | 0.2389 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.089 | 0.2389 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.089 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0076 | 0.2324 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.0951 | 0.2714 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0041 | 0.089 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1251 | 0.5382 |
Schistosoma mansoni | chromobox protein | 0.0076 | 0.2324 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.0951 | 0.7399 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.1251 | 0.5382 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0258 | 0.1109 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1112 | 0.4413 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0168 | 0.0723 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0168 | 0.0667 |
Toxoplasma gondii | ABC1 family protein | 0.0041 | 0.089 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.089 | 0.3531 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.089 | 0.2215 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0041 | 0.089 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.1084 | 0.3419 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1001 | 0.3972 |
Echinococcus granulosus | chromobox protein 1 | 0.0076 | 0.2324 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0041 | 0.089 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.089 | 0.2389 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.089 | 0.5 |
Brugia malayi | beta-lactamase | 0.0041 | 0.089 | 0.2215 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.089 | 0.2389 |
Mycobacterium ulcerans | lipase LipD | 0.0041 | 0.089 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.089 | 0.3531 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.089 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0118 | 0.051 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0046 | 0.1084 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0041 | 0.089 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.089 | 0.3531 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0951 | 0.3774 |
Schistosoma mansoni | chromobox protein | 0.0076 | 0.2324 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.089 | 0.5 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0076 | 0.2324 | 0.9224 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0258 | 0.1109 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.089 | 0.3531 |
Onchocerca volvulus | 0.0041 | 0.089 | 0.6202 | |
Brugia malayi | chromobox protein homolog 3 | 0.0043 | 0.0951 | 0.2475 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0118 | 0.051 |
Brugia malayi | Bromodomain containing protein | 0.0086 | 0.2721 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.089 | 0.3531 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.089 | 0.2215 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.1251 | 0.5382 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.089 | 0.3531 |
Onchocerca volvulus | 0.0041 | 0.089 | 0.6202 | |
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.0998 | 0.2673 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1251 | 0.5382 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0573 | 0.2272 |
Mycobacterium leprae | Probable lipase LipE | 0.0041 | 0.089 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of mushroom tyrosinase using L-DOPA as substrate at 50 uM after 10 mins by UV absorbance method | ChEMBL. | 21840713 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.