Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) | 0.00435291 | 0.186865 | 0.5 |
Toxoplasma gondii | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0123608 | 0.730229 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0163366 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0123608 | 0.730229 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0058345 | 0.287397 | 0.287397 |
Loa Loa (eye worm) | hypothetical protein | 0.00200695 | 0.0276841 | 0.0379116 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0163366 | 1 | 1 |
Echinococcus granulosus | RUN | 0.0058345 | 0.287397 | 0.287397 |
Loa Loa (eye worm) | AStacin protease | 0.00396785 | 0.160738 | 0.22012 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0123608 | 0.730229 | 1 |
Loa Loa (eye worm) | dUTP diphosphatase | 0.0123608 | 0.730229 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0058345 | 0.287397 | 0.287397 |
Echinococcus multilocularis | Tolloid protein 1 | 0.00574331 | 0.281209 | 0.281209 |
Brugia malayi | dUTP diphosphatase | 0.0123608 | 0.730229 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0058345 | 0.287397 | 0.00860787 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0058345 | 0.287397 | 0.287397 |
Onchocerca volvulus | 0.0058345 | 0.287397 | 0.5 | |
Schistosoma mansoni | rab6-interacting | 0.0058345 | 0.287397 | 0.00860787 |
Mycobacterium leprae | PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) | 0.00435291 | 0.186865 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058345 | 0.287397 | 0.393571 |
Plasmodium vivax | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0123608 | 0.730229 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0080079 | 0.434869 | 0.456424 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0123608 | 0.730229 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0058345 | 0.287397 | 0.00860787 |
Loa Loa (eye worm) | hypothetical protein | 0.0058345 | 0.287397 | 0.393571 |
Treponema pallidum | deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) | 0.0123608 | 0.730229 | 0.5 |
Echinococcus multilocularis | RUN | 0.0058345 | 0.287397 | 0.287397 |
Wolbachia endosymbiont of Brugia malayi | dUTPase | 0.0123608 | 0.730229 | 1 |
Onchocerca volvulus | 0.0058345 | 0.287397 | 0.5 | |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0058345 | 0.287397 | 0.287397 |
Brugia malayi | Doublecortin family protein | 0.0058345 | 0.287397 | 0.393571 |
Echinococcus multilocularis | dUTP pyrophosphatase | 0.0123608 | 0.730229 | 0.730229 |
Chlamydia trachomatis | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0123608 | 0.730229 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.00574331 | 0.281209 | 0.385098 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0123608 | 0.730229 | 1 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0058345 | 0.287397 | 0.287397 |
Brugia malayi | hypothetical protein | 0.0058345 | 0.287397 | 0.393571 |
Schistosoma mansoni | polycystin 1-related | 0.0058345 | 0.287397 | 0.00860787 |
Echinococcus granulosus | dUTP pyrophosphatase | 0.0123608 | 0.730229 | 0.730229 |
Entamoeba histolytica | hypothetical protein | 0.0123608 | 0.730229 | 1 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0123608 | 0.730229 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.00574331 | 0.281209 | 0.281209 |
Mycobacterium ulcerans | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.00435291 | 0.186865 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00546094 | 0.262049 | 0.358859 |
Loa Loa (eye worm) | doublecortin family protein | 0.0058345 | 0.287397 | 0.393571 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0163366 | 1 | 1 |
Trichomonas vaginalis | deoxyuridine 5'-triphosphate nucleotidohydrolase, putative | 0.0123608 | 0.730229 | 0.5 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0123608 | 0.730229 | 1 |
Schistosoma mansoni | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0123608 | 0.730229 | 0.624687 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative | 0.0123608 | 0.730229 | 1 |
Brugia malayi | hypothetical protein | 0.0058345 | 0.287397 | 0.393571 |
Schistosoma mansoni | rab6-interacting | 0.0058345 | 0.287397 | 0.00860787 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0058345 | 0.287397 | 0.287397 |
Plasmodium falciparum | deoxyuridine 5'-triphosphate nucleotidohydrolase | 0.0123608 | 0.730229 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0080079 | 0.434869 | 0.456424 |
Schistosoma mansoni | loxhd1 | 0.0058345 | 0.287397 | 0.00860787 |
Mycobacterium ulcerans | deoxycytidine triphosphate deaminase | 0.00435291 | 0.186865 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3 uM | Antimalarial activity against blood stage Plasmodium falciparum infected in human red blood cells after 1 hr by propidium iodide staining based microscopic analysis | ChEMBL. | 21600680 |
Ki (binding) | > 1000 uM | Inhibition of human dUTPase using dUTP as substrate by spectrophotometric analysis | ChEMBL. | 21600680 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 21600680 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.