Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sigma non-opioid intracellular receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | peroxidasin | 0.0258 | 0.519 | 0.9634 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0258 | 0.519 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0258 | 0.519 | 0.519 |
Schistosoma mansoni | lipoxygenase | 0.0265 | 0.5387 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.519 | 0.3104 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0258 | 0.519 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0186 | 0.3332 | 0.6184 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0258 | 0.519 | 0.3104 |
Schistosoma mansoni | peroxidasin | 0.0258 | 0.519 | 0.9634 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.519 | 0.3104 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.519 | 0.3104 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.519 | 0.3104 |
Onchocerca volvulus | 0.0258 | 0.519 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0258 | 0.519 | 0.3104 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0258 | 0.519 | 0.3104 |
Brugia malayi | Animal haem peroxidase family protein | 0.0258 | 0.519 | 0.519 |
Brugia malayi | hypothetical protein | 0.0258 | 0.519 | 0.519 |
Brugia malayi | Animal haem peroxidase family protein | 0.0258 | 0.519 | 0.519 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.519 | 0.3104 |
Onchocerca volvulus | Peroxidasin homolog | 0.0258 | 0.519 | 0.5 |
Brugia malayi | hypothetical protein | 0.0188 | 0.34 | 0.34 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.519 | 0.3104 |
Onchocerca volvulus | 0.0258 | 0.519 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.519 | 0.3104 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0258 | 0.519 | 0.3104 |
Onchocerca volvulus | Peroxidase homolog | 0.0258 | 0.519 | 0.5 |
Brugia malayi | Peroxidasin | 0.0258 | 0.519 | 0.519 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0258 | 0.519 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0258 | 0.519 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.4405 | 0.198 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0265 | 0.5387 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.519 | 0.3104 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.519 | 0.3104 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.34 | 0.0538 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.519 | 0.3104 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.519 | 0.3104 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.519 | 0.3104 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0258 | 0.519 | 0.3104 |
Brugia malayi | Animal haem peroxidase family protein | 0.0258 | 0.519 | 0.519 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.519 | 0.3104 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 1 | 0.5 |
Brugia malayi | hypoxia-induced factor 1 | 0.0174 | 0.3024 | 0.3024 |
Brugia malayi | Animal haem peroxidase family protein | 0.0258 | 0.519 | 0.519 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0265 | 0.5387 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.519 | 0.3104 |
Onchocerca volvulus | 0.0258 | 0.519 | 0.5 | |
Brugia malayi | Blistered cuticle protein 3 | 0.0258 | 0.519 | 0.519 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | nM | In vitro binding affinity at Sigma opioid receptor type 2 on guinea pig brain membranes by [3H]-DTG displacement in the presence of [3H]-pentazocine; Not tested. | ChEMBL. | 10508444 |
IC50 (binding) | nM | In vitro binding affinity at Dopamine receptor D2 of rat striatal membranes by [3H]-raclopride displacement; Not tested. | ChEMBL. | 10508444 |
IC50 (binding) | = 130 nM | In vitro binding affinity at Sigma opioid receptors on guinea pig brain membranes by [3H]-3-PPP displacement. | ChEMBL. | 10508444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.